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2022
ElSharbatly, R., M. Halim, F. Shaker, A. N. Mashhour, and H. azzam, "Role of MRI special diffusion weighted imaging/diffusion tensor imaging techniques in the assessment of perianal fistula activity", Egyptian Journal of Radiology and Nuclear Medicine, vol. 53, no. 1: SpringerOpen, pp. 1–9, 2022. Abstract
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Hmmam, I., A. E. M. Ali, S. M. Saleh, N. Khedr, and A. Abdallatif, "The Role of Salicylic Acid in Mitigating the Adverse Effects of Chilling Stress on “Seddik” Mango Transplants", Agronomy, vol. 12, issue 6: MDPI, pp. 1369, 2022. Abstract
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Hmmam, I., A. E. M. Ali, S. M. Saleh, N. Khedr, and A. Abdellatif, "The Role of Salicylic Acid in Mitigating the Adverse Effects of Chilling Stress on “Seddik” Mango Transplants", Agronomy, vol. 12, no. 6: MDPI, pp. 1369, 2022. Abstract
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Aboulnaga, M., and M. ElSharkawy, "The Role of Shading, Natural Ventilation, Daylighting, and Comfort in Enhancing Indoor Environmental Quality and Liveability in the Age of COVID-19", Achieving Building Comfort by Natural Means, Cham, Switzerland , Springer , 2022. Abstract

The Coronavirus (COVID-19) pandemic has catastrophic impacts worldwide between 2020 and 2021. Such a pandemic highlighted the importance of healthy spaces in all types of buildings, particularly: public, commercial, educational, and residential buildings during the lockdown periods in 2020 and 2021. In light of the urgent need for healthy spaces amid COVID-19, indoor environmental quality (IEQ) is significantly vital to provide healthy buildings and cities. Thus, it is imperative to ensure and guarantee thermal comfort, natural ventilation/cross ventilation, daylighting, and sunlight provision to ensure better IEQ and attain liveability. This book chapter presents a review on the impacts of COVID-19 on buildings in terms of IEQ and liveability in the age of COVID-19. It also highlights benefits of IEQ in providing healthy buildings including thermal comfort, natural ventilation, and daylighting and sunlight. This chapter addresses the benchmark for IEQ in the time of COVID-19. Additionally, global examples of best practices are highlighted to deduce the best lessons, standards, and practice models. This chapter also depicts selected contemporary buildings vs. traditional ones that include the main features to attain IEQ and draw the lessons learned from such traditional buildings. The chapter seeks to answer a main question – Can IEQ achieve liveability in the age of COVID-19? – and presents a comparative analysis of assessed buildings (case studies).

Elbendary, A., R. Youssef, M. R. E. Abdel-Halim, D. abd el halim, D. A. El Sharkawy, M. Alfishawy, M. A. Gad, A. A. Gad, and M. F. Elmasry, "Role of streptococcal infection in the etiopathogenesis of pityriasis lichenoides chronica and the therapeutic efficacy of azithromycin: a randomized controlled trial.", Archives of dermatological research, 2022. Abstract

