Publications

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2018
Rashad, M. S., H. H. Georgey, R. F. George, and N. M. Abdel-Gawad, "Identification of some benzoxazepines as anticancer agents inducing cancer cell apoptosis", Future Medicinal Chemistry, vol. 10, issue 14, pp. 1649–1664, 2018.
Abo-elmagd, N. E., R. F. George, M. A. Ezzat, and R. K. Arafa, "New 1-Phthalazinone scaffold based compounds: Design, synthesis, cytotoxicity and protein kinase inhibition activity.", Mini-Reviews in Medicinal Chemistry, vol. 18, issue 20, pp. 1759-1774, 2018.
Srour, A. M., S. S. Panda, A. M. M. Salman, M. A. El-Manawaty, R. F. George, E. S. M. Shalaby, A. N. Fitch, N. G. Fawzy, and A. S. Girgis, "Synthesis & molecular modeling studies of bronchodilatory active indole–pyridine conjugates", Future Medicinal Chemistry, vol. 10, issue 15, pp. 1787–1804, 2018.
Abo-Ashour, M. F., W. M. Eldehna, R. F. George, M. M. Abdel-Aziz, M. A. H. M. O. U. D. M. ELAASSER, S. M. Abou-Seri, and N. A. M. Gawad, "Synthesis and biological evaluation of 2-aminothiazole-thiazolidinone conjugates as potential antitubercular agents", Future Medicinal Chemistry, vol. 10, issue 12, pp. 1405–1419, 2018.
George, R. F., N. Samir, I. M. Ayoub, E. S. M. Shalaby, N. Demitri, and M. Wink, "Synthesis, antiproliferative activity and 2D-QSAR study of some 8-alkyl-2,4-bisbenzylidene-3-nortropinones", Future Medicinal Chemistry, vol. 10, issue 24, pp. 2815–2833, 2018.
Amin, K. M., A. M. Taha, R. F. George, N. M. Mohamed, and F. F. Elsenduny, "Synthesis, antitumor activity evaluation, and DNA-binding study of coumarin-based agents", Archiv der Pharmazie, vol. 351, issue 1, pp. 1700199, 2018.
Shalaby, E. S. M., A. M. Srour, S. S. Panda, R. F. George, A. N. Fitch, and A. S. Girgis, "Synthesis, X-ray powder diffraction and DFT-D studies of indole-based compounds", Zeitschrift fur Kristallographie - Crystalline Materials, vol. 233, issue 8, pp. 421-427, 2018.
2019
El-Aleam, A. R. H., R. F. George, K. J. Lee, A. B. Keeton, G. A. Piazza, A. A. Kamel, M. E. El-Daly, G. S. Hassan, and H. M. Abdel-Rahman, "Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity", Archiv der Pharmazie, vol. 352, pp. 1900002, 2019.
George, R. F., E. M. Samir, M. N. Abdelhamed, H. A. Abdel-Aziz, and S. E. S. Abbas, "Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors", Bioorganic Chemistry, vol. 83, pp. 186–197, 2019.
Abbas, S. E. S., R. F. George, E. M. Samir, M. M. A. Aref, and H. A. Abdel-Aziz, "Synthesis and anticancer activity of some pyrido[2,3-d]pyrimidine derivatives as apoptosis inducers and cyclin-dependent kinase inhibitors", Future Medicinal Chemistry, vol. 11, issue 18, pp. 2395–2414, 2019.
2020
Osman, E. E. A., N. S. Hanafy, R. F. George, and S. M. El-Moghazy, "Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors", Bioorganic Chemistry, vol. 104, pp. 104198, 2020.
Seliem, I. A., S. S. Panda, A. S. Girgis, Y. I. Nagy, R. F. George, W. Fayed, N. G. Fawzy, T. S. Ibrahim, A. M. M. Al-Mahmoudy, R. Sakhuja, et al., "Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone–dichloroacetic acid hybrids", Chemical Biology & Drug Design, vol. 95, pp. 248-259, 2020.
Elwaie, T. A., S. E. Abbas, E. I. Aly, R. F. George, H. Ali, N. Kraiouchkine, K. S. Abdelwahed, T. E. Fandy, K. E. A. Sayed, Z. A. Y. Elmageed, et al., "HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability", Journal of Medicinal Chemistry, vol. 63, issue 24, pp. 15906−15945, 2020.
George, R. F., M. Kandeel, D. Y. El-Ansary, and A. E. M. Kerdawy, "Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking", Bioorganic Chemistry, vol. 99, pp. 103780, 2020.
George, R. F., M. F. Said, S. Bua, and C. T. Supuran, "Synthesis and selective inhibitory effects of some 2-oxindole benzenesulfonamide conjugates on human carbonic anhydrase isoforms CA I, CA II, CA IX and CAXII", Bioorganic Chemistry, vol. 95, pp. 103514, 2020.
Allam, H. A., A. A. Kamel, M. El-Daly, and R. F. George, "Synthesis and vasodilator activity of some pyridazin-3(2H)-one based compounds", Future Medicinal Chemistry, vol. 12, issue 1, pp. 37–50, 2020.
El-Aleam, R. A. H., R. F. George, G. S. Hassan, and H. M. Abdel-Rahman, "Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking", Bioorganic Chemistry, vol. 94, pp. 103411, 2020.
Panda, S. S., A. S. Girgis, H. H. Honkanadavar, R. F. George, and A. M. Srour, "Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents", Future Medicinal Chemistry, vol. 12, issue 15, pp. 1369–1386, 2020.
Marwa A Ibrahim, R. F. George, S. M. Abou-Seri, and S. M. El-Moghazy, "Synthesis of new phenolic compounds and biological evaluation as antiproliferative agents", Journal of Chemical Research, vol. 44, issue 3-4, pp. 181– 192, 2020.
George, R. F., S. Bua, C. T. Supuran, and F. M. Awadallah, "Synthesis of some N-aroyl-2-oxindole benzenesulfonamide conjugates with carbonic anhydrase inhibitory activity", Bioorganic Chemistry, vol. 96, pp. 103635, 2020.
Samir, N., R. F. George, E. Z. Elrazaz, I. M. Ayoub, E. S. M. Shalaby, J. R. Plaisier, N. Demitri, and M. Wink, "Synthesis of some tropane-based compounds targeting colon cancer", Future Medicinal Chemistry, vol. 12, issue 23, pp. 2123-2140, 2020.
Panda, S. S., A. S. Girgis, S. J. Thomas, J. E. Capito, R. F. George, A. Salman, M. A. El-Manawaty, and A. Samir, "Synthesis, pharmacological profile and 2D-QSAR studies of curcuminamino acid conjugates as potential drug candidates", European Journal of Medicinal Chemistry , vol. 196, pp. 112293, 2020.
2021
Ewida, M. A., H. A. Ewida, M. S. Ahmed, H. A. Allam, R. I. Elbagary, R. F. George, H. H. Georgey, and H. I. El-Subbagh, "3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations", Bioorganic Chemistry, vol. 115, pp. 105205, 2021.
El-Aleam, R. A. H., R. F. George, H. H. Georgey, and H. M. Abdel-Rahman, "Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance", RSC Advances, vol. 11, pp. 36459–36482, 2021.
Mohamed, A. R., A. E. M. Kerdawy, R. F. George, H. H. Georgey, and N. A. M. Gawad, "Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities", Bioorganic Chemistry, vol. 107, pp. 104569, 2021.