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Elgeshya, K. M., and A. H. A. A. Wahab, "Role, Significance and Association of microRNA-10a/b in Physiology of Cancer", MicroRNA, vol. 26, 2020.
Ezzat, S. M., A. M. El-Halawany, A. R. Hamed, and E. Abdel-Sattar, "Role Phytochemicals Play in the Activation of Antioxidant Response Elements (AREs) and Phase II Enzymes and Their Relation to Cancer Progression and Prevention", Studies in Natural Products Chemistry, vol. 60: Elsevier, pp. 345-369, 2018. Abstract
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Ezzat, S. M., A. M. El-Halawany, A. R. Hamed, and E. Abdel-Sattar, "Role Phytochemicals Play in the Activation of Antioxidant Response Elements (AREs) and Phase II Enzymes and Their Relation to Cancer Progression and Prevention", Studies in Natural Products Chemistry, vol. 60: Elsevier, pp. 345–369, 2019. Abstract
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AbdelKhalik, M., M.Zakaria, M.Khorshed, and S.Ahmed, "Role ofBALcellularityinassessmentofseverity of idiopathicpulmonaryfibrosis", Egyptian JournalofChestDiseasesandTuberculosis, pp. 129–134, 2013. bal_published_-_online.pdf
SS, E. - S., H. NM, A. MS, E. T. MA, A. - E. N, and E. EN, "The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value.", Exp Mol Pathol, vol. 110, issue October 2019, 2019.
El-Shazly, S. S., N. M. Hassan, M. S. Abdellateif, M. A. Eltaweel, NahedAbd-Elwahab, and E. N. Ebeid, "The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value.", Experimental and molecular pathology, vol. 110, pp. 104272, 2019. Abstract

BACKGROUND: The expression of β-catenin and paired-like homeobox 2B (PHOX2B) expression were assessed in Neuroblastoma (NB) patients as a diagnostic, prognostic and/or predictive markers.

METHODS: Bone marrow (BM) samples of 52 NB patients were assessed for the expression of β-catenin by immunohistochemistry (IHC), and PHOX2B by real time PCR (RT-PCR), compared to 12 healthy normal controls (NC). The data were correlated to the clinic-pathological features of the patients, response to treatment and disease relapse.

RESULTS: β-catenin was expressed in 40 (76.92%) patients (P < .001). While PHOX2B was expressed in 32/52 (61.5%) patients, with a fold change of 0.29 (0.01-40.0, P = .096). β-catenin expression associated significantly with advanced tumor stage, high risk, positive results by MIBG and bone scan (P = .002, P < .001, P = .006, P = .013; respectively). Also it associated significantly with synaptophysin expression in the BM biopsy (P < .001), with a significant concordance (K = 0.519, P < .001). The expression of β-catenin associated significantly with PHOX2B gene expression [28/32 (87.5%), P = .04], and its fold change (P = .027), with a significant measure of agreement (K = 0.297, P = .022). The fold change of PHOX2B gene expression associated significantly with the high risk of the patients (P = .04). Poor response to treatment associated significantly with the expression of neuron specific enolase (NSE), β-catenin and PHOX2B in NB patients (P = .021, P = .019 and P = .040; respectively). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of synaptophysin for the diagnosis of BM metastasis in NB patients were (69%, 65.2%, 71.4%, 62.5%; respectively, P = .024). While with β-catenin (93.1%, 43.5%, 67.5%, 83.3%; respectively, P = .003), and PHOX2B expression (65.5%, 34.5%, 59.4%, 50%; respectively, P = .574).

CONCLUSION: β-Catenin could be used as a sensitive and reliable marker for detection of BM metastasis and also a good predictor for resistance to treatment in NB patients. While, PHOX2B gene expression in BM aspirate could be a marker for high risk patients and poor response to treatment.

El-Shazly, S. S., N. M. Hassan, M. S. Abdellateif, M. E. L. A. Taweel, NahedAbd-Elwahab, and E. N.Ebeid, "The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value", Experimental and Molecular Pathology., vol. 110, issue 0014-4800, 2019.
Gowayed, M. A., K. Rothe, M. Rossol, A. S. Attia, U. Wagner, C. Baerwald, H. S. El-Abhar, and R. Refaat, "The role of α7nAChR in controlling the anti-inflammatory/anti-arthritic action of galantamine.", Biochemical pharmacology, vol. 170, pp. 113665, 2019 Dec. Abstract

OBJECTIVE: The evolution of the "cholinergic anti-inflammatory pathway" and the fact that the α 7 subunit of the nicotinic acetylcholine receptor (α7nAChR) is present in the spleen, joint and on the surface of lymphocytes, opened up the prospective in this study of targeting the α7nAChR by the anticholinesterase and cholinergic drug, galantamine, to control inflammation in rheumatoid arthritis (RA).

