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Mandour, I., N. Mossad, M. Fathy, M. Samir, M. Halim, M. Adly, A. Haroon, and I. Fakhry, "Vitamin D Receptor (VDR) Gene Polymorphism and Risk of Osteoporosis in Egyptian Post Menopausal Women", Medical Journal of Cairo University, vol. 74 , issue (4) (Suppl. III), pp. 237-246, 2006.
Elsayed", "L. A., "O. M. Tork", "H. Seddieka", "R. M. Taha", and "N. I. Gomaa", Vitamin D protects diabetic rats from neuropathic changes by improving insulin sensitivity and up regulating vitamin D receptors., , 2015.
Eltablawy, N., H. Ashour, L. A. Rashed, and W. M. Hamza, "Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin–angiotensin inhibition", ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, vol. 124, issue 5, pp. 461 – 467, 2018. vitamin_d_protection_from_rat_diabetic_nephropathy_in_volume.pdf
Mohamed, A. A., N. A. Sabry, M. M. Abbassi, W. A. Ibrahim, and Z. A. Ali-Eldin, "Vitamin D levels in Egyptian HCV patients (genotype 4) treated with pegylated interferon.", Acta gastro-enterologica Belgica, vol. 76, no. 1, pp. 38–44, 2013. Abstract
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A, M., S. N, A. M, I. Z, and A. -eldin Z, "Vitamin D Levels in Egyptian HCV Patients (Genotype 4) Treated with Pegylated Interferon", Acta Gastro-entrologica Belgica, vol. 76, issue 1, pp. 38-44, 2013.
huda marzouk, E. E. Ghobrial, M. M. Khorshied, and M. M. Mohammed, "Vitamin D level in nephrotic syndrome, Factors of impact?", geget, vol. 14, 2019. vit_d_in_nephrotic.pdf
huda marzouk, E. E. Ghobrial, M. M. Khorshied, and M. M. Mohammed, "Vitamin D level in nephrotic syndrome, Factors of impact?", geget (The journal of the Egyptian Society of Pediatric Nephrology and Transplantation) , vol. 14, issue 2, pp. 54-61, 2019. vit_d.pdf
Shaheen, I. A. M., R. Aboukhalil, N. Abulata, Rasha Abdel-Raouf, B. Meligy, and Omnia Abdel-Dayem, "Vitamin D Insufficiency is Not Associated With Pediatric and Adolescent Immune Thrombocytopenia: A Study in Conjunction With its Receptor Genetic Polymorphisms.", Journal of pediatric hematology/oncology, vol. 43, issue 1, pp. e1-e6, 2021. Abstract

Idiopathic thrombocytopenic purpura (ITP) is a heterogeneous immunologic disorder. Vitamin D has immune-modulatory effects. The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions. In our study, we measured the serum 25-hydroxyvitamin D levels in 98 Pediatric and Adolescent ITP patients, in addition to 100 apparently healthy controls. Genetic polymorphisms of the VDR gene FokI, BsmI, ApaI, and TaqI were tested using specific restriction enzymes for each polymorphism. Vitamin D deficiency in the studied Pediatric age was a dominant factor, but it was found not to be associated with Pediatric ITP. However, patients carrying the FokI CC genotype had statistically higher vitamin D levels compared with those carrying other genotypes (P=0.036). Patients who were carriers of the BsmI G allele had a nearly 2-fold higher risk of ITP (odds ratio: 2.203; 95% confidence interval: 1.467-3.309). Therefore, the BsmI polymorphism of VDR could be considered a molecular risk factor for ITP.

Shaheen, I. I. A., R. Aboukhalill, N. Abulata, Rasha Abdel-Raouf, B. Meligy, and Omnia Abdel-Dayem, "Vitamin D Insufficiency is Not Associated With Pediatric and Adolescent Immune Thrombocytopenia: A Study in Conjunction With its Receptor Genetic Polymorphisms", J Pediatr Hematol Oncol  , vol. 43, issue 1, pp. e1-e5, 2021.
Shaheen, I. A., R. Aboukhalil, N. Abulata, Rasha Abdel-Raouf, B. Meligy, and Omnia Abdel-Dayem, "Vitamin D Insufficiency is Not Associated With Pediatric and Adolescent Immune Thrombocytopenia A Study in Conjunction With its Receptor Genetic Polymorphisms", Pediatric Hematology / Oncology , vol. 43, issue 3, pp. 1-4, 2021.
Abdulazim, D. O., M. M. Salem, M. Hassan, Ahmed Abdo, E. Rashad, and U. A. A. S. E. Din, "Vitamin D deficiency: an unrecognized cause of flank pain", Journal of bone and mineral metabolism, vol. 36, no. 5: Springer, pp. 605–608, 2018. Abstract
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Rifai, N. M. E., G. A. F. A. Moety, H. M. Gaafar, and D. A. Hamed, "Vitamin D deficiency in Egyptian mothers and their neonates and possible related factors.", The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 27, issue 10, pp. 1064-8, 2014 Jul. Abstract

OBJECTIVE: To correlate vitamin D level in Egyptian mothers with that of their newborns, and examine risk factors related to maternal vitamin D deficiency.

METHODS: A cross-sectional study was carried out at the university teaching hospital in Cairo, Egypt. Serum 25(OH) D levels were measured by enzyme-linked immunosorbent assay in 135 pregnant women at ≥37 weeks' gestation immediately before delivery and in cord blood of their newborns.

