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Zaghloul AM, A. B. Frederic, S. S. Mona, and R. S. Randa, "Health hazards among workers in flour milling industry", Egyptian J of Occupational Medicine, vol. 16, issue 2, pp. 217-226, 1991.
Zaghloul, M. S., "Has hypofractionated radiotherapy become the standard of care in pediatric DIPG?", Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, vol. 31, issue 8, pp. 1221-2, 2015 Aug. Abstract
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Zaghloul, M. A. S., M. Celli, N. M. Salem, S. M. Elsheikh, and L. Ulivi, "High pressure synthesis and in situ Raman spectroscopy of H2 and HD clathrate hydrates", J. Chem. Phys., vol. 137, issue 16, pp. 164320-1-8, 2012.
Zaghloul, M. S., E. Eldebawy, S. Ahmed, A. G. Mousa, A. Amin, A. Refaat, I. Zaky, N. El Khateeb, and M. Sabry, "Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 111, issue 1, pp. 35-40, 2014 Apr. Abstract

BACKGROUND: The pediatric diffuse intrinsic pontine glioma (DIPG) outcome remains dismal despite multiple therapeutic attempts.

PURPOSE: To compare the results of treatment of pediatric diffuse intrinsic pontine glioma (DIPG) using hypofractionated versus conventional radiotherapy.

PATIENTS AND METHODS: Seventy-one newly diagnosed DIPG children were randomized into hypofractionated (HF) (39Gy/13 fractions in 2.6weeks) and conventional (CF) arm (54Gy/30 fractions in 6weeks).

RESULTS: The median and one-year overall survival (OS) was 7.8months and 36.4±8.2% for the hypofractionated arm, and 9.5 and 26.2±7.4% for the conventional arm respectively. The 18-month OS difference was 2.2%. The OS hazard ratio (HR) was 1.14 (95% CI: 0.70-1.89) (p=0.59). The hypofractionated arm had a median and one-year progression-free survival (PFS) of 6.6months and 22.5±7.1%, compared to 7.3 and 17.9±7.1% for the conventional arm. The PFS HR was 1.10 (95% CI: 0.67-1.90) (p=0.71). The 18-month PFS difference was 1.1%. These differences exceed the non-inferiority margin. The immediate and delayed side effects were not different in the 2 arms.

CONCLUSIONS: Hypofractionated radiotherapy offers lesser burden on the patients, their families and the treating departments, with nearly comparable results to conventional fractionation, though not fulfilling the non-inferiority assumption.

Zaghloul, M. S., E. Eldebawy, S. Ahmed, A. G. Mousa, A. Amin, A. Refaat, I. Zaky, N. El Khateeb, and M. Sabry, "Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 111, issue 1, pp. 35-40, 2014 Apr. Abstract

BACKGROUND: The pediatric diffuse intrinsic pontine glioma (DIPG) outcome remains dismal despite multiple therapeutic attempts.

PURPOSE: To compare the results of treatment of pediatric diffuse intrinsic pontine glioma (DIPG) using hypofractionated versus conventional radiotherapy.

PATIENTS AND METHODS: Seventy-one newly diagnosed DIPG children were randomized into hypofractionated (HF) (39Gy/13 fractions in 2.6weeks) and conventional (CF) arm (54Gy/30 fractions in 6weeks).

RESULTS: The median and one-year overall survival (OS) was 7.8months and 36.4±8.2% for the hypofractionated arm, and 9.5 and 26.2±7.4% for the conventional arm respectively. The 18-month OS difference was 2.2%. The OS hazard ratio (HR) was 1.14 (95% CI: 0.70-1.89) (p=0.59). The hypofractionated arm had a median and one-year progression-free survival (PFS) of 6.6months and 22.5±7.1%, compared to 7.3 and 17.9±7.1% for the conventional arm. The PFS HR was 1.10 (95% CI: 0.67-1.90) (p=0.71). The 18-month PFS difference was 1.1%. These differences exceed the non-inferiority margin. The immediate and delayed side effects were not different in the 2 arms.

