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Abulghar, M., A. Nada, O. Azmy, and O. Shawky, "Hysteroscopic Tubal Electrocoagulation In Cases With Communicating Hydrosalpinx And Planning For IVF- A Pilot Study", The International Medical Journal , 2008.
AH, G., "Hysteroscopic resection of type 2 submucous fibroids", The 15th annual conference of the department of obstetrics and gynaecology, Cairo-Egypt, Cairo university-Department of obstetrics and gynaecology, 2014.
Zayed, M., U. M. Fouda, S. M. Zayed, K. A. Elsetohy, and A. T. Hashem, "Hysteroscopic Myomectomy of Large Submucous Myomas in a 1-Step Procedure Using Multiple Slicing Sessions Technique.", J Minim Invasive Gynecol. 2015, vol. 22, issue 7, pp. 1196-202, 2015.
Zayed, M., U. M. Fouda, S. M. Zayed, K. A. Elsetohy, and A. T. Hashem, "Hysteroscopic Myomectomy of Large Submucous Myomas in a 1-Step Procedure Using Multiple Slicing Sessions Technique", Journal of Minimally Invasive Gynecology,, vol. 22, issue 7, pp. 1196-1202, 2015. hysteroscopic_myomectomy_of_large_submucous_myomas_in_a_1-step_procedure_using_multiple_slicing_sessions_technique.pdf
A.L.Aboul-Nasr, H. G. Al-Inany, and S.M.Thabet, "Hysteroscopic metroplasty in recurrent aborters and infertile patients.", Egypt. J. Fertil. Steril. , vol. 4, issue 1, pp. 55-58, 2000.
Shawki, O., A. Wahba, and H. Al-Inany, "Hysteroscopic Management of endometrial bleeding and IUD ", Nezhat's Video assisted and Robotic assisted Laparoscopy and Hysteroscopy, UK, Cambridge University Press , 2013.
A.L.Aboul-Nasr, R.A.Ezzat, A. El-Hennawy, E.Fateen, N. Abdel-Kader, and S.S.Hassan, "Hysteroscopic localization of intrauterine devices in cases with uterine bleeding. ", Med. J. Cairo Univ. , vol. 64, issue 2, pp. 365-376, 1996.
A.L.Aboul-Nasr, S.M.Thabet, H.G.Al-Inany, and M.Aboulghar, "Hysteroscopic evaluation of the uterine cavity following surgical evacuation. ", Middle East Fertil. Soc. J. , vol. 3, issue 2, pp. 137-144, 1998.
A.L.Aboul-Nasr, "Hysteroscopic endometrial ablation. ", Middle East Fertil Soc. J. , vol. 2, issue 3, pp. 185-194, 1997.
Abd ElAziz, A. M., H. S. Abdel Hamid, R. R. Mostafa, and Y. R. A. Shalaby, "Hypoxia-inducible factor-1α expression in colorectal carcinoma", Egypation Journal of Pathology, vol. 38, issue 1, pp. 18–21, 2018.
KANDIL, E. S. R. A. A. A., R. H. Sayed, L. A. Ahmed, M. A. Abd El Fattah, and B. M. El-Sayeh, "Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.", Clinical and experimental pharmacology & physiology, vol. 46, issue 12, pp. 1141-1150, 2019. Abstract

Hypoxia-inducible factor-1 alpha (HIF-1α) and nuclear receptor related-1 (Nurr1) play pivotal roles in the development and survival of dopaminergic neurons, and deficiencies in these genes may be involved in Parkinson's disease (PD) pathogenesis. Recently, anthelminthic benzimidazoles were shown to promote HIF-1α transcription in vitro and were proposed to activate Nurr1 via their benzimidazole group. Therefore, the aim of this study was to explore the neuroprotective effects of albendazole (ABZ), an anthelminthic benzimidazole, in a rotenone model of Parkinson's disease (PD). Rotenone (1.5 mg/kg) was subcutaneously injected into rats every other day for a period of 21 days, resulting in the development of the essential features of PD. In addition to rotenone, ABZ (10 mg/kg) was administered orally starting from the 11th day. Treatment of rats with ABZ markedly mitigated rotenone-induced histological alterations in substantia nigra (SN), restored striatal dopamine (DA) level and motor functions and decreased the expression of α-synuclein (a disease marker protein). ABZ also enhanced expression of Hypoxia-inducible factor-1 alpha (HIF-1α) in the SN along with its downstream target, vascular endothelial growth factor, promoting neuronal survival. Similarly, ABZ augmented nuclear receptor related-1 (Nurr1) expression in the SN and increased transcriptional activation of Nurr1-controlled genes, which are essential for regulation of DA synthesis; additionally, expression of neurotoxic proinflammatory cytokines that induce neuronal death was suppressed. In conclusion, the present study suggests that ABZ exerts a neuroprotective effect in a rotenone-induced PD model associated with HIF-1α and Nurr1 activation and thus may be a viable candidate for treating PD.

