Mohamed M. Sayed-Ahmed

CURRICULUM VITAE

 

 

NAME:

                            

Mohamed Mohamed Sayed-Ahmed

                                                           

MAILING ADDRESS:

       

Pharmacology and Experimental Oncology Unit, National Cancer                                                  Institute, Cairo University, Kasr El-Aini Street, Foum El-Khalig, 11796                                            Cairo, Egypt

.

                                                Mobile.       00201001720659

                                                Fax.           0020223644720

                                                e.mail: sayedahmedmm@hotmail.com

                                                           

DATE OF BIRTH

:              

09/03/1962

 

NATIONALITY:

                 

Egyptian.

 

MARITAL STATUS:          Married to Dr. Amira Zakzouk in 1992.  Have Two Children, Walaa and                                           Ahmed Mohamed Sayed-Ahmed

EDUCATION:

 

1980-1985

                              

B. Pharmaceutical SC. Hon., Zagazig Faculty of Pharmacy.

 

1988-1992                               Master of Pharmacology and Experimental Oncology, Faculty of                                                    Pharmacy, Cairo University. Thesis: Effect of Local Hyperthermia                                                  and Some Anticancer Drugs in the Treatment of Solid Ehrlich                                                        Carcinoma.

 

1992-1995                               Ph.D. Pharmacology and Experimental Oncology, Duke                                                                  University, Medical Center, North Carolina, USA and National                                                        Cancer Institute, Cairo University. Thesis: Pharmacological and                                                      Biochemical Studies on The Mechanisms of Adriamycin Induced-                                                 Cardiotoxicity.

 

EMPLOYMENT RECORDS:

 

1988-1992

                             

Demonstrator of Pharmacology and Experimental Oncology,                                                          Pharmacology Unit, National Cancer Institute, Cairo University.

 

1992-1997                               Assistant Lecturer of Pharmacology and Experimental

                                               Oncology, Pharmacology Unit, National Cancer Institute, Cairo                                                       University.

 

1994-1997:                              Ph.D student at Duke University, Medical Center, USA.

 

1997-2002:                              Assistant Professor of Pharmacology and Experimental                                                                 Oncology, Pharmacology Unit, National Cancer Institute, Cairo                                                      University.

 

2002-2004:                              Director of Pharmacology and Experimental Oncology Unit,                                                           National Cancer Institute, Cairo University.

 

2002-2004:                              Associate Professor of Pharmacology and Experimental                                                                Oncology, Cancer Biology Department, National Cancer Institute,                                                  Cairo University.

 

2004-2007:                              Associate Professor of Pharmacology and Experimental                                                               Oncology, Pharmacology and Toxicology Department, College of                                                   Pharmacy, King Saud University, Kingdom Saudi Arabia.

 

2007-2017                               Professor of  Pharmacology and Experimental Oncology,                                                               Pharmacology and Toxicology Department, College of Pharmacy,                                                   King Saud University, Kingdom Saudi Arabia.

 

2017-Present:                         Professor of Pharmacology and Experimental Oncology,                                                               Pharmacology Unit, National Cancer Institute, Cairo University.

 

May, 2009                     Winner of Distinguished Research and                                                   Publication Award, King Saud University.

 

October, 2010                        Invited Speaker by Sigma-Tau Foundation, Italy and presented 3                                                 lectures in the National Institute of Health, University of Bolognia                                                  and university of Brescia, Italy.

 

2010-2012                               Scientific Consultant for the Research Center, College of                                                               Pharmacy, King Saud University, Kingdom Saudi Arabia.

                                               

May, 2011                              Keynote Speaker in the 4^th Annual World Cancer Congress,                                                          Dalian, China.

 

May, 2012                              Keynote Speaker in the 5^th  Annual World Cancer Congress,                                                      Beijien, China.

 

May, 2013                              Keynote Speaker in the 6^th Annual World Cancer Congress, Xian,                                                 China.

 

April, 2014                             Keynote Speaker in the 4^th  international conference on Clinical                                                    and Experimental Cardiology, San Antonio, Texas, USA.

 

April, 2015                             Keynote Speaker in the 3rd Pharma-Nutrition Conference,                                                               Philadelphia, USA.

 

September, 2019                    Member of the Permanent Committee for promotion of assistant                                                   and associate Professor (Pharmacology and Clinical Pharmacy,                                                       Committee # 96,  Round 13).

 

November, 2019                    Keynote Speaker in Bridging Gaps in Oncology

                                                Conference, National Cancer Institute, Egypt.

 

November, 2020                    Among the top 2 % of the best Scientists worldwide according to                                                        STANFORD UNIVERSIRTY.     

 

November, 2021                    Among the top 2 % of the best Scientists worldwide according to                                                   STANFORD UNIVERSIRTY.     

 

November, 2021                    Keynote Speaker in Bridging Gaps in Oncology

                                                Conference, National Cancer Institute, Egypt.

 

 

 

 

 

 

 

 

 

 

 

 

TEACHING EXPERIENCES:

 

1-      Teaching experience in Pharmacology and Toxicology Department, College of Pharmacy, King Saud University, Kingdom Saudi Arabia.

