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El-Kamary, S. S., M. D. Shardell, M. Abdel-Hamid, S. Ismail, M. El-Ateek, M. Metwally, N. Mikhail, M. Hashem, A. Mousa, A. Aboul-Fotouh, et al., "A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis", Phytomedicine, vol. 16, no. 5: Elsevier, pp. 391–400, 2009. Abstract
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SA, E. - S., "Randomized Controlled Trial on the Use of Intravenous Immune Globulin", J Clin Res Bioeth, issue 170, pp. 2, 2014.
El-Khayat, W., M. Elsharkawi, and A. Hassan, "A randomized controlled trial of uterine exteriorization versus in situ repair of the uterine incision during cesarean delivery.", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 127, issue 2, pp. 163-6, 2014 Nov. Abstract

OBJECTIVE: To compare extra-abdominal repair of the uterine incision at cesarean delivery with in situ repair.

METHODS: The present study was a double-blind randomized controlled trial conducted at a university hospital in Egypt during 2012-2013, and included women with an indication for cesarean delivery. Extra-abdominal repair was used in group 1 (n=500) and in situ repair in group 2 (n=500). The primary outcome measure was the surgery duration.

RESULTS: Surgery duration was significantly longer in group 1 than group 2 (49.9±2.3 minutes vs 39.9±1.8 minutes; P<0.001). More patients in group 1 than in group 2 had postoperative moderate-to-severe pain (165 [33.0%] vs 115 [23.0%]; P=0.001) and needed additional postoperative analgesia (100 [20.0%] vs 50 [10.0%]; P<0.001). Moreover, mean time to bowel movement was longer in group 1 than in group 2 (17.0±2.7 hours vs 14.0±1.9 hours; P<0.001).

CONCLUSION: In situ uterine closure is more advantageous than extra-abdominal repair in terms of surgery duration, postoperative pain and need for additional analgesia, and return of bowel movement. ClinicalTrials.gov:NCT01723605.

El-Khayat, W., M. Elsharkawi, and A. Hassan, "A randomized controlled trial of uterine exteriorization versus in situ repair of the uterine incision during cesarean delivery", International Journal of Gynecology & Obstetrics, pp. -, 2014. AbstractWebsite

AbstractObjective To compare extra-abdominal repair of the uterine incision at cesarean delivery with in situ repair. Methods The present study was a double-blind randomized controlled trial conducted at a university hospital in Egypt during 2012–2013, and included women with an indication for cesarean delivery. Extra-abdominal repair was used in group 1 (n = 500) and in situ repair in group 2 (n = 500). The primary outcome measure was the surgery duration. Results Surgery duration was significantly longer in group 1 than group 2 (49.9 ± 2.3 minutes vs 39.9 ± 1.8 minutes; P < 0.001). More patients in group 1 than in group 2 had postoperative moderate-to-severe pain (165 [33.0%] vs 115 [23.0%]; P = 0.001) and needed additional postoperative analgesia (100 [20.0%] vs 50 [10.0%]; P < 0.001). Moreover, mean time to bowel movement was longer in group 1 than in group 2 (17.0 ± 2.7 hours vs 14.0 ± 1.9 hours; P < 0.001). Conclusion In situ uterine closure is more advantageous than extra-abdominal repair in terms of surgery duration, postoperative pain and need for additional analgesia, and return of bowel movement. ClinicalTrials.gov: \{NCT01723605\}

Maged, A. M., T. Fawzi, M. A. Shalaby, A. Samy, M. A. Rabee, A. S. Ali, E. A. Hussein, B. Hammad, and W. S. Deeb, "A randomized controlled trial of the safety and efficacy of preoperative rectal misoprostol for prevention of intraoperative and postoperative blood loss at elective cesarean delivery", international journal of gynecology and obstetrics, vol. 147, issue 1, pp. 102-107, 2019. ijgo.12922.pdf
Maged, A. M., T. Fawzi, M. A. Shalaby, A. Samy, M. A. Rabee, A. S. Ali, E. A. Hussein, B. Hammad, and W. S. Deeb, "A randomized controlled trial of the safety and efficacy of preoperative rectal misoprostol for prevention of intraoperative and postoperative blood loss at elective cesarean delivery.", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 147, issue 1, pp. 102 - 107, 2019. Abstract

