@article {89200,
	title = {Design and synthesis of novel benzopyran-2-one derivatives of expected antimicrobial activity through DNA gyrase-B inhibition.},
	journal = {Archiv der Pharmazie},
	volume = {341},
	year = {2008},
	note = {n/a},
	month = {2008 Nov},
	pages = {725-33},
	abstract = {<p>In an attempt to find a new class of antibacterial agents, we have synthesized thirty new coumarin (2H-benzopyran-2-one) analogues. These derivatives include substituted azetidin-2-ones (beta-lactam) 3a-f, pyrrolidin-2-ones 4a-f, 2H-1,3,4-oxadiazoles 5a-f, and thiazolidin-4-ones 6a-f attached to 4-phenyl-2H-benzopyran-2-one through an oxyacetamido or an oxymethyl bridge. The target compounds were synthesized starting from 2-oxo-4-phenyl-2H-benzo[b]pyran-7-yl-oxyacetic acid hydrazides 2a-f. The new compounds were evaluated as DNA gyrase-B inhibitors through molecular modeling and docking techniques using the Molsoft ICM 3.4-8C program. The synthesized compounds were also screened for antibacterial activity against four different species of Gram-positive and Gram-negative bacteria; as well as screening against C. albicans for antifungal activity. The molecular modeling data were in accordance with the antimicrobial screening results.</p>
},
	keywords = {Anti-Bacterial Agents, Candida albicans, Computer simulation, Coumarins, Drug Design, Gram-Negative Bacteria, Gram-Positive Bacteria, Models, Molecular, Protein Binding, Topoisomerase II Inhibitors},
	issn = {1521-4184},
	doi = {10.2147/DDDT.S68016},
	author = {Ghaneya S. Hassan and Nahla A. Farag and Gehan H. Hegazy and Reem K. Arafa}
}
