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Ali, R. M., M. Y. Al-Shorbagy, M. W. Helmy, and H. S. El-Abhar, "Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone.", European journal of pharmacology, vol. 831, pp. 68-76, 2018 Jul 15. Abstract

Renal ischemia-reperfusion injury (I/RI) remains a critical clinical situation. Several evidence revealed the potential reno-protective effects of Vitamin D and/or pioglitazone, on renal I/RI. This study addresses the possible involvement of the Wnt4/β-catenin signaling, p-S536NF-κBp65, PPARγ, Ang II/TGF-β, and ACE2 as potential effectors to vitamin D and pioglitazone-mediated renoprotective effects. Two sets of Sprague-Dawley rats (n = 30 rat each), were randomized into sham, I/R, Vit D "alfacalcidol" (5 ng/kg/day), pioglitazone (5 mg/kg/day), and Vit D + pioglitazone groups. In all groups renal biochemical parameters, as well as inflammatory and structural profiles were assessed, besides the expression/contents of Wnt4/β-catenin and pS536-NF-κBp65. All treatments started 7 days before I/RI and animals were killed 24 h after I/RI in the first set, while those in the 2nd set continued their treatments for 14 days. After 24 h, all pre-treatments impeded theI/R effect on neutrophils recruitment, p-S536NF-κBp65, IL-18, NGAL, caspase-3, AngII, ACE-2, PPARγ and TGF-β, besides the expression of Wnt4 and ACE-2 with notable reflection on histological changes. Two weeks after I/RI, except a marked up regulation in Wnt4 expression and a striking elevation in the β-catenin content, the magnitude of the injurious events was relatively less pronounced, an effect that was mostly augmented by the different treatments. The current study pledges a promising and novel reno-protective role of the administration of Vit D and pioglitazone entailing a potential involvement of ICAM-1, MPO, NF-κB, Ang II, ACE2, TGFβ, and a modulation of Wnt4/β-catenin pathway.

Bahnassy, A., A. M. Gawish, A. Mostafa, E. - S. Refaat, and G. Esmat, "Role of Wnt/β-catenin pathway genes in the development and progression of hepatitis C virus-associated hepatocellular carcinoma", Egyptian Journal of Pathology, vol. 32, issue 1: LWW, pp. 99-106, 2012. Abstract
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M.Omar, H., and M. E. Bakr, "Role of wild small mammals in disseminating two helminth parasites transmissible to man", egyptian J.Basic Medical Sci.,, vol. 14, issue 1, pp. 1-8, 1993. omar_bakr_abstract.pdf
M.Omar, H., and M. E. Bakr, "Role of wild small mammals in disseminating two helminth parasites transmissible to man", egyptian J.Basic Medical Sci.,, vol. 14, issue 1, pp. 1-8, 1993. omar_bakr_abstract.pdf
Omar, H. M., and M. E. Bakr, "Role of wild small mammals in disseminating two helminth parasites transmissible to man", egyptian J.Basic Medical Sci.,, vol. 14, issue 1, pp. 1-8, 1993. omar_bakr_abstract.pdf
Hashem, A. M. B., N. M. A. Wahab, and M. Y. Awadallah, "ROLE OF WHOLE-BODY DIFFUSION-WEIGHTED MR IN DETECTION OF METASTATIC LESIONS", repository.cu.edu.eg/index.php/cutheses/article/view/2742, 2012. 2742-5370-1-sm.pdf
M.Abdelwahab, N., M. A. R. Y. S. E. Y. AWADALLAH, and A. Y. A. M. BASSAM, "Role of Whole-Body Diffusion-Weighted MR in Assessment of Neoplastic Leisons", medical journal of cairo university, vol. 81 (2), pp. 213-220, 2013. 1368-2658-1-sm.pdf
SHAALAN, S. H. E. B. L., O. K. Radwan, and H. Saleh, "ROLE OF WHEAT GERM OIL AGAINST CARBON TETRACHLORIDE-INDUCED NEUROTOXICITY IN BRAIN TISSUES OF ADULT MALE MICE", Egypt. J. Zool. , vol. 67, pp. 1-18, 2017.
Nadia A. Fattah1, M. M. Ghobashy, A. - R. I. Bayaumi, and Y. I. asser Els, "The Role of Wave Equation Modeling in Attenuating Water Bottom Multiple Reflectionsin the Gulf of Suez. ", BULL: FAC. SCI., CAIRO UNIV., vol. Vol: 7, pp. 49-64., 2003.
IBRAHIM, M. K., T. Nakamura, K. Kitamura, K. Mori, and Y. Nakamura, "The Role of Vortices in Side Jet/Blunt Body Interaction at Hypersonic Speed", Transaction of The Japan Society for Aeronautical and Space Sciences, Space Technology Japan (Online), vol. 7, pp. 1-10, 2009. PDF
Elsheemy, M. S., W. Ghoneima, M. Abdelwahhab, W. Aboulela, K. Daw, A. M. Shouman, A. I. Shoukry, M. ElGhoneimy, H. A. Morsi, and H. Badawy, "The role of voiding cystourethrography in asymptomatic unilateral isolated ureteropelvic junction obstruction: A retrospective study.", Journal of pediatric urology, vol. 13, issue 2, pp. 206.e1-206.e7, 2017 Apr. Abstract

INTRODUCTION: The presence of concomitant vesicoureteric reflux (VUR) and ureteropelvic junction obstruction (UPJO) is uncommon. Nevertheless, the reported VUR coexisting with asymptomatic unilateral isolated hydronephrosis (AUIH) requiring pyeloplasty for correction of UPJO was of low grade and mostly resolved during conservative follow-up. Therefore, VCUG may be not indicated in these children except if voiding symptoms, urinary tract infection (UTI), dilated ureters, or bladder and ureteric abnormalities are suspected.