The exact aetiology of pityriasis lichenoides chronica (PLC) remains unknown. While phototherapy is the most investigated therapeutic modality, azithromycin has been used scarcely. The aim of this study is to evaluate the therapeutic efficacy of azithromycin in the treatment of PLC compared to NB-UVB and evaluating the presence of streptococcal infection as a possible etiological factor in PLC patients. The study was designed as a randomised controlled trial. Twenty-four patients with PLC were randomly allocated into either azithromycin (n = 13, standard dose every 10 days) or NB-UVB (n = 11, thrice weekly) groups. End of study (EOS) was either complete clearance of lesions or a maximum of 8 weeks. Therapeutic efficacy was defined as percent reduction in lesions and was calculated for the rash as a whole, erythematous papules alone, and hypopigmented lesions alone and graded into complete, very-good, good, poor or no response. Anti-streptolysin O titre (ASOT), anti-deoxyribonuclease B titre (anti-DNaseB) and throat culture were evaluated at day 0. No significant difference existed between both groups as regards therapeutic efficacy. At EOS, NB-UVB achieved significantly more percent reduction in the extent of hypopigmented lesions and consequently in the rash as a whole (p = 0.001, p = 0.034, respectively). The extent of the rash as a whole was significantly less in the NB-UVB at EOS (p = 0.029, respectively). The effect of NB-UVB on hypopigmented lesions appeared early at week 4 of treatment. Only two patients, one from each group, relapsed during the 3 month follow-up. Evidence of recent streptococcal infection was present in 79% of the cases, mainly in the form of elevated ASOT (94.7%). It was significantly more encountered in young children (< 13 years) (p = 0.03) and was associated with more extent of erythematous papules and consequently with more extent of the rash as a whole (p = 0.05 and p = 0.01, respectively). It did not affect outcome of therapy at EOS. Azithromycin did not show more favorable response in patients with recent streptococcal infection. Therapeutic efficacy of azithromycin is comparable to NB-UVB in treatment of PLC; however, NB-UVB is superior in management of hypopigmented lesions. It is highly suggested that PLC could be a post streptococcal immune mediated disorder.Registration number: ClinicalTrials.gov, NCT03831269.

Mansour, A. M., K. Radacki, and O. R. Shehab, "Role of the ancillary ligand in determining the antimicrobial activity of Pd (II) complexes with N^N^N-tridentate coligand", Polyhedron, vol. 221, pp. 115857, 2022.
Mansour, A. M., K. Radacki, and O. R. Shehab, "Role of the ancillary ligand in determining the antimicrobial activity of Pd(II) complexes with N^N^N-tridentate coligand", Polyhedron, vol. 221, pp. 115857, 2022.
Snosy, M. F., M. Abu El Ela, A. El-Banbi, and H. M. Sayyouh, "Role of the Injected Water Salinity and Ion Concentrations on the Oil Recovery in Carbonate Reservoirs", Petroleum Research, vol. Online, 2022.
Snosy, M., M. Abu El Ela, A. El-Banbi, and H. Sayyouh, "Role of the Injected Water Salinity and Ion Concentrations on the Oil Recovery in Carbonate Reservoirs", Petroleum Research, vol. 7, issue 3, pp. 394-400, 2022.
Nawwar, D. A., H. F. Zaki, and R. H. Sayed, "Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats.", Inflammopharmacology, 2022. Abstract

Schizophrenia is a common mental disorder affecting patients' thoughts, behavior, and cognition. Recently, the NRG1/ErbB4 signaling pathway emerged as a candidate therapeutic target for schizophrenia. This study investigates the effects of aripiprazole and sertindole on the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in ketamine-induced schizophrenia in rats. Young male Wistar rats received ketamine (30 mg/kg, intraperitoneally) for 5 consecutive days and aripiprazole (3 mg/kg, orally) or sertindole (2.5 mg/kg, orally) for 14 days. The proposed pathway was investigated by injecting LY294002 (a selective PI3K inhibitor) (25 μg/kg, intrahippocampal injection) 30 min before the drugs. Twenty-four hours after the last injection, animals were subjected to behavioral tests: the open field test, sucrose preference test, novel object recognition task, and social interaction test. Both aripiprazole and sertindole significantly ameliorated ketamine-induced schizophrenic-like behavior, as expected, because of their previously demonstrated antipsychotic activity. Besides, both drugs alleviated ketamine-induced oxidative stress and neurotransmitter level changes in the hippocampus. They also increased the gamma-aminobutyric acid and glutamate levels and glutamate decarboxylase 67 and parvalbumin mRNA expression in the hippocampus. Moreover, aripiprazole and sertindole increased the NRG1 and ErbB4 mRNA expression levels and PI3K, p-Akt, and mTOR protein expression levels. Interestingly, pre-injecting LY294002 abolished all the effects of the drugs. This study reveals that the antipsychotic effects of aripiprazole and sertindole are partly due to oxidative stress reduction as well as NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways activation. The NRG1/ErbB4 and PI3K signaling pathways may offer a new therapeutic approach for treating schizophrenia in humans.