 

Course Code	Course Title	Student Level
PHL 322	Pharmacology-2	Undergraduate
PHL 326	Pharmacology-2	Pharm. D. Undergraduate
PHL 417	Clinical Pharmacology-3	Pharm. D. Undergraduate
PHL 425	Clinical Pharmacology-4	Undergraduate
PHL 433	Clinical Toxicology	Undergraduate
PHL 454	Biological Standardization	Undergraduate
PHL 101	Pharmacology for Nursing	Undergraduate
PHL 512	Advanced Pharmacology	Postgraduate
PHL 522	Advanced Clinical Toxicology	Postgraduate
PHL 534	Environmental and Industrial Toxicology	Postgraduate
PHL 541	Pharmacometrics	Postgraduate
PHL 533	Drugs of Abuse	Postgraduate

 

2- Teaching experience in Pharmacology and Toxicology for Undergraduate students, Faculty of pharmacy, Al-ahram Canidian University.

 

3-Teaching experience in Toxicology, Pharmacology and Experimental

     Oncology for Postgraduate students, National Cancer Institute, Cairo University.

 

4- Teaching experience in Pharmacology and Toxicology for Postgraduate students,

     Faculty of pharmacy, Ain Shams University.

 

 

5- Teaching experience in Clinical pharmacology and Toxicology for Clinical

    Pharmacy Students at National Cancer Institute, Cairo University.

 

5- Teaching experience in Toxicology, Pharmacology and Experimental Oncology

    for M.D. student, South Egypt Cancer Institute, Assuit University.

 

 

RESEARCH EXPERIENCES

:

 

Research Experience in studying gene expression of biological markers as potential therapeutic targets in different types of cancer including, breast and ovarian cancer.

 

Research Experience in using L-carnitine and Propionyl-l-carnitine as protective

agents against Anticancer drug-induced organs toxicity.(Duke University, Medical Center, USA).

 

Research Experience in modulation of Anticancer drugs-induced organ toxicity.

(Duke University, Medical Center, USA).

 

Research Experience in study the effects of anticancer drugs on cardiac and hepatic

metabolism using isotopic dilution technique (Duke University,Medical Center, USA).

 

Research Experience in isolation of Cardiac myocytes and liver hepatocytes as

toxicity model to study radioactive substrate oxidation in response to anticancer drugs (Duke University, Medical Center, USA).

 

Research Experience in modulation of tumour cell drug resistance and in tissue culture Technique dealing with the growth of human tumour cells, tumour cell cycle phase determination using flowcytometery.         

 

Good experience in screening the potentially antiangiogenic and antimetastatic agents as biological therapy of cancer and in screening anticancer agents and the interaction between anticancer drugs and other drugs using different tumour cell lines.

 

Good experience in using HPLC technique for determination of plasma level of

anticancer drugs, Antibiotics, Narcotics, and L-carnitine as a routine used for the treatment and follow up of Egyptian Cancer Patients.(Therapeutic drug monitoring)

 

 

 

 

 

 

 

 

PRINCIPAL INVESTIGATOR OF THE FOLLOWING RESEARCH PROJECTS

 

Principal Investigator of the project (12-MED2889-02-R) entitled “Characterization of Fatty Acid Synthase and Carnitine Palmitoyltransferase I Pathways in Triple-Negative Breast Cancer Saudi Females as Potential Targeted-Therapy” Funded from National Plain for Science and Technology (1.856.450 SR), King Saud University, Saudi Arabia (COMPLETED).

 

Principal Investigator of the project entitled “Identification of some genes in ovarian cancer of saudi women as potential Diagnostic and targeted-therapy” Funded from KACST, Saudi Arabia 1900.000 saudi riyals (COMPLETED).

 

Principal Investigator of the project (09-BIO939-02) entitled “Characterization of Biological Markers in Triple-Negative Breast Cancer Saudi Women as potential Molecular Targeted-Therapy” Funded from National Plain for Science and Technology (1.200.000 SR), King Saud University, Saudi Arabia (COMPLETED).

 

Principal Investigator of the Research Project (CPRC 154) Entitled: Protective Role of carnitine against diethylnitrosamine-induced hepatocarcinogenesis in rats (Completed).

 

     Principal Investigator of the Research Project (CPRC 155) Entitled:   Evaluation of cisplatin-induced cardiac and renal dysfunction in carnitine-depleted rat model (Completed).

 

     Principal Investigator of the Research Project (CPRC 171) Entitled:  Evaluation of

     Gentamicin-Induced Hepatorenal Dysfunction in Carnitine Depleted Rats by D-carnitine and g-Butyrobetaine Hydroxylase Inhibitor (Completed).

 

     Principal Investigator of the Research Project (CPRC 230) Entitled: Role of L-carnitine in  Ifosfamide-induced Fanconi Syndrome in rats (Completed).

 

     Principal Investigator of the Research Project (CPRC 232) Entitled: Does thymoquinone supplementation protect against diethylnitrosamine-induced hepatocarcinogenesis in rats (completed).

 

     Principal Investigator of the Research Project (CPRC 242) Entitled Molecular study on the preventive role of carnitine against induction of hepatocellular carcinoma (completed).

 

     Main Supervisor for the master thesis of the student Amal Qasem Darweesh Entitled: Possible mechanism(s) of oxazaphosphorines-induced cardiotoxicity in normal and carnitine depleted rats, Pharmacology Department, College of Pharmacy, King Saud University             (Completed 2009).

