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Journal Article
Abdelmoniem, A. M., H. F. Hammad, A. F. Darweesh, M. A. Abdelaziz, I. A. Abdelhamid, and A. H. M. Elwahy, "Hantzsch one-pot multicomponent synthesis of a novel series of bis(9,10-diarylhexahydroacridine-1,8-diones)", Synthetic Communications, vol. 51, issue 17: Taylor & Francis, pp. 2695 - 2712, 2021/07//. Abstract

Efficient procedures have been developed for the synthesis of novel series of bis(9,10-diaryl-hexahydroacridine-1,8-diones) in which the two acridine moieties were linked to aliphatic, aromatic, or heteroaromatic spacers via ether or ester linkages. The target products were obtained in good to excellent yields via a multi-component reaction of the appropriate aromatic amine, 5,5-dimethyl-1,3-cyclohexanedione, and the corresponding bis-aldehydes. The reactions were also proceeded to give the target products in good yields via a multi-component reaction of the appropriate cyclic enamines, and the corresponding bis-aldehydes under similar conditions. Bis-alkylation of the appropriate hexahydroacridine-1,8-dione with the corresponding dihalo compound in a basic medium was also proved to be an effective strategy for the synthesis of the target products. The multi-component reaction of the aromatic amine, bis-aldehydes, and barbituric acid or 1,3-dimethylbarbituric acid, instead of 5,5-dimethyl-1,3-cyclohexanedione, afforded the corresponding Knoevenagel condensation adducts in good yield and unfortunately, the expected bis-tetrahydropyrimido[4,5-b]quinolines could not be isolated.

Abdelmoniem, A. M., A. M. Abdella, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with 6-Aminouracil: Synthesis of novel tetrakis(6-Aminouracil-5-yl)methanes and bis(decahydropyrido[2,3-d:6,5-d']dipyrimidine-Tetraones) linked to aliphatic or aromatic cores via ether-Amide or ester-Amide linkages", Arkivoc, vol. 2020, issue 8, pp. 136 - 149, 2020///. Abstract

One-pot three-component cyclo-condensation reaction of bis(aldehydes) containing ether-Amide or ester-Amide linkages with 6-Aminouracil in boiling acetic acid afforded tetrakis(6-Aminopyrimidine-2,4-diones) or bis(tetraoxodecahydropyrido[2,3-d:6,5-d']dipyrimidines) depending on the reaction conditions.

Abdelmoniem, A. M., M. G. M. Abdelrahman, S. A. S. Ghozlan, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with bis-indole-2, 3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo [3, 4-b: 4', 3'-e] pyridine and pyrido [2, 3-d: 6, 5-d'] dipyrimidine", Synthetic Communications: Taylor & Francis, pp. 1-11, 2021. Abstract
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Abdelmoniem, A. M., M. G. M. Abdelrahman, S. A. S. Ghozlan, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with bis-indole-2, 3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo [3, 4-b: 4', 3'-e] pyridine and pyrido [2, 3-d: 6, 5-d'] dipyrimidine", Synthetic Communications: Taylor & Francis, pp. 1-11, 2021. Abstract
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Abdelmoniem, A. M., M. G. M. Abdelrahman, S. A. S. Ghozlan, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with bis-indole-2, 3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo [3, 4-b: 4', 3'-e] pyridine and pyrido [2, 3-d: 6, 5-d'] dipyrimidine", Synthetic Communications: Taylor & Francis, pp. 1-11, 2021. Abstract
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Abdelmoniem, A. M., M. G. M. Abdelrahman, S. A. S. Ghozlan, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with bis-indole-2, 3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo [3, 4-b: 4', 3'-e] pyridine and pyrido [2, 3-d: 6, 5-d'] dipyrimidine", Synthetic Communications, vol. 51, issue 12: Taylor & Francis, pp. 1814-1824, 2021. Abstract
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Abdelmoniem, A. M., M. G. M. Abdelrahman, S. A. S. Ghozlan, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with bis-indole-2, 3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo [3, 4-b: 4', 3'-e] pyridine and pyrido [2, 3-d: 6, 5-d'] dipyrimidine", Synthetic Communications, vol. 51, issue 12: Taylor & Francis, pp. 1814-1824, 2021. Abstract
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Abdelmoniem, A. M., M. G. M. Abdelrahman, S. A. S. Ghozlan, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with bis-indole-2, 3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo [3, 4-b: 4', 3'-e] pyridine and pyrido [2, 3-d: 6, 5-d'] dipyrimidine", Synthetic Communications, vol. 51, issue 12: Taylor & Francis, pp. 1814-1824, 2021. Abstract
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Abdelmoniem, A. M., M. G. M. Abdelrahman, S. A. S. Ghozlan, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with bis-indole-2, 3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo [3, 4-b: 4', 3'-e] pyridine and pyrido [2, 3-d: 6, 5-d'] dipyrimidine", Synthetic Communications, vol. 51, no. 12: Taylor & Francis, pp. 1814–1824, 2021. Abstract
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Abdelmoniem, A. M., M. G. M. Abdelrahman, S. A. S. Ghozlan, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch reaction with bis-indole-2,3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo[3,4-b:4',3'-e]pyridine and pyrido[2,3-d:6,5-d']dipyrimidine", Synthetic Communications, vol. 51, issue 12: Taylor & Francis, pp. 1814 - 1824, 2021///. Abstract

