@article {329,
	title = {Anti-Alzheimer Activity of Novel 1,3,4-Thiadiazole Derivatives},
	journal = {World journal of chemistry},
	volume = {6},
	year = {2011},
	note = {<p>n/a</p>
},
	pages = {96-106},
	abstract = {<p>The reaction of the new enaminone 2 with ?-ketohydrazonoyl chlorides 3 afforded 5-(pyrazol-4-yl)-carbonyl-2-benzoylimino-1,3,4-thiadiazoles 5. Treatment of 5a with hydrazine hydrate led to formation of pyrazolo[3,4-d]pyridazine derivatives 8. The reaction of enaminone 2 with 6-amino-2-thioxopyrimidin-4-one 9 in acetic acid under reflux produced 2-thioxopyridopyrimidinone derivative 10. The latter compound or its methylthio derivative 15 reacts with hydrazonoyl chlorides 3 to give pyridotriazolopyrimidine derivatives 14. The newly synthesized compounds 2, 5, 8 and 14 were tested for their anti-alzheimer activity, and the results which obtained revealed their potency as drugs for Alzheimer disease.</p>
},
	attachments = {https://scholar.cu.edu.eg/sites/default/files/science_sector_publications/files/6.pdf},
	author = {Magda A. Abdallah and Thoraya A. Farghaly and Mohamed M. Abdalla andZienab A. Muhammad}
}