 

Supervisor of Ph.D and M.Sc Thesis:

 

Fatema Alaa El-Din Mohamed Galal Selim

Mechanism(s) of Methotrexat-Induced Nephrotoxicity in Rats: Role of L-carnitine. College of Pharmacy, Cairo University (2021).

Ola Salah Mohamed

 Pharmacological Study on Lactoferrin Effect against Cyclophosphamide-Induced Nephrotoxicity in Rats. College of Pharmacy (Girls), Al-Azhar University (2021).

Riham Mohamed Karkeet

Therapeutic Role of HMG-CoA Reductase Inhibition in Castrated Egyptian Prostate Cancer Patients. National Cancer Institute, Cairo Universiy. (2021)

Hend Sayed Mohamed (M.SC):

IMPACT OF CARBONIC ANHYDRASE INHIBITION ON HUMAN BREAST CANCER CELLS. College of Pharmacy (Girls), Al-Azhar University (2020).

Somow Samy Kamel (M.SC):

Effect of Astaxanthin on Cyclophosphamide-Induced Cardiotoxicity in Rats. College of Pharmacy (Girls), Al-Azhar University (2020).

Esraa Mohamed Montaser Khalifa (Ph.D):

Effect of Resveratrol on Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma. College of Pharmacy, Minia University, Egypt (2019).

Asmaa Soliman (Ph.D):

Possible Mechanism(s) of Paclitaxel-Induced Peripheral Nephropathy. College of Pharmacy, Minia University, Egypt (2019).

Meshan Lafy Al-Delemy (Ph.D):

Characterization of Fatty Acid Synthase in Triple Negative Breast Cancer As a Possible Therapeutic Target.. College of Pharmacy, King Saud University, Saudi Arabia (2016).

Layla A. Alkharashi (Ph.D):

Role of DNA methyltransferase1 in the activation of breast stromal fibroblasts and their pro-carcinogenic effects: use of inhibitors as therapeutic agents. College of Pharmacy (female section), King Saud University, Saudi Arabia (2015).

 

 

Badr Ibrahim Alrufaiq (M.SC):

Effect of L-Carnitine on Sunitinib-Induced cardiotoxicity in Rats. College of Pharmacy, King Saud University, Saudi arabia (2015).

Meshan Lafy Al-Delemy (M.SC):

Molecular Mechanisms of Oxazaphosphorines-Induced cardiotoxicity in  Rats. College of Pharmacy, King Saud University, Saudi Arabia (2012).

Amal Qassem Al-Darweesh (M.SC, Female Section)

 

Possible  Mechanisms of Oxazaphosphorines-Induced cardiotoxicity in Normal and Carnitine Depleted Rats.  College of Pharmacy, King Saud University, Saudi Arabia (2009).

Ashraf Mostafa Fahmey (Ph.D):                

                                                                

Comparative clinical study on pharmacokinetics and toxicity of 5- fluorouracil in Egyptian colorectal cancer patients under iv push or iv perfusion regimen in different protocols. College of Pharmacy, Mansoura University, Egypt (2008)

Marwa Wageh Ahmed (M.Sc):

Molecular mechanisms of cellular resistance to doxorubicin in murine tumours.    College of Pharmacy, Cairo University, Egypt (2006).

Editorial Board Member:

1-      World Journal of Clinical Urology

2-      World Journal of Transplantation

3-      Saudi Pharmaceutical Journal

4-      Journal of Pharmaceutical Care & Health Systems

5-      Journal of Clinical and Laboratory Investigation Updates

6-      Journal of Egyptian National Cancer Institute

Peer Reviewer for International Journals:

 

1-      International Immunopharmacology

2-      European Journal of Pharmacology

3-      Clinical and Experimental Medicine

4-      Forenters

5-      Phytomedicine

6-      PLOSE1

7-      Journal of Physiology and Biochemistry

8-      Human and Experimental Toxicology

9-      Molecular Nutrition and Food Research

10-  Molecular and Cellular Biochemistry

11-  Chemotherapy

12-  Pediatric Research

13-  Pakistani Journal of Pharmacology

14-  BMC Central

15-  Scientific Research and Essays

16-  Saudi Pharmaceutical Journal

17-  King Khalled University Journal

18-  Journal of Basic and Clinical Pharmacology

List of Publications:

1-

         Osman, A. M. ;

Sayed-Ahmed, M. M

.

; Khayyal, M. T. and El-      Merzabani, M. M.

:

Hyperthermic Potentiation of Cisplatin on Solid Ehrlich Carcinoma.

 Tumori 1993, 79:  268-272.

 

2-

         Shouman, S. A.;

Sayed-Ahmed, M. M

. and El-Merzabani, M.M

:

  Potentiation of the Chemotherapeutic Effect of Methotrexate by Hyperthermia in Experimental Animal Tumour Model.

J. Egypt. Nat. Cancer Inst. 1994 , 6:  868-876.

 

3-

         Abdel-aleem, S. ; Sharawi, S. ; Badr, M. ;

Sayed-Ahmed, M. M

. ; Anstadt, M. P. and Lowe, J.E.

