@article {211270,
	title = {Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress.},
	journal = {Archives of physiology and biochemistry},
	year = {2020},
	pages = {1-8},
	abstract = {<p> We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and whether it is associated with the suppression of glycaemia, dyslipidemia and inflammatory and oxidative stress biomarkers. T2DM was induced by streptozotocin (50 mg/kg body weight) and high carbohydrate and fat diet (HCFD). The protective group was put on resveratrol (30 mg/kg) 14 days prior to the induction of diabetes and continued on resveratrol and HCFD until being sacrificed at week 12. Diabetic rats showed a substantial damage to the knee joints and loss of proteoglycans from the articular cartilage, which were effectively but not completly protected by resveratrol. Resveratrol also significantly ( <= .0029) reduced diabetic up-regulation of HbA1c, hyperlipidaemia, inflammation and oxidative stress. Resveratrol protects against T2DM-induced OA associated with the inhibition of glycated haemoglobin, dyslipidemia, and biomarkers of oxidative stress and inflammation.</p>
},
	author = {Ebrahim, Hasnaa A and Alzamil, Norah M and Bahjat Al-Ani and Haidara, Mohamed A and Kamar, Samaa S and Dawood, Amal F}
}
