Patterns of relapse in adult Acute lymphoblastic leukemia ( Retrospective study)

Citation:
Mohammed, M. A. M., Z. H, seleem A, and R. R, Patterns of relapse in adult Acute lymphoblastic leukemia ( Retrospective study), , cairo, Cairo university, 2012.

Abstract

Although ALL is a rare disease yet it has a disproportionately large effect on cancer survival

(Haskel et al, 1995).

 

This study was based on retrospective analysis of the data of 40 adult patients with ALL who presented to NEMROCK in the period from 2000 to 2010. Follow up period extended till the end of December 2011, with analysis of response and survival in relation to different risk factors.

 

During the period 2000-2010, two treatment protocols; Holzer and unit C protocols were used. The overall initial response was 82.5%. Comparing the two groups, CR rate was 87.5 Vs 96.1%, and relapse rate was 71% Vs 26% for the two protocols respectively. Systemic relapse represented 69% of all relapses, followed by CNS relapse which represented 31% of relapsed cases.The 5 years overall survival was 57.8%.

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