Publications

Export 193 results:
Sort by: Author Title Type [ Year  (Desc)]
2013
Mohareb, R. M., N. S. Abbas, and R. A. Ibrahim, "New Approaches for the Synthesis of Thiophene Derivatives with Anti-tumor Activities", Acta Chim. Slov. , pp. 60583–594, 2013.
Mohareb, R. M., N. A. Abas, and R. A. Ibrahim, "New approaches for The Synthesis of Thiophene Derivatives with Anti-tumor Activities", Acta Chemica Solvacia, vol. 60, pp. 583-594 , 2013.
Mohareb, R. M., and M. A. Abd El Aziz, "Reactions of Cyclohexanone with cyanoacetylhydrazine: Synthesis of indole, pyran, oxazine, pyrazole, thiophene and their fused derivatives with anti-tumor activities", Chemistry of Heterocyclic compounds, vol. 49, pp. 1212-1223, 2013.
Mohareb, R. M., and M. A. Abd El Aziz, "SUBSTITUTED 4,5,6,7-TETRAHYDROINDOLES AND THEIR FUSED DERIVATIVES. SYNTHESIS AND CYTOTOXIC ACTIVITY TOWARDS TUMOR AND NORMAL HUMAN CELL LINES", Chemistry of Heterocyclic Compounds, vol. 49, issue 8, pp. 1212-1223, 2013. summary.docx
WARDAKHAN, W. A. G. N. A. T. W. A. H. B. A., N. A. H. E. D. N. A. S. S. E. R. E. I. D. EL-SAYED, and R. M. Mohareb, "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives", Acta pharmaceutica, vol. 63, pp. 45–57, 2013. Abstract

The reaction of cyclopentanone with cyanoacetylhydrazine
gave 2-cyano-2-cyclopentylideneacetohydrazide (1).
Treatment of compound 1 with elemental sulphur in the
presence of triethylamine afforded 2-amino-5,6-dihydro-
-4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which
in-turn formed the corresponding intermediate diazonium
salt. The latter was coupled with either ethyl cyanoacetate
or ethyl acetoacetate to form 2-cyano-2-(3-(hydrazinecarbonyl)-
5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)hydrazono)
acetate (3) and ethyl 2-(2-(3-(hydrazinecarbonyl)-5,6-dihydro-
4H-cyclopenta[b]thiophen-2-yl)hydrazono)-3-oxobutanoate
(4), respectively. On the other hand, the reaction of
compound 1 with either benzaldehyde or acetophenone
afforded N’-benzylidene-2-cyano-2-cyclopentylideneacetohydrazide
(7) and 2-cyano-2-(2-cyclopentylidene)phenylacetohydrazide
(10), respectively. Moreover, compound
1 was used to synthesize 2-cyano-2-cyclopentylidene-
N'-(arylthiazol-2(3H)-ylidene)acetohydrazides
(6a,b), 2-(2-benzylidenecyclopentylidene)-2-cyanoacetohydrazide
(8), 2-amino-N'-benzylidene-5,6-dihydro-4H-
-cyclopenta[b]thiophene-3-carbohydrazide (9), 2-cyano-
-2-(2-(2-phenylhydrazono)cyclopentylidene)acetohydrazide
(11), N'-(1-chloropropan-2-ylidene)-2-cyano-2-cyclopentylideneacetohydrazide
(12), and 2-cyclopentylidene-3-
-(3,5-disubstituted-1H-pyrazol-1-yl)-3-oxopropanenitriles
(13a,b) through its reaction with the respective reagents.
Antitumor evaluation of the newly synthesized compounds
against the three human tumor cells lines, namely,
breast adenocarcinoma (MCF-7), non-small cell lung
cancer (NCI-H460) and CNS cancer (SF-268) showed that
some of the described compounds exhibited higher inhibitory
effects towards the three tumor cell lines than the
reference compound doxorubicin.

Wardakhan, W. W., N. N. El-Sayed, and R. M. Mohareb, "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives", Acta Pharmaceutica, vol. 63, pp. 45- 57, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal[, and H. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur. Chem. Bull. , vol. 2, issue 9, pp. 618-628, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal[, and H. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur. Chem. Bull. , vol. 2, issue 9, pp. 618-628, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal, H. Allah, and N. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur Chem. Bull. , vol. 2(9) , pp. 618-628, 2013.
Mohamed, F. A., and R. M. Mohareb, "Synthesis and applications of new bifunctional dyes bis (monochlorotriazine) based on tetrahydrobenzo[b]thiophene moiety", Pigment & Resin Technology, vol. 42, issue 4, pp. 264–270, 2013.
Ali, F., and R. M. Mohareb, "Synthesis and applications of new bifunctional dyes bis (monochlorotriazine) based on tetrahydrobenzo[b]thiophene moiety", Pigment and Resin technology , vol. 24, pp. 264-270 , 2013.
2012
Wardakhan, W. W., S. M. Sherif, R. M. Mohareb, and A. S. Abouzied, "- The reaction of cyanoacetylhdrazine with furan-2-aldehyde: novel synthesis of thiophene, azole, azine and coumarin derivatives and their antitumor evaluation", International J. of Organic Chem. , vol. 2, pp. 321-331, 2012.
Mohareb, R. M., "Conducting Scientific Research: Research Hypothesis and Null Hypothesis", Current Organic Chemistry: Current Research , vol. 2, pp. 1-3, 2012.
Mohareb, R. M., W. W. Wardakhan, G. A. Elmegeed, and R. S. Ashour, "Heterocyclizations of Pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations", Steroids , vol. 77, pp. 1560–1569, 2012.
Mohareb, R. M., and A. A. Mohamed, "Uses of 1-Cyanoacetyl-4-Phenyl-3-Thiosemicarbazide in the Synthesis of Antimicrobial and Antifungal Heterocyclic Compounds", International Research Journal of Pure & Applied Chemistry, vol. 2, pp. 91-104, 2012.
Mohareb, R. M., N. N. E. El-Sayed, and M. A. Abd El Aziz, "Uses of Cyanoacetylhydrazine in Heterocyclic Synthesis: Novel Synthesis of Pyrazole Derivatives with Anti-Tumor Activities", Molecules, vol. 17, pp. 8449, 2012.
2011
Mohareb, R. M., and R. A. Ibrahim, "- Reaction of phenylhydrazo ethyl acetoacetate with Cyanoacetyl hydrazine: Novel Synthesis of Pyridazine and Pyrazole Derivatives and their anti-tumor evaluations", ; International Journal of Applied Biology & Pharm.Technology , vol. 2(1), pp. 9-18, 2011.
Elmegeed, G. A., W. K. B. Khalil, R. M. Mohareb, H. H. Ahmed, M. M. Abd-Elhalim, and G. H. Elsayed, "Cytotoxicity and Gene Expression Profiles of Novel Synthesized Steroid Derivatives as Chemotherapeutic Anti-Breast Cancer Agents", Bioorg, & Medicinal Chem., vol. 15, pp. 6860-6872, 2011.
Mohareb, R. M., H. H. Ahmed, G. A. Elmegeed, M. Abd-Elhalim, and R. W. Shafic, "Development of New Indole-Derived Neuroprotective Agents", Bioorganic and Medicinal Chemistry , vol. 19, pp. 2966-2974, 2011.
Tourism