Publications

Export 197 results:
Sort by: Author Title [ Type  (Asc)] Year
Journal Article
Mohareb, R. M., H. Z. Shams, and Y. M. El-Kholy, "Reactions of Phenyl Isothiocyanate and Sulfur With Dimeric Adducts: Novel Synthesis of Thiazoles, Thiazolo[4,5- d]pyrimidine and Thiazolo[4,5-d]pyridine Derivatives", Phosphorous, Sulfur and Silicon, vol. 70, pp. 317 , 1992.
Mohareb, R. M., S. I. Aziz, N. I. El-Sayed, and H. Z. Shams, "Reactions of Benzoyl Isothiocyanate With Active Methylene Reagents: A Novel Synthesis of Thiophene, Thiazoline and Thieno[2,3-d]pyrimidine Derivatives", Chin. Chem. Soc. , vol. 39, pp. 181, 1992.
Mohareb, R. M., and M. A. Abd El Aziz, "Reactions of Cyclohexanone with cyanoacetylhydrazine: Synthesis of indole, pyran, oxazine, pyrazole, thiophene and their fused derivatives with anti-tumor activities", Chemistry of Heterocyclic compounds, vol. 49, pp. 1212-1223, 2013.
Habashi, A., N. S. Ibrahim, R. M. Mohareb, and S. M. Fahmy, "Reactions With Acetoacetanilide: New Approaches for the Synthesis of Polyfunctionally Substituted Pyridine Derivatives", Leibigs Ann. Der Chemie , pp. 1632, 1987.
Al-Omran, F., R. M. Moharebb, and A. A. El-Khair, "SPECTROSCOPY STUDIES, X-RAY CRYSTALLOGRAPHY, AND ANTITUMOR", International Journal of Applied Biology and Pharmaceutical Technology, vol. 5, issue 1, pp. 63-75, 2014. 27012-fatima_al-omraninternational_j.pdfWebsite
Mohareb, R. M., A. M. El-Torgoman, S. I. Aziz, S. M. El-kousy, and M. Riad, "Studies With Alkylheteroaromatic Carbonitrile: Synthesis of New Mesoionic Pyridazines, Phthalazines and Thienopyridazines", Gazzetta Chimica Ital. , vol. 122, pp. 503, 1992.
Elnagdi, M. H., R. M. Mohareb, F. A. Abdel-Aal, and H. A. Mohamed, "Studies With Polyfunctionally Substituted Heteroaromatic: A New Route to Polyfunctionally Substituted Mercapto- phthalazines", Phosphorous, Sulfur & Silicon , vol. 82, pp. 195 , 1993.
Zayed, S. E., S. I. Aziz, A. W. Erian, R. M. Mohareb, E. A. El-maged, and M. H. Elnagdi, "Studies with Polyfunctionally Substituted Heteroaromatics: The Reactivity of Alkylazoles Towards Electrophilic Reagents", Phophorous, Sulfur & Silicon , vol. 51, pp. 102, 1995.
Zayed, S. E., S. I. Aziz, A. W. Erian, R. M. Mohareb, A. E. I. Elmaged, S. A. Metwally, and M. H. Elnagdi, "Studies With Polyfunctionally Substituted Heteroaromatics: The Reactivity of Alkylazoles Towards Electrophilic Reage", Phosphorous, sulfur And Silicon , vol. 102, pp. 51, 1995.
Mohareb, R. M., H. Z. Shams, and M. H. Elnagdi, "Studies With Polyfunctionally Substituted Pyridazines: Synthesis of new 4-Coumarin-3-yl-pyridazines", Gazzeta Chimica Ital., vol. 122, pp. 41, 1992.
Mohareb, R. M., and M. A. Abd El Aziz, "SUBSTITUTED 4,5,6,7-TETRAHYDROINDOLES AND THEIR FUSED DERIVATIVES. SYNTHESIS AND CYTOTOXIC ACTIVITY TOWARDS TUMOR AND NORMAL HUMAN CELL LINES", Chemistry of Heterocyclic Compounds, vol. 49, issue 8, pp. 1212-1223, 2013. summary.docx
Herdeis, C., R. M. Mohareb, B. R. Neder, and T. F. Schwabenlander, "Sudies of The Synthesis of Chiral nonracemic 3,4-disubstituted Azepanes, a Formal Synthesis of (+) and (-) Balanol Derivatives", Tetrahedron Asymmetry , vol. 10 (23) , pp. 4521 , 1999.
Doss, S. H., R. M. Mohareb, N. A. Lucca, and G. A. Elghany, "Sultamo-Steroid Analogues Part VII: Synthesis of Epiandrosterons With Potential Activities", Arch. Pharmazie , vol. 22, pp. 496, 1999.
El-Shorafa, Y. E., D. H. Fleita, O. K. Sakka, W. T. A. Harrison, K. Mahmoud, and R. M. Mohareb, "Syntheses, crystal structures, in vitro antitumor and free radical scavenging activity evaluation of a series of 2-substituted thiophenes ", Med Chem Research , vol. 24, pp. 3021–3036, 2015.
WARDAKHAN, W. A. G. N. A. T. W. A. H. B. A., N. A. H. E. D. N. A. S. S. E. R. E. I. D. EL-SAYED, and R. M. Mohareb, "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives", Acta pharmaceutica, vol. 63, pp. 45–57, 2013. Abstract