OBJECTIVES: The aim was to evaluate the need for VCUG in infants <1 year old with AUIH for whom a dismembered pyeloplasty was indicated for correction of UPJO.

METHODS: Ninety-six children <1 year old with pyeloplasty carried out from January 2012 to March 2014 were retrospectively included. Children with voiding symptoms or dilated ureter, duplex system, fused kidneys, bilateral dilatation, or any bladder abnormality on ultrasound were excluded. Anderson-Hynes pyeloplasty was performed through a flank incision. Preoperative VCUG was analyzed in relation to outcome and any UTI during follow-up. The Student t test, Mann-Whitney U test, or Fisher exact test were used to compare variables.

RESULTS: Five children had concomitant VUR with UPJO. Most of the children were circumcised during the first postnatal week. The remaining few children were circumcised at the time of pyeloplasty. Side, grade of detected VUR, and complications (18.75%) (postoperative or during follow-up) are presented in the Table. Outcomes in children with and without VUR were not different. Dismembered pyeloplasty was successful in children with VUR and with no complications except for non-febrile UTI in one child only. Ureters were still not dilated at the last follow-up.

DISCUSSION: The required imaging in infants with AUIH is still a subject of debate. As we expected, there was a low incidence of associated VUR in the present study. They were of low grade without any complications during follow-up and without affecting the outcome. The present study has its limitations, including the retrospective nature and short follow-up. However, as at least 2 years of follow-up were documented without any harm or ureteric dilation, VUR will mostly resolve. The present study is strengthened by inclusion of infants only.

CONCLUSIONS: Our data suggest that VCUG is not indicated in infants with AUIH requiring pyeloplasty for correction of UPJO. VCUG will not affect the treatment decision, operative outcome, or postoperative complications. VCUG may be indicated in case of suspected voiding symptoms, UTI, dilated ureters, or bladder and ureteric abnormalities.

Elsheemy, M. S., W. Ghoneima, M. Abdelwahhab, W. Aboulela, K. Daw, A. M. Shouman, A. I. Shoukry, M. ElGhoneimy, H. A. Morsi, and H. Badawy, "The role of voiding cystourethrography in asymptomatic unilateral isolated ureteropelvic junction obstruction: A retrospective study", Journal of Pediatric Urology , vol. 13, issue 2, pp. 206.e1e206.e7, 2017. the_role_of_voiding_cystourethrography.pdf
Abdulgawad, A. A. H., H. A. Goubran, M. A. E. Farha, and M. F. Yacoub, "ROLE OF VKORC1 AND CYP4502C9 POLYMORHISM IN RESISTANCE TO WARFARIN THERAPY AMONG EGYPTIAN PATIENTS", European Hematology Association 18th annual conference, 16 June, 2013.
M.Hady, M., A. M. E. Nabarawi, and M.M.Zaki, "Role of vitamin E on mycotoxicosis in broiler chicks", Egyptian Journal of Applied Sciences, vol. 6, issue 2, 1991.
M.M.Zaki, M. M.Hady, and H.M.Omar, "Role of vitamin E and selenium on caecal coccidiosis in chickens", Zagazig Veterinary Journal, vol. 17, issue 4, pp. 126-140, 1989.
Latif, M. S. A., M. S. A. Latif, yasmineF Elesawy, S. A. B. R. Y. SHAARAWY, M. Mansour, N. H. Ibrahim, and E. Tharwat1, "The Role of Vitamin D, Platelet-Derived Growth Factor and Insulin-Like Growth Factor 1 in the Progression of Thyroid Diseases", Asian Pacific Journal of Cancer Prevention, vol. 21, issue 10.31557, pp. 2083-2089, 2020.
Mansour, L., M. Sedky, M. AbdelKhader, R. Sabry, M. Kamal, and H. El-Sawah, "The role of vitamin D receptor genes (FOKI and BSMI) polymorphism in osteoporosis", Middle East Fertility Society Journal, vol. 15, issue 2, pp. 79–83, 2010.
D, K., A. R. Rasha, A. G. E, and S. B, "Role of Vitamin D in the prevention of viral respiratory infections in infants", Journal Of Arab ccild , vol. 20, pp. 351-356, 2009.
Kamal, D., R. A. Afifi, E. Abdelghani, and B. Salah, "Role of vitamin D in the prevention of viral respiratory infections in infant.", Journal of Arab Child, vol. 20, issue 6, 2009.
Hassanin, N., Y. Baghdady, M. Shehata, and A. Wagdi, "The role of vitamin D in statin treated patients complaining of myalagia", Cor Vasa, vol. 63, pp. 58–65., 2021.
Desoky, A. A., "The Role of Vitamin C and Electrolytes on Alleviating the Negative Effect of Heat Stress on Broiler Chicks", Mansoura University Journal of Agricultural Sciences, vol. 32, issue 12, pp. 9945-9952, 2007.
Khalifa A, F. R., S. Nasser, G. O, and M. Gadallah, "The role of vitamin A intervention in controlling infantile diarrhea", Egyptian Journal of Paediatrics, vol. 6, issue 3/4, pp. 401-413, 1989.