:

 Reduced Induction of Carbohydrate Utilization by Inhibition of Fatty Acid Oxidation in Myocytes From Diabetic Animals.

Horm. Metab. Res. 1994, 27:  104-106.

 

4-

         Abdel-aleem, S. ;

Sayed-Ahmed, M. M

. ; Nada, M. A. ;      Hendrickson, S. C. ; Louis, J.S. and Lowe, J.E.:  Stimulation of Non-Oxidative Glucose Utilization by

L-carnitine in Isolated Myocytes.

J. Mol. Cell. Cardiol. 1995, 27: 2465-2472

.

 

5-

         Abdel-aleem, S. ;

Sayed-Ahmed, M. M

. ; Nada, M. A. ;      Hendrickson, S. C. ; Louis, J.S., Walthhall, H.P. and Lowe, J.E.:  Regulation of Fatty Acid Oxidation by Acetyl-CoA Generated From Glucose Utilization in Isolated Myocytes.

J. Mol. Cell. Cardiol. 1996,28:  825-833.

 

6-

         Abdel-aleem, S ; El-Merzabani, M. M. ;

Sayed-Ahmed, M. M. ;

Taylor, D. A.

and Lowe, J. E.:  Acute and Chronic Effects of Adriamycin on Fatty Acid Oxidation in Isolated Cardiac Myocytes. 

J. Mol. Cell. Cardiol. 1997, 29:  789-797.

 

7-

         Abidli, N.,

Sayed-Ahmed, M.M.

, El-Gerzawy,S.M.,El-Didi, M.M. Benlatreche,C.,El-Merzabani,M.M. and Osman,A.M: Verapamil enhancement of the cytotoxic and cell cycle perturbation of doxorubicin in Ehrlich ascites carcinoma cells in vivo. 

J. Egyptian National Cancer Institute 1999; 10: 433-438.

 

8-         Sayed-Ahmed, M.M.

,Sharawy, S.,Shouman,S.A. And Osman,A.M..: Reversal

of doxorubicin-induced cardiac metabolic damage by l-carnitine. 

Pharmacol. Res. 1999, 39: 289-295

.

 

9-         Sayed-Ahmed, M.M.

, Khattab, M., Khalifa, A., El-Khabany, M. and Osman, A.M: Potenial promise of using L-carnitine and Coenzyme Q10 as protective agents against Cisplatin-induced nephrotoxicity.

J. Egyptian National Cancer Institute 1999; 11:167-173.

 

 

 

10-

       Hanafy M.,

Sayed-Ahmed, M.M.

and Osman A.M.

: 

The protective effect

of methimazole against cisplatin-induced chromosomal abberrations

. Sc. J. Az. Med. Fac.(Girls) 1999, 20: 637-645.

 

11-       Sayed-Ahmed M.M.

, Shouman, S.A., Rezk, B.M., Khalifa, M.H.,Osman, A.M. and El-Merzabani

,

M.M

:

Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria.

Pharmacol. Res. 2000, 41: 143-150.

 

12-

       Salman T.M. and

Sayed-Ahmed M.M.:

 Effects of trichloroactate, water chlorination by-product, on liver peroxisomes and antioxidant status in rats and mice.

Sc. J. Az. Med. Fac.(Girls) 2000, 21: 631-648.

 

13-

       Osman,A.M. Mohamed M.A., Abdel-Wahab A.A.,and

Sayed-Ahmed M.M.

Modulation by verapamil of doxorubicin induced expression of multidrug resistance gene (MDR-1 P-glycoprotein) in murine tumour mode. 

J. Egyptian Nat. Cancer Inst. 2000; 12: 221-227.

 

14-       Sayed-Ahmed MM

, Kishk AM, Soloma S and Abdel-aleem S

:

Protection by L-carnitine against the inhibition of gene expression of heart fatty acid binding protein by chronic administration of doxorubicin.

J. Egyptian Nat. Cancer Inst. 2000, 12:  275-281.

 

15-

       Osman AM,Gaballa H, Mohamed NH, Ali NM., Sayed-Ahmed MM, Arafa HM : Plasma endothelin( ET-1) as a marker for doxorubicin-induced cardiotoxicity in Egyptian patients.

J.Egypt Soc.Toxicol 2000; 23:  59-64.

 

16-

       Ramadan LA, El-Habit O, Arafa H and

Sayed-Ahmed MM : 

Effect of cremophor-El on cisplatin induced organs toxicity in normal rats.

J. Egyptian Nat.   Cancer Inst. 2001, 13: 11-17.

 

17-       Sayed-Ahmed, M.M

., Salman T.M., Gaballah, H.E., Abo El-Nagah, S.A., Nicolia, R. and  Calvani, M.:  Propionyl-l-carnitine as protector against adriamycin-induced cardiomyopathy.

Pharmacol. Res. 2001, 43:  513-520.

 

18-

       Ramadan LA, Shouman SA,

Sayed-Ahmed Mmand

El-Habit OH

:

 Modulation of radiation induced organs toxicity by Cremophor-El in experimental animals.

Pharmacol Res 2001, 43:  185-191.

 

19-       Sayed-Ahmed M.M.,

Khattab M.M., Gad M.Z. and Osman A.M.:  Increased

plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy.

