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2023
Mohamed, M., A. A. R. Hashem, M. F. Obeid, and A. Abu-Seida, "Histopathological and immunohistochemical profiles of pulp tissues in immature dogs’ teeth to two recently introduced pulpotomy materials", Clinical Oral Investigations, vol. 27, issue 6, pp. 3095–3103, 2023. pulpine-pulptomy.pdf
Elmosbah, D. E., M. S. Khattab, H. O. AbuBakr, and H. M.F.ELMiniawy, "Histopathological, biochemical and molecular studies on a model of systemic autoimmune disease induced by sodium silicate in non-genetically prone rats", Chemico-biological interactions , 2023.
Ahmed, S. A., I. M. E. Taher, D. F. Ghoneim, M. A. Elnaggar, and A. A. Hassan, "Histopathology of Corneal Lenticules Obtained from Small Incision Lenticule Extraction (SMILE) versus Microkeratome Excision", Journal of Ophthalmic & Vision Research, vol. 18, issue 1, pp. 24, 2023.
Abdelkhalek, Z. S., I. G. Mahmoud, H. Omair, M. Abdulhay, and M. A. Elmonem, "Homogentisate 1,2-dioxygenase (HGD) gene variants in young Egyptian patients with alkaptonuria.", Scientific reports, vol. 13, issue 1, pp. 14374, 2023. Abstract

Alkaptonuria (AKU) is a rare autosomal recessive metabolic disorder caused by pathogenic variants in the homogentisate 1,2-dioxygenase (HGD) gene. This leads to a deficient HGD enzyme with the consequent accumulation of homogentisic acid (HGA) in different tissues causing complications in various organs, particularly in joints, heart valves and kidneys. The genetic basis of AKU in Egypt is completely unknown. We evaluated the clinical and genetic spectrum of six pediatric and adolescents AKU patients from four unrelated Egyptian families. All probands had a high level of HGA in urine by qualitative GC/MS before genetic confirmation by Sanger sequencing. Recruited AKU patients were four females and two males (median age 13 years). We identified four different pathogenic missense variants within HGD gene. Detected variants included a novel variant c.1079G > T;p.(Gly360Val) and three recurrent variants; c.1078G > C;p.(Gly360Arg), c.808G > A;p.(Gly270Arg) and c.473C > T;p.(Pro158Leu). All identified variants were properly segregating in the four families consistent with autosomal recessive inheritance. In this study, we reported the phenotypic and genotypic spectrum of alkaptonuria for the first time in Egypt. We further enriched the HGD-variant database with another novel pathogenic variant. The recent availability of nitisinone may promote the need for genetic confirmation at younger ages to start therapy earlier and prevent serious complications.

El-Zawawy, M. A., P. Kaliyar, M. Conti, and S. Katsikas, "Honey-list based authentication protocol for industrial IoT swarms", Computer Communications, vol. 2011, pp. 239-253, 2023.
Sanad, M., M. S. M. Shamseldean, A. Y. Elgindi, Y. Wang, and R. Gaugler, "Host-searching behavior of the mosquito-parasitic mermithids, Romanomermis iyengari and Strelkovimermis spiculatus (Nematoda: Mermithidae).", Journal of Nematology (In manuscript). (USA)., 2023. Abstract
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Alsiary, W. A., H. AbdElgawad, and M. M. Y. Madany, "How could actinobacteria augment the growth and redox homeostasis in barley plants grown in TiO2NPs-contaminated soils? A growth and biochemical study", Plant Physiology and Biochemistry, vol. 202: Elsevier Masson, pp. 107943, 2023. Abstract
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Abduljalil, J. M., A. M. Elghareib, E. AA, A. S. Mohamed, and E. AA, "How helpful were molecular dynamics simulations in shaping our understanding of SARS-CoV-2 Spike protein dynamics?", International Journal of Biological Macromolecules, vol. 242, Part 4, pp. 125153, 2023.
Hamey, R. G., A. A. El-Midany, and H. E. El-Shall, "How reliable the light scattering in sizing the deformable particles by milling?", Particulate Science and Technology , vol. 41, issue 5, pp. 725-729, 2023.
Moorkens, K., J. L. M. R. Leroy, J. Quanico, G. Baggerman, and W. F. A. Marei, "How the Oviduct Lipidomic Profile Changes over Time after the Start of an Obesogenic Diet in an Outbred Mouse Model.", Biology, vol. 12, issue 7, 2023. Abstract

