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Magid, H. A. M., R. E. A. Sabrah, A. R. H. El Nadi, S. I. Abdel-Aal, and R. K. Rabic, "Kinetics of biodegradation rates of chicken manure and municipal refuse in a sandy soil", Journal of Arid Environments, vol. 28, issue 2: Academic Press, pp. 163-171, 1994. Abstract
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Mahmoud, H. K., Y. H. El Nahas, M. A. Samra, R. M. Abdelfattah, M. A. ElEmary, and W. H. El-Metnawy, "Kinetics Of BCR-ABL Transcripts In Patients with Chronic Phase CML (CML-CP) Treated With Imatinib Mesylate (Im): A Predictor Of Response And Progression Free Survival (PFS)", Haematologica, vol. 94, issue S2, pp. 573: Abst 1473., 2009.
Mahmoud, H. K., Y. El Nahas, M. Abdel Moaty, R. Abdel Fattah, M. El Emary, and W. El Metnawy, "Kinetics of BCR-ABL Transcripts in Imatinib Mesylate treated Chronic Phase CML (CPCML), A Predictor of Response and Progression Free Survival.", International journal of biomedical science : IJBS, vol. 5, issue 3, pp. 223-8, 2009 Sep. Abstract

PURPOSE: To assess the kinetics of molecular response to Imatinib Mesylate (IM) therapy in predicting progression free survival (PFS), sustained hematological, and cytogenetic responses in CPCML.

METHODS: Ninety five newly diagnosed CPCML Egyptian patients were treated with IM 400 mg daily dose. Cytogenetic analysis was performed at diagnosis and every 6 months. Molecular monitoring by RT-QPCR was performed at diagnosis and every 3 months during a median follow-up period (FUp) of 26 months. Mutation detection of ABL domain was performed by ASO-PCR.

RESULTS: Hematological response was 98% after three months of IM therapy. Out of 95 patients 59 showed 2 log reduction of BCR-ABL/ABL ratio after 6 months of whom 49 (83%) had complete cytogenetic response (CCyR) and 42 (71%) had major molecular response (MMR) at 12 months. BCR-ABL transcripts remained undetectable in 22 patients (39%) at 26 months. Among the remaining 34 patients not achieving 2 log reduction at 6 months only 5 (15%) had CCyR and MMR by 12 months. ABL domain mutations were detected in 11/15 (73%) resistant and suboptimal responding patients. Achieving 2 log reduction after 6 months of IM therapy significantly correlated with sustained cytogenetic and molecular responses (p<0.0001), with PFS at 2 years (p<0.03) and inversely with ABL gene mutations (p<0.001).

DISCUSSION: These data demonstrated the predictive value of early molecular response to IM in CPCML regarding disease course and PFS. A 2 log reduction at 6 months of IM treatment could be a cut off level predicting resistance, CCyR, or suggesting IM dose modification.

Mahmoud, H., Y. El Nahas, M. Abdel Moaty, R. Abdel Fattah, M. El Emary, and W. El Metnawy, "Kinetics of BCR-ABL Transcripts in Imatinib Mesylate treated Chronic Phase CML (CPCML), A Predictor of Response and Progression Free Survival.", International journal of biomedical science : IJBS, vol. 5, issue 3, pp. 223-8, 2009 Sep. Abstract

PURPOSE: To assess the kinetics of molecular response to Imatinib Mesylate (IM) therapy in predicting progression free survival (PFS), sustained hematological, and cytogenetic responses in CPCML.

METHODS: Ninety five newly diagnosed CPCML Egyptian patients were treated with IM 400 mg daily dose. Cytogenetic analysis was performed at diagnosis and every 6 months. Molecular monitoring by RT-QPCR was performed at diagnosis and every 3 months during a median follow-up period (FUp) of 26 months. Mutation detection of ABL domain was performed by ASO-PCR.

