Publications

Export 364 results:
Sort by: Author Title Type [ Year  (Asc)]
2009
Mahmoud, H. K., Y. El Nahas, M. Abdel Moaty, R. Abdel Fattah, M. El Emary, and W. El Metnawy, "Kinetics of BCR-ABL Transcripts in Imatinib Mesylate treated Chronic Phase CML (CPCML), A Predictor of Response and Progression Free Survival.", International journal of biomedical science : IJBS, vol. 5, issue 3, pp. 223-8, 2009 Sep. Abstract

PURPOSE: To assess the kinetics of molecular response to Imatinib Mesylate (IM) therapy in predicting progression free survival (PFS), sustained hematological, and cytogenetic responses in CPCML.

METHODS: Ninety five newly diagnosed CPCML Egyptian patients were treated with IM 400 mg daily dose. Cytogenetic analysis was performed at diagnosis and every 6 months. Molecular monitoring by RT-QPCR was performed at diagnosis and every 3 months during a median follow-up period (FUp) of 26 months. Mutation detection of ABL domain was performed by ASO-PCR.

RESULTS: Hematological response was 98% after three months of IM therapy. Out of 95 patients 59 showed 2 log reduction of BCR-ABL/ABL ratio after 6 months of whom 49 (83%) had complete cytogenetic response (CCyR) and 42 (71%) had major molecular response (MMR) at 12 months. BCR-ABL transcripts remained undetectable in 22 patients (39%) at 26 months. Among the remaining 34 patients not achieving 2 log reduction at 6 months only 5 (15%) had CCyR and MMR by 12 months. ABL domain mutations were detected in 11/15 (73%) resistant and suboptimal responding patients. Achieving 2 log reduction after 6 months of IM therapy significantly correlated with sustained cytogenetic and molecular responses (p<0.0001), with PFS at 2 years (p<0.03) and inversely with ABL gene mutations (p<0.001).

DISCUSSION: These data demonstrated the predictive value of early molecular response to IM in CPCML regarding disease course and PFS. A 2 log reduction at 6 months of IM treatment could be a cut off level predicting resistance, CCyR, or suggesting IM dose modification.

Mahmoud, H., Y. El Nahas, M. Abdel Moaty, R. Abdel Fattah, M. El Emary, and W. El Metnawy, "Kinetics of BCR-ABL Transcripts in Imatinib Mesylate treated Chronic Phase CML (CPCML), A Predictor of Response and Progression Free Survival.", International journal of biomedical science : IJBS, vol. 5, issue 3, pp. 223-8, 2009 Sep. Abstract

PURPOSE: To assess the kinetics of molecular response to Imatinib Mesylate (IM) therapy in predicting progression free survival (PFS), sustained hematological, and cytogenetic responses in CPCML.

METHODS: Ninety five newly diagnosed CPCML Egyptian patients were treated with IM 400 mg daily dose. Cytogenetic analysis was performed at diagnosis and every 6 months. Molecular monitoring by RT-QPCR was performed at diagnosis and every 3 months during a median follow-up period (FUp) of 26 months. Mutation detection of ABL domain was performed by ASO-PCR.

RESULTS: Hematological response was 98% after three months of IM therapy. Out of 95 patients 59 showed 2 log reduction of BCR-ABL/ABL ratio after 6 months of whom 49 (83%) had complete cytogenetic response (CCyR) and 42 (71%) had major molecular response (MMR) at 12 months. BCR-ABL transcripts remained undetectable in 22 patients (39%) at 26 months. Among the remaining 34 patients not achieving 2 log reduction at 6 months only 5 (15%) had CCyR and MMR by 12 months. ABL domain mutations were detected in 11/15 (73%) resistant and suboptimal responding patients. Achieving 2 log reduction after 6 months of IM therapy significantly correlated with sustained cytogenetic and molecular responses (p<0.0001), with PFS at 2 years (p<0.03) and inversely with ABL gene mutations (p<0.001).

DISCUSSION: These data demonstrated the predictive value of early molecular response to IM in CPCML regarding disease course and PFS. A 2 log reduction at 6 months of IM treatment could be a cut off level predicting resistance, CCyR, or suggesting IM dose modification.

