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kader, A. E. M. A. E., D. S. Abdelfattah, M. M. Kamel, and H. I. H. Shousha, Role of Serum Amyloid A and lncRNA-AF085935 as diagnostic biomarkers in serum of Hepatocellular Carcinoma, hepatitis B virus and hepatitis C virus patients. , , cairo, cairo university, Submitted. Abstract

Background:
Hepatocellular carcinoma (HCC) ranks as 5th most common cancer. Chronic infection by hepatitis viruses especially HBV and HCV lead to complicated microenvironment which may lead to hepatocarcinogenesis. Lnc RNAs and serum Amyloid A (SAA) have been suggested to have role in tumorogenesis and progression. In this work we investigated the role of lnc RNA AF085935 and SAA as a diagnostic biomarkers in sera of HBV, HCV, HCC patients.
Subjects and Methods: RT-PCR technique was used to assess Lnc RNA AF085935 quantitative expression and ELISA technique was used to detect expression level of SAA at sera of 149 adult Egyptian subjects. They were divided as 35 HCC patients on top of HCV and 24 HCC patients on top of HBV, 35 patients with HBV and 35 patients with HCV and 20 healthy donors.
Results: The level of LncRNA-AF085935 and SAA were high significantly upregulated in HCC patients, HCV patients and HBV patients compared with that in normal controls (p value = <0.001). In addition, higher expressions of Lnc RNA-AF085935 and SAA were observed in HCC patients than in HCV and HBV patients. SAA showed a relatively high accuracy for HCC screening (area under the curve (AUC) = 0.927, 95 % confidence interval (CI) = 0.858-0.997) to be differentiated from normal control. LncRNA-AF085935 showed a relatively higher accuracy for HCC screening ( AUC= 0.931, 95 % CI  = 0.862-1.00) than SAA (AUC = 0.74, 95 % CI = 0.587-0.894) from HBV patients.
Conclusion: Lnc RNA-AF085935 and SAA were observed with an aberrant serum level in sera of HCC, HCV and HBV patients. Lnc RNA-AF085935 and/or SAA can be used as potential biomarkers in HCC tumorogenesis.

EL-Maraghy, S. A., R. S. El-Dine, S. M. Rizk, and E. Abdel-Sattar, Russelioside B from Caralluma quadrangula improved hepatic glucose metabolism in diabetic rats, , Submitted. Abstract
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Aal, A. A. E., Hesham El Aassar, Mohamed Hammouda, K. Hussien, M. M. Sherif Hamed, and S. M. Hassan Khaled, "Radiofrequency Catheter Ablation of Atrial Fibrillation. Pulmonary Vein Osteal Isolation vs. 3-D Guided Circumferential Ablation", Egyptian Heart J 58(3): 595-604, September. 2006., Submitted.
Aziz, M. S. A., S. Ghaleb, and hazem el shafie, "A Rapid and Simple Procedure for Monitoring Valproic acid by Gas Chromatography J", ournal of Biological Research,, pp. 1-18, Submitted.
Elbalawy, Y. M., A. Atteya, E. M. Fahmy, and W. T. Mansour, "Reaching kinematics improvement after using modified constrained induced movement therapy in hemiparetic pateints", the medical journal of cairo university, vol. september 1 2015, Submitted.
ElTaweel, M. E. S., and E. S. Taghreed, "Red Cell Aggregation In First Episode Drug Nave Male Inpatients With Schizophrenia :A Cross Sectional Study", Middle East Current Psychiatry, Submitted.
ElTaweel, M. E. S., E. S. Taghreed, A. J.Kochar, and H. H.Mohamed, "Red Cell Aggregation In First Episode Drug Nave Male Inpatients With Schizophrenia :A Cross Sectional Study", Middle East Current Psychiatry, Submitted.
do Ossama E. Gouda, U. C.;;, U. B. de Ghada M. Amer, and U. V. S. A.(E.)- do do Adel Z. El Dein, "Redução da capacidade de corrente pela formação de zonas secas no solo", CABOS SUBTERRÂNEOS, pp. 130-142, Submitted. 2_em_portuguese_1_2010.pdf
M.Ahmed, G., A. Y. M. A. N. A. NASSIF, B. Elnassag, E. M. Fahmy, and S. A. N. D. Y. N. HANNA, "Relationship between the Balance Evaluation System Test and The Biodex stability system as a measurement of Balance in Stroke Patients.", Medical Journal of Cairo University, Submitted.
el deeb, H. A., E. H. Mobarak, and M. M. Akah, "Repair bond strength of dual-cured resin composite core buildup materials ", Journal of Advanced Research, Submitted. paper.pdf
Abdelaziz, O., "Res Judicata of Arbitral Awards: The Theory in Practice", IALS Student Law Review , vol. 5, issue 4, Submitted.
Saleh, D. S., Research Titles, , Submitted. lbhth_llmy.docx
Rahman, H. A., asmaa hamoda, M. Sedky, and naglaa elkanaie, results of treatment of lymphoblastic lymphoma at the children cancer hospital egypt-a single center experience, , Submitted.
Nabil, Z., and S. E. M. Sayed, "RETENTION OF ZIRCONIUM OXIDE AND RESIN NANO-CERAMIC COPINGS CEMENTED WITH TWO DIFFERENT ADHESIVE SYSTEMS", Egyptian Dental journal, vol. 59, pp. 4531-4540, Submitted. 2._retention_pdf.pdf
Mogawer, M. S., H. Morad, H. Sherif, N. R. Ahmed, and A. A. Aziz, "Revising the criteria for the predictors of variceal haemorrhage outcome", Arab journal of gastroenterology, vol. 14(2013), pp. 154-157, Submitted. ajg242.pdf
Ali, M. T., M. F. Osman, M. D. Homos, and D. M. Nabil, "Role of 3-T diffusion-weighted magnetic resonance imaging in differentiation between benign and malignant hepatic lesions", The Egyptian Journal of Radiology and Nuclear Medicine, vol. 47, issue 2016, pp. 1231-1241, Submitted.
Aasar, H. E. M., and K. Soliman, "The role of Carnosine in protection against the damaging effect of maternal nicotine exposure during gestation and lactation on the lung of albino rat ", International Journal : Journal of medical sciences, vol. vol (7) , issue January 2007, pp. 19-30 , Submitted.
Aasar, H. E. M., and K. Soliman, "The role of Carnosine in protection against the damaging effect of maternal nicotine exposure during gestation and lactation on the lung of albino rat ", International Journal : Journal of medical sciences, vol. vol (7) , issue January 2007, pp. 19-30 , Submitted.
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