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Morsi, N., D. Ghorab, H. Refai, and H. Teba, "Ketoroloac tromethamine loaded nanodispersion incorporated into thermosensitive in situ gel for prolonged ocular delivery.", International journal of pharmaceutics, vol. 506, issue 1-2, pp. 57-67, 2016 Jun 15. Abstract

The present study was designed to improve the ocular availability of ketorolac tromethamine and to prolong its precorneal residence time for the treatment of postoperative ocular inflammation. Ketorolac tromethamine nanodispersions were successfully prepared by nanoprecipitation method using Eudragit(®) RL100. These nanodispersions were characterized in terms of particle size, zeta potential, entrapment efficiency and in vitro release. Consequently, the optimum nanodispersion was incorporated into thermosensitive in situ gel. The optimum gelling capacity was obtained by 20% Pluronic(®) F-127 and 14% Pluronic(®) F-127/1.5% HPMC K4m. The gelling temperature and gelation time of the in situ gels increased by decreasing the concentration of Pluronic(®) F-127. The mucoadhesive strength was significantly improved by the addition of HPMC. Incorporation of ketorolac tromethamine loaded nanodispersions into in situ gel bases sustained the release of ketorolac tromethamine, improved its ocular availability and prolonged its residence time without causing irritation to eye.

Zaki, R., K. M. Hosny, A. Khames, and A. Abd-elbary, "Ketorolac Tromethamine in-Situ Ocular Hydrogel: Preparation, Characterization and in Vivo Evaluation", International journal of drug delivery, 2011. Abstract

Aim of the work: To evaluate the associations of serum 25 hydroxy (OH) vitamin D [25(OH)D] levels with cardiovascular risk factors as well as disease activity in women with SLE. Patients and methods: Fifty women with SLE as well as 30 controls were included in our study. Data collected included, demographics, SLE activity and damage assessments, cardiovascular risk factors, medications and laboratory assessment of inflammatory markers and 25(OH)D levels. Stepwise logistic regression analysis were used to estimate the association of 25(OH)D levels with cardiovascular risk factors. Results: A significant lower 25(OH)D levels was found in SLE patients compared to controls (P <0.001). A positive correlation was found between 25(OH)D and diastolic blood pressure, fasting blood sugar, cholesterol, triglycerides, LDL, BMI, as well as proteinuria and C3 levels. Furthermore, a significant positive correlation was found between 25(OH)D and the RT carotid artery stenosis and RT carotid artery plaque and the intima media thickness of both left and right carotid arteries. Lower 25(OH)D levels were also significantly associated with higher SLE disease activity and damage scores and steroid cumulative dose. Stepwise logistic regression analysis showed that higher BMI, diastolic blood pressure, cholesterol, triglycerides, LDL and diabetes mellitus act as predictors of lower 25(OH)D levels. Conclusion: Our study found an association between lower 25(OH)D levels and increased cardiovascular disease (CVD) risk factors, as well as increased SLE disease activity and damage indices. Future studies are needed to determine relation of 25(OH)D and cardiovascular risk factors in patients with lupus.

Othman, A. I., A. A. El-Ghaffar, and A. M. Mahmoud, "Ketorolac and Warfarin Induced Renal Toxicity: Ultrastructural and Biochemical Study", Journal of Basic and Applied Zoology, vol. 80 (36), pp. 1-9, 2019.
Hebatallah A. Darwish, Nermin A. H. Sadik, O. K., "Ketoprofen microspheres for targeted drug delivery: Biochemical evaluation of their efficacy against colonic inflammation in rats", The Egyptian Journal of Biochemistry and Molecular Biology (EJBMB), vol. 26, pp. 392 – 407, 2008.
Darwish, H. A., N. A. H. Sadik, and O. M. Khowessah, "Ketoprofen microspheres for targeted drug delivery: Biochemical evaluation of their efficacy against colonic inflammation in rat", The Egyptian Journal of Biochemistry and Molecular Biology (EJBMB), vol. 26, pp. 392 – 407, 2008.
Abd-Elrahman, A. A., M. E. A. Nabarawi, D. H. Hassan, and A. A. Taha, "Ketoprofen mesoporous silica nanoparticles SBA-15 hard gelatin capsules: preparation and in vitro/in vivo characterization", Drug delivery, vol. 23, issue 9, pp. 3387-3398, 2016. nab-amal-dooa-2016.pdf
Elhamid, B. A., S. Samy, A. Abdullah, A. Saad, M. Ollaek, and A. Ahmed, "Ketamine versus neostigmine as adjuvants to bupivacaine during ultrasound-guided serratus anterior plane block in modified radical mastectomy. A randomized controlled trial", Egyptian Journal of Anesthesia. , vol. 37, issue 1, pp. 356–363, 2021.
Eskander, A. E., N. E. R. Baroudy, and A. E. S. Refay, "Ketamine Sedation in Gastrointestinal Endoscopy in Children.", Open access Macedonian journal of medical sciences, vol. 4, issue 3, pp. 392-396, 2016. Abstract

BACKGROUND: Moderate sedation for gastrointestinal endoscopy has traditionally been provided by the endoscopist. Controversy has ensued over safe and efficient sedation practice as endoscopy has increased in numbers and complexity.

