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Zaghloul, M. S., E. Eldebawy, S. Ahmed, A. G. Mousa, A. Amin, A. Refaat, I. Zaky, N. El Khateeb, and M. Sabry, "Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 111, issue 1, pp. 35-40, 2014 Apr. Abstract

BACKGROUND: The pediatric diffuse intrinsic pontine glioma (DIPG) outcome remains dismal despite multiple therapeutic attempts.

PURPOSE: To compare the results of treatment of pediatric diffuse intrinsic pontine glioma (DIPG) using hypofractionated versus conventional radiotherapy.

PATIENTS AND METHODS: Seventy-one newly diagnosed DIPG children were randomized into hypofractionated (HF) (39Gy/13 fractions in 2.6weeks) and conventional (CF) arm (54Gy/30 fractions in 6weeks).

RESULTS: The median and one-year overall survival (OS) was 7.8months and 36.4±8.2% for the hypofractionated arm, and 9.5 and 26.2±7.4% for the conventional arm respectively. The 18-month OS difference was 2.2%. The OS hazard ratio (HR) was 1.14 (95% CI: 0.70-1.89) (p=0.59). The hypofractionated arm had a median and one-year progression-free survival (PFS) of 6.6months and 22.5±7.1%, compared to 7.3 and 17.9±7.1% for the conventional arm. The PFS HR was 1.10 (95% CI: 0.67-1.90) (p=0.71). The 18-month PFS difference was 1.1%. These differences exceed the non-inferiority margin. The immediate and delayed side effects were not different in the 2 arms.

CONCLUSIONS: Hypofractionated radiotherapy offers lesser burden on the patients, their families and the treating departments, with nearly comparable results to conventional fractionation, though not fulfilling the non-inferiority assumption.

Zaghloul, M. S., E. Eldebawy, S. Ahmed, A. G. Mousa, A. Amin, A. Refaat, I. Zaky, N. El Khateeb, and M. Sabry, "Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 111, issue 1, pp. 35-40, 2014 Apr. Abstract

BACKGROUND: The pediatric diffuse intrinsic pontine glioma (DIPG) outcome remains dismal despite multiple therapeutic attempts.

PURPOSE: To compare the results of treatment of pediatric diffuse intrinsic pontine glioma (DIPG) using hypofractionated versus conventional radiotherapy.

PATIENTS AND METHODS: Seventy-one newly diagnosed DIPG children were randomized into hypofractionated (HF) (39Gy/13 fractions in 2.6weeks) and conventional (CF) arm (54Gy/30 fractions in 6weeks).

RESULTS: The median and one-year overall survival (OS) was 7.8months and 36.4±8.2% for the hypofractionated arm, and 9.5 and 26.2±7.4% for the conventional arm respectively. The 18-month OS difference was 2.2%. The OS hazard ratio (HR) was 1.14 (95% CI: 0.70-1.89) (p=0.59). The hypofractionated arm had a median and one-year progression-free survival (PFS) of 6.6months and 22.5±7.1%, compared to 7.3 and 17.9±7.1% for the conventional arm. The PFS HR was 1.10 (95% CI: 0.67-1.90) (p=0.71). The 18-month PFS difference was 1.1%. These differences exceed the non-inferiority margin. The immediate and delayed side effects were not different in the 2 arms.

CONCLUSIONS: Hypofractionated radiotherapy offers lesser burden on the patients, their families and the treating departments, with nearly comparable results to conventional fractionation, though not fulfilling the non-inferiority assumption.

Zaghloul, M. S., E. Eldebawy, S. Ahmed, A. G. Mousa, A. Amin, A. Refaat, I. Zaky, N. El Khateeb, and M. Sabry, "Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 111, issue 1, pp. 35-40, 2014 Apr. Abstract

BACKGROUND: The pediatric diffuse intrinsic pontine glioma (DIPG) outcome remains dismal despite multiple therapeutic attempts.

PURPOSE: To compare the results of treatment of pediatric diffuse intrinsic pontine glioma (DIPG) using hypofractionated versus conventional radiotherapy.

PATIENTS AND METHODS: Seventy-one newly diagnosed DIPG children were randomized into hypofractionated (HF) (39Gy/13 fractions in 2.6weeks) and conventional (CF) arm (54Gy/30 fractions in 6weeks).

RESULTS: The median and one-year overall survival (OS) was 7.8months and 36.4±8.2% for the hypofractionated arm, and 9.5 and 26.2±7.4% for the conventional arm respectively. The 18-month OS difference was 2.2%. The OS hazard ratio (HR) was 1.14 (95% CI: 0.70-1.89) (p=0.59). The hypofractionated arm had a median and one-year progression-free survival (PFS) of 6.6months and 22.5±7.1%, compared to 7.3 and 17.9±7.1% for the conventional arm. The PFS HR was 1.10 (95% CI: 0.67-1.90) (p=0.71). The 18-month PFS difference was 1.1%. These differences exceed the non-inferiority margin. The immediate and delayed side effects were not different in the 2 arms.