CONCLUSIONS: Hypofractionated radiotherapy offers lesser burden on the patients, their families and the treating departments, with nearly comparable results to conventional fractionation, though not fulfilling the non-inferiority assumption.

Zaghloul, M. A. S., J. H. Mason, M. Wang, M. Buric, Z. Peng, S. Lee, P. Ohodnicki, H. Abernathy, and K. P. Chen, "High spatial resolution temperature profile measurements of solid-oxide fuel cells", Applied Energy, vol. 288: Elsevier, pp. 116633, 2021. Abstract
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Zaghloul, M. S., E. Eldebawy, S. Ahmed, A. G. Mousa, A. Amin, A. Refaat, I. Zaky, N. El Khateeb, and M. Sabry, "Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 111, issue 1, pp. 35-40, 2014 Apr. Abstract

BACKGROUND: The pediatric diffuse intrinsic pontine glioma (DIPG) outcome remains dismal despite multiple therapeutic attempts.

PURPOSE: To compare the results of treatment of pediatric diffuse intrinsic pontine glioma (DIPG) using hypofractionated versus conventional radiotherapy.

PATIENTS AND METHODS: Seventy-one newly diagnosed DIPG children were randomized into hypofractionated (HF) (39Gy/13 fractions in 2.6weeks) and conventional (CF) arm (54Gy/30 fractions in 6weeks).

RESULTS: The median and one-year overall survival (OS) was 7.8months and 36.4±8.2% for the hypofractionated arm, and 9.5 and 26.2±7.4% for the conventional arm respectively. The 18-month OS difference was 2.2%. The OS hazard ratio (HR) was 1.14 (95% CI: 0.70-1.89) (p=0.59). The hypofractionated arm had a median and one-year progression-free survival (PFS) of 6.6months and 22.5±7.1%, compared to 7.3 and 17.9±7.1% for the conventional arm. The PFS HR was 1.10 (95% CI: 0.67-1.90) (p=0.71). The 18-month PFS difference was 1.1%. These differences exceed the non-inferiority margin. The immediate and delayed side effects were not different in the 2 arms.

CONCLUSIONS: Hypofractionated radiotherapy offers lesser burden on the patients, their families and the treating departments, with nearly comparable results to conventional fractionation, though not fulfilling the non-inferiority assumption.

Zaghloul, M. A. S., A. Yan, R. Chen, M. - J. Li, R. Flammang, M. Heibel, and K. P. Chen, "High spatial resolution radiation detection using distributed fiber sensing technique", IEEE Transactions on Nuclear Science, vol. 64, issue 9: IEEE, pp. 2569-2577, 2017. Abstract
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Zaafar, D., H. M. A. Khalil, R. A. Rasheed, R. F. A. Eltelbany, and S. A. Zaitone, "Hesperetin mitigates sorafenib-induced cardiotoxicity in mice through inhibition of the TLR4/NLRP3 signaling pathway.", PloS one, vol. 17, issue 8, pp. e0271631, 2022. Abstract

Sorafenib is an oral multi-kinase receptor inhibitor that targets various signaling pathways. It is used as the first line of treatment in advanced hepatocellular and renal cell carcinomas. Sorafenib was reported to induce cardiotoxicity due to myocyte necrosis. Hesperetin is a naturally occurring flavonoid with antioxidant and anti-inflammatory capabilities. This study investigated the putative protective effect of hesperetin against sorafenib-induced cardiotoxicity in mice through downregulation of NLRP3/TLR4 signaling and inhibition of apoptosis. Twenty-four male Swiss mice were distributed into four groups: untreated control, hesperetin (50 mg/kg/day, orally), sorafenib (100 mg/kg/day, orally), and combination (Hesperetin+Sorafenib). After a three-week treatment period, various biochemical parameters in cardiac tissues were assessed. TNF-α, IL-1β, and IL-6 levels were measured. Moreover, TLR4 and NLRP3 expressions were evaluated using Western blot analysis. Histopathological examination and immunohistochemical assessment of apoptotic activity were done. Compared with the sorafenib group, the combination group exhibited reduced TNF-α, IL-1β, IL-6 levels and lower NLRP3/TLR4 expressions. Histologically, the combination group showed improved myocardial histology and a marked decrease in collagen deposition. Immunohistochemical examination showed decreased caspase-3 and increased Bcl-2 expression. Before recommending hesperetin as an adjuvant, clinical studies are warranted for mitigating sorafenib cardiotoxicity.