Pharmacology & Toxicology 2001, 89:  140-144

.

 

20-       Sayed-Ahmed M.M. ,

Khattab M.M.,  Gad M.Z. and  Mostafa N.

:

 L-carnitine

prevents the progression of Atherosclerotic lesions in hypercholesterolemic rabbits. 

Pharmacol Res  2001; 44:  235-242.

 

21-       Sayed-Ahmed M.M

., Shouman S.A., and Ramadan L.A.: Contribution of nitric oxide in doxorubicin-related cytotoxicity in murine tumour model.  

J Egyptian Nat Cancer Inst 2002; 14:  111-116.

  

22-

       Arafa H.M. and

Sayed-Ahmed M.M.:

Protective role of carnitine esters against alcohol-induced gastric lesions in rats.

Pharmacol Res 2003;  48:  285-290.

 

23-

       El-Demerdash E., Ali A.A.,

Sayed-Ahmed M.M.

and Osman A.M.:  New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity. 

Cancer  Chemother and Pharmacol  2003; 52:  411-416.

 

24-       Sayed-Ahmed MM,

Eissa MA, Kenawy SA, Mostafa M, Calvani M, Osman AM. Progression of cisplatin-induced nephrotoxicity in a carnitine depleted rat model.

Chemotherapy 2004; 50:  162-170.

 

 

25-       Sayed-Ahmed M.M.,

Mansour H.H., Gharib O.A. and Hafez F.H:

 

Acetyl-L carnitine Modulates bleomycin-induced oxidative stress and energy depletion in lung tissues. 

JEgyptian Nat Cancer Inst 2004; 16:  237-243.

 

26-       El-Demerdash E., Awad  A.S, Taha R.M,  El-Hady A.M., and                             Sayed-Ahmed M.M.  Probucol attenuates oxidative stress and energy decline in isoproterenol-induced congestive heart failure in rat.  Pharmacol Res 2005;  51:  311-318.

 

27-       Sayed-Ahmed M.M

and Mohamed A. M.: Contribution of nitric oxide and

epidermal growth factor receptor in antimetastatic potenial of paclitaxel in human

liver cancer cells (Heb G2).

J Egyptian Nat Cancer Inst 2005; 17:  35-41.

 

28-       Al-Majed A.A., Sayed-Ahmed M.M., Al-Yahya A.A., Aleisa A.M., Al-Rejaie S.S. Al-Shabanah O.A.  Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. Pharmacol Res 2006; 53:  278-286.

 

29-       Al-Majed A.A., Sayed-Ahmed M.M.,  Al-Omar F.A., Al-Yahya A.A., Aleisa A.M.and Al-Shabanah O.A.:  Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischemia in the rat hippocampus. Clin  Exp Pharmacol Physiol 2006; 33:  725-733.

 

30        Kamel M.W., Salama S.A., Saleh S., Osman A.M., Sayed-Ahmed M.M, Al-Hendy A.  Reversal of doxorubicin resistance by adenovirus-mediated transfer of cyclooxygenase-2 antisense in multidrug-resistant MCF-7 cells.  Cancer Therapy 2007; 5: 1-10.

 

 

31-       Sayed-Ahmed MM:

 Increased Serum and Cardiac Acyl-carnitine/Free Carnitine ratio During Development of  Doxorubicin-Induced Cardiotoxicity.

Saudi Pharmaceutical Journal 2007: 15:  120-126.

 

32-       Sayed-Ahmed MM:

Multidrug resistance to cancer chemotherapy: Genes involved and blockers.

Saudi Pharmaceutical Journal 2007: 15:  161-175.

 

33-

      

Sayed-Ahmed MM

, Nagi MN. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats.

Clin Exp Pharmacol Physiol. 2007 May-Jun; 34(5-6):399-405.

 

34-

       Aleisa AM, Al-Majed AA, Al-Yahya AA, Al-Rejaie SS, Bakheet SA, Al-Shabanah OA,

Sayed-Ahmed MM.

Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues.

Clin Exp Pharmacol Physiol. 2007 Dec; 34(12): 1252-9.

 

35-

       Al-Rejaie SS, Aleisa AM, Al-Yahya AA, Bakheet SA, Alsheikh A, Fatani AG, Al-Shabanah OA,

Sayed-Ahmed MM

. Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats.

World  J Gastroenterol. 2009 Mar 21; 15(11):1373-80

 

36-

       Al-Shabanah OA, Aleisa AM, Al-Yahya AA, Al-Rejaie SS, Bakheet SA, Fatani AG,

Sayed-Ahmed MM.

Increased urinary losses of carnitine and decreased intramitochondrial coenzyme A in gentamicin-induced acute renal failure in rats. Nephrol

Dial Transplant. 2010 Jan; 25(1): 69-76.

 

37-

       Fatani AG, Darweesh AQ, Rizwan L, Aleisa AM, Al-Shabanah OA,

Sayed-Ahmed MM

.  Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats.

Chemotherapy. 2010 Mar 19; 56(1): 71-81.

                                                                                                                               

38-

      

Sayed-Ahmed MM

, Al-Shabanah OA, Hafez MM, Aleisa AM, Al-Rejaie SS. Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model.

Eur J Pharmacol. 2010 May 12; 640(1-3): 143-9.