The reaction of cyclopentanone with cyanoacetylhydrazine
gave 2-cyano-2-cyclopentylideneacetohydrazide (1).
Treatment of compound 1 with elemental sulphur in the
presence of triethylamine afforded 2-amino-5,6-dihydro-
-4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which
in-turn formed the corresponding intermediate diazonium
salt. The latter was coupled with either ethyl cyanoacetate
or ethyl acetoacetate to form 2-cyano-2-(3-(hydrazinecarbonyl)-
5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)hydrazono)
acetate (3) and ethyl 2-(2-(3-(hydrazinecarbonyl)-5,6-dihydro-
4H-cyclopenta[b]thiophen-2-yl)hydrazono)-3-oxobutanoate
(4), respectively. On the other hand, the reaction of
compound 1 with either benzaldehyde or acetophenone
afforded N’-benzylidene-2-cyano-2-cyclopentylideneacetohydrazide
(7) and 2-cyano-2-(2-cyclopentylidene)phenylacetohydrazide
(10), respectively. Moreover, compound
1 was used to synthesize 2-cyano-2-cyclopentylidene-
N'-(arylthiazol-2(3H)-ylidene)acetohydrazides
(6a,b), 2-(2-benzylidenecyclopentylidene)-2-cyanoacetohydrazide
(8), 2-amino-N'-benzylidene-5,6-dihydro-4H-
-cyclopenta[b]thiophene-3-carbohydrazide (9), 2-cyano-
-2-(2-(2-phenylhydrazono)cyclopentylidene)acetohydrazide
(11), N'-(1-chloropropan-2-ylidene)-2-cyano-2-cyclopentylideneacetohydrazide
(12), and 2-cyclopentylidene-3-
-(3,5-disubstituted-1H-pyrazol-1-yl)-3-oxopropanenitriles
(13a,b) through its reaction with the respective reagents.
Antitumor evaluation of the newly synthesized compounds
against the three human tumor cells lines, namely,
breast adenocarcinoma (MCF-7), non-small cell lung
cancer (NCI-H460) and CNS cancer (SF-268) showed that
some of the described compounds exhibited higher inhibitory
effects towards the three tumor cell lines than the
reference compound doxorubicin.

Wardakhan, W. W., N. N. El-Sayed, and R. M. Mohareb, "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives", Acta Pharmaceutica, vol. 63, pp. 45- 57, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal1, and G. J. Mofeed, "Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine", Acta Chim. Slov. , vol. 68, pp. 604-616, 2021.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal[, and H. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur. Chem. Bull. , vol. 2, issue 9, pp. 618-628, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal[, and H. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur. Chem. Bull. , vol. 2, issue 9, pp. 618-628, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal, H. Allah, and N. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur Chem. Bull. , vol. 2(9) , pp. 618-628, 2013.
Mohamed, F. A., and R. M. Mohareb, "Synthesis and Application of Novel Reactive Disperse Dye Based on Tetrahydrobenzo[b]Thiophene Moiety", Research Journal of Textile and Apparel , vol. 18 (3), pp. 28-34, 2014.
Mohamed, F. A., and R. M. Mohareb, "Synthesis and applications of new bifunctional dyes bis (monochlorotriazine) based on tetrahydrobenzo[b]thiophene moiety", Pigment & Resin Technology, vol. 42, issue 4, pp. 264–270, 2013.
Tourism