METHODS: Twelve-adjuvant arthritic rats were exposed to the selective α7nAChR blocker methylcaconitine citrate 15 min before galantamine treatment. As control, six adjuvant arthritic rats were treated with galantamine and six others were untreated. After five days TNF-α levels were assessed in spleen and joints, while reduced glutathione was measured in blood and joint tissue. In the second part, magnetically sorted CD4 + T cells from peripheral blood mononuclear cells of RA patients and healthy donors were used to sort CD4 + CD25 - primary T cells (Tresp) and CD4 + CD25 + CD127low Tregs. The suppressive function of Tregs was investigated after incubation with galantamine using flow cytometry. Cell culture supernatants were analyzed for TNF-α and IL-10 levels after three days incubation period of Tregs with Tresp. The effect of galantamine on Tregs was then blocked by α-Bungarotoxin and the same assay has been repeated.

RESULTS & CONCLUSION: Selective α7nAChR blockade interrupted the anti-inflammatory effect of galantamine in the spleen and joints of arthritic rats. In healthy donors, galantamine could strengthen the suppressive activity of Tregs; while in RA patients it did not modulate the function of Tregs significantly. Further studies are necessary to investigate whether modulation of the cholinergic nervous system, especially α7nAChR, could have impact on the disturbed immune system in RA, which may open up a new treatment option of autoimmune diseases.

Gowayed, M. A., K. Rothe, M. Rossol, A. S. Attia, U. Wagner, C. Baerwald, H. S. El-Abhar, and R. Refaat, "The role of α7nAChR in controlling the anti-inflammatory/anti-arthritic action of galantamine.", Biochemical pharmacology, vol. 170, pp. 113665, 2019. Abstractthe_role_of_a7nachr_in_controlling_the_anti-inflammatory_anti-arthritic_action_of_galantamine.pdf

OBJECTIVE: The evolution of the "cholinergic anti-inflammatory pathway" and the fact that the α 7 subunit of the nicotinic acetylcholine receptor (α7nAChR) is present in the spleen, joint and on the surface of lymphocytes, opened up the prospective in this study of targeting the α7nAChR by the anticholinesterase and cholinergic drug, galantamine, to control inflammation in rheumatoid arthritis (RA).

METHODS: Twelve-adjuvant arthritic rats were exposed to the selective α7nAChR blocker methylcaconitine citrate 15 min before galantamine treatment. As control, six adjuvant arthritic rats were treated with galantamine and six others were untreated. After five days TNF-α levels were assessed in spleen and joints, while reduced glutathione was measured in blood and joint tissue. In the second part, magnetically sorted CD4 + T cells from peripheral blood mononuclear cells of RA patients and healthy donors were used to sort CD4 + CD25 - primary T cells (Tresp) and CD4 + CD25 + CD127low Tregs. The suppressive function of Tregs was investigated after incubation with galantamine using flow cytometry. Cell culture supernatants were analyzed for TNF-α and IL-10 levels after three days incubation period of Tregs with Tresp. The effect of galantamine on Tregs was then blocked by α-Bungarotoxin and the same assay has been repeated.

RESULTS & CONCLUSION: Selective α7nAChR blockade interrupted the anti-inflammatory effect of galantamine in the spleen and joints of arthritic rats. In healthy donors, galantamine could strengthen the suppressive activity of Tregs; while in RA patients it did not modulate the function of Tregs significantly. Further studies are necessary to investigate whether modulation of the cholinergic nervous system, especially α7nAChR, could have impact on the disturbed immune system in RA, which may open up a new treatment option of autoimmune diseases.

