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Abdel Aziz, M. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function.", The journal of sexual medicine, vol. 6, issue 1, pp. 49-60, 2009 Jan. Abstract

INTRODUCTION: Erectile response depends on nitric oxide (NO) generated by NO synthase (NOS) enzyme of the nerves and vascular endothelium in the cavernous tissue. NO activates soluble guanylate cyclase (sGC), leading to the production of cyclic guanosine monophosphate (cGMP). cGMP activates cGMP-dependent protein kinase that activates Ca(2+)/ATPase pump that activates Ca(2+)/K efflux pump extruding Ca(2+) across the plasma membrane with consequent smooth muscle cell relaxation. A role similar to that of NOS/NO signaling has been postulated for carbon monoxide (CO) produced in mammals from heme catabolism by heme oxygenase (HO) enzyme.

AIM: To assess CO signaling pathway for erectile function by reviewing published studies.

METHODS: A systematic review of published studies on this affair based on Pubmed and Medical Subject Heading databases, with search for all concerned articles.

MAIN OUTCOME MEASURES: Documentation of positive as well as negative criteria of CO/HO signaling focused on penile tissue.

RESULTS: The concept that HO-derived CO could play a role in mediating erectile function acting in synergism with, or as a potentiator for, NOS/NO signaling pathway is gaining momentum. CO/HO signaling pathway has been shown to partially mediate the actions of oral phosphodiesterase type 5 inhibitors. In addition, it was shown that the use of CO releasing molecules potentiated cavernous cGMP levels. However, increased CO production or release was reported to be associated, in some studies, with vasoconstriction.

CONCLUSION: This review sheds a light on the significance of cavernous tissue CO signaling pathway that may pave the way for creation of therapeutic modalities based on this pathway.

Aziz, A. M. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", J Sex Med, vol. 6, issue 1, pp. 49-60, 2009.
Abdel Aziz, M. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", The journal of sexual medicine, vol. 6, no. 1: Wiley Online Library, pp. 49–60, 2009. Abstract
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Abdel Aziz, M. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", The journal of sexual medicine, vol. 6, issue 1: Wiley Online Library, pp. 49-60, 2009. Abstract
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Abdel Aziz, M. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", The journal of sexual medicine, vol. 6, no. 1: Wiley Online Library, pp. 49–60, 2009. Abstract
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aziz, M. A. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", The Journal of Sexual Medicine, vol. 6, no. 1: Elsevier, pp. 49–60, 2009. Abstract
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Al-Naggar, A. M. M., M. M. Shafik, and M. O. A. Elsheikh, "Putative Mechanisms of Drought Tolerance in Maize (Zea mays L.) via Root System Architecture Traits ", Annual Research & Review in Biology, vol. 32, issue (2), pp. 1-19, 2019. 30079-article_text-56436-1-10-20190628_4.pdf
Elgendy, A. M., M. Tufail, A. A. Mohamed, and M. Takeda, "A putative direct repeat element plays a dual role in the induction and repression of insect vitellogenin-1 gene expression.", CBPB, vol. 234, pp. 1-8, 2019.
Elgendy, A. M., M. Tufail, A. A. Mohamed, and M. Takeda, "A putative direct repeat element plays a dual role in the induction and repression of insect vitellogenin-1 gene expression", Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology, vol. 234, pp. 1-8, 2019. AbstractWebsite
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Mesalam, N. M., S. A. Aldhumri, S. A. Gabr, Marwa A Ibrahim, A. K. Al‑Mokaddem, and A. ‑M. E. Abdel‑Moneim, "Putative abrogation impacts of Ajwa seeds on oxidative damage, liver dysfunction and associated complications in rats exposed to carbon tetrachloride", Molecular Biology Reports, vol. 48, pp. 5305–5318, 2021. mesalam2021_article_putativeabrogationimpactsofajw.pdf
Hamouda, S., and N. Wanas, "PUT-Tag: personalized user-centric tag recommendation for social bookmarking systems", Social network analysis and mining , 2013.
EA, E., E. E. RA, A. SH, and I. YM, "Pushed monocanalicular intubation versus probing as a primary management for congenital nasolacrimal obstruction. ", Clin Ophthalmol, vol. Sep 7, issue 10, pp. 1487-93, 2016.
Elsawaby, E. A., R. A. El Essawy, S. H. Abdelbaky, and Y. M. Ismail, "Pushed monocanalicular intubation versus probing as a primary management for congenital nasolacrimal obstruction.", Clinical ophthalmology (Auckland, N.Z.), vol. 10, pp. 1487-93, 2016. Abstract

PURPOSE: Evaluation of efficiency, complications, and advantages of pushed monocanalicular intubation using Masterka(®) tube versus simple probing in patients with congenital nasolacrimal duct obstruction (CNLDO).

PATIENTS AND METHODS: This is a case-controlled study that included 60 eyes (of 53 patients); 30 eyes underwent probing and 30 eyes intubation using the Masterka tube as a primary treatment for CNLDO. The children were aged between 6 months and 36 months at the time of surgery, with no previous nasolacrimal surgical procedure, and had one or more of the following clinical signs of nasolacrimal duct obstruction: epiphora, mucous discharge, and/or increased tear lake.

RESULTS: We defined success by absence of epiphora, mucous discharge, or increased tear lake 1 month after tube removal. The overall success rate in the probing group was 80%, while it was 83.3% in the intubation group.

CONCLUSION: Pushed monocanalicular intubation is an effective method for treatment of CNLDO; it requires only mask inhalation anesthesia and could be considered as an appropriate alternative procedure with imperceptible complications.

Elsawaby, E., R. Elessawy, S. Abdelbaky, and Y. ismail, Pushed monocanalicular intubation for management of congenital nasolacrimal duct obstruction, , 2014.
Elkassas, D., H. Sallam, and A. Ghoneim, "Push-out-bond strength of glass fiber composite posts cemented using two different adhesive approaches", Egyptian Dental Journal, vol. 56, issue 3, pp. 1595-1605, 2010. 1595-1605-44.pdf
Abdel-Salam, A.M., A. - K. E. - S. H. S. S. M., and MHHussein, "Purification, serology, and molecular detection of Egyptian isolates of banana bunchy top babuvirus and faba bean necrotic yellows nanovirus.", Arab J. Biotech, vol. 7, no. (1), pp. 141–155, 2004. Abstract
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Abdel-Salam, A. M., H. S. Abdel-Kader, S. M. El-Saghir, and MHHussein, "Purification, serology and molecular detection of Egyptian isolates of banana bunchy top babuvirus and faba bean necrotic yellows nanovirus", Arab J. Biotechnol, vol. 7, pp. 141-155, 2004. Abstract
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Abdel-Rahman, T. M., N. M. Khalil, M. N. A. El-Ghany, and E. Yosef, "Purification, characterization and medicinal application of tyrosinase extracted from Saccharomyces cerevisiae", Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 6, issue 1, pp. 1-11, 2019.
Abdel-Rahman, T. M., N. M. Khalil, M. N. Abd El-Ghany, and E. Yosef, "Purification, characterization and medicinal application of tyrosinase extracted from Saccharomyces cerevisiae", Journal of Innovations in Pharmaceutical and Biological Sciences (JIPBS, vol. 6, issue 1, pp. 1-11, 2019.
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