Ishak, S. K. I., F. E. Aguizy, E. H. Elsebaie, M. R. L. Youssef, M. M. Ismail, Fatma H. Abdelraouf, H. A. E. A. Ghaffar, and N. M. Riad, "Role of urinary NGAL and microalbuminuria in the detection of subclinical acute kidney injury in pediatric intensive care unit and diabetic children", La Pediatria Medica e Chirurgica, vol. 44:285, 2022.
Sayed, E. G., A. W. M. Mahmoud, A. Abdel-Wahab, R. M. El-Bahbohy, and S. N. Azoz, "Rootstock Priming with Shikimic Acid and Streptomyces griseus for Growth, Productivity, Physio-Biochemical, and Anatomical Characterisation of Tomato Grown under Cold Stress", Plants, vol. 11, issue 21: MDPI, pp. 2822, 2022. Abstract
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Albadawy, R., A. H. Hasanin, S. H. A. Agwa, S. Hamady, Y. M. Aboul-Ela, M. H. Raafat, S. S. Kamar, M. Othman, Y. A. Yahia, and M. Matboli, "Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death.", International journal of molecular sciences, vol. 23, issue 17, 2022. Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease that urgently needs effective therapy. Rosavin, a major constituent of the Rhodiola Rosea plant of the family Crassulaceae, is believed to exhibit multiple pharmacological effects on diverse diseases. However, its effect on non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, and the underlying mechanisms are not fully illustrated.

AIM: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related () mRNAs and their upstream noncoding RNA regulators ( and ) in NASH rats.

RESULTS: High sucrose high fat (HSHF) diet-induced NASH rats were treated with different concentrations of rosavin (10, 20, and 30 mg/kg/day) for the last four weeks of dietary manipulation. The data revealed that rosavin had the ability to modulate the expression of the hepatic cell death-related RNA panel through the upregulation of both () mRNAs and their epigenetic regulators ( and ). Moreover, rosavin ameliorated the deterioration in both liver functions and lipid profile, and thereby improved the hepatic inflammation, fibrosis, and apoptosis, as evidenced by the decreased protein levels of IL6, TNF-α, and caspase-3 in liver sections of treated animals compared to the untreated NASH rats.

CONCLUSION: Rosavin has demonstrated a potential ability to attenuate disease progression and inhibit hepatic cell death in the NASH animal model. The produced effect was correlated with upregulation of the hepatic cell death-related (, , , and ) mRNAs-(-() RNA panel.