 

39-

       Nagi MN, Almakki HA,

Sayed-Ahmed MM

, Al-Bekairi AM. Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver.

Food  Chem Toxicol. 2010 Jun 1; 48(8-9): 2361-5.

 

40-

       El-Azab AS, Al-Omar MA, Abdel-Aziz AA, Abdel-Aziz NI, el-Sayed MA, Aleisa AM,

Sayed-Ahmed MM

, Abdel-Hamide SG. Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study.

Eur J Med Chem. 2010 Jun 16; 45(9): 4188-98.

 

41-      

Abdel Baky NA, Zaidi ZF, Fatani AJ,

Sayed-Ahmed MM

, Yaqub H

.

Nitric oxide pros and cons: The role of L-arginine, a nitric oxide precursor, and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat.

Brain Res Bull. 2010 Jul 15; 83(1-2): 49-56.

 

42-

       Sayed-Ahmed MM. Progression of cyclophosphamide-induced acute renal metabolic damage in carnitine-depleted rat model.

Clin Exp Nephrol. 2010 Jul 23, 14(5):  418-26.

                                                                                             

43-

      

Sayed-Ahmed MM.

Role of carnitine in cancer chemotherapy-induced

multiple organ toxicity. 

Saudi Pharmaceutical Journal (2010) August 5, 18: 195–206.

 

44-

      

Sayed-Ahmed MM

, Aleisa AM, Al-Rejaie SS, Al-Yahya AA, Othman A. Al-Shabanah OA, Hafez MM, Nagi MN. Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling.

Oxidative Medicine and Cellular Longevity 2010 July/August, 3:4, 254-261.

 

45-

      

Sayed-Ahmed MM

, Darweesh AQ, Fatani AJ. Carnitine deficiency and oxidative stress provoke cardiotoxicity in an ifosfamide-induced Fanconi Syndrome rat model.

Oxidative Medicine and Cellular Longevity 2010 July/August, 3:4, 266-274.

46-

      Al-shabanah OA, Hafez MM, Al-Harbi MM, Hassan ZK, Al Rejaie SS, Asiri YA,

Sayed-Ahmed MM.

Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation.

Oxid Med Cell Longev. 2010 Nov-Dec;3(6):428-33.

47-

       Nagi MN, Al-Shabanah OA, Hafez MM,

Sayed-Ahmed MM.

Thymoquinone Supplementation Attenuates Cyclophosphamide-Induced Cardiotoxicity in Rats.  

J Biochem Mol Toxicol. 2011 May; 25(3):135-42.

 

48-

      

Sayed-Ahmed MM

.  L-carnitine attenuates Ifosfamide-Induced Carnitine Deficiency and Decreased Intramitochondrial CoA-SH in Rat Kidney Tissues.

J Nephrol. 2011 Jul-Aug;24(4):490-8.

 

49.

       Alhaider AA, Korashy HM,

Sayed-Ahmed MM

, Mobark M, Kfoury H, Mansour MA. Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression.

Chem Biol Interact. 2011 Jul 15; 192(3):233-42.

 

50-

       El-Subbagh HI, Hassan GS, El-Azab AS, Abdel-Aziz AA, Kadi AA, Al-Obaid AM, Al-Shabanah OA,

Sayed-Ahmed MM. 

Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues. 

Eur J Med Chem. 2011 Nov; 46(11):5567-72.

 

1. 51.

         Hafez MM, Hassan ZK, Zekri AR, Gaber AA, Al Rejaie SS,

   Sayed-Ahmed MM

   , Al Shabanah OA.  MicroRNAs and Metastasis-related Gene Expression in Egyptian Breast Cancer Patients.

   Asian Pac J Cancer Prev. 2012;13(2):591-8.

 

1. 52.

          Al-Shabanah OA,  Aleisa AM,  Hafez MM, Al-Rejaie SS, Al-Yahya AA, Saleh A. Bakheet, Mohamed M. Al-Harbi and

   Sayed-Ahmed MM

   .  Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through  TGF-β/Smad p53 pathway in rat model..

   Oxid Med Cell Longev. 2012;2012:619185. Epub 2012 Apr 30.

 

1. 53.

          Sayed-Ahmed MM, Aldelemy ML, Hafez MM, Al-rejaie SS and Al-Shabanah OA. Inhibition of Gene Expression of Organic Cation/Carnitine Transporter and Antioxidant Enzymes in Oxazaphosphorines-Induced Acute Cardiomyopathic

   Rat Models.

   Oxidative Medicine and Cellular Longevity, Volume 2012, Article ID 452902, 13 pages doi:10.1155/2012/452902.

54.       Sayed-Ahmed MM

, Hafez MM, Aldelemy ML, Aleisa AM, Al-Rejaie SS, Al-Hosaini KA, Al-Harbi NO, Al-Harbi MM, Al-Shabanah OA. Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced fanconi syndrome rat model.

Oxid Med Cell Longev. 2012;2012:696704. doi: 10.1155/2012/696704. Epub 2012 Nov 13.

55.      

El-Azab AS, Abdel-Hamide SG,

Sayed-Ahmed  MM

, Hassan GS, El-Hadiyah TM,

Al-Shabanah OA, Al-Deeb OA, El-Subbagh

HI:

Novel 4(3H)-quinazolinone analogs: synthesis and anticonvulsant activity

. Med Chem Res (2013) 22:2815–2827.

