Publications

Conzelmanu, H., M. Schluckebier, T. Pfeiffer, K. Muskalla, W. Schmiilling, D. Kamke, M. A. Harith, J. P. Zhang, S. U. Campisano, H. J. Klaar, et al., "N 2 Laser Frequency Conversion by Stimulated Raman Scattering in H 2", Applied Physics A, vol. 42, no. 1: Springer, 1987. Abstract

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Ali, M. M., M. S., A. T. Hossam, and F. A. Attaby, "N acetyl transferase 2 gene polymorphism in bladder cancer: A study from Egypt.", New Egypt. J. Med., vol. 35, issue 2, pp. 87-93 , 2007.

Mahmoud, A. M., M. N. Saad, E. S. Elzanfaly, S. M. Amer, and H. A. M. Essam, "n electrochemical sensing platform to determine tetrahydrozoline HCl in pure form, pharmaceutical formulation, and rabbit aqueous humor", : Anal. Methods, 2020, DOI: 10.1039/d0ay00882f rsc.li/methods This journal is © The Royal Society of Chemistry 2020 Anal. Methods, 2020, 12, 2903–2913 | 2903 Analytic, vol. 12, pp. 2903, 2020.

electrooo.pdf

Ghozlan, S. A. S., M. A. Ramadan, A. M. Abdelmoniem, and I. A. Abdelhamid, "N-(Pyrazol-5-yl) cyanoacetamide in heterocyclic synthesis: synthesis of novel N-(pyrazol-5-yl) pyridine-3, 5-dicarbonitrile, pyrazolo [1, 5-a]-pyrido [3, 2-e] pyrimidine-7-carbonitrile and pyrazolo [4, 3-e] pyrido [1, 2-a]-pyrimidine-6, 8", Arkivoc, issue part vii, pp. 30-41, 2019. Abstract

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Ghozlan, S. A. S., M. A. Ramadan, A. M. Abdelmoniem, and I. A. Abdelhamid, "N-(Pyrazol-5-yl) cyanoacetamide in heterocyclic synthesis: synthesis of novel N-(pyrazol-5-yl) pyridine-3, 5-dicarbonitrile, pyrazolo [1, 5-a]-pyrido [3, 2-e] pyrimidine-7-carbonitrile and pyrazolo [4, 3-e] pyrido [1, 2-a]-pyrimidine-6, 8", Arkivoc, issue part vii, pp. 30-41, 2019. Abstract

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Ghozlan, S. A. S., M. A. Ramadan, A. M. Abdelmoniem, and I. A. Abdelhamid, "N-(Pyrazol-5-yl) cyanoacetamide in heterocyclic synthesis: synthesis of novel N-(pyrazol-5-yl) pyridine-3, 5-dicarbonitrile, pyrazolo [1, 5-a]-pyrido [3, 2-e] pyrimidine-7-carbonitrile and pyrazolo [4, 3-e] pyrido [1, 2-a]-pyrimidine-6, 8-dicarbonitrile m", Organic Chemistry, issue part vii, pp. 0 - 0, 2018///. Abstract

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, N-Acetyl Transferase 2 (NAT2) Polymorphism as a Risk Modifier of Susceptibility to Pediatric Acute Lymphoblastic Leukemia, , 2015. tumor_biology_nat2.pdf

tumor_biology_nat2.pdf

M., M. A., M. M. S., F. A. Attaby, and A. - T. H., "N-Acetyl Transferase 2 Gene Polymorphism in Bladder Cancer.", Arab. J. Lab. Med. , vol. 33, pp. 83, 2007.

Rizk, A. Y., M. A. Bedaiwy, and H. G. Al-Inany, "N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate–resistant patients with polycystic ovary syndrome", Fertility and Sterility, vol. 83, pp. 367–370, 2005. Abstract

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sherif. Zaki, M., E. A. Mohamed, A. G. Motawie, and S. Abdelfattah, "N-acetylcysteine versus progesterone on the cisplatin-induced peripheral neurotoxicity", folia morphologica, vol. 77, issue 2, pp. 234-245, 2017.

nerve.pdf

Zaki, S. M., E. A. Mohamed, A. G. Motawie, and S. Abdelfattah, "N-acetylcysteine versus progesterone on the cisplatin-induced peripheral neurotoxicity.", Folia morphologica, vol. 77, issue 2, pp. 234-245, 2018. Abstract

BACKGROUND: Cisplatin-induced peripheral nerve neurotoxicity (CIPN) is the main obstacle in cisplatin treatment. The aim of this study was to compare the modulatory effects of N-acetylcysteine (NAC) and progesterone on CIPN, because there are scarce literature data on the protective effect of the proge-sterone on the CIPN.