AIM: To evaluate the safety of ketamine sedation given by non-anesthesiologist during gastrointestinal endoscopy in children.

METHODS: A prospective study of 100 paediatric patients with gastrointestinal symptoms who were a candidate for upper or lower gastrointestinal endoscopy in paediatric endoscopy unit at Abo El-Reesh Paediatric Hospital, Cairo University. All children were > 2 years old and weighed > 6 kg. The analysis was performed in terms of sedation-related complications.

RESULTS: A total 100 paediatric patients including 53 males and 47 females with mean age of 5.04 years were involved in the study. All children were medicated with ketamine with a mean dose of 3.77mg/kg. No complications occurred in 87% of cases. Desaturation occurred in 13% of the cases and was reversible by supplemental nasal oxygen. Desaturation was more frequent during Upper GI Endoscopy and with the intramuscular route (p value=0.049). No apnea, bradycardia, arrest or emergence reactions were recorded.

CONCLUSION: Ketamine sedation found to be safe for paediatric gastrointestinal endoscopy in Egyptian children without co-morbidities. Transient Hypoxia (13%) may occur but easily reversed by nasal oxygen therapy.

Elbaroudy, N., "Ketamine Sedation in Endoscopy", Macedonian Journal, 2016.
Soliman, A. M., "Kerwin-Huelsman-Newcomb circuit using current conveyors", Electronics Letters, vol. 30, no. 24: IET Digital Library, pp. 2019–2020, 1994. Abstract15-1994-pp_2019-2020.pdf

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Soliman, A. M., "Kerwin Huelsman Newcomb Filter Using Inverting CCII", Active and Passive Electronic Devices, vol. 3, pp. 273–279, 2008. vol3_no_3-4khn_online_oct_2008.pdf
S. Hanafi, K. Mostafa, A. H. W., "Kernel-Based Double Conjugated Clustering", Egyptian informatics Journal, vol. 8, issue 1, pp. 87-99, 2007. Abstract

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Elbasty, M. K., and S. A. G. El-Din, "Keratoprothesis with biocolonizable microporous flurocarbon haptic", Bull. Ophthalmol. Soc. Egypt, vol. 93, 2000.
Sharaf, E. F., and N. M. Khalil, "Keratinolytic activity of purified alkaline keratinase produced by Scopulariopsis brevicaulis (Sacc.) and its amino acids profile", Saudi journal of biological sciences , vol. 18 , issue 2, pp. 117-121, 2011.
KAMAL, K. A. R. E. E. M., H. Hefny, A. E. Hassanien, and M. Tolba, "Kekre’s Transform for Protecting Fingerprint Template.", 13th IEEE International Conference on Hybrid Intelligent Systems |(HIS13) Tunisia, 4-6 Dec. pp. 186-191, 2013, Tunisia, , 4-6 Dec, 2013.
Ghany, K. K. A., H. A. Hefny, A. E. Hassanien, and M. F. Tolba, "Kekre's transform for protecting fingerprint template", Hybrid Intelligent Systems (HIS), 2013 13th International Conference on, 2013.
Ghany, K. K. A., H. A. Hefny, A. E. Hassanien, and M. F. Tolba, "Kekre's transform for protecting fingerprint template", Hybrid Intelligent Systems (HIS), 2013 13th International Conference on: IEEE, pp. 185–190, 2013. Abstract
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Abdel-Aziz, M. E., and N. F. S. Morsy, "Keeping Quality of Frozen Beef Patties by Marjoram and Clove Essential oils.", Journal of Food Processing and Preservation, vol. 39, pp. 956–965, 2015. Abstract
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Abdel‐Aziz, M. E., and N. F. S. Morsy, "Keeping Quality of Frozen Beef Patties by Marjoram and Clove Essential Oils", Journal of Food Processing and Preservation, vol. 39, issue 6: Wiley Online Library, pp. 956-965, 2015. Abstractabstract1.pdf

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Johnson, L., and G. H. Galal, "KBS methodologies: principles and misconceptions", Systems Research and Information Science, vol. 6: GORDON & BREACH SCIENCE PUBLISHERS SA, pp. 69–69, 1993. Abstract
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