Publications

Export 9053 results:
Sort by: Author [ Title  (Desc)] Type Year
A B C D E F G H I J K L M N O [P] Q R S T U V W X Y Z   [Show ALL]
P
Yaccoubi, F., M. El-Naggar, F. M. Abdelrazek, S. M. Gomha, M. S. Farghaly, T. Z. Abolibda, L. A. Ali, and A. H. Abdelmonsef, "Pyrido-pyrimido-thiadiazinones: green synthesis, molecular docking studies and biological investigation as obesity inhibitors", J. Taibah University for Science, vol. 16, issue 1, pp. 1275-1286, 2022.
Chen, W., S. A. Elfeky, Y. Nonne, L. Male, K. Ahmed, C. Amiable, P. Axe, S. Yamada, T. D. James, S. D. Bull, et al., "A pyridinium cation–$π$ interaction sensor for the fluorescent detection of alkyl halides", Chemical Communications, vol. 47, no. 1: Royal Society of Chemistry, pp. 253–255, 2011. Abstract
n/a
Chen, W., S. A. Elfeky, Y. Nonne, L. Male, K. Ahmed, C. Amiable, P. Axe, S. Yamada, T. D. James, S. D. Bull, et al., "A pyridinium cation-? interaction sensor for the fluorescent detection of alkyl halides", Chemical Communications, vol. 47, no. 1, pp. 253-255, 2011. Abstract
n/a
Sanad, S. M. H., A. M. Abdel‐Fattah, F. A. Attaby, and M. A. A. Elneairy, "Pyridine‐2(1H)‐thiones: Versatile Precursors for Novel Pyrazolo[3,4‐b]pyridine, Thieno[2,3‐b]pyridines, and Their Fused Azines", Journal of Heterocyclic Chemistry, vol. 56, issue 2, pp. 651-662, 2019. 12_j_heterocyclic_chem_2019.pdf
Sanad, S. M. H., A. E. M. Mekky, A. Y. Said, and M. A. A. Elneairy, "Pyridine-2(1H)-thiones: Versatile precursors for one-pot synthesis of new nicotinonitrile-thiazole hybrids", Journal of Heterocyclic Chemistry, vol. 58, no. 7, pp. 1461-1471, 2021. AbstractWebsite
n/a
Sanad, S. M. H., A. E. M. Mekky, A. Y. Said, and M. A. A. Elneairy, "Pyridine-2(1H)-thiones: Versatile Precursors for One-pot Synthesis of New Nicotinonitrile-Thiazole Hybrids", J. Heterocyclic Chem. , vol. 58, issue 7, pp. 1461-1471, 2021. 034_j_heterocyclic_chem_2021.pdf
Ismail, M. M., R. H. Omar, M. M. Said, A. Ahmady, A. H. Omar, and B. H. Naguib, "Pyridine carbonitrile derivatives as versatile synthons for some heterocyclic compounds of pharmaceutical interest", Bulletin of the faculty of Pharmacy, Cairo University, vol. 41 , issue 3, pp. 1-11, 2003.
Abouzid, K. K., M. A. Hakeem, OmnyaKhalil, and YosriaMaklad, "Pyridazinone derivatives: Design, synthesis, and in vitro vasorelaxant activity", Bioorganic & Medicinal Chemistry, vol. 16, issue 1, pp. 382-389, 2008.
Eldin, A. S. M., "Pyridazine, oxazine, pyrrole, and pyrrolo [1, 2-a] quinazoline derivatives from malononitrile dimer", Heteroatom Chemistry, vol. 14, no. 7: Wiley Online Library, pp. 612–616, 2003. Abstract
n/a
Ewieda, S. Y., E. M. Ahmed, R. A. Hassan, and M. S. A. Hassan, "Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates", Drug Development Research, vol. 84, issue 8, pp. 1595-1623, 2023.
Osman, E. O., N. A. Khalil, A. Magdy, and Y. El-Dash, "Pyridazine and pyridazinone derivatives: Synthesis and in vitro investigation of their anti-inflammatory potential in LPS-induced RAW264.7 macrophages", Drug Development Research, vol. 85, no. 2, pp. e22173, 2024. AbstractWebsite