MATERIALS AND METHODS: Twenty-four rats were divided into four groups: control, cisplatin-treated, concomitant cisplatin-treated and NAC-treated, and concomitant cisplatin-treated and progesterone-treated. Electron microscopic, immunohistochemical, real time polymerase chain reaction and histomorphome-tric analysis; oxidative/antioxidative markers (MDA/GSH and SOD), neurotoxic/ neuroprotective markers (iNOS/nNOS), inflammatory mediators (TNF-a and NF-kB) and BAX were done.

RESULTS: The myelin sheath in the cisplatin-treated group elucidated infolding. The myelin was disfigured, degenerated, and extensively split with areas of focal loss. The axoplasm was atrophic. Ballooning and vacuolations of the mitochon-dria with alterations of Remak bundles structures were observed. Fewer of these changes were noted in the NAC and progesterone-treated groups. Decrease of the antioxidant SOD and GSH (81% and 64%) and increase of the oxidant MDA (9 folds), increment of the neurotoxic iNOS (1.9 folds) and decrement of the neuroprotective nNOS (64%) and elevation of the inflammatory mediators' TNF-a and NF-kB (8.3 and 11 folds) in the cisplatin-treated group. Increase of the antioxidant SOD (1.3 and 2.5 folds) and GSH (120% and 79%) and decrease of the oxidant MDA (69% and 88%), decrement of the neurotoxic iNOS (56% and 68%) and increment of the neuroprotective nNOS (1.6 and one folds) and elevation of the inflammatory mediators' TNF-a and NF-kB were observed in the NAC and progesterone-treated groups, respectively.

CONCLUSIONS: The toxic effect of CIPN might be attributed to either oxidative or severe inflammatory stress. Progesterone is efficient in ameliorating these effects; however, NAC is better. (Folia Morphol 2018; 77, 2: 234-245).

Zaki, S. M., E. A. Mohamed, A. G. Motawie, and S. Abdelfattah, "N-acetylcysteine versus progesterone on the cisplatin-induced peripheral neurotoxicity.", Folia morphologica, vol. 77, issue 2, pp. 234-245, 2018. Abstract

BACKGROUND: Cisplatin-induced peripheral nerve neurotoxicity (CIPN) is the main obstacle in cisplatin treatment. The aim of this study was to compare the modulatory effects of N-acetylcysteine (NAC) and progesterone on CIPN, because there are scarce literature data on the protective effect of the proge-sterone on the CIPN.

MATERIALS AND METHODS: Twenty-four rats were divided into four groups: control, cisplatin-treated, concomitant cisplatin-treated and NAC-treated, and concomitant cisplatin-treated and progesterone-treated. Electron microscopic, immunohistochemical, real time polymerase chain reaction and histomorphome-tric analysis; oxidative/antioxidative markers (MDA/GSH and SOD), neurotoxic/ neuroprotective markers (iNOS/nNOS), inflammatory mediators (TNF-a and NF-kB) and BAX were done.

RESULTS: The myelin sheath in the cisplatin-treated group elucidated infolding. The myelin was disfigured, degenerated, and extensively split with areas of focal loss. The axoplasm was atrophic. Ballooning and vacuolations of the mitochon-dria with alterations of Remak bundles structures were observed. Fewer of these changes were noted in the NAC and progesterone-treated groups. Decrease of the antioxidant SOD and GSH (81% and 64%) and increase of the oxidant MDA (9 folds), increment of the neurotoxic iNOS (1.9 folds) and decrement of the neuroprotective nNOS (64%) and elevation of the inflammatory mediators' TNF-a and NF-kB (8.3 and 11 folds) in the cisplatin-treated group. Increase of the antioxidant SOD (1.3 and 2.5 folds) and GSH (120% and 79%) and decrease of the oxidant MDA (69% and 88%), decrement of the neurotoxic iNOS (56% and 68%) and increment of the neuroprotective nNOS (1.6 and one folds) and elevation of the inflammatory mediators' TNF-a and NF-kB were observed in the NAC and progesterone-treated groups, respectively.

CONCLUSIONS: The toxic effect of CIPN might be attributed to either oxidative or severe inflammatory stress. Progesterone is efficient in ameliorating these effects; however, NAC is better. (Folia Morphol 2018; 77, 2: 234-245).

