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1973
Abdou, M. S. S., A. B. El-Wishy, and G. Singh, "Preservation of buffalo semen. I— Effect of adjustment of pH on viability of buffalo spermatozoa in vitro", 11th Arab Vet. Congr, 1973.
, "Prevention of early histopathological changes in the liver in extensive burns", British Journal of Plastic Surgery, vol. 26, pp. 132-139, 1973.
Khayyal, M. T., S. Saleh, and A. M. El-Masri, "Penicillamine as an adjuvant to antimonial therapy of schistosomiasis: effect on liver function tests in rabbits and on antischistosomal activity.", Bulletin of the World Health Organization, vol. 48, issue 4, pp. 415-20, 1973. Abstract

Earlier work has shown that penicillamine reduces the acute toxicity of antimonyl potassium tartrate (APT) as well as the abnormal ECG changes it induces. In the present study, the possible protective effect of penicillamine on the hepatic toxicity of APT was investigated. Tests of liver function showed changes in the level of serum aspartate and alanine aminotransferase and of alkaline phosphatase, and in the beta-/alpha-lipoprotein ratio, in response to antimony treatment. The changes were significantly reduced by penicillamine, though the effect depended on the dose. Penicillamine was found to give the best overall protection without affecting the antischistosomal efficacy of the antimonial when a 1:2 APT/penicillamine ratio was used. The findings provide further evidence of the potential usefulness of penicillamine in the antimonial treatment of schistosomiasis.

Khayyal, M. T., S. Saleh, and A. M. El-Masri, "Penicillamine as an adjuvant to antimonial therapy of schistosomiasis: effect on liver function tests in rabbits and on antischistosomal activity.", Bulletin of the World Health Organization, vol. 48, issue 4, pp. 415-20, 1973. Abstract

Earlier work has shown that penicillamine reduces the acute toxicity of antimonyl potassium tartrate (APT) as well as the abnormal ECG changes it induces. In the present study, the possible protective effect of penicillamine on the hepatic toxicity of APT was investigated. Tests of liver function showed changes in the level of serum aspartate and alanine aminotransferase and of alkaline phosphatase, and in the beta-/alpha-lipoprotein ratio, in response to antimony treatment. The changes were significantly reduced by penicillamine, though the effect depended on the dose. Penicillamine was found to give the best overall protection without affecting the antischistosomal efficacy of the antimonial when a 1:2 APT/penicillamine ratio was used. The findings provide further evidence of the potential usefulness of penicillamine in the antimonial treatment of schistosomiasis.

Khayyal, M. T., S. Saleh, and A. M. El-Masri, "Penicillamine as an adjuvant to antimonial therapy of schistosomiasis: effect on liver function tests in rabbits and on antischistosomal activity.", Bulletin of the World Health Organization, vol. 48, issue 4, pp. 415-20, 1973. Abstract

Earlier work has shown that penicillamine reduces the acute toxicity of antimonyl potassium tartrate (APT) as well as the abnormal ECG changes it induces. In the present study, the possible protective effect of penicillamine on the hepatic toxicity of APT was investigated. Tests of liver function showed changes in the level of serum aspartate and alanine aminotransferase and of alkaline phosphatase, and in the beta-/alpha-lipoprotein ratio, in response to antimony treatment. The changes were significantly reduced by penicillamine, though the effect depended on the dose. Penicillamine was found to give the best overall protection without affecting the antischistosomal efficacy of the antimonial when a 1:2 APT/penicillamine ratio was used. The findings provide further evidence of the potential usefulness of penicillamine in the antimonial treatment of schistosomiasis.