CONCLUSIONS: Hypofractionated radiotherapy offers lesser burden on the patients, their families and the treating departments, with nearly comparable results to conventional fractionation, though not fulfilling the non-inferiority assumption.

Sakr, S. S., and S. A. A. Dawood, "Hypocholestrolemic effect of pomegranate yoghurt", Indian Journal of Dairy Science, vol. 68, issue 1, 2015. Abstract

Uses of agricultural wastes such as juice-making wastes as alternative low-cost sources of phenolic compounds are in increase. In this case, Pomegranate is a good example. About 50% of its weight is peel, which is usually discarded as waste. However, it has a significant portion of polyphenols. For these reasons we used experimental animals to study the effect of pomegranate juice or pomegranate’s peel extract incorporated in yogurt manufacture as a heart healthy dairy product. Our results indicated that yogurt with either pomegranate's juice or peel's water extract has good effect on lowering Total lipid, Total tri glycerides and Total cholesterol. In contrast the lipid peroxidation determined by Malondialdehyde was decreased. In the same trend, the histopathological changes in liver and heart of rat groups fed orally with Pomegranate's juice yogurt (JG) and Peel's extract yogurt (EG) showed marked improvement and no histopathological changes to be nearest to negative control group (NC). It could be concluded that JG and EG treatments under our study are useful for the treatment of hypercholesterolemia.

Sakr, S. S., and S. A. A. Dawood, "Hypocholesterolemic effect of pomegranate's peel (water extract) supplemented yoghurt in hypercholesterolemic rats", Indian J. Dairy Sci, vol. 68, pp. 1, 2015. Abstract
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M. M., M., A. E. G. I. A., M. A. M., and E. D. S. M., "The hypocholesterolaemic effect of yoghurt and acidophilus buttermilk", Egypt. J. Appl. Sci., vol. 5, no. 7, pp. 76–84, 1990. Abstract
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Abd El-Gawad, I. A., E. M. El-Sayed, S. A. Hafez, H. M. El-Zeini, and F. A. Saleh, "The hypocholesterolaemic effect of milk yoghurt and soy-yoghurt containing bifidobacteria in rats fed on a cholesterol-enriched diet", International Dairy Journal, vol. 15, issue 1: Elsevier, pp. 37-44, 2005. Abstract
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Abd El-Gawad, I. A., E. M. El-Sayed, S. A. Hafez, H. M. El-Zeini, and F. A. Saleh, "The hypocholesterolaemic effect of milk yoghurt and soy-yoghurt containing bifidobacteria in rats fed on a cholesterol-enriched diet", International Dairy Journal, vol. 15, issue 1: Elsevier, pp. 37-44, 2005. Abstract
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El-Gawad, I. A. A., E. M. El-Sayed, S. A. Hafez, H. M. El-Zeini, and F. A. Saleh, "The hypocholesterolaemic effect of milk yoghurt and soy-yoghurt containing bifidobacteria in rats fed on a cholesterol-enriched diet", International Dairy Journal, vol. 15, issue 1: Elsevier, pp. 37-44, 2005. Abstract
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El-Gawad, I. A. A., E. M. El-Sayed, S. A. Hafez, H. M. El-Zeini, and F. A. Saleh, "The hypocholesterolaemic effect of milk yoghurt and soy-yoghurt containing bifidobacteria in rats fed on a cholesterol- enriched diet.", International Dairy Journal, vol. 15, pp. 37-44, 2004. Abstract
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M M Metwally, I A Abd El Gawad, M. E. A. M. S. M., "The hypocholesterolaemic effect of butter milk. IV. The hypocholesterolaemic effect of yoghurt and acidophilus butter milk.", Egyptian J. Appl. Sci.,., vol. 5, issue 6, pp. 67, 1990. Abstract
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I A Abd El Gawad, M M Metwally, M. E. A. M. S. M., "The hypocholesterolaemic effect of butter milk. II. The effect of butter milk and cholesterol in the diet milk on rats serum and hepatic lipids.", Egyptian J. Dairy Sci.,, vol. 16, pp. 185, 1988. Abstract
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M M Metwally, I A Abd El Gawad, M. E. A. M. S. M., "The hypocholesterolaemic effect of butter milk. I. The effect of butter oil, butter milk, casein and cream on rats serum and hepatic lipids.", Egyptian J. Dairy Sci.,, vol. 16, pp. 175, 1988. Abstract
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M M Metwally, IA Abd El Gawad, H. E. M. M. S. M., "The hypocholesterolaemic effect of butter milk .” III- The effect of orotic acid, buffaloes and cows butter milk on rats serum cholesterol and lipids.", Fayoum Journal of Agricultural Research and Development (EGYPT), vol. 5, issue 1, 1991. Abstract
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Badee, A. Z. M.;, S. A. Helmy, A. A. Atia, and A. E. A. S. Azim, "Hypocholesterlimic activity of coriander and cumin fruits or their essential oils with or without turmeric powder. ", J. Agric. Sci. Mansoura Univ.,, vol. 30, issue 10, pp. 6335 - 6355., 2005.
Salem, M. A., and N. G. Gomaa, "Hypoallergic Tape: A Tool for Prevention of Peri-Incision Skin Injury after Hip Surgery", World Journal of Medical Sciences, vol. 5, issue 3, pp. 74-80, 2010. Abstract
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Assem, M., M. Amin, O. khalaf ALLAH, A. Hussien, A. Saif, and S. Mousa, "Hypoadiponectinemia as a marker of increased cardiovascular risk in patients with non-alcoholic fatty liver disease: correlation with albumin/creatinine ratio.", Archives of endocrinology and metabolism, 2020. Abstract

