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2023
Montasser, R. K., and I. M. A. Helal, "Process Discovery Automation: Benefits and Limitations", 2023 Intelligent Methods, Systems, and Applications (IMSA): IEEE, pp. 496–501, 2023. Abstract
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Shalabi, A. A., A. E. - Halawany, A. M. El-Desoky, S. O. Mohamed, E. Abdel-Sattar, and M. R. Meselhy, "Production of a gingerol-rich extract from ginger rhizome powder using a green extraction protocol.", Journal of Food & Nutrition Research, vol. 62, issue 1, 2023. Abstract
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H. Moubasher, A.M. Abu-Taleb, A. El-Kholy, and S. A. El-Salmy, "Production of Antibacterial Compounds from Aspergillus terreus Against MDR Acinetobacter baumannii Using Co-culture", European Journal of Medical and Health Sciences ., vol. 5, issue 3, pp. 63 - 73, 2023.
Amany Abdelfattah, Reham Samir, H. A. M., "Production of highly immunogenic and safe Triton X-100 produced bacterial ghost vaccine against Shigella flexneri 2b serotype", Gut Pathogen, vol. 15, issue 1, pp. 41, 2023.
Abdelrahman, A. G., N. A. Yassien, H. M. H. Mohamed, K. S. Tolba, and H. H. S. Abdel-Naeem, "Production of value-added meat patties from spent hen meat by addition of kiwi and pineapple extracts", Advances in Animal and Veterinary Sciences, vol. 11, issue 1, pp. 72-82, 2023.
El-Kheir, G. A. A., A. A.shaker, Hallie P. Street, Nicholas R. Longrich, Amin Strougo, Anhar Asan, and M. Abdel Gawad, "A Prognathodontin Mosasaur from the Maastrichtian of the Dakhla Oasis,Western Desert, Egypt", Fossil Studies, vol. 1, pp. 60-75, 2023.
Nabil, R., N. M. Hassan, M. S. Abdellateif, R. M. Gawdat, and S. S. Elshazly, "The prognostic role of C-KIT, TET1 and TET2 gene expression in Acute Myeloid Leukemia.", Molecular biology reports, vol. 50, issue 1, pp. 641-653, 2023. Abstract

AIM: was to assess the role of C-KIT, TET1 and TET2 expression in the diagnosis and prognosis of acute myeloblastic leukemia (AML).

METHODS: The expression levels of C-KIT, TET1 and TET2 were assessed in the bone marrow (BM) aspirate of 152 AML patients compared to 20 healthy control using quantitative real-time polymerase chain reaction (qRT-PCR). Data were correlated with the clinico-pathological features of the patients, response to treatment, disease-free survival (DFS), and overall survival (OS) rates.

RESULTS: C-KIT, TET1 and TET2 were significantly upregulated in AML patients [0.25 (0-11.6), 0.0113 (0-3.301), and 0.07 (0-4); respectively], compared to the control group [0.013 (0.005-0.250), P < 0.001, 0.001 (0-0.006), P < 0.001, and 0.02 (0.008-0.055), P = 0.019; respectively]. The sensitivity, specificity, and area under curve of of C-KIT were (48.7%, 100%, 0.855; respectively, P = 0.001), and that of TET1 were (63.4%, 100%, 0.897; respectively, P = 0.001), while that of TET2 were (56.8%, 100%, 0.766; respectively, P = 0.019). When combining the three markers, the sensitivity was 77.5%, however it reached the highest sensitivity (78.6%) and specificity (100%) when combining both c-KIT + TET1 together for the diagnosis of AML. C-KIT overexpression associated with shorter DFS (P = 0.05) and increased incidence of relapse (P = 0.019). Lymph nodes involvement [HR = 2.200, P = 0.005] is an independent risk factor for shorter OS rate of AML patients. Increased BM blast % [HR = 7.768, P = 0.002], and FLT3-ITD mutation [HR = 2.989, P = 0.032] are independent risk factors for shorter DSF rate of the patients.

CONCLUSION: C-KIT, TET1, and TET2 could be used as possible useful biomarkers for the diagnosis of AML.

alhelf, M., R. M. S. Shoaib, A. Elsaid, N. Bastawy, N. S. Elbeltagy, E. T. Salem, S. Refaat, and E. H. Abuelnadar, "Prognostic significance of the genetic variant of lymphotoxin alpha (p. Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma", Molecular Biology Reports, vol. 50, no. 5: Springer Netherlands Dordrecht, pp. 4317–4327, 2023. Abstract
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Hafez, N., L. Refaat, O. K. ElGebaly, H. M. Elhariry, M. Ghareeb, and L. A. Fathalla, "Prognostic value of RGS1 and mTOR Immunohistochemical expression in Egyptian multiple myeloma patients; A single center study.", PloS one, vol. 18, issue 7, pp. e0288357, 2023. Abstract

INTRODUCTION: Prognostic factors in plasma cell myeloma were proved to be related to signaling pathways and associated transcription factors. RGS1 and mTOR were known to play an important role in the pathogenesis of multiple myeloma. The aim of the study was to evaluate the expression and the prognostic value of RGS1 and mTOR and their relation to clinical as well as other diagnostic criteria in multiple myeloma.