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Yusufoglu, H., G. A. Soliman, R. F. Abdel-Rahman, and Ö. Alankus-Caliskan, "Hepatoprotective Potential of Astragalus kurdicus and Astragalus cinereus Extracts against Paracetamol Induced Liver Damage in Rats", Pakistan Journal of Biological Sciences, vol. 18, no. 6: Asian Network for Scientific Information (ANSINET), pp. 252, 2015. Abstract

The objective of this study was to investigate the potential hepatoprotective effect of the ethanol extracts of Astragalus kurdicus Boiss. var. kurdicus (A. kurdicus) and Astragalus cinereus Willd. (A. cinereus) in a rat model of paracetamol (PCM) induced liver damage. Paracetamol administration caused severe hepatic damage in rats as evidenced by elevated serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase (γ-GT) and serum level of total bilirubin (BRN) while decreased serum levels of total protein (TP) and albumin (ALB). In liver homogenates, PCM elevated malondialdehyde (MDA) but decreased glutathione (GSH) levels as well as glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities. Administration of A. kurdicus and A. cinereus extracts (200 and 400 mg kgG1) for 7 days before PCM inhibited the elevation of the serum activities of ALT, AST, ALP and γ-GT enzymes and serum level of BRN. Moreover, they elevated the serum level of TP. Paracetamol-induced lipid peroxidation was also reduced by both extracts. Likewise, both extracts increased the activities of the antioxidant enzymes (GPx, SOD, CAT) in the liver homogenates and reduced GSH concentration. The results of the in vitro antioxidant effect revealed marked antioxidant activity for both extracts. The histopathological analysis suggested that both extracts obviously alleviated the degree of liver damage due to PCM administration. The present study suggests that A. kurdicus and A. cinereus possess hepatoprotective activities that could be partly attributed to their antioxidant effects.

Youssef, N. F., G. B. Hanna, and M. F. Abadir, "Humidity properties of rigid foam materials used in building ", ISES ,Solar World Congress , Denver, Colorado, US, August, 1991.
Youssef, R., O. ABU-ZEID, K. SAYED, S. OSMAN, D. Omran, A. EL SHAFEI, and doaa ghaith, "Hepatitis C Infection in Egyptian Psoriatic Patients: Prevalence and Correlation with Severity of Disease", Iran J Public Health, vol. 44, issue 9, pp. 1294-1295, 2015.
Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study.", The American Journal of dermatopathology, vol. 40, issue 10, pp. 727-735, 2018 Oct. Abstract