1974
Mahran, G. H., S. H. Hilal, and T. S. El-Alfy, "A phytochemical investigation of Hedera helix L. growing in Egypt", Egyptian Journal of Pharmaceutical Sciences (Egypt), 1974. Abstract
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Shafie, M. M., and M. M. Mashaly, "Pre-and postnatal thyroid development in bovines", Cells Tissues Organs, vol. 87, issue 4: Karger Publishers, pp. 615-634, 1974. Abstract
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Reid, W. M., J. W. Dick, and F. K. R. Stino, "Preventing coccidiosis by continuous medication", Georgia agricultural research, 1974. Abstract
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Mashaly, M. M., and B. C. Wentworth, "A profile of progesterone in turkey sera", Poultry science, vol. 53, issue 6: Poultry Science Association, pp. 2030-2035, 1974. Abstract
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Mashaly, M. M., E. L. B. E. G. E. A. R. M, and W. E. N. T. W. O. R. T. BC, "PROGESTERONE AND 17 BETA-ESTRADIOL LEVELS IN PERIPHERAL-BLOOD DURING OVULATORY CYCLE OF TURKEY HEN", POULTRY SCIENCE, vol. 53, issue 5: POULTRY SCIENCE ASSOC INC 1111 NORTH DUNLAP AVE, SAVOY, IL 61874, pp. 1952-1952, 1974. Abstract
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Linser, H., A. Raafat, and F.A.Zeid, "Pure protein and chlorophyll of Daucus carota throughout the vegetative period of first year as influenced by growth regulators (CCC, GA and BA).", Journal of Plant Nutrition and Soil Science (Germany),, vol. 137, pp. 36–40, 1974. Abstract
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1975
Shabana, M. M., T. S. M. El Alfy, and G. H. Mahran, "A pharmacognostical study of Lycopersicum pruniforme mill. root bark", Bull. Fac. Pharm., Cairo, vol. 12, no. 2, pp. 141–50, 1975. Abstract
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Jackson, M. J., Principles of {Program} {Design}, , London, Academic Press, 1975. Abstract
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Baccanari, D., A. Phillips, S. Smith, D. Sinski, and J. Burchall, "Purification and properties of Escherichia coli dihydrofolate reductase.", Biochemistry, vol. 14, issue 24, pp. 5267-73, 1975 Dec 2. Abstract

Dihydrofolate reductase has been purified 40-fold to apparent homogeneity from a trimethoprim-resistant strain of Escherichia coli (RT 500) using a procedure that includes methotrexate affinity column chromatography. Determinations of the molecular weight of the enzyme based on its amino acid composition, sedimentation velocity, and sodium dodecyl sulfate gel electrophoresis gave values of 17680, 17470 and 18300, respectively. An aggregated form of the enzyme with a low specific activity can be separated from the monomer by gel filtration; treatment of the aggregate with mercaptoethanol or dithiothreitol results in an increase in enzymic activity and a regeneration of the monomer. Also, multiple molecular forms of the monomer have been detected by polyacrylamide gel electrophoresis. The unresolved enzyme exhibits two pH optima (pH 4.5 and pH 7.0) with dihydrofolate as a substrate. Highest activities are observed in buffers containing large organic cations. In 100 mM imidazolium chloride (pH 7), the specific activity is 47 mumol of dihydrofolate reduced per min per mg at 30 degrees. Folic acid also serves as a substrate with a single pH optimum of pH 4.5. At this pH the Km for folate is 16 muM, and the Vmax is 1/1000 of the rate observed with dihydrofolate as the substrate. Monovalent cations (Na+, K+, Rb+, and Cs+) inhibit dihydrofolate reductase; at a given ionic strength the degree of inhibition is a function of the ionic radius of the cation. Divalent cations are more potent inhibitors; the I50 of BaCl2 is 250 muM, as compared to 125 mM for KCl. Anions neither inhibit nor activate the enzyme.

