Publications

Export 1340 results:
Sort by: Author [ Title  (Desc)] Type Year
A B C D E F G H I J K L M N O P Q R S T U [V] W X Y Z   [Show ALL]
V
Ashour, H., S. M. Gamal, N. B. Sadek, L. A. Rashed, R. E. Hussein, S. S. Kamar, H. Ateyya, M. N. Mehesen, and A. M. Shamseldeen, "Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis.", Frontiers in physiology, vol. 12, pp. 744548, 2021. Abstract

Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuity. Vitamin D (VD) deficiency has been linked to the failure of implantation. Therefore, we tested the link between the Homeobox transcription factor-10/immunophilin FK506-binding protein 52 (HOXA-10/FKBP52) axis and the uterine receptivity in VD-deficient rats. The effect of VD supplementation at different doses was also investigated. Forty-eight pregnant rats were divided into six groups (eight/group); normal control rats fed with standard chow (control), control rats supplemented with VD (equivalent dose of 400 IU/day) (control-D400). VD-deficient group (DEF) and the three VD deficiency groups with VD supplementation were equivalent to 400, 4,000, and 10,000 IU/day (DEF-D400, DEF-D4000, and DEF-D10000, respectively). The expression levels of HOXA-10/FKBP52, progesterone level, and histological evaluation of decidualization using osteopontin (OSN) and progesterone receptor (PGR) were estimated. An assessment of the uterine contractility was conducted for all rats. This study showed the downregulation of HOXA-10/FKBP52 together with increased amplitude and frequency of the uterine contractility in the DEF group compared to control. VD dose-dependent supplementation restored progesterone/receptor competency, upregulated the expressional response of HOXA-10 and its downstream FKBP52, and improved uterine receptivity and endometrial decidualization at the time of implantation that was documented by increased area% of OSN and the number of implantation beads.

Ashour, H., S. M. Gamal, N. B. Sadek, L. A. Rashed, R. E. Hussein, S. S. Kamar, H. Ateyya, M. N. Mehesen, and A. M. Shamseldeen, "Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis.", Frontiers in physiology, vol. 12, pp. 744548, 2021. Abstract

Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuity. Vitamin D (VD) deficiency has been linked to the failure of implantation. Therefore, we tested the link between the Homeobox transcription factor-10/immunophilin FK506-binding protein 52 (HOXA-10/FKBP52) axis and the uterine receptivity in VD-deficient rats. The effect of VD supplementation at different doses was also investigated. Forty-eight pregnant rats were divided into six groups (eight/group); normal control rats fed with standard chow (control), control rats supplemented with VD (equivalent dose of 400 IU/day) (control-D400). VD-deficient group (DEF) and the three VD deficiency groups with VD supplementation were equivalent to 400, 4,000, and 10,000 IU/day (DEF-D400, DEF-D4000, and DEF-D10000, respectively). The expression levels of HOXA-10/FKBP52, progesterone level, and histological evaluation of decidualization using osteopontin (OSN) and progesterone receptor (PGR) were estimated. An assessment of the uterine contractility was conducted for all rats. This study showed the downregulation of HOXA-10/FKBP52 together with increased amplitude and frequency of the uterine contractility in the DEF group compared to control. VD dose-dependent supplementation restored progesterone/receptor competency, upregulated the expressional response of HOXA-10 and its downstream FKBP52, and improved uterine receptivity and endometrial decidualization at the time of implantation that was documented by increased area% of OSN and the number of implantation beads.

Ashour, H., S. M. Gamal, N. B. Sadek, L. A. Rashed, R. E. Hussein, S. S. Kamar, H. Ateyya, M. N. Mehesen, and A. M. Shamseldeen, "Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis.", Frontiers in physiology, vol. 12, pp. 744548, 2021. Abstract

Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuity. Vitamin D (VD) deficiency has been linked to the failure of implantation. Therefore, we tested the link between the Homeobox transcription factor-10/immunophilin FK506-binding protein 52 (HOXA-10/FKBP52) axis and the uterine receptivity in VD-deficient rats. The effect of VD supplementation at different doses was also investigated. Forty-eight pregnant rats were divided into six groups (eight/group); normal control rats fed with standard chow (control), control rats supplemented with VD (equivalent dose of 400 IU/day) (control-D400). VD-deficient group (DEF) and the three VD deficiency groups with VD supplementation were equivalent to 400, 4,000, and 10,000 IU/day (DEF-D400, DEF-D4000, and DEF-D10000, respectively). The expression levels of HOXA-10/FKBP52, progesterone level, and histological evaluation of decidualization using osteopontin (OSN) and progesterone receptor (PGR) were estimated. An assessment of the uterine contractility was conducted for all rats. This study showed the downregulation of HOXA-10/FKBP52 together with increased amplitude and frequency of the uterine contractility in the DEF group compared to control. VD dose-dependent supplementation restored progesterone/receptor competency, upregulated the expressional response of HOXA-10 and its downstream FKBP52, and improved uterine receptivity and endometrial decidualization at the time of implantation that was documented by increased area% of OSN and the number of implantation beads.

