Publications

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Journal Article
Mohareb, R. M., N. Y. Megalley, and W. N. Aldarkazali, "Heterocyclization of 2-Arylidenecyclohexan-1,3-dion: Synthesis of Thiophene, Thiazole and Isoxazole Derivatives with Potential Antitumor Activities", Amti-camcer Agent in Medicinal Chemistry, vol. 20, pp. 335-345, 2020.
Mohareb, R. M., W. W. Wardakhan, G. A. Elmegeed, and R. S. Ashour, "Heterocyclizations of Pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations", Steroids , vol. 77, pp. 1560–1569, 2012.
Dhorajiya, B. D., B. Z. Dholakiya, and R. M. Mohareb, "Hybrid probes of aromatic amine and barbituric acid: highly promising leads for anti-bacterial, anti-fungal and anti-cancer activities", Med Chem Res, vol. 23, pp. 3941–3952, 2014. mcr-article.pdf
Dhorajiya, D., B. Z. Dholakiya, and R. M. Mohareb, "Hybrid probes of aromatic amine and barbituric acid: highly promising leads for anti-bacterial, anti-fungal and anti-cancer activities", Med Chem Res , vol. 23, pp. 3941–3952, 2014.
Mohareb, R. M., R. A. Ibrahim, and H. E. Moustafa, "Hydrazide-Hydrazones in the Synthesis of 1,3,4-Oxadiazine, 1,2,4-Triazine and Pyrazole Derivatives with Antitumor Activities", The open Organic Chemistry Journal, vol. 4, pp. 8-14, 2010.
RM, M., E. - S. NN, and A. MA, "The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines.", Steroids, vol. 78, issue 12-13, pp. 1209–1219, 2013. Abstract

The reaction of pregnenolone with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile or 3-oxo-3-phenylpropanenitrile gave the Knoevenagel condensation products 3 and 6, respectively. Separation of the E and Z isomeric compounds of 3 and 6 together with their structure elucidation were carried out. Some chemical transformations of the latter products were carried out and the cytotoxicity of the newly obtained products was evaluated against some cancer cell lines and a human normal cell line. The results indicated that compounds 15, 17a, 18 and 20e among the tested compounds showed the highest cytotoxicity against the cancer cell lines.

Heba Hafez, Rafat M. Mohareb, S. S. A. M. E. E. H. A. M. A. F. H., "Molecular Mechanisms Underlying the Anti-Breast Cancer Stem Cell Activity of Pterocladia capillacea and Corallina officinalis Polysaccharides", Anti-Cancer Agents in Med Chem, vol. 22, pp. 1213-1225, 2022.
Mohareb, R. M., A. E. M. Abdallah, and M. A. Abdelaziz, "New approaches for the synthesis of pyrazole, thiophene, thieno[2,3-b]pyridine, and thiazole derivatives together with their anti-tumor evaluations", Med Chem Res, vol. 22, pp. 1-13, 2013.
Mohareb, R. M., N. A. Abas, and R. A. Ibrahim, "New approaches for The Synthesis of Thiophene Derivatives with Anti-tumor Activities", Acta Chemica Solvacia, vol. 60, pp. 583-594 , 2013.
Mohareb, R. M., A. M. Abdelazim, and A. Abdallah, "New Approaches for the Synthesis, Cytotoxicity and Toxicity of Heterocyclic Compounds Derived from 2-Cyanomethylbenzo[c]imidazole", Acta Chem Slov, vol. 63(2), pp. 227-40., 2016.
Ibrahim, N. S., R. M. Mohareb, and H. Z. Shams, "Nitriles In Heterocyclic Synthesis: New Approaches For the Synthesis of Some Pyridine Derivatives", Zeitschrift. Fur Naturforschung , pp. 1023, 1988.
Ibrahim, N. S., A. A. Hafez, and R. M. Mohareb, "Nitriles In Heterocyclic Synthesis: New Approaches for the Synthesis of Pyrazoles, Isoxazoles and Pyrimidines", Heterocycles, vol. 243, pp. 2085, 1986.
Mohareb, R. M., H. Z. Shams, and S. I. Aziz, "Novel Synthesis of Coumarin-3-yl-1,3-thiazole, 2-(Coumarin- 3-carbonyl)-thieno[2,3-b]pyridine and 2-(Coumarin-3-carbonyl)- thiophene Derivatives", J. Chem. Research , pp. (S), 154, (M), 1132, 1992.
R. M. Mohareb, and A. A. El-Khair, "Novel Synthesis of Hydrazide-Hydrazone and their uses for the synthesis of 1,3,4-oxadiazine, 1,2,4-triazine , pyrazole and pyridazine derivatives with antimicrobial and antifungal activities", International Journal of Applied and Pharmaceutical Technology, vol. 2, pp. 435-446, 2011.
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