Nohammed, H. M. E. - H. S., M. H. K. Eldin, A. K. Alsawy, and S. S. I. Badawy, N-acetylsysteine versus Prostaglandin E1 as a Renal Protective Strategy in Infra Renal Aortic Cross Clamping Surgery;, , Giza, Cairo University, 2014. PhD thesis.docx

Kame, A., G. Thabet, and H. S. Moussa, "N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia", Tumor Biology, vol. 36(8), 2015.

Mohamed., R. R., "N-Acryloyl benzhydrazide as a thermal stabilizer for rigid Poly (vinyl chloride)", Journal of Vinyl & Additive Technology, ,, vol. 14 , issue 4, pp. 184– 190. , 2008.

Elshatory, A., W. Awad, and H. Said, N-Acytel cysteine ameliorates Methotrexate Induced Hepatic Toxicity and Genotoxicity in Male Albino Rats., , 2015. shatory_final_1.pdf

, "N-alkyl 2-pyridone versus O-alkyl 2-pyridol: Ultrasonic synthesis, DFT, docking studies and their antimicrobial evaluation", Journal of Molecular Structure, 2020.

Mohamed, O. G., Z. G. Khalil, and R. J. Capon, "N-Amino-l-Proline Methyl Ester from an Australian Fish Gut-Derived Fungus: Challenging the Distinction between Natural Product and Artifact", Marine Drugs, vol. 19, no. 3, 2021. AbstractWebsite

Further investigation into a fish gut-derived fungus Evlachovaea sp. CMB-F563, previously reported to produce the unprecedented Schiff base prolinimines A–B (1–2), revealed a new cryptic natural product, N-amino-l-proline methyl ester (5)—only the second reported natural occurrence of an N-amino-proline, and the first from a microbial source. To enable these investigations, we developed a highly sensitive analytical derivitization methodology, using 2,4-dinitrobenzaldehyde (2,4-DNB) to cause a rapid in situ transformation of 5 to the Schiff base 9, with the latter more readily detectable by UHPLC-DAD (400 nm) and HPLC-MS analyses. Moreover, we demonstrate that during cultivation 5 is retained in fungal mycelia, and it is only when solvent extraction disrupts mycelia that 5 is released to come in contact with the furans 7–8 (which are themselves produced by thermal transformation of carbohydrates during media autoclaving prior to fungal inoculation). Significantly, on contact, 5 undergoes a spontaneous condensation with 7–8 to yield the Schiff base prolinimines 1–2, respectively. Observations made during this study prompted us to reflect on what it is to be a natural product (i.e., 5), versus an artifact (i.e., 1–2), versus a media component (i.e., 7–8).

Mohamed, O. G., Z. G. Khalil, and R. J. Capon, "N-Amino-l-Proline Methyl Ester from an Australian Fish Gut-Derived Fungus: Challenging the Distinction between Natural Product and Artifact", Marine drugs, vol. 19, issue 3: Multidisciplinary Digital Publishing Institute, pp. 151, 2021. Abstract

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Salaheldin, A. M., A. M. F. Oliveira-Campos, and L. {\'ıgiaM. Rodrigues, "N-Bromosuccinimide assisted oxidation of 5-aminopyrazoles: formation of bis diazenylderivatives", Tetrahedron Letters, vol. 48, no. 50: Elsevier, pp. 8819–8822, 2007. Abstract

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, "N-C co-doped-mesoporous bi-phasial anatase and brookite mixture TiO2 for degradation of ibuprofen", Egypt J. Anal. Chem., vol. in press, 2015.

Darweesh, M. F., L. O. Elfarouk, and M. S. Negm, "N-Cadherin Expression in Glioblastoma and its Correlation with the Histopathological Findings", Academic Journal of Cancer Research, vol. 9, issue 1, pp. 07-12, 2016.

Syunsuke Kanai, Joseph Adu-Gymfi, K. L., J. Ito, R. E. A. Moghaieb, P. Hany El-Shemy, Rashmi Mohapatra, and K. F. Hirofumi Saneoka, "N-deficiency damps out circadian rhythmic changes of stem diameter dynamics in tomato plant", Plant science, vol. 174, issue 2, pp. 183-191, 2008.

Kanai, S., J. Adu-Gymfi, K. Lei, J. Ito, K. Ohkura, R. E. A. Moghaieb, H. El-Shemy, R. Mohapatra, P. K. Mohapatra, and H. Saneoka, "N-deficiency damps out circadian rhythmic changes of stem diameter dynamics in tomato plant", Plant science, vol. 174, issue 2: Elsevier, pp. 183-191, 2008. Abstract

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Eldeeb, M. A., and M. A. Ragheb, "N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase", Current Genetics, vol. 66, pp. 693–701, 2020.

Recent Publications