Crow, T. J., J. F. Deakin, and A. Longden, "Proceedings: Do anti-psychotic drugs act by dopamine receptor blockade in the nucleus accumbens.", British journal of pharmacology, vol. 55, issue 2, pp. 295P-296P, 1975 Oct. Abstract
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Coscia, L., P. Causa, E. Giuliani, and A. Nunziata, "Pharmacological properties of new neuroleptic compounds.", Arzneimittel-Forschung, vol. 25, issue 9, pp. 1436-42, 1975 Sep. Abstract

RMI 61 140, RMI 61 144 and RMI 61 280 are newly synthetized N-[8-R-dibenzo(b,f)oxepin-10-yl]-N'-methyl-piperazine-maleates which show interesting psychopharmacologic effects. This work contains the results of a study performed with these three compounds, in order to demonstrate their neuropsycholeptic activity in comparison with chloropromazine (CPZ) and chlordiazepoxide (CPD). The inhibition of motility observed in mice shows that the compounds reduce the normal spontaneous motility as well as the muscle tone. The central-depressant activity is evidenced by increased barbiturate-induced sleep and a remarkable eyelid ptosis can also be observed. Our compounds do not show any activity on electroshock just as do CPZ and CPD. As to the antipsychotic outline, our compounds show strong reduction of lethality due to amphetamine in grouped mice and a strong antiapomorphine activity. They show also an antiaggressive effect and an inhibitory activity on avoidance behaviour much stronger than CPZ. We have also found extrapyramidal effects, as catalepsy, common to many tranquillizers of the kind of the standards used by us. As for vegetative phenomena, the compounds show hypotensive dose related action ranging from moderate to strong, probably due to an a-receptor inhibition. Adrenolytic activity against lethal doses of adrenaline, antiserotonin and antihistaminic effects, as well as other actions (hypothermia, analgesia, etc.) confirm that RMI 61 140, RMI 61 144 and RMI 61 280 are endowed with pharmacologic properties similar and more potent than those of CPZ. Studies on the metabolism of brain catecholamines show that they are similar to CPZ, although with less effect on dopamine level.

Coscia, L., P. Causa, E. Giuliani, and A. Nunziata, "Pharmacological properties of new neuroleptic compounds.", Arzneimittel-Forschung, vol. 25, issue 9, pp. 1436-42, 1975 Sep. Abstract

RMI 61 140, RMI 61 144 and RMI 61 280 are newly synthetized N-[8-R-dibenzo(b,f)oxepin-10-yl]-N'-methyl-piperazine-maleates which show interesting psychopharmacologic effects. This work contains the results of a study performed with these three compounds, in order to demonstrate their neuropsycholeptic activity in comparison with chloropromazine (CPZ) and chlordiazepoxide (CPD). The inhibition of motility observed in mice shows that the compounds reduce the normal spontaneous motility as well as the muscle tone. The central-depressant activity is evidenced by increased barbiturate-induced sleep and a remarkable eyelid ptosis can also be observed. Our compounds do not show any activity on electroshock just as do CPZ and CPD. As to the antipsychotic outline, our compounds show strong reduction of lethality due to amphetamine in grouped mice and a strong antiapomorphine activity. They show also an antiaggressive effect and an inhibitory activity on avoidance behaviour much stronger than CPZ. We have also found extrapyramidal effects, as catalepsy, common to many tranquillizers of the kind of the standards used by us. As for vegetative phenomena, the compounds show hypotensive dose related action ranging from moderate to strong, probably due to an a-receptor inhibition. Adrenolytic activity against lethal doses of adrenaline, antiserotonin and antihistaminic effects, as well as other actions (hypothermia, analgesia, etc.) confirm that RMI 61 140, RMI 61 144 and RMI 61 280 are endowed with pharmacologic properties similar and more potent than those of CPZ. Studies on the metabolism of brain catecholamines show that they are similar to CPZ, although with less effect on dopamine level.

1976
Yoho, T. P., L. Butler, and J. E. Weaver, "Photodynamic killing of house flies fed food, drug, and cosmetic dye additives", Environmental Entomology, vol. 5, issue 1: Oxford University Press Oxford, UK, pp. 203-204, 1976. Abstract
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Hilal, S. H., M. D. Sayed, T. S. El-Alfy, and M. M. El-Sherei, "Phytochemical study of Conyza linifolia (Willd) growing in Egypt. 2.-Steroidal content [drug plant]", Egyptian Journal of Pharmaceutical Sciences (Egypt), 1976. Abstract
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Tourism