@article {191899, title = {Subconjunctival bevacizumab for corneal neovascularization.}, journal = {Acta ophthalmologica}, volume = {88}, year = {2010}, pages = {868-71}, abstract = {

PURPOSE: This work aimed to study and evaluate the effect of subconjunctival bevacizumab injection in patients with corneal neovascularization (CNV) resulting from different ocular surface disorders.

METHODS: Ten eyes with CNV caused by different ocular surface disorders were studied. All eyes had both major and minor vessel CNV caused by factors such as healed corneal ulcers, long-standing chronic inflammatory diseases and corneal ischaemia (caused by contact lenses). All eyes received a single subconjunctival injection of 2.5mg (0.1ml) bevacizumab. Morphological changes in the major and minor vessels were evaluated using slit-lamp biomicroscopy and corneal photography.

RESULTS: Conspicuous recession of the minor vessels of CNV was observed in all eyes at 2 weeks post-injection. The extent of CNV of the major vessels was significantly decreased at 2 weeks post-injection. The level of CNV continued to decrease noticeably for 3 months and then stabilized for the remainder of the 6-month follow-up period. Parameters used for evaluation included the total area of CNV, which amounted to 14.0 {\textpm} 5.4\% of the corneal surface pre-injection, compared with 9.4 {\textpm} 3.9\% post-injection (p \< 0.01), reflecting a mean decrease in CNV of 33 {\textpm} 8\%, and the extent of neovascularization, which decreased from 4.3 {\textpm} 1.5 clock hours pre-injection to 2.4 {\textpm} 1.1 clock hours post-injection (p \<0.01). During the 6-month follow-up, none of the 10 eyes showed any complication that could be related to subconjunctival bevacizumab injection.

CONCLUSIONS: Bevacizumab can be used safely and effectively for CNV resulting from different ocular surface disorders. It represents an effective treatment for minor vessel neovascularization caused by long-standing chronic inflammation (e.g. trachoma) or long-standing corneal ischaemia (e.g. contact lenses), as well as for major vessel neovascularization resulting from different causes. Bevacizumab was well tolerated over the 6-month follow-up period.

}, author = {Zaki, Ahmed A and Farid, Samar F} }