Ashour Hend, M., Gamal Sara Mahmoud, Sadek Nermeen Bakr, R. Laila, Hussein Rania Elsayed, Kamar Samaa Samir, Ateyya Hayam, Mehesen Marwa Nagi, and S. E. A. Mohammed, "Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis", Frontiers in Physiology, 2021.
Aly, H., L. Mohsen, I. Bhattacharjee, A. Malash, A. Atyia, S. Elanwary, and R. E. Hawary, "Vitamin D Supplementation and T Cell Regulation in Preterm Infants: A Randomized Controlled Trial", Journal of Pediatric Gastroenterology and Nutrition., vol. 69, issue 5, pp. 607–610, 2019.
Elmazny, A., H. Amer, L. Rashed, S. Khalil, and R. Magdy, "Vitamin D status of untreated children and adolescent Egyptian patients with genetic generalized epilepsy: A case–control study", Epilepsy & Behavior, vol. 103, 2020.
Gheita, T. A., S. Sayed, and H. A. Gheita, "Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome. ", Intl J Rheum Dis, issue doi: 10.1111/1756-185X.12426. [Epub ahead of print], 2014.
Gheita, T., S. Sayed, H. Gheita, and S. Kenawy, "Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome.", Int J Rheum Dis, vol. 19, issue 3, pp. 294-9, 2016.
Fahmy, E. M., M. E. Elawady, sahar sharaf, S. Heneidy, and R. S. Ismail, "Vitamin D status in idiopathic Parkinson’s disease: an Egyptian study", The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, vol. 56, issue 45, pp. 1-4, 2020. s41983-020-00175-.pdf
sahar sharaf, E. M. Fahmy, M. E. Elawady, S. Heneidy, and R. S. Ismail, "Vitamin D status in idiopathic Parkinson’s disease: an Egyptian study", The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, issue doi.org/10.1186/s41983-020-00175-2, 2020.
Hanna, H. W. Z., C. Rizzo, R. M. AbdelHalim, H. E. El Haddad, R. Salam, and H. El-Sayed Abou-Youssef, "Vitamin D status in Hashimoto's thyroiditis and its association with vitamin D receptor genetic variants.", The Journal of steroid biochemistry and molecular biology, vol. 212, pp. 105922, 2021. Abstract

BACKGROUND: Hashimoto's thyroiditis (HT) is considered the predominant cause of hypothyroidism in iodine sufficient countries. The deficiency of 25-OH-vitamin D3 serum level and the variation of vitamin D receptor (VDR) gene were implicated in a number of autoimmune disorders. This study aimed to test the hypothesis linking between VDR FokI and BsmI variants and HT, in addition to explain their impact on 25-OH-vitamin D3 serum level.

MATERIALS AND METHODS: Cross sectional study included 160 hypothyroid subjects, 112 patients with HT and 48 hypothyroid non-HT controls. They were diagnosed based on anti-TPO Ab and or anti-TG Ab results. All cases were subjected to full history taking, thyroid ultrasound examination and a panel of assays (TSH, f.T3, f.T4, anti-TPO Ab, anti-TG Ab, calcium, alkaline phosphatase and phosphate). Serum 25-OH-vitamin D3 was assayed using HPLC-UV method. VDR variants (FokI and BsmI) were genotyped using real-time PCR.

RESULTS: FokI AA genotype was statistically higher in HT patients than control group (P value = 0.02) with subsequently higher serum 25-OH-vitamin D3 level in comparison to all other genotypes (P value = 0.039). Serum 25-OH-vitamin D3 level was statistically indifferent between HT and control group (P value = 0.223). A statistically significant increase in total thyroid volume was observed in HT group (P value = 0.002).

CONCLUSION: FokI AA genotype is more associated with HT in Egyptian patients compared to hypothyroid non-HT controls. Moreover, patients with FokI AA genotype have statistically higher levels of 25-OH-vitamin D3 suggesting VDR dysfunction even in patients expressing normal level of vitamin D.