OBJECTIVE: To assess the safety and efficacy of preoperative rectal misoprostol for the prevention of intraoperative and postoperative blood loss in women undergoing elective cesarean delivery. METHODS: A single-blind randomized controlled trial of 200 full-term pregnant women scheduled for elective cesarean delivery. Computer-generated randomization allocated women to receive 400 μg rectal misoprostol at urinary catheter insertion plus 400 μg rectally after abdominal closure (preoperative group, n=100) or 800 μg of rectal misoprostol after abdominal closure (postoperative group, n=100). Primary outcome was intraoperative blood loss. RESULTS: Intraoperative blood loss was significantly lower in the preoperative misoprostol group compared with the postoperative group (528.7 ± 114.8 mL vs 788.6 ± 165.8 mL; P<0.001). Blood loss during the first 24 hours after delivery was also lower in the preoperative group (199.3 ± 84.5 mL vs 302.9 ± 125.6 mL; P<0.001). Fewer women in the preoperative group needed additional uterotonics (7 vs 21; P<0.001). After delivery, the decrease in both hemoglobin and hematocrit levels was significantly less in the preoperative group (-6.8 vs -12.8% and -6.05 vs -17.8%, respectively; P<0.001). CONCLUSION: Preoperative rectal administration of misoprostol significantly reduced intraoperative and postoperative blood loss during and after elective cesarean delivery. ClinicalTrial.gov ID: NCT03680339. Date of registration 9/2018.

Maged, A. M., H. Rashwan, S. Abdelaziz, W. Ramadan, W. A. I. Mostafa, A. A. Metwally, and M. Katta, "Randomized controlled trial of the effect of endometrial injury on implantation and clinical pregnancy rates during the first ICSI cycle.", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 140, issue 1, pp. 211-2167, 2017 Oct 19, 2018. Abstractrandomized_controlled_trial_of_the_effect_of_endometrial_injury.pdf

OBJECTIVE: To assess whether endometrial injury in the cycle preceding controlled ovarian hyperstimulation during intracytoplasmic sperm injection (ICSI) improves the implantation and pregnancy rates.

METHODS: Between January 1, 2016, and March 31, 2017, a randomized controlled trial was conducted at a center in Egypt among 300 women who met inclusion criteria (first ICSI cycle, aged <40 years, day-3 follicle-stimulating hormone <10 IU/L, normal serum prolactin, no uterine cavity abnormality). The women were randomly allocated using a web-based system to undergo endometrial scratch in the cycle preceding controlled ovarian hyperstimulation (n=150) or to a control group (n=150). Only data analysts were masked to group assignment. The primary outcomes were the implantation and clinical pregnancy rates at 14 days and 4 weeks after embryo transfer, respectively. Analyses were by intention to treat.

RESULTS: The implantation rate was significantly higher in the endometrial scratch group (41.3% [90/218]) than in the control group (30.0% [63/210]; P<0.001). The clinical pregnancy rate was also significantly higher in the endometrial scratch group (44.2% [61/138]) than in the control group (30.4% [41/135]; P<0.001).

CONCLUSION: Endometrial injury in the cycle preceding the stimulation cycle improved implantation and pregnancy rates during ICSI. CLINICALTRIALS.GOV: NCT02660125.

Metwally, A. A., A. M. Maged, and M. Katta, "Randomized controlled Trial of the effect of endometrial injury on implantation and clinical pregnancy rates during the first ICSI cycle", International Journal of Gynecology and Obstetrics, vol. 140, issue 1, pp. 211-216, 2017. Randomized_controlled_trial_of_the_effect_of_endometrial_injury.
Samy, A., M. K. Ali, A. M. Abbas, H. A. Wahab, A. A. Wali, A. H. Hussien, M. Mostafa, M. A. Taymour, A. I. Ogila, Y. Ahmad, et al., "Randomized controlled trial of the effect of bilateral uterine artery ligation during cesarean among women at risk of uterine atony.", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 148, issue 2, pp. 219 - 224, 2020. Abstract