RESULTS: Hematological response was 98% after three months of IM therapy. Out of 95 patients 59 showed 2 log reduction of BCR-ABL/ABL ratio after 6 months of whom 49 (83%) had complete cytogenetic response (CCyR) and 42 (71%) had major molecular response (MMR) at 12 months. BCR-ABL transcripts remained undetectable in 22 patients (39%) at 26 months. Among the remaining 34 patients not achieving 2 log reduction at 6 months only 5 (15%) had CCyR and MMR by 12 months. ABL domain mutations were detected in 11/15 (73%) resistant and suboptimal responding patients. Achieving 2 log reduction after 6 months of IM therapy significantly correlated with sustained cytogenetic and molecular responses (p<0.0001), with PFS at 2 years (p<0.03) and inversely with ABL gene mutations (p<0.001).

DISCUSSION: These data demonstrated the predictive value of early molecular response to IM in CPCML regarding disease course and PFS. A 2 log reduction at 6 months of IM treatment could be a cut off level predicting resistance, CCyR, or suggesting IM dose modification.

Mahmoud, H. K., Y. H. Elnahass, M. Abdel Moaty, R. Abdel Fattah, M. El Emary, and W. El Metnawy, "Kinetics of BCR-ABL Transcripts in Imatinib Mesylate treated Chronic Phase CML (CPCML), a Predictor of Response and Progression free Survival", International journal of biomedical science, vol. 5, issue 3, pp. 223-228. , 2009. Abstract

Purpose: To assess the kinetics of molecular response to Imatinib Mesylate (IM) therapy in predicting progression free survival (PFS), sustained hematological, and cytogenetic responses in CPCML. Methods: Ninety five newly diagnosed CPCML Egyptian patients were treated with IM 400 mg daily dose. Cytogenetic analysis was performed at diagnosis and every 6 months. Molecular monitoring by RT-QPCR was performed at diagnosis and every 3 months during a median follow-up period (FUp) of 26 months. Mutation detection of ABL domain was performed by ASO-PCR. Results: Hematological response was 98% after three months of IM therapy. Out of 95 patients 59 showed 2 log reduction of BCR-ABL/ABL ratio after 6 months of whom 49 (83%) had complete cytogenetic response (CCyR) and 42 (71%) had major molecular response (MMR) at 12 months. BCR-ABL transcripts remained undetectable in 22 patients (39%) at 26 months. Among the remaining 34 patients not achieving 2 log reduction at 6 months only 5 (15%) had CCyR and MMR by 12 months. ABL domain mutations were detected in 11/15 (73%) resistant and suboptimal responding patients. Achieving 2 log reduction after 6 months of IM therapy significantly correlated with sustained cytogenetic and molecular responses (p<0.0001), with PFS at 2 years (p<0.03) and inversely with ABL gene mutations (p<0.001). Discussion: These data demonstrated the predictive value of early molecular response to IM in CPCML regarding disease course and PFS. A 2 log reduction at 6 months of IM treatment could be a cut off level predicting resistance, CCyR, or suggesting IM dose modification.