El-Garf, K., huda marzouk, Y. Farag, L. Rasheed, and A. El-Garf, "Vitamin D status in Egyptian patients with juvenile‑onset systemic lupus erythematosus", Rheumatol. Int, vol. 35, pp. 1535-40, 2015.
El-Garf, K., huda marzouk, yomna farag, L. Rasheed, and A. El-Garf, "Vitamin D status in Egyptian patients with juvenile‑onset systemic lupus erythematosus", Rheumatol. Int, vol. DOI 10.1007/s00296-015-3245-x, 2015.
Garf, K. E., A. E. Garf, huda marzouk, yomna farag, and L. Rashed, "Vitamin D status in Egyptian patients with juvenile-onset systemic lupus erythematosus", Rheumatology International, 2015.
Garf, K. E., huda marzouk, yomna farag, L. Rasheed, and A. E. Garf, "Vitamin D status in Egyptian patients with juvenile-onset systemic lupus erythematosus", Rheumatol Int. , vol. 35, issue 9, pp. 1535-40, 2015.
Hafez, M., M. Hassan, N. Musa, S. A. E. Atty, and S. A. Azim, "Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control.", Journal of pediatric endocrinology & metabolism : JPEM, vol. 30, issue 4, pp. 389–394, 2016 Dec 20, 2017. Abstractvitamin_d_status_in_egyptian_children_with__type_1_diabetes_and_the_role_of_vitamin_d_replacement_in_glycemic__control.pdf

BACKGROUND: The association of low serum 25 hydroxy cholecalciferol (25OHD) levels with high glucose level and diminished insulin sensitivity suggests that vitamin D (VD) may modulate insulin metabolism. The aim of the study was to screen for vitamin D deficiency (VDD) in pediatric patients with type 1 diabetes (T1D) and study the effect of VD supplementation on their glycemic control and insulin requirements.

METHODS: A prospective cohort study including 50 patients with T1D. VD level was assessed initially and after 3 months of VD supplementation (in those with VDD). HbA1c and insulin requirements were studied at 0, 3 and 6 months of supplementation.

RESULTS: Fifty patients with T1D were included with mean diabetes duration of 4.11±2.34 years. VD level ranged from 0.2 to 33 ng/mL. VD status correlated significantly with daily insulin dose (p=0.030, r=0.306) and HbA1c (p<0.001, r=0.243). Thirty-five patients (70%) had VDD and were allocated for VD supplementation for 3 months. The mean HbA1c improved significantly after supplementation (p=0.003), followed by a significant deterioration at 6 months with no change in their insulin requirements at 3 or 6 months.

CONCLUSIONS: VD was highly prevalent in Egyptian T1D patients. VD supplementation improved glycemic control at 3 months after therapy with no reduction in insulin requirements.

Garf, K. E., huda marzouk, yomna farag, A. E. Garf, and L. Rasheed, "vitamin D status in egyptian children with juvenile systemic lupus erythematosus", Rheumatology international, vol. 35, issue 0172-8172, pp. 1535-1540, 2015. published_vit_d_in_sle_.pdf
Zidan, A. E., M. A. El-Desouky, A. O. Lotfy, H. K. Abdelhakim, and E. A. Sultan, "VITAMIN D STATUS AND VARIOUS PREDICTORS IN EGYPTIAN ADOLESCENT FEMALES", Plant Archives, vol. 20, issue 2, pp. 2117-2121, 2020.
Sherief, L. M., A. Ali, A. Gaballa, G. M. Abdellatif, N. M. Kamal, M. R. Afify, D. H. Abdelmalek, S. A. El-Emari, A. S. A. Soliman, and W. A. Mokhtar, "Vitamin D status and healthy Egyptian adolescents Where do we stand?", Medicine, vol. 100, issue 29, pp. 1-6, 2021. vit_d_adolescents.pdf
undefined, D. S. Hamdy, D. A. Kamal, and D. Z. Sayed, vitamin D receptor polymorphisms associated with HCV related hepatocellular carcinoma, , 2015.
Saad, M. N., S. Mai, A. M. Eldeib, and O. G. Shaker, "Vitamin D Receptor Gene Polymorphisms in Rheumatoid Arthritis Patients Associating Osteoporosis", the 7th Cairo International Biomedical Engineering Conference -CIBEC 2014, December 11-13, pp. 75–78, 2014. Abstract

n/a

Gendy, H. I. E., noha adly sadik, M. Y. Helmy, and L. A. Rashed, "Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients", Journal of Clinical & Translational Endocrinology, vol. 15, pp. 25-29, 2019.