We investigated whether a high-fat/high-sugar (HF/HS) diet alters the lipidomic profile of the oviductal epithelium (OE) and studied the patterns of these changes over time. Female outbred Swiss mice were fed either a control (10% fat) or HF/HS (60% fat, 20% fructose) diet. Mice ( = 3 per treatment per time point) were sacrificed and oviducts were collected at 3 days and 1, 4, 8, 12 and 16 weeks on the diet. Lipids in the OE were imaged using matrix-assisted laser desorption ionisation mass spectrometry imaging. Discriminative / values and differentially regulated lipids were determined in the HF/HS versus control OEs at each time point. Feeding the obesogenic diet resulted in acute changes in the lipid profile in the OE already after 3 days, and thus even before the development of an obese phenotype. The changes in the lipid profile of the OE progressively increased and became more persistent after long-term HF/HS diet feeding. Functional annotation revealed a differential abundance of phospholipids, sphingomyelins and lysophospholipids in particular. These alterations appear to be not only caused by the direct accumulation of the excess circulating dietary fat but also a reduction in the de novo synthesis of several lipid classes, due to oxidative stress and endoplasmic reticulum dysfunction. The described diet-induced lipidomic changes suggest alterations in the OE functions and the oviductal microenvironment which may impact crucial reproductive events that take place in the oviduct, such as fertilization and early embryo development.

Gendy, E. S. N., M. I. Ezzat, E. L. A. M. Sayed, E. L. A. M. Sayed, and A. K. Elmotayam, "HPLC-PDA-ESI-MS-MS Analysis of Acids Content of Lantana camara L. Flower Extract and Its Anticoagulant Activity", Egyptian Journal of Chemistry, vol. 66, pp. 249 - 256, 2023.
Ali, D. E., S. M. Bassam, S. Ela, E. S. Habiba, E. A. Allam, E. M. Omar, D. A. Ghareeb, S. A. Abdulmalek, and E. Abdel-Sattar, "HR LC-MS/MS metabolomic profiling of Yucca aloifolia fruit and the potential neuroprotective effect on rotenone-induced Parkinson’s disease in rats", Plos One, vol. 18, issue 2, pp. e0282246, 2023.
ABDELMISSIH, S. H. E. R. I. N. E., "https://biomedres.us/pdfs/BJSTR.MS.ID.007849.pdf", BJSTR, vol. 49, issue 4, pp. 40966-40968, 2023. Abstractbjstr.ms_.id_.007849.pdf

Raw data on exopodite beating in the first three developmental stages of the lobster Homarus gammarus were collected and analysed for key beating parameters. The analysis was computer assisted and the main procedures used are described. Beating patterns are the same in all three stages and are usually very regular although perturbations do occur (figures 1, 2). When beating stops the deceleration and subsequent re-acceleration is very rapid (figure 1) and limb movement sequences usually start posteriorly and move forwards (figures 1, 2d). Ipsilateral phase relations are generally maintained at 0.4-0.6 (figures, 3,4) and while the coupling between adjacent exopodites is usually stronger than for those further apart various deviations from this are occasionally seen (figure 5). No significant correlation between the ipsilateral phase relations of adjacent exopodites and base cycle duration was detected for any of the stages (figure 6). Contralateral phase relations undergo a constant progression (figures 7, 9) and this was found to be due to a heterodyne effect (figure 8) also described as gliding coordination. The powerstroke/returnstroke ratio for all stages was approximately 0.5 (figure 10) and no significant correlation was found with cycle duration (figure 11). The only substantial difference between the three larval stages which was noted was that of cycle duration, the cycles of stage III being shorter than those of the first two stages. The exopodite beating pattern was discussed in context with other metachronously cycling systems in arthropods and the implications of the present study discussed.

