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Mohammed, H. S., "Hypothermia mitigates neurochemical alterations in rat's cerebral cortex during status epilepticus induced by pilocarpine.", General Physiology and Biophysics, vol. 34, no. 4, pp. 425–432, 2015. Abstract
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El-Darouti, M. A., M. M. Fawzy, R. A. HEGAZY, and R. M. Abdel Hay, "Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: a report of 34 patients and a 7-year experience.", Journal of the American Academy of Dermatology, vol. 67, issue 6, pp. 1182-8, 2012 Dec. Abstract

BACKGROUND: In the past 7 years we have extensively studied an uncommon hypopigmented disorder that, apart from hypopigmentation, showed many common features with parapsoriasis en plaque (PSEP), both clinically and histopathologically.

OBJECTIVE: We sought to verify whether this disorder should be considered a hypopigmented variant of PSEP and thus be referred to as hypopigmented PSEP.

METHODS: A total of 34 patients presenting with this peculiar hypopigmented disorder were included (2003-2010). Patients were subjected to a predesigned algorithm excluding all possible differential diagnoses of hypopigmented lesions.

RESULTS: Our findings indicated that this disorder can be diagnosed as hypopigmented PSEP. These findings included: (1) exclusion of all other disorders causing similar hypopigmented lesions; (2) shape and size of the lesions being very similar to those of classic small PSEP (small-plaque parapsoriasis [SPP]); (3) similar distribution of the lesions (trunk, proximal upper and lower limbs) to the classic PSEP; (4) digitiform extensions of most the lesions (70.5% of our patients) as in SPP; (5) absence of itching as in PSEP (SPP type); (6) good response to narrowband ultraviolet B in 76.4% of the patients (n = 26); and (7) during follow-up 5 patients (14.7%) converted into hypopigmentd mycosis fungoides.

LIMITATIONS: A limitation in our study is that we did not perform clonal T-cell receptor gene rearrangement because of limited resources.

CONCLUSION: Based on our findings we believe that this hypopigmented disorder is a well-defined new variant of the PSEP family that shows, apart from the hypopigmentation, all the features of PSEP, particularly the SPP variant, and accordingly could be referred to as hypopigmented PSEP.

El-Darouti, M. A., M. M. Fawzy, R. A. HEGAZY, and R. M. Abdel Hay, "Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: A report of 34 patients and a 7-year experience", Journal of the American Academy of Dermatology, vol. 67, no. 6: Elsevier, pp. 1182–1188, 2012. Abstract
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El-Darouti, M. A., M. M. Fawzy, R. A. HEGAZY, and R. A. M. Hay, "Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: a report of 34 patients and a 7-year experience", Journal of the American Academy of Dermatology, vol. 67, no. 6: Mosby, pp. 1182–1188, 2012. Abstract
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Elbendary, A., M. R. E. Abdel-Halim, R. Youssef, D. abd el halim, M. F. Elmasry, A. A. Gad, and D. A. El Sharkawy, "Hypopigmented lesions in pityriasis lichenoides chronica patients: Are they only post-inflammatory hypopigmentation?", The Australasian journal of dermatology, 2021. Abstract

BACKGROUND/OBJECTIVES: Pityriasis lichenoides chronica (PLC) lesions are reported to subside with post-inflammatory hypopigmentation (PIH); hence, the most widely perceived nature of hypopigmented macules in PLC is PIH. However, to the best of our knowledge, no studies describing histopathological findings in these lesions are reported in literature. The aim of this study is to evaluate the hypopigmented lesions encountered in PLC patients and to shed light on their histopathological features.

METHODS: A cross-sectional observational study included twenty-one patients with PLC recruited in a period of twelve months. Clinical characteristics of each patient were collected. A skin biopsy from hypopigmented lesions whenever present was taken and assessed with routine haematoxylin and eosin stain.