2010
Fatayer, T. S., S. Khattab, and F. A. Omara, "A key-agreement protocol based on the stack-overflow software vulnerability", Computers and Communications (ISCC), 2010 IEEE Symposium on: IEEE, pp. 411–416, 2010. Abstract
n/a
Essam, T., M. A. Amin, O. E. L. Tayeb, B. Mattiasson, and B. Guieysse, "Kinetics and metabolic versatility of highly tolerant phenol degrading Alcaligenes strain TW1", Journal of Hazardous Materials, vol. 173, no. 1-3: Elsevier, pp. 783–788, 2010. Abstract
n/a
Essam, T., M. A. Amin, O. E. L. Tayeb, B. Mattiasson, and B. Guieysse, "Kinetics and metabolic versatility of highly tolerant phenol degrading Alcaligenes strain TW1", Journal of Hazardous Materials, vol. 173, no. 1-3: Elsevier, pp. 783–788, 2010. Abstract
n/a
Osman, H. M., and T. E. El-Diraby, "Knowledge-Enabled Decision Support System for Routing Urban Utilities", Journal of Construction Engineering and Management, vol. 137, no. 3: American Society of Civil Engineers, pp. 198–213, 2010. Abstract
n/a
Ghnaim, W. A. - E., N. I. Ghali, and A. E. Hassanien, "Known-ciphertext cryptanalysis approach for the Data Encryption Standard technique", Computer Information Systems and Industrial Management Applications (CISIM), 2010 International Conference on: IEEE, pp. 600–603, 2010. Abstract
n/a
Ghnaim, W. A. - E., N. I. Ghali, and A. E. Hassanien, "Known-ciphertext cryptanalysis approach for the Data Encryption Standard technique", Computer Information Systems and Industrial Management Applications (CISIM), 2010 International Conference on: IEEE, pp. 600–603, 2010. Abstract
n/a
Hamza, H. S., J. Martinez, and J. L. Mugartza, "KOPLE: knowledge-oriented product line engineering", Proceedings of the ACM international conference companion on Object oriented programming systems languages and applications companion: ACM, pp. 275–276, 2010. Abstract
n/a
Hamza, H. S., J. Martinez, and J. L. Mugartza, "KOPLE: knowledge-oriented product line engineering", Proceedings of the ACM international conference companion on Object oriented programming systems languages and applications companion: ACM, pp. 275-276, 2010. Abstract
n/a
Abo-Madyan, Y., O. Aldabbas, G. Welzel, J. Schaefer, M. Puetz, M. Polednik, F. Lohr, and F. Wenz, "KOSIMA-study: comparison of cosmetic results of hypogractioned intensity modulated radiation therapy (IMRT) with fractionated radiation therapy (IMRT) in a case of breast cancer", STRAHLENTHERAPIE UND ONKOLOGIE, vol. 186: URBAN & VOGEL NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY, pp. 45–45, 2010. Abstract
n/a
Folco, L., M. D. Martino, A. E. Barkooky, M. D'Orazio, A. Lethy, S. Urbini, I. Nicolosi, M. Hafez, C. Cordier, M. van Ginneken, et al., "The Kamil Crater in Egypt", SCIENCE, vol. 329, pp. 804, 2010.
authors, 66, and M. E. E. K. amr and Editors:Samir Galal, Kasr El-Aini Introduction To Surgery,3rd -7th Editions, , Cairo, University Book Center,Sayed mahmoud, 2010.
Fatayer, T., F. A. Omara, and S. Khattab, "A key-agreement protocol based on The Stack-Overflow Vulnerability", The IEEE symposium on Computers and Communications (ISCC’10), Riccione, Italy, pp. 411 – 416, 2010.
Shoukry, A. A., M. M. Shoukry, and M. N. Hafez, "Kinetics of base hydrolysis of -amino acid esters catalyzed by palladium(II) piperazine complex ", Central European Journal of Chemistry , , vol. 8, issue 4, pp. 797-805, 2010.
Hamza, H. S., J. Martinez, and J. L. Mugartza, "KOPLE: knowledge-oriented product line engineering", Proceedings of the ACM international conference companion on Object oriented programming systems languages and applications companion: ACM, pp. 275–276, 2010. Abstract

The maturity of Knowledge Engineering (KE) theory and practice presents a real opportunity for advancing the state-of-the-art and state-of-the-practice in software Product-line Engineering (PLE). Several challenges that face the adoption and implementation of PLE in practice can be addressed by exploiting advanced technique from KE. This paper introduces the concept of KOPLE and describes the related one-day workshop that will be held in conjunction with SPLASH 2010.

Mohamed, A. A., L. Rashed, H. Amin, M. Abu-Farha, S. A. El Fadl, and S. Pakhoum, "K469E polymorphism of the intercellular adhesion molecule-1 gene in Egyptians with coronary heart disease.", Annals of Saudi medicine, vol. 30, issue 6, pp. 432-6, 2010 Nov-Dec. Abstract

BACKGROUND AND OBJECTIVES: The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intercellular adhesion molecule-1 (ICAM-1). This study aimed to investigate the association of K469E polymorphism of the ICAM-1 gene and soluble ICAM-1 (sICAM-1) serum level with coronary heart disease (CHD) in Egyptian subjects.