 

56.

      

Sayed-Ahmed MM

, Hafez MM, Al-Shabanah AA,  Al-Rejaie SS, Aleisa AM, Al-Yahya AA, Alsheikh A, Al Diab AI, and AL-Akeely MH. Increased expression of biological markers as potential therapeutic targets in Saudi women with triple-negative breast cancer.

Tumori. 2013; 99(4): 545-54.

 

57.      

Lam T, Chen Z,

Sayed-Ahmed MM

, Krassioukov A, Al-Yahya AA. Potential role of oxidative stress on the prescription of rehabilitation interventions in spinal cord injury.

Spinal Cord. 2013 Sep;51(9):656-62.

 

58.

       Al-Rejaie SS, Aleisa AM,

Sayed-Ahmed MM

, Al-Shabanah OA, Abuohashish HM, Ahmed MM, Al-Hosaini KA, Hafez MM Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat.

BMC Complement Altern Med. 2013 Jun 17;13:136. doi: 10.1186/1472-6882-13-136.

 

59.

       Al-Shabanah OA, Hafez MM, Hassan ZK,

Sayed-Ahmed MM

, Abozeed WN, Al-Rejaie SS, Alsheikh AA.  Human papillomavirus genotyping and integration in ovarian cancer Saudi patients. 

Virol J. 2013 Nov 20;10(1):343.

 

60.

    

Sayed-Ahmed MM,

 Aldelemy ML, Al-Shabanah OA, Hafez MM, Al-Hosaini KA, Al-Harbi NO, Al-Sharary SD, Al-Harbi MM. Inhibition of Gene Expression of Carnitine Palmitoyltransferase I and Heart Fatty Acid Binding Protein in Cyclophosphamide and Ifosfamide-Induced Acute Cardiotoxic Rat Models.

Cardiovasc Toxicol. 2014 Jan 28. [Epub ahead of print]

 

61.

       Al-Shabanah OA, Hafez MM, Hassan ZK,

Sayed-Ahmed MM

, Abozeed WN, Alsheikh A, Al-Rejaie SS: Methylation of SFRPs and APC Genes in Ovarian Cancer Infected with High Risk Human Papillomavirus.

Asian Pac J Cancer Prev. 2014

; 15(6):2719-25.

 

62.

       Nadeem A, Siddiqui N, Alharbi NO, Alharbi MM, Imam F,

Sayed-Ahmed MM:

Glutathione modulation during sensitization as well as challenge phase regulates airway reactivity and inflammation in mouse model of allergic asthma..

Biochimie. 2014 Apr 14. pii: S0300-9084(14)00110-2. doi:

 

63.

       Wang X, Patel ND, Hui D, Pal R, Hafez MM,

Sayed-Ahmed MM

, Al-Yahya AA, Michaelis EK:  Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.

BMC Neurosci. 2014 Mar 4; 15:37. doi: 10.1186/1471-2202-15-37.

64.

      Al-Harbi NO, Imam F, Al-Harbi MM, Iqbal M, Nadeem A,

Sayed-Ahmed MM

, Alabidy AD, Almukhallafi AF: Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue.

Biomed Res Int. 2014;2014:607246. doi: 10.1155/2014/607246. Epub 2014 May 28.

65.

       Hafez MM, Al-Shabanah OA, Al-Harbi NO, Al-Harbi MM, Al-Rejaie SS, Alsurayea SM,

Sayed-Ahmed MM

. Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4.

Oxid Med Cell Longev. 2014;2014:893212. doi: 10.1155/2014/893212.

66.

       Hafez MM, Al-Shabanah OA, Al-Rejaie SS, Al-Harbi NO, Hassan ZK, Alsheikh A, Al Theyab AI, Aldelemy ML,

Sayed-Ahmed MM

. Increased Hypermethylation of Glutathione S-Transferase P1, DNA-Binding Protein Inhibitor, Death Associated Protein Kinase and Paired Box Protein-5 Genes in Triple-Negative Breast Cancer Saudi Females.

Asian Pac J Cancer Prev. 2015;16(2):541-9.

67.

       Nadeem A, Alharbi NO, Vliagoftis H, Tyagi M, Ahmad SF,

Sayed-Ahmed MM

. Protease activated receptor-2 mediated dual oxidase-2 upregulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma.

Immunology. 2015 Jul; 145(3): 391-403.

 68.     

Al-Harbi NO, Nadeem A, Al-Harbi MM, Imam F, Al-Shabanah OA, Ahmad SF, 

Sayed-Ahmed MM

, Bahashwan SA. Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma.

      Int Immunopharmacol. 2015 Apr 3;26(1):237-245.

69.      

Al-Harbi NO, Imam F, Nadeem A, Al-Harbi MM, Korashy HM,

Sayed-Ahmed MM

, Hafez MM, Al-Shabanah OA, Nagi MN, Bahashwan S. Riboflavin attenuates lipopolysaccharide-induced lung injury in rats.

Toxicol Mech Methods. 2015 Jun;25(5):417-23.

70.

