Publications

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Ewida, M. A., H. A. Ewida, M. S. Ahmed, H. A. Allam, R. I. Elbagary, R. F. George, H. H. Georgey, and H. I. El-Subbagh, "3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations", Bioorganic Chemistry, vol. 115, pp. 105205, 2021.
A
Hassan, G. S., H. H. Georgey, R. F. George, and E. R. Mohamed, "Aurones and furoaurones: Biological activities and synthesis", Bulletin of Faculty of Pharmacy, Cairo University, vol. 56, pp. 121-127, 2018.
B
El-Aleam, R. A. H., R. F. George, H. H. Georgey, and H. M. Abdel-Rahman, "Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance", RSC Advances, vol. 11, pp. 36459–36482, 2021.
C
Hassan, G. S., H. H. Georgey, R. F. George, and E. R. Mohammed, "Construction of some cytotoxic agents with aurone and furoaurone scaffolds", Future Medicinal Chemistry, vol. 18, issue 1, pp. 27-52, 2018.
D
El-Aleam, A. R. H., R. F. George, K. J. Lee, A. B. Keeton, G. A. Piazza, A. A. Kamel, M. E. El-Daly, G. S. Hassan, and H. M. Abdel-Rahman, "Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity", Archiv der Pharmazie, vol. 352, pp. 1900002, 2019.
El-Aleam, R. A. H., A. M. Sayed, M. N. Taha, R. F. George, H. H. Georgey, and H. M. Abdel-Rahman, "Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation", European Journal of Medicinal Chemistry, vol. 241, pp. 114629, 2022.
Ghanem, N. M., F. Farouk, R. F. George, S. E. S. Abbas, and O. M. El-Badry, "Design and synthesis of novel imidazo[4,5-b]pyridine based compounds as potent anticancer agents with CDK9 inhibitory activity", Bioorganic Chemistry, vol. 80, pp. 565–576, 2018.
Osman, E. E. A., N. S. Hanafy, R. F. George, and S. M. El-Moghazy, "Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors", Bioorganic Chemistry, vol. 104, pp. 104198, 2020.
Farouk, A. K. B. A. W., H. A. Allam, E. Rashwan, R. F. George, and S. E. - S. Abbas, "Design and synthesis of some new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines as multi tyrosine kinase inhibitors", Bioorganic Chemistry, vol. 128, pp. 106099, 2022.
Mohamed, A. R., A. E. M. Kerdawy, R. F. George, H. H. Georgey, and N. A. M. Gawad, "Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities", Bioorganic Chemistry, vol. 107, pp. 104569, 2021.
George, R. F., N. S. M. Ismail, J. Stawinski, and A. S. Girgis, "Design, synthesis and QSAR studies of dispiroindole derivatives as new antiproliferative agents", European Journal of Medicinal Chemistry, vol. 68, pp. 339-351, 2013. eur._j._med._chem._68_339-351_2013.pdf
Abo-Ashour, M. F., W. M. Eldehna, R. F. George, M. M. Abdel-Aziz, M. A. H. M. O. U. D. M. ELAASSER, N. A. M. Gawad, A. Gupta, S. Bhakta, and S. M. Abou-Seri, "Design, synthesis and whole cell phenotypic evaluation as a novel class of antimicrobial agents. ", European Journal of Medicinal Chemistry, vol. 160, pp. 49-60, 2018.
Amin, K. M., G. H. Hegazy, R. F. George, N. R. Ibrahim, and N. M. Mohamed, "Design, synthesis, and pharmacological characterization of some 2‐substituted‐3‐phenyl‐quinazolin‐4(3H)‐one derivatives as phosphodiesterase inhibitors", Archiv der Pharmazie, vol. 354, pp. e2100051, 2021.
Seliem, I. A., S. S. Panda, A. S. Girgis, Y. I. Nagy, R. F. George, W. Fayed, N. G. Fawzy, T. S. Ibrahim, A. M. M. Al-Mahmoudy, R. Sakhuja, et al., "Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone–dichloroacetic acid hybrids", Chemical Biology & Drug Design, vol. 95, pp. 248-259, 2020.
Aziz, N. A. A. M., R. F. George, K. El-Adl, and W. R. Mahmoud, "Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/ EGFRT790M tyrosine kinase inhibitors", RSC Advances, vol. 12, pp. 12913–12931, 2022.
F
Hanna, M. M., and R. F. George, "Facile Synthesis and Quantitative Structure–Activity Relationship Study of Antitumor Active 2-(4-Oxo-thiazolidin-2-ylidene)-3-oxo-propionitriles", Chem. Pharm. Bull, vol. 60, issue 9, pp. 1195–1206, 2012.
George, R. F., "Facile synthesis of simple 2-oxindole-based compounds with promising antiproliferative activity", Future Medicinal Chemistry, vol. 10, issue 3, pp. 269-282, 2018.
Eid, N. M., and R. F. George, "Facile synthesis of some pyrazoline-based compounds with promising anti-inflammatory activity", Future Medicinal Chemistry, vol. 10, issue 2, pp. 183-199, 2018.
Bokhita, R. M., S. S. Panda, A. S. Girgis, H. H. Honkanadavar, T. S. Ibrahim, R. F. George, M. O. N. A. T. KASHEF, W. A. L. I. D. FAYAD, R. Sakhuja, E. H. Abdel-Aal, et al., "Flouroquinolone-3-carboxamide amino acid conjugates: Synthesis, antibacterial properties and molecular modeling studies", Medicinal Chemistry, vol. 17, pp. 71-84, 2021.
H
Elwaie, T. A., S. E. Abbas, E. I. Aly, R. F. George, H. Ali, N. Kraiouchkine, K. S. Abdelwahed, T. E. Fandy, K. E. A. Sayed, Z. A. Y. Elmageed, et al., "HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability", Journal of Medicinal Chemistry, vol. 63, issue 24, pp. 15906−15945, 2020.
I
Rashad, M. S., H. H. Georgey, R. F. George, and N. M. Abdel-Gawad, "Identification of some benzoxazepines as anticancer agents inducing cancer cell apoptosis", Future Medicinal Chemistry, vol. 10, issue 14, pp. 1649–1664, 2018.
Mohamed, A. R., H. H. Georgey, R. F. George, W. I. El-Eraky, D. O. Saleh, and N. A. M. Gawad, "Identification of some novel xanthinebased derivatives with bronchodilator activity", Future Medicinal Chemistry, vol. 9, issue 15, pp. 1731-1747, 2017.
M
Hassan, G. S., H. H. Georgey, E. Z. Mohammed, R. F. George, W. R. Mahmoud, and F. A. Omar, "Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 inhibitors", European Journal of Medicinal Chemistry , vol. 218, pp. 113389, 2021.
Tiwari, A. D., S. S. Panda, A. S. Girgis, S. Sahu, R. F.George, A. M. Srour, B. L. Starza, A. M. Asiri, D. C. Hall, and A. R. Katritzky, "Microwave assisted synthesis and QSAR study of novel NSAID acetaminophen conjugates with amino acid linkers", Organic & Biomolecular Chemistry, vol. 12, issue 37, pp. 7238-7249, 2014.
N
Ewida, M. A., H. A. Ewida, M. S. Ahmed, H. A. Allam, R. I. Elbagary, R. F. George, H. H. Georgey, and H. I. El‐Subbagh, "Nanomolar potency of imidazo[2,1‐b]thiazole analogs as indoleamine 2,3‐dioxygenase inhibitors", Archiv der Pharmazie, vol. 354, pp. e2100202, 2021.