PATIENTS AND METHODS: Using a case-control design, we studied 100 patients with CHD, including 73 patients with acute myocardial infarction (MI) and 27 with unstable angina (UA). The control group consisted of 50 healthy subjects with normal left ventricular function. All participants were genotyped for the ICAM-1 polymorphism by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Serum sICAM-1 was measured by enzyme-linked immunoassay (ELISA).

RESULTS: In CHD patients, the frequencies of K genotype (KK and EK) were significantly higher when compared to controls (P<.001) and were associated with an increased risk of disease development (OR=3.8, 95% CI: 1.7 to 8.5; P=.001). K genotype frequencies in patients with MI showed no significant difference when compared to patients with UA (P= .121). Serum sICAM-1 levels were comparable between CHD patients and controls (P= .37) and between MI and UA patients (P=.23). There were no significant differences in sICAM-1 levels among patients with different genotypes (P=.532). Men presented with higher sICAM-1 levels than women (P=.004).

CONCLUSION: ICAM-1 gene polymorphism in codon 469 is associated with a risk for CHD development in Egyptian subjects. Serum sICAM-1 is not influenced by this polymorphism and is not necessarily elevated in CHD.

2011
Folco, L., D. M. Martino, E. A. Barkooky, M. D'Orazio, A. Lethy, S. Urbini, I. Nicolosi, M. Hafez, C.Cordier, M. van Ginneken, et al., "Kamil Crater (Egypt): Ground truth for small-scale meteorite impacts on Earth", Geology, 2011.
Sharaf, E. F., and N. M. Khalil, "Keratinolytic activity of purified alkaline keratinase produced by Scopulariopsis brevicaulis (Sacc.) and its amino acids profile", Saudi journal of biological sciences , vol. 18 , issue 2, pp. 117-121, 2011.
Zaki, R., K. M. Hosny, A. Khames, and A. Abd-elbary, "Ketorolac Tromethamine in-Situ Ocular Hydrogel: Preparation, Characterization and in Vivo Evaluation", International journal of drug delivery, 2011. Abstract

Aim of the work: To evaluate the associations of serum 25 hydroxy (OH) vitamin D [25(OH)D] levels with cardiovascular risk factors as well as disease activity in women with SLE. Patients and methods: Fifty women with SLE as well as 30 controls were included in our study. Data collected included, demographics, SLE activity and damage assessments, cardiovascular risk factors, medications and laboratory assessment of inflammatory markers and 25(OH)D levels. Stepwise logistic regression analysis were used to estimate the association of 25(OH)D levels with cardiovascular risk factors. Results: A significant lower 25(OH)D levels was found in SLE patients compared to controls (P <0.001). A positive correlation was found between 25(OH)D and diastolic blood pressure, fasting blood sugar, cholesterol, triglycerides, LDL, BMI, as well as proteinuria and C3 levels. Furthermore, a significant positive correlation was found between 25(OH)D and the RT carotid artery stenosis and RT carotid artery plaque and the intima media thickness of both left and right carotid arteries. Lower 25(OH)D levels were also significantly associated with higher SLE disease activity and damage scores and steroid cumulative dose. Stepwise logistic regression analysis showed that higher BMI, diastolic blood pressure, cholesterol, triglycerides, LDL and diabetes mellitus act as predictors of lower 25(OH)D levels. Conclusion: Our study found an association between lower 25(OH)D levels and increased cardiovascular disease (CVD) risk factors, as well as increased SLE disease activity and damage indices. Future studies are needed to determine relation of 25(OH)D and cardiovascular risk factors in patients with lupus.

Badawy, W. A., K. M. Ismail, and S. S. Medany, "Kinetics of Electropolymerization of 1-Amino-9, 10-Anthraquinone", Int. J. Chem. Kinetics, 2011. Abstract

1-amino-9, 10-anthraquinone, AAQ, was electropolymerized on platinum substrates either from aqueous or non-aqueous electrolytes. The aqueous electrolyte was 6.0 mol L-1 H2SO4 and the non-aqueous solvent was acetonitrile containing lithium perchlorate, LiClO4, as supporting electrolyte. The formed polyaminoanthraquinone, PAAQ, was stable and the polymerization process was reproducible. The kinetics of the electropolymerization process was investigated by determining the charge consumed during the electropolymerization as a function of time at different concentrations of the electrolyte components. The results of chronoamperometry have been used to determine the orders of reaction. In either aqueous or non-aqueous solution, the electropolymerization process follows first order kinetics with respect to the monomer concentration. In non-aqueous solution, the very small concentrations of water did not affect the order of reaction. The order of reaction with respect to the traces of water and the supporting electrolyte concentration was found to be zero. In aqueous solution the order of the electropolymerization reaction with respect to the concentration of H2SO4 was found to be negative (-0.66) which means that the aqueous electrolyte inhibits the polymerization reaction.

Tourism