Publications

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2022
El-Aleam, R. A. H., A. M. Sayed, M. N. Taha, R. F. George, H. H. Georgey, and H. M. Abdel-Rahman, "Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation", European Journal of Medicinal Chemistry, vol. 241, pp. 114629, 2022.
Farouk, A. K. B. A. W., H. A. Allam, E. Rashwan, R. F. George, and S. E. - S. Abbas, "Design and synthesis of some new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines as multi tyrosine kinase inhibitors", Bioorganic Chemistry, vol. 128, pp. 106099, 2022.
Aziz, N. A. A. M., R. F. George, K. El-Adl, and W. R. Mahmoud, "Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/ EGFRT790M tyrosine kinase inhibitors", RSC Advances, vol. 12, pp. 12913–12931, 2022.
Abbas, S. E. - S., N. M. Abdel-Gawad, R. F. George, M. A. G. Elyazid, M. A. Zaater, and M. K. El-Ashrey, "Some 2-(4-bromophenoxymethyl)-6-iodo-3-substituted quinazolin-4(3H)ones: Synthesis, cytotoxic activity, EGFR inhibition and molecular docking", Journal of Molecular Structure , vol. 1269 , pp. 133851, 2022.
Said, M. F., R. F. George, A. Petreni, C. T. Supuran, and N. M. Mohamed, "Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity", Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 37, issue 1, pp. 701-717, 2022.
2021
Ewida, M. A., H. A. Ewida, M. S. Ahmed, H. A. Allam, R. I. Elbagary, R. F. George, H. H. Georgey, and H. I. El-Subbagh, "3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations", Bioorganic Chemistry, vol. 115, pp. 105205, 2021.
El-Aleam, R. A. H., R. F. George, H. H. Georgey, and H. M. Abdel-Rahman, "Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance", RSC Advances, vol. 11, pp. 36459–36482, 2021.
Mohamed, A. R., A. E. M. Kerdawy, R. F. George, H. H. Georgey, and N. A. M. Gawad, "Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities", Bioorganic Chemistry, vol. 107, pp. 104569, 2021.
Amin, K. M., G. H. Hegazy, R. F. George, N. R. Ibrahim, and N. M. Mohamed, "Design, synthesis, and pharmacological characterization of some 2‐substituted‐3‐phenyl‐quinazolin‐4(3H)‐one derivatives as phosphodiesterase inhibitors", Archiv der Pharmazie, vol. 354, pp. e2100051, 2021.
Bokhita, R. M., S. S. Panda, A. S. Girgis, H. H. Honkanadavar, T. S. Ibrahim, R. F. George, M. O. N. A. T. KASHEF, W. A. L. I. D. FAYAD, R. Sakhuja, E. H. Abdel-Aal, et al., "Flouroquinolone-3-carboxamide amino acid conjugates: Synthesis, antibacterial properties and molecular modeling studies", Medicinal Chemistry, vol. 17, pp. 71-84, 2021.
Hassan, G. S., H. H. Georgey, E. Z. Mohammed, R. F. George, W. R. Mahmoud, and F. A. Omar, "Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 inhibitors", European Journal of Medicinal Chemistry , vol. 218, pp. 113389, 2021.
Ewida, M. A., H. A. Ewida, M. S. Ahmed, H. A. Allam, R. I. Elbagary, R. F. George, H. H. Georgey, and H. I. El‐Subbagh, "Nanomolar potency of imidazo[2,1‐b]thiazole analogs as indoleamine 2,3‐dioxygenase inhibitors", Archiv der Pharmazie, vol. 354, pp. e2100202, 2021.
Mahdally, N. H., R. F. George, M. O. N. A. T. KASHEF, M. Al-Ghobashy, F. E. Murad, and A. S. Attia, "Staquorsin: A Novel Staphylococcus aureus Agr-Mediated Quorum Sensing Inhibitor Impairing Virulence in vivo Without Notable Resistance Development", Frontiers in Microbiology, vol. 12, pp. 700494, 2021.
Mohammed, E. Z., W. R. Mahmoud, R. F. George, G. S. Hassan, F. A. Omar, and H. H. Georgey, "Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs)", Bioorganic Chemistry, vol. 116, pp. 105347, 2021.
2020
Osman, E. E. A., N. S. Hanafy, R. F. George, and S. M. El-Moghazy, "Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors", Bioorganic Chemistry, vol. 104, pp. 104198, 2020.
Seliem, I. A., S. S. Panda, A. S. Girgis, Y. I. Nagy, R. F. George, W. Fayed, N. G. Fawzy, T. S. Ibrahim, A. M. M. Al-Mahmoudy, R. Sakhuja, et al., "Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone–dichloroacetic acid hybrids", Chemical Biology & Drug Design, vol. 95, pp. 248-259, 2020.
Elwaie, T. A., S. E. Abbas, E. I. Aly, R. F. George, H. Ali, N. Kraiouchkine, K. S. Abdelwahed, T. E. Fandy, K. E. A. Sayed, Z. A. Y. Elmageed, et al., "HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability", Journal of Medicinal Chemistry, vol. 63, issue 24, pp. 15906−15945, 2020.
George, R. F., M. Kandeel, D. Y. El-Ansary, and A. E. M. Kerdawy, "Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking", Bioorganic Chemistry, vol. 99, pp. 103780, 2020.
George, R. F., M. F. Said, S. Bua, and C. T. Supuran, "Synthesis and selective inhibitory effects of some 2-oxindole benzenesulfonamide conjugates on human carbonic anhydrase isoforms CA I, CA II, CA IX and CAXII", Bioorganic Chemistry, vol. 95, pp. 103514, 2020.
Allam, H. A., A. A. Kamel, M. El-Daly, and R. F. George, "Synthesis and vasodilator activity of some pyridazin-3(2H)-one based compounds", Future Medicinal Chemistry, vol. 12, issue 1, pp. 37–50, 2020.
El-Aleam, R. A. H., R. F. George, G. S. Hassan, and H. M. Abdel-Rahman, "Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking", Bioorganic Chemistry, vol. 94, pp. 103411, 2020.
Panda, S. S., A. S. Girgis, H. H. Honkanadavar, R. F. George, and A. M. Srour, "Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents", Future Medicinal Chemistry, vol. 12, issue 15, pp. 1369–1386, 2020.
Marwa A Ibrahim, R. F. George, S. M. Abou-Seri, and S. M. El-Moghazy, "Synthesis of new phenolic compounds and biological evaluation as antiproliferative agents", Journal of Chemical Research, vol. 44, issue 3-4, pp. 181– 192, 2020.
George, R. F., S. Bua, C. T. Supuran, and F. M. Awadallah, "Synthesis of some N-aroyl-2-oxindole benzenesulfonamide conjugates with carbonic anhydrase inhibitory activity", Bioorganic Chemistry, vol. 96, pp. 103635, 2020.
Samir, N., R. F. George, E. Z. Elrazaz, I. M. Ayoub, E. S. M. Shalaby, J. R. Plaisier, N. Demitri, and M. Wink, "Synthesis of some tropane-based compounds targeting colon cancer", Future Medicinal Chemistry, vol. 12, issue 23, pp. 2123-2140, 2020.
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