KANDIL, E. S. R. A. A. A., R. H. Sayed, L. A. Ahmed, M. A. Abd El Fattah, and B. M. El-Sayeh, "Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.", Clinical and experimental pharmacology & physiology, vol. 46, issue 12, pp. 1141-1150, 2019. Abstract

Hypoxia-inducible factor-1 alpha (HIF-1α) and nuclear receptor related-1 (Nurr1) play pivotal roles in the development and survival of dopaminergic neurons, and deficiencies in these genes may be involved in Parkinson's disease (PD) pathogenesis. Recently, anthelminthic benzimidazoles were shown to promote HIF-1α transcription in vitro and were proposed to activate Nurr1 via their benzimidazole group. Therefore, the aim of this study was to explore the neuroprotective effects of albendazole (ABZ), an anthelminthic benzimidazole, in a rotenone model of Parkinson's disease (PD). Rotenone (1.5 mg/kg) was subcutaneously injected into rats every other day for a period of 21 days, resulting in the development of the essential features of PD. In addition to rotenone, ABZ (10 mg/kg) was administered orally starting from the 11th day. Treatment of rats with ABZ markedly mitigated rotenone-induced histological alterations in substantia nigra (SN), restored striatal dopamine (DA) level and motor functions and decreased the expression of α-synuclein (a disease marker protein). ABZ also enhanced expression of Hypoxia-inducible factor-1 alpha (HIF-1α) in the SN along with its downstream target, vascular endothelial growth factor, promoting neuronal survival. Similarly, ABZ augmented nuclear receptor related-1 (Nurr1) expression in the SN and increased transcriptional activation of Nurr1-controlled genes, which are essential for regulation of DA synthesis; additionally, expression of neurotoxic proinflammatory cytokines that induce neuronal death was suppressed. In conclusion, the present study suggests that ABZ exerts a neuroprotective effect in a rotenone-induced PD model associated with HIF-1α and Nurr1 activation and thus may be a viable candidate for treating PD.

MASHALY, M. A. G. D. I. M., S. A. N. D. R. A. L. YOUTZ, and R. F. Wideman, "Hypothyroidism and Antibody Prodction in Immature Male Chickens", Immunological Investigations, vol. 12, issue 6: Informa UK Ltd UK, pp. 551-563, 1983. Abstract
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K.M., M., S. F.K., S. S.S., S. K.F., and K. M.G., "Hypothermic effect of ethanol in mice selected for differential sleep-time response to pentobarbital.", Pharmacol Biochem Behav., vol. 51, issue 2-3, pp. 525-8., 1995. Abstract
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El-Darouti, M. A., M. M. Fawzy, R. A. HEGAZY, and R. M. Abdel Hay, "Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: a report of 34 patients and a 7-year experience.", Journal of the American Academy of Dermatology, vol. 67, issue 6, pp. 1182-8, 2012 Dec. Abstract

BACKGROUND: In the past 7 years we have extensively studied an uncommon hypopigmented disorder that, apart from hypopigmentation, showed many common features with parapsoriasis en plaque (PSEP), both clinically and histopathologically.

OBJECTIVE: We sought to verify whether this disorder should be considered a hypopigmented variant of PSEP and thus be referred to as hypopigmented PSEP.

METHODS: A total of 34 patients presenting with this peculiar hypopigmented disorder were included (2003-2010). Patients were subjected to a predesigned algorithm excluding all possible differential diagnoses of hypopigmented lesions.

RESULTS: Our findings indicated that this disorder can be diagnosed as hypopigmented PSEP. These findings included: (1) exclusion of all other disorders causing similar hypopigmented lesions; (2) shape and size of the lesions being very similar to those of classic small PSEP (small-plaque parapsoriasis [SPP]); (3) similar distribution of the lesions (trunk, proximal upper and lower limbs) to the classic PSEP; (4) digitiform extensions of most the lesions (70.5% of our patients) as in SPP; (5) absence of itching as in PSEP (SPP type); (6) good response to narrowband ultraviolet B in 76.4% of the patients (n = 26); and (7) during follow-up 5 patients (14.7%) converted into hypopigmentd mycosis fungoides.

LIMITATIONS: A limitation in our study is that we did not perform clonal T-cell receptor gene rearrangement because of limited resources.

CONCLUSION: Based on our findings we believe that this hypopigmented disorder is a well-defined new variant of the PSEP family that shows, apart from the hypopigmentation, all the features of PSEP, particularly the SPP variant, and accordingly could be referred to as hypopigmented PSEP.

