FUROSEMIDE LOADED SUPERPOROUS HYDROGEL COMPOSITE AS A CONTROLLED RELEASE DEVICE: DIFFERENT STRATEGIES FOR DRUG LOADING
- Citation:
- R., L., A. H. S.A, and A. K. O.M, "FUROSEMIDE LOADED SUPERPOROUS HYDROGEL COMPOSITE AS A CONTROLLED RELEASE DEVICE: DIFFERENT STRATEGIES FOR DRUG LOADING", Journal of Pharmaceutical Research and Opinion, vol. 3, issue 6, pp. 28 - 35., 2013.
Abstract:
The aim of the present work was to develop controlled release, gastroretentive device
using superporous hydrogel composite (SPHC). Furosemide was chosen as good
candidate for such system due to its narrow absorption window, low bioavailability
and short half-life. Plain hydrogel was evaluated with respect to swelling ratio,
apparent density and floating time. Scanning electron micrographs of SPHC showed
large interconnected pores and extensive capillary insertion. Prepared Microspheres
were tested for drug content, and tablets evaluated with respect to quality control
tests. All loaded formulae inside SPHC were tested for drug release profile.
Microspheres, tablets and drug solutions were tested for loading inside SPHC. Kinetic
treatment of release data revealed that soaked drug solution was unable to control
drug release, where it gave a t1/2(0.5hrs) very similar to that of the free drug (0.6hrs).
Loaded microspheres showed only a slight retardation in release t1/2 to 1.06 hrs along
with a high percent of flush (~30mg %). However, loaded tablet demonstrated a
promising sustained effect corresponding to a release t1/2= 6hrs and a low percent of
initial flush (~1.2mg %). Therefore, the applicability of SPHC as a controlled release
device proved to be largely dependent on the type of dosage form included.