Atorvastatin

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Darwish, H. W., S. A. Hassan, M. Y. Salem, and B. A. El-Zeany, "Three different methods for determination of binary mixture of Amlodipine and Atorvastatin using dual wavelength spectrophotometry", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 104, pp. 70–76, 2013. Abstractabstract.pdfWebsite

Three simple, specific, accurate and precise spectrophotometric methods depending on the proper selection of two wavelengths are developed for the simultaneous determination of Amlodipine besylate (AML) and Atorvastatin calcium (ATV) in tablet dosage forms. The first method is the new Ratio Difference method, the second method is the Bivariate method and the third one is the Absorbance Ratio method. The calibration curve is linear over the concentration range of 4–40 and 8–32 μg/mL for AML and ATV, respectively. These methods are tested by analyzing synthetic mixtures of the above drugs and they are applied to commercial pharmaceutical preparation of the subjected drugs. Methods are validated according to the ICH guidelines and accuracy, precision, repeatability and robustness are found to be within the acceptable limit. The mathematical explanation of the procedures is illustrated.

Darwish, H. W., S. A. Hassan, M. Y. Salem, and B. A. El-Zeany, "Development and validation of H-point standard addition method applied for the analysis of binary mixture of amlodipine and atorvastatin", International Journal of Pharma and Bio Sciences, vol. 4, issue 2, pp. 230 - 243, 2013. Abstractabstract.pdfWebsite

Simple, specific, accurate and precise spectrophotometric method was developed for
the simultaneous determination of Amlodipine besylate (AML) and Atorvastatin calcium
(ATV) in tablet dosage forms. The proposed H-Point Standard Addition Method
(HPSAM) involves addition of the analyte of interest on the binary mixture, measuring
the absorbance at two wavelengths and then the calibration curves are used to estimate
the concentration of the main analyte and interfernt one. Two analytical wavelengths
selected were 241.0-252.4 nm and 278.0-305.6 nm for the estimation of AML and ATV;
respectively. The calibration curves were linear over the concentration range of 4-40
and 8-32 µg/mL for AML and ATV, respectively. This method was tested by analyzing
synthetic mixtures of the above drugs and they were applied to commercial
pharmaceutical preparation of the subjected drugs. The standard deviation was < 1.5 in
the assay of raw materials and tablets. Methods were validated as per ICH guidelines
and accuracy, precision, repeatability and robustness were found to be within the
acceptable limit.

Darwish, H. W., S. A. Hassan, M. Y. Salem, and B. A. El-Zeiny, "Three different spectrophotometric methods manipulating ratio spectra for determination of binary mixture of Amlodipine and Atorvastatin", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 83, pp. 140– 148, 2011. Abstractabstract.pdfWebsite

Three simple, specific, accurate and precise spectrophotometric methods manipulating ratio spectra are developed for the simultaneous determination of Amlodipine besylate (AM) and Atorvastatin calcium (AT) in tablet dosage forms. The first method is first derivative of the ratio spectra (1DD), the second is ratio subtraction and the third is the method of mean centering of ratio spectra. The calibration curve is linear over the concentration range of 3–40 and 8–32 μg/ml for AM and AT, respectively. These methods are tested by analyzing synthetic mixtures of the above drugs and they are applied to commercial pharmaceutical preparation of the subjected drugs. Standard deviation is <1.5 in the assay of raw materials and tablets. Methods are validated as per ICH guidelines and accuracy, precision, repeatability and robustness are found to be within the acceptable limit.

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