, "A Rose Amongst the Thorns: the Mission of the J Project in a Conflictual World", Journal of Clinical Immunology, pp. 1151-1155, 2022.
Fadel, M., D. A. El Fadeel, A. Tawfik, A. I. El-Kholy, and Y. O. Mosaad, "Rose Bengal-gold-polypyrrole nanoparticles as a photothermal/ photodynamic dual treatment of recalcitrant plantar warts: Animal and clinical study", Journal of Drug Delivery Science and Technology, vol. 69 , pp. 103095, 2022.
Fadel, M., D. A. Fadeel, A. Tawfik, A. I. El-Kholy, and Y. O. Mosaad, "Rose Bengal-gold-polypyrrole nanoparticles as a photothermal/photodynamic dual treatment of recalcitrant plantar warts: Animal and clinical study", Journal of Drug Delivery Science and Technology, vol. 69, 2022. AbstractWebsite
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fadel, Fadeel, D.A., Tawfik, A., El-Kholy, A.F., and Y. O. Mosaad, "Rose Bengal-gold-polypyrrole nanoparticles as a photothermal/photodynamic dual treatment of recalcitrant plantar warts: Animal and clinical study", Journal of Drug Delivery Science and Technology, vol. 69, issue 3, pp. 103095, 2022.
Fahmy, M. I. M., R. H. Sayed, M. F. El-Yamany, R. El-Naggar, and H. A. Eliwa, "Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden", Biomedicine & Pharmacotherapy, vol. 153, pp. 113526, 2022.
Ismail, D. K., M. S. Sherief, D. M. Hassan, A. S. Hegab, and R. M..Hassan, "Routine Use of 16S rRNA Gene Sequencing for Diagnosis of Culture-Negative Bacterial Infections in Body Fluids Other than Blood: Benefits in a Limited Resource Hospital", Egyptian Journal of Medical Microbiology, vol. 31(1), issue 2537-0979, pp. 15-21, 2022. routine_use_of_16s_rrna_gene_sequencing.pdf
Hassan, A. A. -moneim, Y. E. Elenany, A. Nassrallah, W. Cheng, and A. A. A. El-Maksoud, "Royal jelly improves the physicochemical properties and biological activities of fermented milk with enhanced probiotic viability", LWT - Food Science and Technology, vol. 155, pp. 112912, 2022.
Hassan, A. A. -moeim, Y. E. Elenany, A. Nassrallah, and A. A. A. El-Maksoud, "Royal jelly improves the physicochemical properties and biological activities of fermented milk with enhanced probiotic viability", LWT - Food Science and Technology , vol. 155, pp. 112912, 2022. 1-s2.0-s002364382102065x-main_2.pdf
Motawi, T. M. K., N. A. H. Sadik, D. Sabry, S. A. Fahim, and N. N. Shahin, "rs62139665 Polymorphism in the Promoter Region of EpCAM Is Associated With Hepatitis C Virus-Related Hepatocellular Carcinoma Risk in Egyptians", Frontiers in Oncology, vol. 11, 2022. AbstractWebsite

Hepatocellular carcinoma (HCC) is a universal health problem that is particularly alarming in Egypt. The major risk factor for HCC is hepatitis C virus (HCV) infection which is a main burden in Egypt. The epithelial cell adhesion molecule (EpCAM) is a stem cell marker involved in the tumorigenesis and progression of many malignancies, including HCC. We investigated the association of -935 C/G single nucleotide polymorphism in EpCAM promoter region (rs62139665) with HCC risk, EpCAM expression and overall survival in Egyptians. A total of 266 patients (128 HCV and 138 HCC cases) and 117 age- and sex-matched controls participated in this study. Genotyping, performed using allelic discrimination and confirmed by sequencing, revealed a significant association between EpCAM rs62139665 and HCC susceptibility, with higher GG genotype and G allele distribution in HCC patients than in non-HCC subjects. Such association was not detected in HCV patients compared to controls. EpCAM gene expression levels, determined in blood by RT-qPCR, and its serum protein expression levels, determined by ELISA, were significantly higher in GG relative to GC+CC genotype carriers in HCV and HCC patients in a recessive model. ROC analysis of EpCAM protein levels revealed significant discriminatory power between HCC patients and non-HCC subjects, with improved diagnostic accuracy when combining α-fetoprotein and EpCAM compared to that of α-fetoprotein alone. Altogether, EpCAM rs62139665 polymorphism is significantly associated with HCC and with EpCAM gene and protein expression levels in the Egyptian population. Moreover, serum EpCAM levels may hold promise for HCC diagnosis and for improving the diagnostic accuracy of α-fetoprotein.

Helmy, S. A., H. M. Ebeid, M. A. Hanafy, Adel Eid Mohamed Mahmoud, and R. R. A. El-Tanany, "Rumen Parameters, Nutrients Digestibility and Milk Production of Lactating Boer Goats Fed Diets Containing Clay Minerals", Pakistan Journal of Biological Sciences, vol. 25, issue 8, pp. 755-764, 2022.
Mansour, A. M., R. M. Khaled, E. Khaled, S. K. Ahmed, O. S. Ismael, A. Zeinhom, and H. Magdy, "Ruthenium(II) carbon monoxide releasing molecules: Structural perspective, antimicrobial and anti-inflammatory properties", Biochemical Pharmacology, pp. 114991, 2022.
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