Abstract New pyridazine and pyridazinone derivatives 3a–g, 4a–f, 6a, and 6b were designed and synthesized. Cell viability of all compounds was established based on the viability of lipopolysaccharide-induced RAW264.7 macrophage cells determined via the MTT assay. In vitro inhibition assays on human COX-1 and COX-2 enzymes were conducted to probe the newly synthesized compounds' anti-inflammatory activity. The half maximal inhibitory concentration values for the most active compounds, 3d, 3e, and 4e towards COX-2 were 0.425, 0.519, and 0.356 µM, respectively, in comparison with celecoxib. The newly synthesized compounds' ability to inhibit the production of certain proinflammatory cytokines, such as inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-6, and prostaglandin-E2, was also estimated in lipopolysaccharide-induced macrophages (RAW264.7 cells). Compounds 3d and 3e were identified as the most potent cytokine production inhibitors. The results of molecular modeling studies suggested that these compounds were characterized by a reasonable binding affinity toward the active site of COX-2, when compared to a reference ligand. These results might be taken into consideration in further investigations into new anti-inflammatory agents.

Tageldin1, R., A. Zayed, E. Abd-EI-Samie, H. Mahmoud, and undefined, "Pyrethroid Resistance Monitoring in Culex pipiens Mosquito Populations from Three Egyptian Governorates.", J. Nucl. Tech. Appl. Sci, vol. 6, issue 3, 2018.
Tageldin, R. A., A. Zayed, E. M. Abd-EI-Samie, H. I. Mahmoud, and A. B. Zayed, "Pyrethroid Resistance Monitoring in Culex pipiens Mosquito Populations from Three Egyptian Governorates", J. Nucl. Tech. Appl. Sci., Vol. 6, No. 3, PP. 133 : 141, 2018. Abstract
n/a
Sanad, S. M. H., A. E. M. Mekky, and A. A. M. Ahmed, "Pyrazolo[5,1-b]quinazolines and Their Bis-analogues Linked to Different Spacers: Regioselective Synthesis, Antibacterial Screening and SwissADME Prediction Study", ChemistrySelect , vol. 8, issue 22, pp. e202300171, 2023. 23-03.pdf
KASSAB, A. S. M. A. A. E., "Pyrazolo[3,4‐d]pyrimidine scaffold: A review on synthetic approaches and EGFR and VEGFR inhibitory activities", Archiv der Pharmazie, vol. 356, pp. e2200424, 2023.
Latif, N. A. S., P. H. O. E. B. E. F. LAMIE, A. M. El-Kalaawy, L. A. Rashed, and J. N. Philoppes, "Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structureeactivity relationship and biological activity as potential antitumor and anticonvulsant agents", European Journal of Medicinal Chemistry, vol. 214, issue 113222, 2021.
Metwally, N. H., and M. S. Mohamed, "Pyrazoloquinazoline derivatives: Synthesis, reactions, and biological applications", Synthetic communications, vol. 48, issue 7, pp. 721-745, 2018. metwally2018.pdf
Ragab, F. A., N. A. M. Gawad, H. H. Georgey, and M. F. Said, "Pyrazolone Derivatives: Synthesis, Anti-inflammatory, Analgesic, Quantitative Structure–Activity Relationship and in Vitro Studies", Chem Pharm Bull, vol. 61, issue 8 , pp. 834–845, 2013. chem_pharm_bull.pdf
Ragab, F. A. E. - F., N. M. Abdel-Gawad, H. H. Georgey, and M. F. Said, "Pyrazolone Derivatives: Synthesis, Anti-inflammatory, Analgesic, Quantitative Structure–Activity Relationship and in Vitro Studies", Chem. Pharm. Bull, vol. 61, issue 8, pp. 834–845, 2013. bull._manuscript.pdf
Farghaly, T. A., M. A. Abdallah, H. K. Mahmoud, N. El‐Metwaly, and M. Elaasser, "Pyrazolo [5, 1‐c][1, 2, 4] triazoles: Antimicrobial, Antitumor Activities, and Computational Docking Studies", Journal of Heterocyclic Chemistry, vol. 54, issue 5: Wiley Online Library, pp. 2859-2866, 2017. Abstract
n/a
Al-Soliemy, A. M., R. Sabour, and T. A. Farghaly, "Pyrazoles and Fused Pyrimidines: Synthesis, Structure Elucidation, Antitubercular Activity and Molecular Docking Study", Medicinal Chemistry, vol. 18, pp. 181-198, 2022.
Tourism