Objective: We assessed plasma adiponectin and its correlation with carotid intima-media-thickness (CIMT), as a marker of atherosclerosis, and urine albumin/creatinine ratio (ACR) in patients with non-alcoholic fatty liver disease (NAFLD).

Methods: The study included 100 Egyptian subjects (50 patients with NAFLD with no history of diabetes or hypertension and 50 age and sex-matched normal healthy control subjects). Urine albumin/creatinine ratio (ACR) was assessed in all participants and fasting plasma adiponectin was measured using ELISA technique. Ultrasonography was used to diagnose NAFLD. CIMT was assessed using high-resolution Doppler ultrasonography.

Results: Mild albuminuria was detected in patients with NAFLD (mean urine ACR = 42 ± 30 mg/g). Plasma adiponectin was significantly lower and urine ACR and CIMT significantly higher in patients with NAFLD as compared with the control group (P < 0.001 for all). A significant negative correlation was found between plasma adiponectin and both urine ACR and CIMT in patients with NAFLD (P < 0.001 and < 0.05 respectively). A significant positive correlation was also found between CIMT and urine ACR in those patients (P < 0.05). Plasma adiponectin and urine ACR were independent determinants of CIMT in patients with NAFLD (P < 0.01 and < 0.05 respectively).

Conclusion: Patients with NAFLD, without diabetes, have an increased risk of atherosclerosis and cardiovascular disease. Hypoadiponectinemia and low-grade albuminuria are important markers of that risk.

Assem, M., M. Amin, O. khalaf ALLAH, A. Hussien, A. Saif, and S. Mousa, "Hypoadiponectinemia as a marker of increased cardiovascular risk in patients with non-alcoholic fatty liver disease: correlation with albumin/creatinine ratio.", Archives of endocrinology and metabolism, 2020. Abstract

Objective: We assessed plasma adiponectin and its correlation with carotid intima-media-thickness (CIMT), as a marker of atherosclerosis, and urine albumin/creatinine ratio (ACR) in patients with non-alcoholic fatty liver disease (NAFLD).

Methods: The study included 100 Egyptian subjects (50 patients with NAFLD with no history of diabetes or hypertension and 50 age and sex-matched normal healthy control subjects). Urine albumin/creatinine ratio (ACR) was assessed in all participants and fasting plasma adiponectin was measured using ELISA technique. Ultrasonography was used to diagnose NAFLD. CIMT was assessed using high-resolution Doppler ultrasonography.

Results: Mild albuminuria was detected in patients with NAFLD (mean urine ACR = 42 ± 30 mg/g). Plasma adiponectin was significantly lower and urine ACR and CIMT significantly higher in patients with NAFLD as compared with the control group (P < 0.001 for all). A significant negative correlation was found between plasma adiponectin and both urine ACR and CIMT in patients with NAFLD (P < 0.001 and < 0.05 respectively). A significant positive correlation was also found between CIMT and urine ACR in those patients (P < 0.05). Plasma adiponectin and urine ACR were independent determinants of CIMT in patients with NAFLD (P < 0.01 and < 0.05 respectively).

Conclusion: Patients with NAFLD, without diabetes, have an increased risk of atherosclerosis and cardiovascular disease. Hypoadiponectinemia and low-grade albuminuria are important markers of that risk.

Shafik A, Shafik AA, S. E. - S. I. O., "The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome", BMC Urology , 2006.
Khaled, A. - E. L. - S., "Hypnotic and general anaesthetic effects of Citrus aurantium L. oil on rats", 3rd Global Summit on Herbals & Traditional Medicine, Osaka, Japan, 18-20 October, pp. 8, 2017.
Fahim, E. - S., "Hypervitaminosis and monoamines in different CNS areas of albino rat. II- Effect of thiamine", J. Egypt. Ger. Soc. Zool., vol. 24 (A), pp. 49-68, 1997.
Fahim, E. - S., "Hypervitaminosis and monoamines in different CNS areas of albino rat I- Effect of pyridoxine", J. Egypt. Ger. Soc. Zool., vol. 24 (A): , pp. 17-34, 1997.
Abdel-Aziz, M., "Hypertrophied tonsils impair velopharyngeal function after palatoplasty", Laryngoscope . , vol. 122, issue 3, pp. 528-532, 2012. laryngoscope_1.pdf
SA, E. - S., S. ZS, and E. RI, "Hypertrophic cardiomyopathy: prognostic factors and survival analysis in 128 Egyptian patients", Cardiol Young, vol. 29, pp. 1-7, 2013.