Faid, A. H., E. M. Mostafa, F. E. Z. Hussein, S. A. Shouman, Y. A. Badr, and M. A. Sliem, "Hybrid chitosan gold nanoparticles for photothermal therapy and enhanced cytotoxic action of 6-mercaptopurine on breast cancer cell line", Beni-Suef Univ J Basic Appl Sci, vol. 12, issue 83, 2023. hybrid_beniseuif.pdf
Abdelaziz, A., M. Ahmed, and T. Musah, "Hybrid Timing Error Detector for Baud Rate Multilevel Clock and Data Recovery", IEEE Open Journal of Circuits and Systems, vol. 4, pp. 324-335, 2023.
Tawfik, A. M., "Hydraulic solutions of pipeline systems using artificial neural networks", Ain Shams Engineering Journal, vol. 14, issue 3, pp. 101896, 2023.
Omar, M. A., R. A. El-Shiekh, D. H. Dawood, A. Temirak, and A. M. Srour, "Hydrazone–sulfonate hybrids as potential cholinesterase inhibitors: design, synthesis and molecular modeling simulation", Future Medicinal Chemistry, vol. 15, no. 24: Newlands Press Ltd London, UK, pp. 2269–2287, 2023. Abstract
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Hamdy, S. A., M. M. Hashem, E. H. M. Hefnawy, S. M. Azzam, and E. A. Aboutabl, "Hydrocotyle umbellata L.; a natural source of bioactives to mitigate diabetes mellitus and its complications", Natural Product Research, pp. 1-4, 2023.
Kaood, A., A. ElDegwy, and A. Aboulmagd, "Hydrothermal and entropy generation performance of convergent tubes with various dimple shapes", International Journal of Thermal Sciences, vol. 197, issue 2024, 2023.
Khalil, H. M. A., H. M. A. El Henafy, I. A. Khalil, A. F. Bakr, M. I. Fahmy, N. S. Younis, and R. A. El-Shiekh, "Hypericum perforatum L. Nanoemulsion Mitigates Cisplatin-Induced Chemobrain via Reducing Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation, and Apoptosis in Adult Rats", Toxics, vol. 11, no. 2: MDPI, pp. 159, 2023. Abstract
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Biancari, F., A. Kaserer, A. Perrotti, V. G. Ruggieri, S. - M. Cho, J. K. Kang, M. Dalén, H. Welp, K. Jónsson, S. Ragnarsson, et al., "Hyperlactatemia and poor outcome After postcardiotomy veno-arterial extracorporeal membrane oxygenation: An individual patient data meta-Analysis.", Perfusion, pp. 2676591231170978, 2023. Abstract

INTRODUCTION: Postcardiotomy veno-arterial extracorporeal membrane oxygenation (V-A-ECMO) is associated with significant mortality. Identification of patients at very high risk for death is elusive and the decision to initiate V-A-ECMO is based on clinical judgment. The prognostic impact of pre-V-A-ECMO arterial lactate level in these critically ill patients has been herein evaluated.

METHODS: A systematic review was conducted to identify studies on postcardiotomy VA-ECMO for the present individual patient data meta-analysis.

RESULTS: Overall, 1269 patients selected from 10 studies were included in this analysis. Arterial lactate level at V-A-ECMO initiation was increased in patients who died during the index hospitalization compared to those who survived (9.3 vs 6.6 mmol/L, < 0.0001). Accordingly, in hospital mortality increased along quintiles of pre-V-A-ECMO arterial lactate level (quintiles: 1, 54.9%; 2, 54.9%; 3, 67.3%; 4, 74.2%; 5, 82.2%, < 0.0001). The best cut-off for arterial lactate was 6.8 mmol/L (in-hospital mortality, 76.7% vs. 55.7%, < 0.0001). Multivariable multilevel mixed-effect logistic regression model including arterial lactate level significantly increased the area under the receiver operating characteristics curve (0.731, 95% CI 0.702-0.760 vs 0.679, 95% CI 0.648-0.711, DeLong test < 0.0001). Classification and regression tree analysis showed the in-hospital mortality was 85.2% in patients aged more than 70 years with pre-V-A-ECMO arterial lactate level ≥6.8 mmol/L.

CONCLUSIONS: Among patients requiring postcardiotomy V-A-ECMO, hyperlactatemia was associated with a marked increase of in-hospital mortality. Arterial lactate may be useful in guiding the decision-making process and the timing of initiation of postcardiotomy V-A-ECMO.

Mario, E., D. Hamza, and K. Abdel-Moein, "Hypervirulent Klebsiella pneumoniae among diarrheic farm animals: A serious public health concern", Comparative Immunology, Microbiology and Infectious Diseases, vol. 102, pp. 102077, 2023.
Saber, F. R., S. H. Aly, M. A. Khallaf, H. A. S. El-Nashar, N. M. Fahmy, and S. P. Mohamed El-Shazly, Radha Radha, Hyphaene thebaica (Areceaeae) as a Promising Functional Food: Extraction, Analytical Techniques, Bioactivity, Food, and Industrial Applications, , 2023.
Abdel-Sattar, O. E., R. M. Allam, A. M. Al-Abd, A. M. El-Halawany, and A. E. L. - D. M. S. H. S. M. K. E. A. - S. * M. M. O. R. hanaz Meselhy, "Hypophyllanthin and Phyllanthin from Phyllanthus niruri Synergize Doxorubicin Anticancer Properties against Resistant Breast Cancer Cells", ACS Omega, vol. 8, issue 31, pp. 28563–28576, 2023. hypophyllanthin_and_phyllanthin_from_phyllanthus_niruri_synergize.pdf
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