Ibrahim, S. A., W. Ahmed, and T. Youssef, "Role of ZnS shell on stability, cytotoxicity, and photocytotoxicity of water-soluble CdSe semiconductor quantum dots surface modified with glutathione", Physical Chemistry of Interfaces and Nanomaterials XIII, San Diego-CA/USA, 9165, pp. 91651H, 2014.
Ibrahim, S. A., W. Ahmed, and T. Youssef, "Role of ZnS shell on stability, cytotoxicity, and photocytotoxicity of water-soluble CdSe semiconductor quantum dots surface modified with glutathione", Journal of Nanophotonics, vol. 9(1), pp. 093090 doi:10.1117/1.JNP.9.093090, 2015.
Ibrahim, S. A., W. Ahmed, and T. Youssef, "Role of ZnS shell on stability, cytotoxicity, and photo-cytotoxicity of water-soluble CdSe semiconductor quantum dots surface modified with glutathione", Journal of Nanophotonics, vol. 9, issue 1, pp. 093090-1:093090-12, 2015.
Fathy, M. M., H. H. Eid, A. Hussein, H. H. Ahmed, and A. A. Hussein, "The Role of Zingiber officinale in the Treatment of Alzheimer ’s disease:In-Vitro and In-Vivo Evidences", Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 6, pp. 735-749, 2015. the_role_of_zingiber_officinale_in_the_treatment_of_alzheimer_s_disease.pdf
Mansour, M. M. S., A. A. Hafiez, Z. H. M. El‐Kirdassy, M. N. El‐Malkh, F. A. Halawa, and E. M. I. El‐Zayat, "Role of zinc in regulating the testicular function. Part 2. Effect of dietary zinc deficiency on gonadotropins, prolactin and testosterone levels as well as 3β‐hydroxysteroid dehydrogenase activity in testes of male albino rats", Food/Nahrung, vol. 33, issue 10: WILEY‐VCH Verlag GmbH Weinheim, pp. 941-947, 1989. Abstract
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Hafiez, A. A., Z. H. M. El‐Kirdassy, M. M. S. Mansour, H. M. Sharada, and E. M. I. El‐Zayat, "Role of zinc in regulating the testicular function. Part 1. Effect of dietary zinc deficiency on serum levels of gonadotropins, prolactin and testosterone in male albino rats", Food/Nahrung, vol. 33, issue 10: WILEY‐VCH Verlag GmbH Weinheim, pp. 935-940, 1989. Abstract
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Hafiez, A. A., Z. H. M. El‐Kirdassy, N. M. El‐Malkh, and E. M. I. El‐Zayat, "Role of zinc in regulating the testicular function part 3. Histopathological changes induced by dietary zinc deficiency in testes of male albino rats", Food/Nahrung, vol. 34, issue 1: WILEY‐VCH Verlag GmbH Weinheim, pp. 65-73, 1990. Abstract
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Abdelzaher, W. Y., D. A. A. Labib, and N. D. M. Toni, "The Role of Zileuton in Indomethacin- Induced Gastric Ulceration in Pyloric- Ligated Diabetic Rats", Egyptian journal of basic and clinical pharmacology. Sep 2017, vol. 7, issue 1, pp. 1-13, 2017.
Ali, R. M., M. Y. Al-Shorbagy, M. W. Helmy, and H. S. El-Abhar, "Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone.", European journal of pharmacology, vol. 831, pp. 68-76, 2018 Jul 15. Abstract

Renal ischemia-reperfusion injury (I/RI) remains a critical clinical situation. Several evidence revealed the potential reno-protective effects of Vitamin D and/or pioglitazone, on renal I/RI. This study addresses the possible involvement of the Wnt4/β-catenin signaling, p-S536NF-κBp65, PPARγ, Ang II/TGF-β, and ACE2 as potential effectors to vitamin D and pioglitazone-mediated renoprotective effects. Two sets of Sprague-Dawley rats (n = 30 rat each), were randomized into sham, I/R, Vit D "alfacalcidol" (5 ng/kg/day), pioglitazone (5 mg/kg/day), and Vit D + pioglitazone groups. In all groups renal biochemical parameters, as well as inflammatory and structural profiles were assessed, besides the expression/contents of Wnt4/β-catenin and pS536-NF-κBp65. All treatments started 7 days before I/RI and animals were killed 24 h after I/RI in the first set, while those in the 2nd set continued their treatments for 14 days. After 24 h, all pre-treatments impeded theI/R effect on neutrophils recruitment, p-S536NF-κBp65, IL-18, NGAL, caspase-3, AngII, ACE-2, PPARγ and TGF-β, besides the expression of Wnt4 and ACE-2 with notable reflection on histological changes. Two weeks after I/RI, except a marked up regulation in Wnt4 expression and a striking elevation in the β-catenin content, the magnitude of the injurious events was relatively less pronounced, an effect that was mostly augmented by the different treatments. The current study pledges a promising and novel reno-protective role of the administration of Vit D and pioglitazone entailing a potential involvement of ICAM-1, MPO, NF-κB, Ang II, ACE2, TGFβ, and a modulation of Wnt4/β-catenin pathway.

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