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Z
Zayed, S. E., S. I. Aziz, A. W. Erian, R. M. Mohareb, A. E. I. Elmaged, S. A. Metwally, and M. H. Elnagdi, "Studies With Polyfunctionally Substituted Heteroaromatics: The Reactivity of Alkylazoles Towards Electrophilic Reage", Phosphorous, sulfur And Silicon , vol. 102, pp. 51, 1995.
Zayed, S. E., S. I. Aziz, A. W. Erian, R. M. Mohareb, E. A. El-maged, and M. H. Elnagdi, "Studies with Polyfunctionally Substituted Heteroaromatics: The Reactivity of Alkylazoles Towards Electrophilic Reagents", Phophorous, Sulfur & Silicon , vol. 51, pp. 102, 1995.
Y
Yahya, S. M. M., G. A. Elmegeed, M. S. Mohamed, R. M. Mohareb, M. M. Abd-Elhalim, and G. H. Elsayed, "The Effect of Newly Synthesized Heterosteroids on miRNA34a, 98, and 214 Expression Levels in MCF-7 Breast Cancer Cells", Ind J Clin Biochem , pp. 1-6, 2017.
W
Wardakhan, W. W., N. N. El-Sayed, and R. M. Mohareb, "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives", Acta Pharmaceutica, vol. 63, pp. 45- 57, 2013.
WARDAKHAN, W. A. G. N. A. T. W. A. H. B. A., N. A. H. E. D. N. A. S. S. E. R. E. I. D. EL-SAYED, and R. M. Mohareb, "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives", Acta pharmaceutica, vol. 63, pp. 45–57, 2013. Abstract

The reaction of cyclopentanone with cyanoacetylhydrazine
gave 2-cyano-2-cyclopentylideneacetohydrazide (1).
Treatment of compound 1 with elemental sulphur in the
presence of triethylamine afforded 2-amino-5,6-dihydro-
-4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which
in-turn formed the corresponding intermediate diazonium
salt. The latter was coupled with either ethyl cyanoacetate
or ethyl acetoacetate to form 2-cyano-2-(3-(hydrazinecarbonyl)-
5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)hydrazono)
acetate (3) and ethyl 2-(2-(3-(hydrazinecarbonyl)-5,6-dihydro-
4H-cyclopenta[b]thiophen-2-yl)hydrazono)-3-oxobutanoate
(4), respectively. On the other hand, the reaction of
compound 1 with either benzaldehyde or acetophenone
afforded N’-benzylidene-2-cyano-2-cyclopentylideneacetohydrazide
(7) and 2-cyano-2-(2-cyclopentylidene)phenylacetohydrazide
(10), respectively. Moreover, compound
1 was used to synthesize 2-cyano-2-cyclopentylidene-
N'-(arylthiazol-2(3H)-ylidene)acetohydrazides
(6a,b), 2-(2-benzylidenecyclopentylidene)-2-cyanoacetohydrazide
(8), 2-amino-N'-benzylidene-5,6-dihydro-4H-
-cyclopenta[b]thiophene-3-carbohydrazide (9), 2-cyano-
-2-(2-(2-phenylhydrazono)cyclopentylidene)acetohydrazide
(11), N'-(1-chloropropan-2-ylidene)-2-cyano-2-cyclopentylideneacetohydrazide
(12), and 2-cyclopentylidene-3-
-(3,5-disubstituted-1H-pyrazol-1-yl)-3-oxopropanenitriles
(13a,b) through its reaction with the respective reagents.
Antitumor evaluation of the newly synthesized compounds
against the three human tumor cells lines, namely,
breast adenocarcinoma (MCF-7), non-small cell lung
cancer (NCI-H460) and CNS cancer (SF-268) showed that
some of the described compounds exhibited higher inhibitory
effects towards the three tumor cell lines than the
reference compound doxorubicin.