PATIENTS AND METHODS: The present study included 44 denovo Myeloma patients, recruited from the Medical Oncology Department, National Cancer Institute, Cairo University. Detection of RGS1 and mTOR expression was performed using Immunohistochemical staining on bone marrow biopsy sections.

RESULTS: The median age was 51 years with male to female ratio 1.58:1. There was a positive highly statistically significant correlation between RGS1 and mTOR among all studied cases (p value <0.001). Regarding their prognostic value, there was a highly statistically significant association of the expression levels of RGS1 and mTOR with treatment response (p <0.001). Finally, there was a significant influence of RGS1 and mTOR on overall survival probability (p value <0.001 and <0.002 respectively) with better survival for those having low expression.

CONCLUSION: RGS1 and mTOR were suggested as poor prognostic markers in MM patients, being associated with lower response rate and inferior OS. We recommend considering RGS1 and mTOR as one of the prognostic criteria in different risk stratification and staging classifications. Further trials for RGS1 and mTOR targeting in multiple myeloma are recommended.

Mazeed, H. M., "A Program for Developing Some Motor Skills for Down Syndrome Children Using Music", International Journal of Early Childhood, vol. 55, pp. 47-68, 2023.
Sharobim, B. K., S. K. Abd-El-Hafiz, and A. G. Radwan, "Progressive Multi-Secret Sharing of Color Images Using Lorenz Chaotic System", 2023 12th International Conference on Modern Circuits and Systems Technologies (MOCAST): IEEE, pp. 1-6, 2023. Abstract
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Bawish, B. M., M. A. Rabab, S. T. Gohari, M. S. Khattab, N. A. AbdElKader, S. H. Elsharkawy, A. M. Ageez, M. M. Zaki, S. Kamel, and E. M. A. N. M. ISMAIL, "Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on Aspirin-induced gastric ulcers in Wistar rats: anxiolytic behavioural effect, antioxidant activity, and protective pathways.", Inflammopharmacology, vol. 31, issue 6, pp. 3183-3201, 2023. Abstract

BACKGROUND: Many drugs have been restricted in the treatment of gastric ulcers (GU). So, herbal medicines are now in great demand for their better cultural acceptability, compatibility, and minimal side effects. Therefore, our study aimed to assess the protective efficacy of Aloe vera gel and Geranium robertianum extracts against Aspirin®-induced GU in Wistar rats.

METHODS: Antioxidant activity and chemical composition of both herbs were analysed. Then, we divided forty female Wistar rats into five groups: a negative control group, a positive control group of Aspirin®-induced GU, and pretreated groups with Aloe Vera, geranium, and Famotidine (reference drug). The locomotor disability, anxiety-like behaviour, and ultrasonography were assessed. Ultimately, scarification of animals to determine gastric juice pH and ulcer index. Then the collection of stomach and liver for histopathological and immunohistochemical examinations, besides tracing the oxidative stress biomarkers and related genes.

RESULTS: High content of polyphenols was revealed in both extracts. The pretreatment with Aloe vera gel and geranium showed significant antioxidant activities with free radical scavenging and ferric-reducing power (FRAP). Moreover, they improved the stomach architecture and alleviated anxiety-like behaviour and motor deficits. They significantly reduced the expression of proinflammatory cytokine (TNF-α), inflammatory, and oxidative stress genes (NF-KB, HO-1, Nrf-2) while increasing the Keap-1 in gastric mucosa.

CONCLUSION: Data presented a significant protective effect of Aloe vera gel and geranium against Aspirin®-induced GU; they reduced gastric mucosal injury with potential anxiolytic effects through their anti-inflammatory and antioxidant properties. Therefore, they may be considered promising agents for preventing or treating gastric ulceration.