El-Darouti, M. A., M. M. Fawzy, R. A. HEGAZY, and R. M. Abdel Hay, "Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: A report of 34 patients and a 7-year experience", Journal of the American Academy of Dermatology, vol. 67, no. 6: Elsevier, pp. 1182–1188, 2012. Abstract
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El-Darouti, M. A., M. M. Fawzy, R. A. HEGAZY, and R. A. M. Hay, "Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: a report of 34 patients and a 7-year experience", Journal of the American Academy of Dermatology, vol. 67, no. 6: Mosby, pp. 1182–1188, 2012. Abstract
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Elbendary, A., M. R. E. Abdel-Halim, R. Youssef, D. abd el halim, M. F. Elmasry, A. A. Gad, and D. A. El Sharkawy, "Hypopigmented lesions in pityriasis lichenoides chronica patients: Are they only post-inflammatory hypopigmentation?", The Australasian journal of dermatology, 2021. Abstract

BACKGROUND/OBJECTIVES: Pityriasis lichenoides chronica (PLC) lesions are reported to subside with post-inflammatory hypopigmentation (PIH); hence, the most widely perceived nature of hypopigmented macules in PLC is PIH. However, to the best of our knowledge, no studies describing histopathological findings in these lesions are reported in literature. The aim of this study is to evaluate the hypopigmented lesions encountered in PLC patients and to shed light on their histopathological features.

METHODS: A cross-sectional observational study included twenty-one patients with PLC recruited in a period of twelve months. Clinical characteristics of each patient were collected. A skin biopsy from hypopigmented lesions whenever present was taken and assessed with routine haematoxylin and eosin stain.

RESULTS: Seventeen patients (81%) were less than 13 years old. Most patients (85.7%) demonstrated diffuse distribution of lesions. Hypopigmented lesions were present on the face in 12 (57.14%) patients. Histopathologically, hypopigmented lesions showed features of post-inflammatory hypopigmentation in 19% of patients, residual PLC in 52.4% and active PLC 28.6% of patients.

CONCLUSION: Hypopigmented lesions in PLC were noted mainly in younger ages, histopathologically they may show features of active or residual disease, beyond post-inflammatory hypopigmentation. Consequently active treatment for patients presenting predominantly with hypopigmented lesions could be required to control the disease.

Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study.", The American Journal of dermatopathology, vol. 40, issue 10, pp. 727-735, 2018 Oct. Abstract

Hypopigmented interface T-cell dyscrasia (HITCD) is a distinct form of lymphoid dyscrasia that may progress to hypopigmented mycosis fungoides (HMF). We compared both diseases as regards their CD4/CD8 phenotype and expression of granzyme B and tumor necrosis factor-alpha (TNF-α) and how these are affected by narrow-band UVB (nb-UVB). The study included 11 patients with HITCD and 9 patients with HMF. They received nb-UVB thrice weekly until complete repigmentation or a maximum of 48 sessions. Pretreatment and posttreatment biopsies were stained using anti CD4, CD8, TNF-α, and granzyme B monoclonal antibodies. Epidermal lymphocytes were CD8 predominant in 54.5% and 66.7% of HITCD and HMF cases, respectively, whereas dermal lymphocytes were CD4 predominant in 63.6% and 66.7%, respectively. Significantly, more dermal infiltrate was encountered in HMF (P = 0.041). In both diseases, granzyme B was only expressed in the dermis, whereas TNF-α was expressed both in the epidermis and dermis. No difference existed as regards the number of sessions needed to achieve repigmentation or cumulative nb-UVB dose reached at end of study. (P > 0.05). Narrow-band UVB significantly reduced only the epidermal lymphocytes in both diseases (P ≤ 0.05) with their complete disappearance in 8 (72.7%) HITCD and 6 (66.7%) HMF cases. In both diseases, nb-UVB did not affect granzyme B or TNF-α expression (P > 0.05). In conclusion, both diseases share the same phenotype, with HITCD being a milder form of T-cell dysfunction. In both diseases, epidermal lymphocytes are mainly CD8-exhausted cells lacking cytotoxicity, whereas dermal cells are mostly reactive cells exerting antitumor cytotoxicity. Tumor necrosis factor-alpha mediates hypopigmentation in both diseases and prevents disease progression. Repigmentation after nb-UVB in both diseases occurs before and independently from disappearance of the dermal infiltrate.

Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study", The American Journal of Dermatopathology, vol. 40, issue 10, pp. 727-735, 2018.
TAHA, O. M. A. R. A., A. L. A. A. BARAKAT, H. k.AbdelHakim, M. A. Shemis, and Z. A. I. N. A. B. ZAKARIA, "Hypolipidimic and anti-fatty liver effects exerted by standardized punica granatum L.peel extract in HEPG2 cell-line and high fat diet induced mice", International journal of pharmacy and pharmaceutical science , vol. 8, issue 6, pp. 156-161, 2016. 11226-42912-2-pb.pdf