One-pot three-component cyclo-condensation reaction of bis(indole-2,3-diones) with dimedone, 3-methyl-1H-pyrazol-5(4H)-one, or 6-aminouracil in boiling acetic acid afforded bis-spirocyclic oxindoles linked to acridine, dipyrazolo[3,4-b:4',3'-e]pyridine, and pyrido[2,3-d:6,5-d']dipyrimidine, respectively.

Sanad, S. M. H., M. A. E. Hawass, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch synthesis of bis (1, 4-dihydropyridines) and bis (tetrahydrodipyrazolo [3, 4-b: 4′, 3′-e] pyridines) linked to pyrazole units as novel hybrid molecules", Synthetic Communications, vol. 50, issue 13: Taylor & Francis, pp. 1982-1992, 2020. Abstract
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Sanad, S. M. H., M. A. E. Hawass, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch synthesis of bis (1, 4-dihydropyridines) and bis (tetrahydrodipyrazolo [3, 4-b: 4′, 3′-e] pyridines) linked to pyrazole units as novel hybrid molecules", Synthetic Communications, vol. 50, issue 13: Taylor & Francis, pp. 1982-1992, 2020. Abstract
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Sanad, S. M. H., M. A. E. Hawass, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch synthesis of bis (1, 4-dihydropyridines) and bis (tetrahydrodipyrazolo [3, 4-b: 4′, 3′-e] pyridines) linked to pyrazole units as novel hybrid molecules", Synthetic Communications, vol. 50, no. 13: Taylor & Francis, pp. 1982–1992, 2020. Abstract
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Hawass, M. A. E., S. M. H. Sanad, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch synthesis of bis (pyrido [2, 3-d: 6, 5-d'] dipyrimidines), bis (pyrimido [4, 5-b] quinolines), and bis (benzo [4, 5] imidazo [2, 1-b] quinazolines) linked to pyrazole units as novel hybrid molecules", Synthetic Communications, vol. 51, issue 12: Taylor & Francis, pp. 1899-1912, 2021. Abstract
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Hawass, M. A. E., S. M. H. Sanad, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch synthesis of bis (pyrido [2, 3-d: 6, 5-d'] dipyrimidines), bis (pyrimido [4, 5-b] quinolines), and bis (benzo [4, 5] imidazo [2, 1-b] quinazolines) linked to pyrazole units as novel hybrid molecules", Synthetic Communications, vol. 51, issue 12: Taylor & Francis, pp. 1899-1912, 2021. Abstract
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Hawass, M. A. E., S. M. H. Sanad, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch synthesis of bis (pyrido [2, 3-d: 6, 5-d'] dipyrimidines), bis (pyrimido [4, 5-b] quinolines), and bis (benzo [4, 5] imidazo [2, 1-b] quinazolines) linked to pyrazole units as novel hybrid molecules", Synthetic Communications, vol. 51, no. 12: Taylor & Francis, pp. 1899–1912, 2021. Abstract
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Sanad, S. M. H., M. A. E. Hawass, A. H. M. Elwahy, and I. A. Abdelhamid, "Hantzsch synthesis of bis(1,4-dihydropyridines) and bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridines) linked to pyrazole units as novel hybrid molecules", Synth. Commun. , vol. 50, issue 13, pp. 1982-1992, 2020. 020_synth_commun_2020.pdf
Abdelmoniem, A. M., F. M. Sroor, M. A. Ramadan, S. A. S. Ghozlan, and I. A. Abdelhamid, "Hantzsch-Like One-Pot Three-Component Synthesis of Heptaazadicyclopenta [a, j] anthracenes: A New Ring System", Synlett: © Georg Thieme Verlag, 2020. Abstract
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Abdelmoniem, A. M., F. M. Sroor, M. A. Ramadan, S. A. S. Ghozlan, and I. A. Abdelhamid, "Hantzsch-Like One-Pot Three-Component Synthesis of Heptaazadicyclopenta [a, j] anthracenes: A New Ring System", Synlett: © Georg Thieme Verlag, 2020. Abstract
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