SWG, B., E. M, A. AR, and H. MS, "Assessment of left ventricular function in systemic lupus erythematosus patients by speckle tracking echocardiography: Relation to circulating endothelial progenitor cells", The Egyptian Rheumatologist, vol. 37, pp. S33-S41, 2015. Abstract

Background Systemic lupus erythematosus (SLE) is an autoimmune disease associated with reduced number and impaired function of endothelial progenitor cells (EPCs) responsible for vascular regeneration. Aim The aim of this study was to assess left ventricular (LV) function of SLE patients using the relatively new speckle tracking echocardiography (STE) and examine whether any detected abnormalities of LV function have any relation with peripheral circulating EPCs level. Methods Fifty SLE patients and 25 healthy controls were subjected to quantification of peripheral circulating VEGFR2+/CD133+ and VEGFR2+/CD34+ EPCs, transthoracic echocardiography (TTE), tissue Doppler imaging (TDI) and STE. Results Patients showed a significantly lower CD133+/VEGFR2+ EPCs (p= 0.009) and CD34+/VEGFR2+ EPCs counts (p= 0.0001) compared to controls. TTE/TDI revealed a significantly lower LV ejection fraction (EF) (p=0.007), higher LV end systolic dimensions (p=0.02), myocardial performance index (MPI) (p=0.0001) and mitral flow E/lateral annulus E' ratio (p=0.002) in patients compared to controls. STE showed a significantly lower global longitudinal strain (GLS) (p value <0.001), global circumferential strain (GCS) (p<0.001) and global strain rate during isovolumic relaxation period (GSRivr) (p=0.01) in patients compared to controls. No correlation was detected between age of the patients, duration of disease, prednisolone dose or intake duration, use of azathioprine vs. cyclophosphamide, SLE disease activity index, LV MPI, LV EF, CD133+/VEGFR2+ EPCs or CD34+/VEGFR2+ EPCs count and GLS. By multiple logistic regression analysis, the independent variables affecting GCS and GSRivr were the prednisolone dose and the LVEF respectively. (95% CI = -0.46 to -0.03; p= 0.03 and 95% CI = 0.001 to 0.01; p=0.021; respectively). Conclusion
STE detected subclinical systolic and diastolic abnormalities of LV function in SLE patients. These abnormalities of LV function did not show however any relation with the significantly lower EPCs count detected in patients.
 

HH, H., B. SWG, M. M, and Z. A, "Comparison of Immediate Results of Percutaneous Mitral Commissurotomy using the Metallic Valvulotome versus Inoue Balloon Technique.", European Society of Cardiology Annual meeting , Amsterdam, The Netherlands, August, 2000.
SWG, B., A. R. H. A, and F. HA, "Assessment of Diastolic and Systolic Left Ventricular Function by Tissue Doppler Imaging in Patients with Type 2 Diabetes Mellitus: Predictive Value of B-Natriuretic Peptide", European Society of Cardiology Annual meeting , Munich, Germany, August, 2008.
A, F., B. S, S. MA, and E. - F. A, "Young diabetic patients had increased coronary and extracoronary atherosclerotic burden as detected by multidetector computed tomography.", 23rd Scientific meeting of the International Society of Hypertension, Vancouver, Canada, September, 2010.
SWG, B., A. SA, B. DA, and E. - T. SMR, "Psoriasis: a localized skin disorder or a systemic inflammatory disease affecting left ventricular myocardial function.", European Heart Failure Annual meeting , Belgrade, Serbia, 2012.
SWG, B., S. SM, E. MZ, and R. HZ, "Impact of waist Impact of waist circumference on hospital outcome and coronary angiographic findings of patients with acute ST-segment elevation myocardial infarction.", Tenth International Congress on Coronary Artery Disease , Florence, Italy, October, 2013.
HS, T., B. SWG, K. HH, and S. MA, "Quality of cardiopulmonary resuscitation and its relation to outcome during in hospital cardiac arrest in university hospital cardiology departments : the egyptian experience.", European Society of Cardiology Annual Acute Cardiovascular Care Congress., Geneve,Switzerland, October 2014.
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