Shoukry, A. A., M. M. Shoukry, and M. N. Hafez, "Kinetics of base hydrolysis of -amino acid esters catalyzed by palladium(II) piperazine complex ", Central European Journal of Chemistry , , vol. 8, issue 4, pp. 797-805, 2010.
Mahmoud M. A Mohamed., M. S. M., A. A. Shoukry, and M. M. Shoukry, "Kinetics of base hydrolysis of  –amino acid esters catalyzed by the copper(II) complex of N,N,N',N'-Tetramethylethylenediamine (Me4en", International journal of chemical kinetics , vol. 38, issue 12, pp. 737-745, 2006.
Shahin, R. R., and R. M. M. El-Kilani, "Kinetics of ammonium, nitrates and manganese release from different organic composts as affected by sulphur.", Egyptian Journal of Soil Science, vol. 48, pp. 143- 157, 2007. Abstract
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Shahin, R. R., and R. M. M. El-Kilani, "Kinetics of ammonium, nitrates and manganese release from different organic composts as affected by sulphur.", Egyptian Journal of Soil Science, vol. 48, pp. 143- 157, 2007. Abstract
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Shahin, R. R., and R. M. M. EI-Kilani, "Kinetics of Ammonium Volatilization from Nitrogen Fertilizers as Affected by Sulphur", Egypt 1 Soil Scz., vol. 47, issue 4, pp. 367- 383, 2007. Abstract
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Shahin, R. R., and R. M. M. EI-Kilani, "Kinetics of Ammonium Volatilization from Nitrogen Fertilizers as Affected by Sulphur", Egypt 1 Soil Scz., vol. 47, issue 4, pp. 367- 383, 2007. Abstract
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and A. G. Gad-Alla, W. A. Badawy, A. E. - R. A. - R. H. A. M. M., W. A. Badawy, A. E. - H. A. Rahma, and M. M. Abou-Romia, ""Kinetics of the Passivation of Molybdenum in Salt Solutions as Inferred from Impedance and Potential Measurements", Surface and Coatings Tech. ., vol. 31, pp. 117, 1987.
Hefny, M. M., W. A. Badawy, and S. S. El-Egamy, ""Kinetics of Passivation of Lead in Phosphate Solutions ", Electrochim. Acta, vol. 35, pp. 799, 1990.
Ali, S. K., A. R. Hamed, M. M. Soltan, A. M. El-Halawany, U. M. Hegazy, and A. A. Hussein, "Kinetics and molecular docking of vasicine from Adhatoda vasica: An acetylcholinesterase inhibitor for Alzheimer's disease", South African Journal of Botany, vol. 104: Elsevier, pp. 118–124, 2016. Abstract
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Essam, T., M. A. Amin, O. E. L. Tayeb, B. Mattiasson, and B. Guieysse, "Kinetics and metabolic versatility of highly tolerant phenol degrading Alcaligenes strain TW1", Journal of Hazardous Materials, vol. 173, no. 1-3: Elsevier, pp. 783–788, 2010. Abstract
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Essam, T., M. A. Amin, O. E. L. Tayeb, B. Mattiasson, and B. Guieysse, "Kinetics and metabolic versatility of highly tolerant phenol degrading Alcaligenes strain TW1", Journal of Hazardous Materials, vol. 173, no. 1-3: Elsevier, pp. 783–788, 2010. Abstract
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Azza A. Shoukry, T. Rau, M. M. Shoukry, and R. and van Eldik, "Kinetics and mechanisms of ligand substitution reactions of bis(amine) (cyclobutane-1,1-dicarboxylato) palladium(II) ", Journal of Chemical Society., Dalton Trans., pp. 3105-3112, 1998.
Azza Shoukry, Malgorzata Brindell, and R. van Eldik, "Kinetics and mechanism of the substitution behaviour of Pd(II) piperazine complexes with different biologically relevant nucleophiles", Journal of Chemical Society, Dalton Trans.,, vol. 37, pp. 4169-4174, 2007.
Shoukry, A. A., Malgorzata Brindell, D. Piotrowska, and R. van Eldik, "Kinetics and mechanism of the reduction of (ImH) [trans- RuCl4(dmso)(Im)] by ascorbic acid in acidic aqueous solution", Journal of biological Inorganic chemistry, vol. 12, pp. 809-818, 2007.
Al-QALAF, F. A., A. A. A. BASSAM, and M. M. Shoukry, "KINETICS AND MECHANISM OF BASE HYDROLYSIS OF A-AMINOACID ESTERS CATALYSED BY [Pd(1,3- DIAMINO-2-HYDROXYPROPANE)(H2O)2]2+ COMPLEX", J. Chil. Chem. Soc., vol. 58, issue 2, pp. 1706-1708, 2013. j._chil_chem_soc.pdf
Al-QALAF, F. A., A. A. A. BASSAM, and M. M. Shoukry, "KINETICS AND MECHANISM OF BASE HYDROLYSIS OF A-AMINOACID ESTERS CATALYSED BY [Pd(1,3- DIAMINO-2-HYDROXYPROPANE)(H2O)2]2+ COMPLEX", J. Chil. Chem. Soc., vol. 58, issue 2, pp. 1706-1708, 2013. j._chil_chem_soc.pdf