OBJECTIVE: To assess the effectiveness of prophylactic bilateral uterine artery ligation (BUAL) in reducing the incidence of postpartum hemorrhage (PPH) during cesarean delivery among women at risk of uterine atony. METHODS: A randomized clinical trial at Cairo University Maternity Hospital, Egypt, from December 2017 to December 2018. Women at risk of uterine atony undergoing scheduled or emergency cesarean were randomized to two groups. In the BUAL group, women underwent BUAL before placental delivery; in the control group, women had cesarean delivery without BUAL. The primary outcome was the estimated blood loss during cesarean. RESULTS: Intraoperative blood loss during cesarean was significantly lower in the BUAL group than in the control group (523.4 ± 41.0 vs 619.6 ± 36.1 mL; P=0.003). Blood loss in the first 6 hours after cesarean was also significantly lower in the BUAL group than in the control group (246.1 ± 21.4 vs 326.1 ± 18.5 mL; P=0.006). There was no difference in operative time between the two groups (52.1 ± 6.1 vs 52.2 ± 6.8, P=0.880). CONCLUSION: BUAL during cesarean was found to be an effective method for decreasing blood loss during and after cesarean delivery among women at risk of uterine atony and subsequent PPH. CLINICALTRIALS.GOV: NCT03591679.

Samy, A., M. K. Ali, A. M. Abbas, H. A. Wahab, A. A. Wali, A. H. Hussien, M. Mostafa, M. A. Taymour, A. I. Ogila, and Y. Ahmad, Randomized controlled trial of the effect of bilateral uterine artery ligation during cesarean among women at risk of uterine atony, , 2019. Abstract
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Fadlalla, W. M., A. Hanafy, mahmoud abdel hakim, H. A. Kassem, E. S. Ashraf, and A. A. Elbary, "Randomized Controlled Trial of Laparoscopic versus Open Radical Cystectomy in a Laparoscopic Naïve Center.", Advances in urology, vol. 2021, pp. 4731013, 2021. Abstract

Background: Laparoscopic radical cystectomy is a challenging surgical procedure; however, it has been largely abandoned in favor of the more intuitive robotic-assisted cystectomy. Due to the prohibitive cost of robotic surgery, the adoption of laparoscopic cystectomy is of relevance in low-resource institutes. . This is a randomized controlled trial comparing laparoscopic radical cystectomy (LRC) to open radical cystectomy (ORC) at a single institute. Each group included thirty patients. The trial was designed to compare both approaches regarding operative time, blood loss, transfusion requirements, length of hospital stay, time to oral intake, requirement of opioid analgesia, and complications.

Results: LRC was associated with less hospital stay (9.8 vs. 13.8 days, =0.001), less time to oral solid intake (6 vs. 8.6 days, =0.031), and lower opioid requirements (23.3% vs. 53.3%, =0.033). There was a trend towards lower blood loss and transfusion requirements, but this did not reach statistical significance. Overall complication rates were comparable.

Conclusion: Laparoscopic radical cystectomy was associated with comparable postoperative outcomes when compared to ORC in the first laparoscopic cystectomy experience in our center. Benefitting from the assistance of an experienced laparoscopic surgeon is recommended to shorten the learning curve.

El-Khayat, W., G. Abdel Moety, M. A. Mohammady, and D. Hamed, "A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome.", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 132, issue 2, pp. 206-9, 2016 Feb. Abstract

OBJECTIVE: To examine the efficacy of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone among women with polycystic ovary syndrome (PCOS) resistant to clomifene citrate.

METHODS: A prospective double-blind randomized controlled trial of women younger than 40 years who had primary/secondary infertility associated with PCOS and had not ovulated in response to clomifene citrate regimens previously was conducted at a center in Cairo, Egypt, between August 1, 2013, and December 31, 2014. Computer-generated random number tables and opaque envelopes were used to assign participants to group A or group B. Participants allocated to group A received 100mg clomifene citrate daily for 5 days from the third day of the menstrual cycle, whereas those in group B received 5mg letrozole daily in the same regimen. All patients received 850 mg metformin and 15 mg pioglitazone for 10 days from the first day of the menstrual cycle. The primary outcome was cumulative ovulation rate. Analyses were by intention to treat.

