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Gaber, H. M., A. W. Erian, S. M. Sherif, and S. A. Ouf, "Pyrrolopyridine o-aminonitriles in heterocyclic synthesis: Synthesis and antimicrobial effects of novel pyridopyrrolopyrimidines and related molecules", Afinidad, vol. 62, no. 516: Asociacion de Quimicos del Instituto Quimico de Sarria, pp. 143–150, 2005. Abstract
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Khalil, O. M., S. Bua, H. E. S. Teba, Y. M. Nissan, and C. T. Supuran, "Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases,", European Journal of Medicinal Chemistry , vol. 188 , pp. 112021, 2020.
Zaafan, M. A., H. F. Zaki, A. I. El-Brairy, and S. A. Kenawy, "Pyrrolidinedithiocarbamate attenuates bleomycininduced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parameters", Experimental Lung Research, vol. 42, pp. 408-416, 2016. pdtc_pulmonary_fibrosis.pdf
Abd-El-Fattah, M. A., N. F. Abdelakader, and H. F. Zaki, "Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats", European Journal of Pharmacology, vol. 723, pp. 330-338, 2014. 330.pdf
Abd-El-Fattah, M. A., N. F. Abdelakader, and H. F. Zaki, "Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats", European Journal of Pharmacology, vol. 723, pp. 330-338, 2014. Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that leads to disturbances of cognitive
functions. Although the primary cause of AD remains unclear, brain acetylcholine deficiency, oxidative
stress and neuroinflammation may be considered the principal pathogenic factors. The present study was
constructed to investigate the anti-amnestic effect of pyrrolidine dithiocarbamate (PDTC) on
scopolamine-induced behavioral, neurochemical and biochemical changes in rats. PDTC (50 and
100 mg/kg) and donepezil (2.5 mg/kg) were orally administered for 14 successive days. Dementia was
induced at the end of the treatment period by a single injection of scopolamine (20 mg/kg; i.p.), and
Y-maze test was conducted 30 min thereafter. Rats were then sacrificed and homogenates of cortical and
hippocampal tissues were used for the estimation of noradrenaline, dopamine, serotonin and heat shock
protein 70 contents along with acetylcholinesterase activity. In addition, certain oxidative stress markers,
pro-inflammatory and anti-inflammatory cytokines were assessed. Histological examination of cortical
and hippocampal tissues was also performed. Scopolamine resulted in memory impairment that was
coupled by alterations in the estimated neurotransmitters, heat shock protein 70, acetylcholinesterase
activity, oxidative stress as well as inflammatory biomarkers. Histological analysis revealed serious
damaging effects of scopolamine on the structure of cerebral cortex and hippocampus. Pretreatment of
rats with PDTC in both doses mitigated scopolamine-induced behavioral, biochemical, neurochemical
and histological changes in a manner comparable to donepezil. The observed anti-amnestic effect of
PDTC makes it a promising candidate for clinical trials in patients with cognitive impairment.

Elmahmoudy, B. M., M. A. E. A. Fattah, M. F. Elyamany, and L. A. Rashed, "Pyrrolidine dithiocarbamate and saxagliptin ameliorate ulcerative colitis in rats", Asian Pacific Journal of Tropical Biomedicine, vol. 9, pp. 373-380, 2019. asianpacjtropbiomed_2019.pdf
Abdelkader, N. F., N. M. Arafa, A. S. Attia, A. A. Ain-Shoka, and D. M. Abdallah, "Pyrrolidine dithiocarbamate ameliorates rotenone-induced Parkinson’s disease in rats", Bulletin of Faculty of Pharmacy, Cairo University, vol. 55, issue 1, pp. 107-113, 2017.
Fatahala, S. S., S. Hasabelnaby, A. Goudah, G. I. Mahmoud, and R. H. A. - E. Hameed, "Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators", Molecules, vol. 22, issue 461, 2017.
Fatahala, S. S., S. Hasabelnaby, A. Goudah, G. I. Mahmoud, and H. A. - E. R. Hameed, "Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators", Molecules, vol. 22, issue 3, pp. 461, 2017.
Mohamed, N. A., and N. A. A. El-Ghany, "Pyromellitimide benzoyl thiourea crosslinked carboxymethyl chitosan hydrogels as antimicrobial agents", International Journal of Polymeric Materials and Polymeric Biomaterials , vol. 66, issue 17, pp. 861-870,, 2017.
Al-Awadi, N. A., M. M. Abdelkhalik, I. A. Abdelhamid, and M. H. Elnagdi, "Pyrolytic methods in organic synthesis: Novel routes for the synthesis of 3-oxoalkanenitriles, 2-acyl anilines, and 2-aroyl anilines", Synlett, issue 19, pp. 2979 - 2982, 2007. AbstractWebsite
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Al-Awadi, N. A., M. M. Abdelkhalik, I. A. Abdelhamid, and M. H. Elnagdi, "Pyrolytic methods in organic synthesis: Novel routes for the synthesis of 3-oxoalkanenitriles, 2-acyl anilines, and 2-aroyl anilines", Synlett, no. 19: Thieme, pp. 2979–2982, 2007. Abstract
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Amin, M., K. A. Darwish, and S. S. Ibrahim, "Pyroelectricity and electrical conductivity in polycrystalline triglycine sulfate (TGS)", Ferroelectrics, vol. 76, no. 1: Taylor & Francis, pp. 33–41, 1987. Abstract
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El‐Kabbany, F., Y. Badr, and G. Said, "Pyroelectric and dielectric behaviour of ammonium nitrate at the phase transition II–I", physica status solidi (a), vol. 63, no. 1, pp. 355-362, 1981. AbstractWebsite
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Y.Khormi, A., T. A.Farghaly, and M. R.Shaaban, "Pyrimidyl formamidine palladium(II) complex as a nanocatalyst for aqueous Suzuki-Miyaura coupling", Heliyon, vol. 5, pp. e01367-19, 2019.
Khormi, A. Y., T. A. Farghaly, and M. R. Shaaban, "Pyrimidyl formamidine palladium(II) complex as a nanocatalyst for aqueous Suzuki-Miyaura coupling", Heliyon, vol. 5, issue 5, pp. e1367, 2019. 1-s2.0-s2405844019310370-main_1.pdf
Mansour, A. M., and O. R. Shehab, "Pyridylbenzimidazole‐Based Gold (III) Complexes: Lysozyme Metalation, DNA Binding Studies, and Biological Activity", European Journal of inorganic Chemistry, vol. 2019, pp. 2830, 2019.
Mansour, A. M., and O. R. Shehab, "Pyridylbenzimidazole-Based Gold(III) Complexes: Lysozyme Metalation, DNA Binding Studies, and Biological Activity", European Journal of Inorganic Chemistry, pp. 2830, 2019.
Sanad, S. M. H., A. M. Abdel‐Fattah, F. A. Attaby, and M. A. A. Elneairy, "Pyridine‐2(1H)‐thiones: Versatile Precursors for Novel Pyrazolo[3,4‐b]pyridine, Thieno[2,3‐b]pyridines, and Their Fused Azines", Journal of Heterocyclic Chemistry, vol. 56, issue 2, pp. 651-662, 2019. 12_j_heterocyclic_chem_2019.pdf
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