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Magdy, S., M. Gamal, N. A. N. C. Y. F. SAMIR, L. Rashed, B. E. Aboulhoda, H. S. Mohammed, and N. Sharawy, "IκB kinase inhibition remodeled connexins, pannexin-1, and excitatory amino-acid transporters expressions to promote neuroprotection of galantamine and morphine.", Journal of cellular physiology, vol. 236, issue 11, pp. 7516-7532, 2021. Abstract

Inflammatory pathway and disruption in glutamate homeostasis join at the level of the glia, resulting in various neurological disorders. In vitro studies have provided evidence that membrane proteins connexions (Cxs) are involved in glutamate release, meanwhile, excitatory amino-acid transporters (EAATs) are crucial for glutamate reuptake (clearance). Moreover, pannexin-1 (Panx-1) activation is more detrimental to neurons. Their expression patterns during inflammation and the impacts of IκB kinase (IKK) inhibition, morphine, and galantamine on the inflammatory-associated glutamate imbalance remain elusive. To investigate this, rats were injected with saline or lipopolysaccharide. Thereafter, vehicles, morphine, galantamine, and BAY-117082 were administered in different groups of animals. Subsequently, electroencephalography, enzyme-linked immunosorbent assay, western blot, and histopathological examinations were carried out and various indicators of inflammation and glutamate level were determined. Parallel analysis of Cxs, Panx-1, and EAAts in the brain was performed. Our findings strengthen the concept that unregulated expressions of Cxs, Panx-1, and EAATs contribute to glutamate accumulation and neuronal cell loss. Nuclear factor-kB (NF-κB) pathway can significantly contribute to glutamate homeostasis via modulating Cxs, Panx-1, and EAATs expressions. BAY-117082, via inhibition of IkK, promoted the anti-inflammatory effects of morphine as well as galantamine. We concluded that NF-κB is an important component of reshaping the expressions of Cxs, panx-1, and EAATs and the development of glutamate-induced neuronal degeneration.

Stańczak1, J., R. M. Gabre, W. K. Łozowska, M. Racewicz, and B. Kubica-Biernat, "IXODES RICINUS AS A VECTOR OF BORRELIA BURGDORFERI SENSU LATO, ANAPLASMA PHAGOCYTOPHILUM AND BABESIA MICROTI IN URBAN AND SUBURBAN FORESTS -RD", Ann Agric Environ Med , vol. 11, pp. 109-114, 2004.
Moustafa, M. K., A. R. Abdelwahed, I. Abosekena, S. Abdelazim, A. M. Abou-Setta, and H. G. Al-Inany, "IVF Outcomes with Either Highly Purified FSH vs. Recombinant FSH in Down-Regulated Normogonadotrophic Women: A Prospective Comparative Study in a Developing Country and Meta-Analysis", The Open Women' S Health Journal, vol. 3, pp. 11–15, 2009. Abstract
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Dikomey, E., K. Borgamnn, M. Kriegs, W. Y. Mansour, C. Petersen, and T. Rieckmann, "IV. Strahlenempfindlichkeit von Tumorzellen", Onkologie. Grundlagen - Diagnostik - Therapie - Entwicklung: ecomed , 2012.
Raziky, M. E., N. A. Zayed, A. A. Baki, S. A. Mansour, and R. M. H. Shahin, "ITPA gene polymorphism (94C>A) effects on ribavirin-induced anemia during therapy in Egyptian patients with chronic hepatitis C.", Journal of medical virology, vol. 89, issue 10, pp. 1823-1829, 2017 Oct. Abstract

Inosine triphosphatase (ITPA) gene variants can protect against ribavirin (RBV)-induced anemia in patients treated for chronic hepatitis C. The aim of this study was to determine the relationship between genetic variants of ITPA polymorphism, anemia, RBV dose reduction, and treatment response in hepatitis C virus (HCV)-infected patients. This study was conducted on 97 Egyptian chronic HCV patients who were scheduled for pegylated-interferon (PEG-INF) /RBV therapy. ITPA genotypes rs1127354 were determined by Real Time PCR melting curve analysis. Effects of ITPA polymorphism on hemoglobin (Hb) levels, RBV dose reduction and treatment response were analyzed. The homozygous wild genotype (CC) was associated with Hb reduction at week 4 (P = 0.004). The minor allele protected against Hb reduction. No association with sustained virological response was observed (P = 0.492). Female gender; lower baseline Hb and higher baseline WBC were associated with week 4 anemia (P = 0.04; P = 0.023; 0.033, respectively). The ITPA gene polymorphism rs1127354 heterozygous genotype (CA) may influence Hb levels and protect against hemolytic anemia during RBV-containing regimens for HCV. However, such findings were not significantly related to treatment outcomes. Patients with wild ITPA genotype (CC) experienced a more Hb drop and RBV dose reductions more frequently.