Hypopigmented interface T-cell dyscrasia (HITCD) is a distinct form of lymphoid dyscrasia that may progress to hypopigmented mycosis fungoides (HMF). We compared both diseases as regards their CD4/CD8 phenotype and expression of granzyme B and tumor necrosis factor-alpha (TNF-α) and how these are affected by narrow-band UVB (nb-UVB). The study included 11 patients with HITCD and 9 patients with HMF. They received nb-UVB thrice weekly until complete repigmentation or a maximum of 48 sessions. Pretreatment and posttreatment biopsies were stained using anti CD4, CD8, TNF-α, and granzyme B monoclonal antibodies. Epidermal lymphocytes were CD8 predominant in 54.5% and 66.7% of HITCD and HMF cases, respectively, whereas dermal lymphocytes were CD4 predominant in 63.6% and 66.7%, respectively. Significantly, more dermal infiltrate was encountered in HMF (P = 0.041). In both diseases, granzyme B was only expressed in the dermis, whereas TNF-α was expressed both in the epidermis and dermis. No difference existed as regards the number of sessions needed to achieve repigmentation or cumulative nb-UVB dose reached at end of study. (P > 0.05). Narrow-band UVB significantly reduced only the epidermal lymphocytes in both diseases (P ≤ 0.05) with their complete disappearance in 8 (72.7%) HITCD and 6 (66.7%) HMF cases. In both diseases, nb-UVB did not affect granzyme B or TNF-α expression (P > 0.05). In conclusion, both diseases share the same phenotype, with HITCD being a milder form of T-cell dysfunction. In both diseases, epidermal lymphocytes are mainly CD8-exhausted cells lacking cytotoxicity, whereas dermal cells are mostly reactive cells exerting antitumor cytotoxicity. Tumor necrosis factor-alpha mediates hypopigmentation in both diseases and prevents disease progression. Repigmentation after nb-UVB in both diseases occurs before and independently from disappearance of the dermal infiltrate.

Youssef, G., "Hypertension in pregnancy", E-Journal of Cardiology Practice, vol. 17, issue N° 22, 2019. escardio.org-hypertension_in_pregnancy.pdf
Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study", The American Journal of Dermatopathology, vol. 40, issue 10, pp. 727-735, 2018.
Youssef, S. A., A. Ramadan, N. A. Afifi, and M. D. Aziz, "Haemodynamic alterations induced by toxic level of sodium taurocholate.", DTW. Deutsche tierarztliche Wochenschrift, vol. 98, issue 2, pp. 56-60, 1991 Feb. Abstract

Haemodynamic effects of sodium taurocholate (S.T.) were studied on isolated guinea pig's auricles, rabbit's heart, rabbit's aortic strip, guinea pig's tracheal chain as well as the blood pressure and ECG pattern changes in pentobarbital anaesthetized dogs. S.T. induced significant negative inotropic and chronotropic effects on the isolated auricles of guinea pig's especially in higher concentrations. Using isolated rabbit's heart, the negative inotropic and chronotropic effects induced by S.T. were found to be depending on the concentration. Cardio-inhibitory actions of the salt are not due to either cholinergic beta 1-adrenergic blocking effect or nicotine like activity. S.T. in all tested concentrations had no effect on the contractile response of isolated rabbit's aortic strip or guinea pig's tracheal chain and did not prevent the contractile response induced by noradrenaline and histamine. In anaesthetized dogs, i.v. injections of the salt in a dose of 30 mg/kg b. wt. produced a significant decrease in systolic and diastolic pressure, but lower doses induced no significant changes. A dose of 30 mg/kg b. wt. of the salt potentiates the decrease in systolic and diastolic pressure when coadministered with the neuromuscular blocking agent, atracurium besylate. Atropine, propranolol and phentolamine did not alter the hypotensive effect of S.T. (neither cholinergic nor beta 1-adrenergic blocking effect). The electrocardiographic pattern induced by S.T. (20-30 mg/kg b. wt.) in dogs were mainly characterized by decrease in heart rate and prolongation of P-T interval.

Youssef, R., A. B. U. - Z. E. I. D. Ola, K. SAYED, S. OSMAN, D. Omran, A. EL SHAFEI, and doaa ghaith, "Hepatitis C Infection in Egyptian Psoriatic Patients: Prevalence and Correlation with Severity of Disease", Iranian journal of public health, vol. 44, no. 9: Tehran University of Medical Sciences, pp. 1294, 2015. Abstract
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Youssef, N. F., G. B. Hanna, and M. F. Abadir, "Humidity Properties of Vermiculite-Cement Mixtures Used as Thermal Insulations in Buildings ", CIB 1992 , World Building Congress , Ontario, Canada, May, 1992.
Youssef, N. F. A., M. El Kassas, A. Farag, and Ashley Shepherd, "Health-related quality of Life in patients with chronic hepatitis C receiving Sofosbuvir-based treatment, with and without Interferon: a prospective observational study in Egypt.", BMC gastroenterology, vol. 17, issue 1, pp. 18, 2017. Abstract