Wardakhan, W. W., S. M. Sherif, R. M. Mohareb, and A. S. Abouzied, "- The reaction of cyanoacetylhdrazine with furan-2-aldehyde: novel synthesis of thiophene, azole, azine and coumarin derivatives and their antitumor evaluation", International J. of Organic Chem. , vol. 2, pp. 321-331, 2012.
S
Sherif, S. M., N. I. Abdel-Sayed, S. M. El-kousy, and R. M. Mohareb, "Reaction of Carbon Disulphide With Diethyl 3-Amino-2- Cyano-2-penten-1,5-Dicarboxylate: A Convenient Synthesis of Polyfunctionally Substituted Thiophenes and Their Fused Derivatives", Monatshefte fur Chemie , vol. 126, pp. 601, 1995.
Sherif, S. M., W. W. Wardakhan, and R. M. Mohareb, "-Enaminonitrilers in Heterocyclic Sytnthesis: A Novel one- pot Synthesis of Thiophenes and Their Fused Derivatives", J. of Chem. Research (1996), , pp. (M), 1970 (S), 356 , 1996.
Sherif, S. M., R. M. Mohareb, G. E. Elgemeie, and R. P. Singh, "20- Nitriles In Heterocyclic Synthesis: 1-Cyanoformamide as a Precursor for a Variety of Heterocyclic Ring Systems", Heterocycles, vol. 27, pp. 1579, 1988.
Sherif, S. M., R. M. Mohareb, H. Z. Shams, and H. M. M. Gaber, "A Convenient Synthesis of Polyfunctionally Substituted Benzo[b]thiophen-2-yl-pyrimidine, pyrazole, isoxazole and pyridine derivatives", J. Chem. Res. , pp. (S), 434, (M) 2658, 1995.
Sadek, K. U., S. M. Fahmy, R. M. Mohareb, and M. H. Elnagdi, "3- Activated Nitriles In Heterocyclic Synthesis: Synthesis of Several New Pyrimidine and Pyridazine Derivatives", J. Chem. Engin. Data , vol. 29, pp. 101, 1984.
Sadek, K. U., S. M. Fahmy, R. M. Mohareb, and M. H. Elnagdi, "3- Activated Nitriles In Heterocyclic Synthesis: Synthesis of Several New Pyrimidine and Pyridazine Derivatives", J. Chem. Engin. Data , vol. 29, pp. 101, 1984.
R
RM, M., E. - S. NN, and A. MA, "The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines.", Steroids, vol. 78, issue 12-13, pp. 1209–1219, 2013. Abstract

The reaction of pregnenolone with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile or 3-oxo-3-phenylpropanenitrile gave the Knoevenagel condensation products 3 and 6, respectively. Separation of the E and Z isomeric compounds of 3 and 6 together with their structure elucidation were carried out. Some chemical transformations of the latter products were carried out and the cytotoxicity of the newly obtained products was evaluated against some cancer cell lines and a human normal cell line. The results indicated that compounds 15, 17a, 18 and 20e among the tested compounds showed the highest cytotoxicity against the cancer cell lines.

Rapoport, H., Y. Ghen, R. M. Mohareb, J. Hahn, T. B. Sim, and J. Z. Ho, "An Efficient Procedure for Preparation of (1S,3R)- and (1S,3S)-1-Amino-3-(hydroxymethyl)cyclopentanes", Chem. Pharm. Bull. , vol. 51 (10), pp. 1153-1156 , 2003.
Rafat M Mohareb, Nadia Y Megally Abdou, R. I. E. S. A. M., "Anti-proliferative, c-Met Inhibitions, and PAINS Evaluations of New Thiophene, Thiazole, Coumarin, Pyran, and Pyridine Derivatives", Anti-Cancer Agents in Med Chem, vol. 22, pp. 2125-2141, 2022.
R. M. Mohareb, and A. A. El-Khair, "Novel Synthesis of Hydrazide-Hydrazone and their uses for the synthesis of 1,3,4-oxadiazine, 1,2,4-triazine , pyrazole and pyridazine derivatives with antimicrobial and antifungal activities", International Journal of Applied and Pharmaceutical Technology, vol. 2, pp. 435-446, 2011.
R. M. Mohareb, S. M. Sherif, H. M. Gaber, S. S. Ghabrial, and S. I. Aziz, "Thiophenylhydrazonoacetates in Heterocyclic Synthesis", Heteroatom Chem. , vol. 15, pp. 15, 2004.
R. M. Mohareb, S. M. Sherif, H. M. Gaber, S. S. Ghabrial, and S. I. Aziz, "Thiophenylhydrazonoacetates in Heterocyclic Synthesis", Heteroatom Chem. , vol. 15, pp. 15, 2004.
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