M, E. R. M., N. A. Zayed, A. A. Baki, S. A. Mansour, and R. M. H. Shahin, "ITPA gene polymorphism (94C>A) effects on ribavirin-induced anemia during therapy in Egyptian patients with chronic hepatitis C.", J Med Virol., vol. 89, issue 10, pp. 1823-1829, 2107.
Raziky, M. E., N. A. Zayed, A. A. Baki, and R. M. H. Shahin, "ITPA gene polymorphism (94C>A) effects on ribavirin-induced anemia during therapy in Egyptian patients with chronic hepatitis C", Journal of Medical Virology, vol. 89, pp. 1823-1829, 2017. itpa.pdf
El-Gueretly, H., and I. Eshrah, "ITIDA's role in supporting radio science R&D in Egypt", Radio Science Conference (NRSC), 2014 31st National: IEEE, pp. xxvii–xxvii, 2014. Abstract
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Deif, S. A., and S. R. Grace, "Iterative refinement for a system of linear integro-differential equations of fractional type", Journal of Computational and Applied Mathematics, vol. 294, issue 1 March 2016, pp. 138–150, 2016.
Deif, S. A., and S. R. Grace, "Iterative refinement for a system of linear integro-differential equations of fractional type", Journal of Computational and Applied Mathematics, vol. 294, issue 1 March 2016, pp. 138–150, 2016.
Deif, S. A., and S. R. Grace, "Iterative refinement for a system of linear integro-differential equations of fractional type", Journal of Computational and Applied Mathematics, vol. 294: Elsevier, pp. 138-150, 2016. Abstract
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Gomaa, A., and A. Elezabi, "Iterative MMSE estimation of SINR for turbo‐coded FH‐SS systems in partial‐band interference and fading channels", European Transactions on Telecommunications, vol. 22, issue 2, pp. 93-97, 2011.
Al-Said, A. B., "The Iterative Lexicon for the words of the Holy Quran (The Curriculum & the Model)", International Symposium of the Holy Quran and Modern Technology, King Fahd Complex for Printing the Holy Quran, Madina, Saudi Arabia., Oct. 2009. moataz-madinah-01.pdf
Gamal, H. E., M. M. Khairy, and E. Geraniotis, "Iterative decoding and channel estimation of DS/CDMA over slow Rayleigh fading channels", Personal, Indoor and Mobile Radio Communications, 1998. The Ninth IEEE International Symposium on, vol. 3: IEEE, pp. 1299–1303, 1998. Abstract
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Akcakaya, M., S. Nam, T. Basha, V. Tarokh, W. J. Manning, and R. Nezafat, "Iterative compressed sensing reconstruction for 3d non-cartesian trajectories without gridding & regridding at every iteration", Proceedings of the annual meeting of ISMRM, vol. 19, pp. 2550, 2011. Abstract
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Akcakaya, M., S. Nam, T. Basha, V. Tarokh, W. J. Manning, and R. Nezafat, "Iterative compressed sensing reconstruction for 3d non-cartesian trajectories without gridding & regridding at every iteration", Proceedings of the annual meeting of ISMRM, vol. 19, pp. 2550, 2011. Abstract
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Hafez, H., Y. A. Fahmy, and M. M. Khairy, "Iterative channel estimation and turbo decoding for OFDM systems", Wireless and Mobile Computing, Networking and Communications (WiMob), 2011 IEEE 7th International Conference on: IEEE, pp. 428–432, 2011. Abstract

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Hafez, H., Y. A. Fahmy, and M. M. Khairy, "Iterative channel estimation and turbo decoding for OFDM systems", Wireless and Mobile Computing, Networking and Communications (WiMob), 2011 IEEE 7th International Conference on: IEEE, pp. 428–432, 2011. Abstract
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Awad, A., R. Goré, Z. Hou, J. Thomson, and M. Weidlich, "An iterative approach to synthesize business process templates from compliance rules", Inf. Syst., vol. 37, no. 8, pp. 714-736, 2012. Abstract
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Abdelrahman, E. M., T. M. El-Araby, and K. S. Essa, "An Iterative Approach to Depth Determination from Second Moving Average Residual Magnetic Anomalies", Journal of King Abdulaziz University: Earth Sciences, vol. 15, pp. 181–196, 2004. Abstract
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Abdelrahman, E. M., and T. M. El-Araby, "An Iterative Approach to Depth Determination from Moving Average Residual Self-Potential Anomalies", King Abdulaziz univ. earth[2] Burr, SV (1981). A Guide to prospecting by the self-potential method, vol. 9, pp. 17–27, 1997. Abstract
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