       Hafez MM, Alhoshani AR, Al-Hosaini KA, Alsharari SD, Al Rejaie SS,

Sayed-Ahmed MM

, Al-Shabanah OA. SKP2/P27Kip1 pathway is associated with Advanced Ovarian Cancer in Saudi Patients.

Asian Pac J Cancer Prev. 2015;16(14):5807-15.

71.

       Hafez MM, Al-Harbi NO, Al-Hoshani AR, Al-Hosaini KA, Al Shrari SD, Al Rejaie SS,

Sayed-Ahmed MM

, Al-Shabanah OA. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats.

Biol Res. 2015 Jun 11;48:30.

72.

       Al-Harbi NO, Imam F, Nadeem A, Al-Harbi MM, Korashy HM,

Sayed-Ahmed MM

, Hafez MM, Al-Shabanah OA, Nagi MN, Bahashwan S. Riboflavin attenuates lipopolysaccharide-induced lung injury in rats.

Toxicol Mech Methods. 2015; 25(5):417-23.

73.

       Al-Harbi NO, Imam F, Al-Harbi MM, Ansari MA, Zoheir KM, Korashy HM,

Sayed-Ahmed MM

, Attia SM, Shabanah OA, Ahmad SF.Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-κB, COX-2, and Pro-inflammatory Mediators. 

Immunol Invest.2016 May;45(4):349-69.

74.

       Imam F, Al-Harbi NO, Al-Harbia MM, Korashy HM, Ansari MA,              

Sayed-Ahmed MM

, Nagi MN, Iqbal M, Khalid Anwer M, Kazmi I, Afzal M, Bahashwan S.  Rutin Attenuates Carfilzomib-Induced Cardiotoxicity Through Inhibition of NF-κB, Hypertrophic Gene Expression and Oxidative Stress.

Cardiovasc Toxicol. 2017 Jan; 17(1): 58-66.

 

75.      

Hafez MM, Hamed SS, El-Khadragy MF, Hassan ZK, Al Rejaie SS,                       

Sayed-Ahmed MM

, Al-Harbi NO, Al-Hosaini KA, Al-Harbi MM, Alhoshani AR, Al-Shabanah OA, Alsharari SD. Effect of ginseng extract on the TGF-β1 signaling pathway in CCl₄-induced liver fibrosis in rats.

BMC Complement Altern Med

.

2017 Jan 13;17(1):45.

 

76.       Sayed-Ahmed MM,

Alrufaiq BI, Alrikabi A, Aldelemy ML, Hafez MM,              Al-Shabanah OA. Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signal in Cardiac Tissues.

Cardiovasc Toxicol, 2019, 19 (4):344-356.

 

77.

       Osman AM, Al-Harthy SE, Mohamed RM, Huwait EA, Al-Kreathy HM, Alkhaled  M,

Sayed-Ahmed MM

:  Dimethyl Sulfoxide Potentiates the Anticancer Activity of Cisplatin Against the Growth of Lung Cancer Cells.

International Journal of Pharmacology; 2019; 15(5): 586-592.

 

78.      

Al-harthy SE, Mashael S. Al-Motairi MS, Al-Kreathy HM, Kamel FO,

        Sayed-Ahmed MM

, Huwait EA, Al-Malkey HS and Osman AM: Enhancement of Doxorubicin Cytotoxicity by Verapamil in Human Breast Cancer Cells.

Journal of Pharmaceutical Research International; 2019; 27 (6): 1-10.

 

79.      

Osman AM, Al-Johani HS,  Kamel FO, Ahmed OA, Huwait and

Sayed-AhmedMM:

5-Fluorouracil and Simvastatin Loaded Solid Lipid Nanoparticles for Effective Treatment of Colorectal Cancer Cells.

International Journal of Pharmacology; 2020; 16(3): 205-213.

 

80.

       Fouad MA ,

Sayed-Ahmed MM

, Huwait EA, Hafez HF and Osman AM. Epigenetic Immunomodulatory effect of Eugenol and Astaxanthin on Doxorubicin Cytotoxicity in Hormonal Positive Breast Cancer Cells.

BMC Pharmacology and Toxicology 2021; 22 (1): 1-15.

81.      

Thabet NA, El-Khouly D

, Sayed-Ahmed MM,

Omran MM

:

Thymoquinone chemosensitizes human colorectal cancer cells to imatinib via uptake/efflux genes modulation.

Clin Exp Pharmacol Physiol, 2021 Jun;48(6): 911-920.

82.

       Abdelhafiz AS, Fouad MA, 

Sayed-Ahmed   MM

 , Kamel MM, Ali A, Fouda M,  Khalil MA, Abdel-Moneim  AS, Kamal  LM: Upregulation of FOXP3 is associated with severity of hypoxia and poor outcomes in COVID-19 patients.

Virology 2021 Nov; 563: 74-81.

83.

       Kamel  SA,  Abdel Baky NA, Karkeet  RM, Osman AM, 

Sayed-Ahmed MM

,  Fouad MA: Astaxanthin extenuates the inhibition of aldehyde dehydrogenase and Klotho protein expression ihn cyclophosphamide-induced acute cardiomyopathic

rat model. Clin Exp Pharmacol Physiol. 2022;49:291–301.

 

 

(Last updated: Mon, 2022-02-14 15:22)