BACKGROUND: The Egyptian government introduced the first directly acting antivirals (DAAs) into Egypt through the government funded National Treatment Program. As yet, there has been no investigation into the effects of these new DAAs therapies on patient reported outcomes (PROs). This study aimed to (1) assess the PROs (health-related quality of life (HRQoL), mental health and perceived social support) of HCV patients receiving DAAs therapy prior, during and at the end of therapy; (2) evaluate PROs of Interferon-free (dual) users versus Interferon-containing (triple) users cross the three different time periods; and (3) identify the predictors of HRQoL of DAAs therapy users cross the three different time periods.

METHODS: A prospective observational design was used. Patients with chronic HCV undergoing treatment following the Egyptian National Guidelines at one of the national treatment centers were approached. Data collection occurred in the period from February to October 2015. Data was collected at three time points: (1) baseline (time 0: T0), before initiating therapy); (2) 5/6 weeks after initiation of therapy (time 1 of therapy: T1) and at the end of the therapy (Time 2: T2). Four PROs questionnaires were utilized for data collection: (1) Multidimensional Scale of Perceived Social Support (MSPSS), (2) The Depression Anxiety Stress Scales (DASS-21), (3) the Liver Disease Symptom Index-2.0 (LDSI-2.0) for testing disease specific HRQoL and (4) the Center for Adherence Support Evaluation (CASE) Index, alongside the background data sheet.

RESULTS: Sixty-two patients participated. There was a change in HRQoL, symptom experience and mental health across the three different time periods. HRQoL was impaired more after starting the course of therapy (T1) than at baseline (T0) and end of therapy (T2), z ≥ -2.04, p ≤ .04. Also, symptom experience deteriorated more during the treatment period than at the baseline, Z ≥ -1.97, p ≤ .04. Anxiety and stress were significantly higher during the treatment period than at the end of treatment. Perceived social support was significantly higher during the treatment period than at baseline and end of therapy, Z ≥ -2.27, p ≤ .023. During the course of therapy, triple users were more likely to report poorer HRQoL and anxiety than dual users (p ≤ .04). By the end of therapy, the two arms of therapy had no significant differences in any of the PROs. At baseline, the predictor model significantly (p = .000) explained 37.5% of the variation in the HRQoL prior to therapy. Depression was the main variable that contributed to (41.3%) predicting change in HRQoL prior to therapy. During therapy, the model significantly (p = .000) explained 76% of the variation in the HRQoL-T1. Stress-T1, body mass index (BMI)-T1 and HRQoL-T0 significantly and respectively predicted 44.4, 46.5 and 31.1% of the variation in HRQoL-T1. At the end of therapy, the model significantly (p = .000) predicted 80.5% of the variation in the HRQoL-T2. HRQoL-T1 and anxiety-T2 significantly predicted 72.3 and 61.6% of the variation in HRQoL-T2.

CONCLUSIONS: Baseline HRQoL, depression and BMI should be systematically assessed before starting the antiviral therapy for early detection and the improvement of the impairment before the initiation of therapy. Anxiety should be frequently assessed and followed up through the course of antiviral therapy. The triple group required more nursing and practitioner attention due to increased anxiety levels and impaired HRQoL during the treatment therapy.

Youssef, N., M. A. Mohamed, M. A. Mohamed, S. M. Abd-ElKader, N. A. Abdullah, and E. A. Mohamed, "Health information need correlated with quality of life among cancer patients receiving chemotherapy: a cross-sectional study in Egypt", Quality of Life Research, vol. 28: SPRINGER VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, pp. S142–S142, 2019. Abstract
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