Hassan, S. A., and S. A. Abdel-Gawad, "Application of wavelet and Fuorier transforms as powerful alternatives for derivative spectrophotometry in analysis of binary mixtures: A comparative study", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 191: Elsevier, pp. 365-371, 2018. Abstract
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Quality Control 115 (2017)

Semester: 
Spring
Hassan, S. A., E. S. Elzanfaly, S. B. A. El-Zeany, and M. Y. Salem, "Development and validation of HPLC and CE methods for simultaneous determination of amlodipine and atorvastatin in the presence of their acidic degradation products in tablets", Acta pharmaceutica, vol. 66, issue 4, pp. 479-490, 2016. Abstract
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Analytical Chemistry II (2015)

Semester: 
Spring
Elzanfaly, E. S., S. A. Hassan, M. Y. Salem, and B. A. El-Zeany, "In-line potentiometric monitoring of dissolution behavior of verapamil hydrochloride versus traditional pharmacopeial method: A comparative study", Sensors and Actuators B: Chemical: Elsevier, 2016. Abstract
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Darwish, H. W., S. A. Hassan, M. Y. Salem, and B. A. El-Zeany, "Advanced stability indicating chemometric methods for quantitation of amlodipine and atorvastatin in their quinary mixture with acidic degradation products", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 154: Elsevier, pp. 58-66, 2016. Abstract
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Hassan, S. A., E. S. Elzanfaly, M. Y. Salem, and B. A. El-Zeany, "Mean centering of double divisor ratio spectra, a novel spectrophotometric method for analysis of ternary mixtures", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 153: Elsevier, pp. 132-142, 2016. AbstractAbstract.pdfWebsite

A novel spectrophotometric methodwas developed for determination of ternary mixtureswithout previous separation, showing significant advantages over conventionalmethods. The newmethod is based onmean centering of double divisor ratio spectra. The mathematical explanation of the procedure is illustrated. The method was evaluated by determination of model ternary mixture and by the determination of Amlodipine (AML), Aliskiren (ALI) and Hydrochlorothiazide (HCT) in laboratory prepared mixtures and in a commercial pharmaceutical preparation. For proper presentation of the advantages and applicability of the new method, a comparative study was established between the new mean centering of double divisor ratio spectra (MCDD) and two similar methods used for analysis of ternary mixtures, namely mean centering (MC) and double divisor of ratio spectraderivative spectrophotometry (DDRS-DS). The methodwas also comparedwith a reported one for analysis of the pharmaceutical preparation. The method was validated according to the ICH guidelines and accuracy, precision, repeatability and robustness were found to be within the acceptable limits.

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