RESULTS: The levels of serum 25(OH) D were 32.6 ± 21.4 ng/ml in mothers and 16.7 ± 10 ng/ml in their newborns. Maternal vitamin D level was strongly correlated with that of the newborns (r = 0.7, p < 0.0001). Maternal vitamin D deficiency/insufficiency and neonatal vitamin D deficiency/insufficiency were encountered in (40%, 28.9% and 60%, 32.6% respectively). Maternal vitamin D levels showed significant correlations with maternal body mass index (BMI; r = -0.201, p = 0.021), gestational age at delivery (r = 0.315, p ≤ 0.0001), fish consumption (r = 0.185, p = 0.032), educational level (r = 0.29, p = 0.001), and skin exposure (r = 0.247, p = 0.004).

CONCLUSION: Maternal vitamin D levels strongly correlate with neonatal levels. Maternal vitamin D deficiency is a real problem in Egypt; this is generally related to high BMI, low fish consumption, low educational level, and limited skin exposure.

Refaie, N. E. M., G. A. A. Moety, H. M. Gaafar, and D. A. Hamed, "Vitamin D deficiency in Egyptian mothers and their neonates and possible related factors", Journal of Maternal-fetal and neonatal Medicine, 2014.
Afify, M. I., and M. K.Nour, "Vitamin D deficiency in critically ill patients, does its deficiency matter?", Biolife Journal, vol. 5, issue 4, pp. 551-556, 2017.
Afify, M. I., and M. K.Nour, "Vitamin D deficiency in critically ill patients, does its deficiency matter?", Biolife Journal, vol. 5, issue 4, pp. 551-556, 2017.
BADAWI, N. O. R. A. E. L. S. A. I. D., H. A. F. Algebaly, R. E. Sayed, and E. S. A. Zeid, "Vitamin D deficiency in critically ill children", Kasr Alainy Medical Journal, vol. 23, issue 1, pp. 6-11, 2017. vitamin_d_deficiency_in_critically_ill_children.pdf
Din, U. A. A. S. E., M. M. Salem, D. O. Abdulazim, A. Abdou, M. Hassan, and E. Rashad, "Vitamin D Deficiency as a Cause of Flank Pain", Journal of Clinical & Experimental Nephrology, vol. 2, no. 2: iMedPub, 2017. Abstract
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Hamouda, H. A., S. M. Mansour, and M. F. Elyamany, "Vitamin D Combined with Pioglitazone Mitigates Type-2 Diabetes-induced Hepatic Injury Through Targeting Inflammation, Apoptosis, and Oxidative Stress.", Inflammation, vol. 45, issue 1, pp. 156-171, 2022. Abstract

Inflammation is a major pathophysiological factor in development of type-2 diabetes mellitus (T2DM). Vitamin D (VITD) plays an imperative role in modulation of several inflammatory responses. The current study aimed to investigate the possible beneficial effects of coadministration of VITD with pioglitazone (PIO), a PPAR-γ agonist, in fructose/streptozotocin (F/STZ) T2DM model in male Wistar rats. T2DM was induced by maintaining rats on 10% (w/v) fructose in drinking water for 9 weeks with an intraperitoneal injection of sub-diabetogenic dose of STZ (35 mg/kg) by the end of the fourth week. One week after STZ injection, PIO (10 mg/kg/day) alone or with VITD (500 IU/kg/day) was administered orally to diabetic rats till the end of the experiment. Blood samples were collected, livers were homogenized to determine biochemical parameters, and samples of livers were fixed in 10% formalin in saline for histological examination. Administration of PIO alone improved diabetes-induced inflammatory and oxidative states besides controlling hyperglycemia and decreasing apoptosis. Coadministration of VIT D with PIO promoted additional improvement in glycemic and lipid profiles, provided further control on diabetic-induced hepatic inflammation evident by downregulating TLR2, TLR4, and IKK-β while upregulating IκB-α expression and reducing inflammatory cytokines namely; NF-κB, TNF-α, IL-6, and IL-1β, decreasing apoptosis and oxidative stress by hampering caspase-3 and MDA contents, respectively, and improved liver histology than PIO alone. These beneficial effects of VIT D may expand its use by diabetics combined with antidiabetic drugs due to its anti-inflammatory, antioxidant, and antiapoptotic properties.

nehal hamdy elsaid, N. A. G. Mohamed, R. F. Salam, and mary wadie, "Vitamin D as a risk factor for premature atherosclerosis in patients with type 2 diabetes", Therapeutic Advances in Endocrinology and Metabolism, Submitted.
nehal hamdy elsaid, N. A. G. Mohamed, R. F. Salam, and mary wadie, "Vitamin D as a risk factor for premature atherosclerosis in patients with type 2 diabetes", Therapeutic Advances in Endocrinology and Metabolism, 2015.
Mostafa, W. Z., and R. A. Hegazy, "Vitamin D and the skin: Focus on a complex relationship: A review.", Journal Advanced Research, vol. 6, issue 6, pp. 793-804, 2015. Vitamin D in the skin
Mostafa, W. Z., and R. A. HEGAZY, "Vitamin D and the skin: Focus on a complex relationship: A review", Journal of Advanced Research, vol. 6, issue 6, pp. 793-804, 2015. vitamin_d.pdf
El-Sawaf, E. S., S. Saleh, D. M. Abdallah, K. A. Ahmed, and H. S. El-Abhar, "Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10α, TGF-β and NRF-1 crosstalk", Life Sci. , vol. 279, pp. 119697, 2021.
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