RESULTS: Fifty women were assigned to each group. Ovulation occurred in 108 (92.3%) of 117 cycles in group A and 93 (86.9%) of 107 cycles in Group B (P=0.184).

CONCLUSION: Combined treatment with letrozole, metformin, and pioglitazone was efficacious among women with PCOS resistant to clomifene citrate. ClinicalTrials.gov: NCT01909141.

Shaltout, M. F., A. E. Sheikhah, A. M. Maged, M. M. Elsherbini, S. S. Zaki, S. Dahab, and R. O. Elkomy, "A randomized controlled trial of a new technique for laparoscopic management of ovarian endometriosis preventing recurrence and keeping ovarian reserve", Journal of Ovarian Research, vol. 12, issue 66, pp. 1-8, 2019. laparoscopic_management_of_ovarian_endometriosis._a_new_technique_to_prevent.pdf
Tantawy, S. A., D. M. Kamel, W. K. Abdelbasset, and G. NAMBI, "A RANDOMIZED CONTROLLED TRIAL INVESTIGATING THE IMPACT OF INTERFERENTIAL THERAPY ON PAIN, RANGE OF MOTION AND QUALITY OF LIFE IN PATIENTS WITH CHRONIC NON-SPECIFIC LOW BACK PAIN", Archives of the Balkan Medical Union , vol. 55, issue 1, pp. 47-51, 2020.
Maged, A. M., E. H. Sorour, M. M. ElSadek, S. M. Hassan, and A. Y. Shoab, "A randomized controlled study of the effect of hyoscine butylbromide on duration of labor in primigravida women with prolonged labor", Archives of Gynecology and Obstetrics, vol. 304, pp. 1513–1518, 2021. hyoscine.pdf
Ammar, T., "A randomized comparison of supervised clinical exercise versus a home exercise program in patients with chronic low back pain", Physical Therapy and Rehabilitation, vol. 4, issue 7, pp. 4-7, 2017.
REDA, D. R. W. A. L. E. E. D., "Randomized Comparative Study between Mathieu Flip-Flap and Snodgrass Techniques for Repair of Distal Hypospadias", Egyptian Journal of Plastic and Reconstructive Surgery., vol. 31, issue 2, pp. JULY, 2007.
Abdel Magid, A. M., M. M. Abbassi, E. E. M. Iskander, O. Mohamady, and S. F. Farid, "Randomized comparative efficacy and safety study of intermittent simvastatin versus fenofibrate in hemodialysis.", Journal of comparative effectiveness research, vol. 6, issue 5, pp. 413-424, 2017 Jul. Abstract

AIM: Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients.

PATIENTS & METHODS: Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment.

RESULTS: After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0.05) and no significant changes in C-reactive protein (p > 0.05) were observed in both groups. Both drugs were well tolerated with no serious side effects reported by the patients.

CONCLUSION: Both drugs have comparable efficacy and safety when used as intermittent low dose regimen in hemodialysis. Larger studies with longer follow-up periods are needed to confirm our new findings.

Abdel Magid, A. M., M. M. Abbassi, E. E. M. Iskander, O. Mohamady, and S. F. Farid, "Randomized comparative efficacy and safety study of intermittent simvastatin versus fenofibrate in hemodialysis.", Journal of comparative effectiveness research, vol. 6, issue 5, pp. 413-424, 2017. Abstract

AIM: Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients.

PATIENTS & METHODS: Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment.

RESULTS: After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0.05) and no significant changes in C-reactive protein (p > 0.05) were observed in both groups. Both drugs were well tolerated with no serious side effects reported by the patients.

CONCLUSION: Both drugs have comparable efficacy and safety when used as intermittent low dose regimen in hemodialysis. Larger studies with longer follow-up periods are needed to confirm our new findings.

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