Bawish, B. M., M. A. Rabab, S. T. Gohar, M. S. Khattab, N. A. AbdElkade, S. H. Elsharkawy, A. M. Ageez, M. M. Zaki, S. Kame, and E. M. A. N. M. ISMAIL, "Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on Aspirin®‑induced gastric ulcers in Wistar rats: anxiolytic behavioural effect, antioxidant activity, and protective pathways", Inflammopharmacology, vol. 31, pp. 3183–3201, 2023.
Abdelrahim, A.M., M. G. Abd El-Moghny, M. E. El-Shakre, and M. S. El-Deab, "Promoted glucose electrooxidation at Ni(OH)2/graphene layers exfoliated facilely from carbon waste material", RSC Advances, vol. 13, pp. 1811-1822, 2023.
Assem, M., R. E. El-Araby, A. A. Al-karmalawy, R. Nabil, M. A. M. Kamal, A. Belal, H. I. Ghamry, M. A. S. Abourehab, M. M. Ghoneim, M. Y. Alshahrani, et al., "PROMOTER METHYLATION MIGHT SHIFT THE BALANCE OF gALECTIN-3&12 EXPRESSION IN DE NOVO AML PATIENTS", FRONTIERS IN GENETICS, issue 10.3389, pp. 13, 2023. fgene-14-1122864_1.pdf
Ali, A., and O. Abd El Hameed, "A PROPOSAL FOR PREVENTIVE CONSERVATION AND ACHIEVING SUSTAINABILITY OF THE KHAFRE’S VALLEY TEMPLE IN EGYPT", Egyptian Journal of Archaeological and Restoration Studies, vol. 13, issue 2, pp. 241-253, 2023.
SELIM, A. M. R., N. Al-Hadithy, N. M. Diab, A. M. Ahmed, K. F. Abdelkader, M. Hegazy, H. Abdelazeem, and A. S. Barakat, "Proposal of a modified tip apex distance for prediction of lag screw cut-out in trochanteric hip fractures.", SICOT-J, vol. 9, pp. 28, 2023. Abstract

INTRODUCTION: Lag screw cut-out is a serious complication of dynamic hip screw fixation of trochanteric hip fractures. The lag screw position has been acknowledged as one of the important factors affecting the lag screw cut-out. We propose a modification of the Tip Apex Distance (TAD) and hypothesise that it could improve the reliability of predicting lag screws cut-out in these injuries.

MATERIALS AND METHODS: A retrospective study was conducted for hip fracture entries in the period from Jan 2018 to July 2022. A hundred and nine patients were suitable for the final analysis. The modified TAD was measured in millimetres based on the sum of the traditional TAD in the lateral view and the net value of two distances in the AP view, the first distance is from the tip of the lag screw to the opposite point on the femoral head along the axis of the lag screw while the second distance is from that point to the femoral head apex. The first distance is a positive value, whereas the second distance is positive if the lag screw is superior and negative if inferior. A receiver operating characteristic curve was used to evaluate the reliability of the different parameters assessing the lag screw position within the femoral head.

RESULTS: Reduction quality, fracture pattern as per the AO/OTA classification, TAD, Calcar Referenced TAD, Axis Blade Angle, Parker's ration in the AP view, Cleveland Zone 1, and modified TAD were statistically associated with lag screw cut-out. Among the tested parameters, the modified TAD had 90.1% sensitivity and 90.9% specificity for lag screw cut-out at a cut-off value of 25 mm with a P-value < 0.001.

CONCLUSION: The modified TAD had the highest reliability in the prediction of lag screw cut-out. A value ≤ 25 mm could potentially protect against lag screw cut-out in trochanteric hip fractures.

Gouda, O. E., A. E. Z. Dein, E. Tag‐Eldin, M. A. T. T. I. LEHTONEN, and M. O. H. A. M. E. D. M. F. DARWISH, "Proposed Approach to Investigate the Current and Voltage Distributions of Isolated and Grounded Systems During Earth Fault Conditions", IEEE Access, vol. 11, pp. 98362-98375, 2023.
Hammad, H., Y. Elhakim, Y. Hossam, M. Mahmoud, T. Ismail, and I. S. Fahim, "A proposed framework for measuring direct and indirect carbon emissions in the operational phase of a construction project: a case study", International Journal of Sustainable Engineering, vol. 16, no. 1: Taylor & Francis, pp. 224–235, 2023. Abstract
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Shalaby, E. A., and A. - E. M. Ahmed, "Proposed Mathematical equations for evaluation the quality of scientifi author outputs.", المجلة العلمية للبحوث الإدارية والمحاسبية والاقتصادية والقانونية, vol. 1, issue 1, pp. 25-30 , 2023.
Eldehn, A. F., M. Abdel-Aziz, O. Sabry, and A. Yousef, "Proptosis in Children Caused by Sinonasal Pathology: A Retrospective Study", EJENTAS , vol. 00, issue 00, pp. 1-7, 2023.
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