Zschöck, M., A. El-Sayed, N. Eissa, C. Lämmler, and H. Castañeda-Vazquez,
Resistencia a penicilina G y oxacilina, de cepas de Staphylococcus aureus aisladas de mastitis bovina subclínica,
, vol. 42, issue 3: Facultad de Medicina Veterinaria y Zootecnia, UNAM, pp. 207 - 217, 2011.
Abstractn/a
Zohir, N., R. Afifi, A. Ahmed, Z. Aly, M. Elsobekey, H. Kareem, and R. Helmy,
"Role of CYP2C9, VKORC1 and Calumenin Genotypes in Monitoring Warfarin Therapy: An Egyptian Study",
Macedonian Journal of Medical Sciences, vol. 6, issue 4, pp. 414-420, 2013.
AbstractBackground: Oral anticoagulant therapy is conditioned by environmental and genetic factors.
Objectives: To verify the effect of the calumenin, cytochrome P-450 variants and VKORC1 genetic
polymorphisms on the response to warfarin therapy and warfarin dose adjustment.
Patients and Methods: We selected fifty warfarin treated patients with dose adjusted at INR value
between 2 and 3. PCR-RFLP is used for of calumenin gene polymorphism. Insitu Hybridization was
used for identification of VKORC1 promoter and CYP2C9 variants polymorphisms.
Results: The warfarin dose in the patients with Calumenin and CYP2C9 genetic polymorphism was
lower than the wild type gene. The warfarin dose in the patients with VKORC1 variants was
statistically lower compared to that of the wild-type. The presence of combined CYP2C9 genetic
variants and VKORC1 polymorphism was associated with lower warfarin dose than that the wild
types.
Conclusion: Calumenin (CALU) might be a new genetic factor involved in the pharmacogenetics of
anticoagulant therapy.
Introduction
Zohdi, H. F., H. A. Emam, and A. O. Abdelhamid,
"Reactions with hydrazonoyl halides XIV. A Convenient synthesis of 2,3-dihydro-1,3,4-thiadiazole derivatives",
Phosphorus, Sulfur and Silicon, vol. 129, pp. 147, 1997.
Zohdi, H. F., N. M. Rateb, M. M. M. Sallam, and A. O. Abdelhamid,
"Reactions with hydrazonoyl halides XX: Synthesis of new unsymmeterical azines, dihydro-1,3,4-thiadiazoles",
J. Chem. Res, pp. (S), 742, (M) 4429 , 1998.
Zohdi, H. F., N. M. Rateb, M. M. M. Sallam, and A. O. Abdelhamid,
"Reactions with Hydrazonoyl Halides Part 20. Synthesis of New Unsymmetrical Azines, Dihydro-1,3,4-thiadiazoles and 5-Arylazothiazoles",
J. Chem. Res., pp. (S)742, (M)3329-3347, 1998.
Zohdi, H. F., H. A. Emam, and A. O. Abdelhamid,
"Reactions with Hydrazonoyl Halides XIV: A Convenient Synthesis of 2,3-dihydro- 1,3,4-Thiadiazole Derivatives",
Phosph. Sulfur and Silicon, vol. 129, pp. 147, 1997.