Publications

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2015
Mohareb, R. M., W. W. Wardakhan, and F. I. Hamed, "Synthesis and cytotoxicity of fused thiophene and pyrazole derivatives derived from 2-N-acetyl-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene", Med Chem Res , vol. 24, pp. 2043-2054, 2015.
Mohareb, R. M., E. M. Samir, and E. E. Elarab, "Synthesis of Pyrazole and Thiophene Derivatives Together with their Antitumor Evaluations", Journal of Modern Medicinal Chemistry, vol. 3, pp. 69-79, 2015.
Abd El Aziz, M. A., H. M. El-Sehrawi, and R. M. Mohareb, "Synthesis, cytotoxicity and toxicity of thieno[2,3-d]pyrimidine derivatives derived from 2-amino-3-cyano-4,5,6,7- tetrahydrobenzo[b]thiophene", Med Chem research , vol. 24, pp. 3932–3948, 2015.
2014
Mohareb, R. M., "Heterocyclic Compounds as Anticancer Agents", J. of Chemical Bonding and Molecular Structure Analysis, vol. 1, pp. 1-3, 2014. rafat_single_autor.pdf
Mohareb, R. M., N. S. Abbas, and M. A. Abdelaziz, "Heterocyclic ring extension of androstenedione: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives", Steroids , vol. 88, pp. 45-58, 2014.
Mohareb, R. M., F. Al-Omran, and R. A. Azzam, "Heterocyclic ring extension of estrone: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives", Steroids, vol. 84 , pp. 46–56, 2014.
Dhorajiya, B. D., B. Z. Dholakiya, and R. M. Mohareb, "Hybrid probes of aromatic amine and barbituric acid: highly promising leads for anti-bacterial, anti-fungal and anti-cancer activities", Med Chem Res, vol. 23, pp. 3941–3952, 2014. mcr-article.pdf
Dhorajiya, D., B. Z. Dholakiya, and R. M. Mohareb, "Hybrid probes of aromatic amine and barbituric acid: highly promising leads for anti-bacterial, anti-fungal and anti-cancer activities", Med Chem Res , vol. 23, pp. 3941–3952, 2014.
Al-Omran, F., R. M. Moharebb, and A. A. El-Khair, "SPECTROSCOPY STUDIES, X-RAY CRYSTALLOGRAPHY, AND ANTITUMOR", International Journal of Applied Biology and Pharmaceutical Technology, vol. 5, issue 1, pp. 63-75, 2014. 27012-fatima_al-omraninternational_j.pdfWebsite
Mohamed, F. A., and R. M. Mohareb, "Synthesis and Application of Novel Reactive Disperse Dye Based on Tetrahydrobenzo[b]Thiophene Moiety", Research Journal of Textile and Apparel , vol. 18 (3), pp. 28-34, 2014.
Mohareb, R. M., F. A. O. Farouk, S. M. Sherif, and K. Karaghiosoff, "Synthesis of progesterone derivatives and evaluation of their efficiency as pneumococcal vaccines", Med Chem Res, vol. 23, pp. 3165–3177, 2014. fatmamcre-d-14-00255.pdf
Mohareb, R. M., F. A. O. Farouk, S. M. Sherif, and K. Karaghiosoff, "Synthesis of progesterone derivatives and evaluation of their efficiency as pneumococcal vaccines", Med Chem Res, vol. 23, pp. 3165–3177, 2014. fatmamcre-d-14-00255.pdf
2013
Fleita, H., R. M. Mohareb, and O. K. Sakka, "Antitumor and Anti-leishmanial Evaluation of Novel Heterocycles Derived from Quinazoline Scaffold: a Molecular Modeling Approach", Journal of Medicinal Chemical Research, vol. 22, pp. 2207-2221, 2013.
Fleita, D. H., R. M. Mohareb, and O. K. Sakka, "Antitumor and antileishmanial evaluation of novel heterocycles derived from quinazoline scaffold: a molecular modeling approach", Med Chem Res , vol. 22, pp. 2207–2221, 2013.
Mohareb, R. M., and A. A. Fahmy, "CYTOTOXICITY OF NOVEL 4,5,6,7-TETRAHYDRO BENZO[b]THIOPHENE DERIVATIVES AND THEIR USES AS ANTI-LEISHMANIAL AGENTS", Eur. Chem. Bull. , vol. 2, issue 8, pp. 545-553, 2013.
and, M. R. M., and A. G. A. Fahmy, "CYTOTOXICITY OF NOVEL 4,5,6,7-TETRAHYDROBENZO[ b]THIOPHENE DERIVATIVES AND THEIR USES AS ANTI-LEISHMANIAL AGENTS", Eur. Chem. Bull. , vol. 2(8), pp. 545-553, 2013.
RM, M., E. - S. NN, and A. MA, "The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines.", Steroids, vol. 78, issue 12-13, pp. 1209–1219, 2013. Abstract

The reaction of pregnenolone with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile or 3-oxo-3-phenylpropanenitrile gave the Knoevenagel condensation products 3 and 6, respectively. Separation of the E and Z isomeric compounds of 3 and 6 together with their structure elucidation were carried out. Some chemical transformations of the latter products were carried out and the cytotoxicity of the newly obtained products was evaluated against some cancer cell lines and a human normal cell line. The results indicated that compounds 15, 17a, 18 and 20e among the tested compounds showed the highest cytotoxicity against the cancer cell lines.

Mohareb, R. M., A. E. M. Abdallah, and M. A. Abdelaziz, "New approaches for the synthesis of pyrazole, thiophene, thieno[2,3-b]pyridine, and thiazole derivatives together with their anti-tumor evaluations", Med Chem Res, vol. 22, pp. 1-13, 2013.
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