RESULTS: Seventeen patients (81%) were less than 13 years old. Most patients (85.7%) demonstrated diffuse distribution of lesions. Hypopigmented lesions were present on the face in 12 (57.14%) patients. Histopathologically, hypopigmented lesions showed features of post-inflammatory hypopigmentation in 19% of patients, residual PLC in 52.4% and active PLC 28.6% of patients.

CONCLUSION: Hypopigmented lesions in PLC were noted mainly in younger ages, histopathologically they may show features of active or residual disease, beyond post-inflammatory hypopigmentation. Consequently active treatment for patients presenting predominantly with hypopigmented lesions could be required to control the disease.

Elbendary, A., M. R. E. Abdel-Halim, R. Youssef, A. D. Halim, M. F. Elmasry, A. Gad, and E. D. A. Sharkawy, "Hypopigmented lesions in pityriasis lichenoides chronica patients: Are they only post-inflammatory hypopigmentation?", Australas J Dermatol, vol. 63, issue 1, pp. 68-73, 2022.
Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study.", The American Journal of dermatopathology, vol. 40, issue 10, pp. 727-735, 2018 Oct. Abstract

Hypopigmented interface T-cell dyscrasia (HITCD) is a distinct form of lymphoid dyscrasia that may progress to hypopigmented mycosis fungoides (HMF). We compared both diseases as regards their CD4/CD8 phenotype and expression of granzyme B and tumor necrosis factor-alpha (TNF-α) and how these are affected by narrow-band UVB (nb-UVB). The study included 11 patients with HITCD and 9 patients with HMF. They received nb-UVB thrice weekly until complete repigmentation or a maximum of 48 sessions. Pretreatment and posttreatment biopsies were stained using anti CD4, CD8, TNF-α, and granzyme B monoclonal antibodies. Epidermal lymphocytes were CD8 predominant in 54.5% and 66.7% of HITCD and HMF cases, respectively, whereas dermal lymphocytes were CD4 predominant in 63.6% and 66.7%, respectively. Significantly, more dermal infiltrate was encountered in HMF (P = 0.041). In both diseases, granzyme B was only expressed in the dermis, whereas TNF-α was expressed both in the epidermis and dermis. No difference existed as regards the number of sessions needed to achieve repigmentation or cumulative nb-UVB dose reached at end of study. (P > 0.05). Narrow-band UVB significantly reduced only the epidermal lymphocytes in both diseases (P ≤ 0.05) with their complete disappearance in 8 (72.7%) HITCD and 6 (66.7%) HMF cases. In both diseases, nb-UVB did not affect granzyme B or TNF-α expression (P > 0.05). In conclusion, both diseases share the same phenotype, with HITCD being a milder form of T-cell dysfunction. In both diseases, epidermal lymphocytes are mainly CD8-exhausted cells lacking cytotoxicity, whereas dermal cells are mostly reactive cells exerting antitumor cytotoxicity. Tumor necrosis factor-alpha mediates hypopigmentation in both diseases and prevents disease progression. Repigmentation after nb-UVB in both diseases occurs before and independently from disappearance of the dermal infiltrate.

Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study", The American Journal of Dermatopathology, vol. 40, issue 10, pp. 727-735, 2018.
Abdel-Sattar, O. E., R. M. Allam, A. M. Al-Abd, A. M. El-Halawany, and A. E. L. - D. M. S. H. S. M. K. E. A. - S. * M. M. O. R. hanaz Meselhy, "Hypophyllanthin and Phyllanthin from Phyllanthus niruri Synergize Doxorubicin Anticancer Properties against Resistant Breast Cancer Cells", ACS Omega, vol. 8, issue 31, pp. 28563–28576, 2023. hypophyllanthin_and_phyllanthin_from_phyllanthus_niruri_synergize.pdf
TAHA, O. M. A. R. A., A. L. A. A. BARAKAT, H. k.AbdelHakim, M. A. Shemis, and Z. A. I. N. A. B. ZAKARIA, "Hypolipidimic and anti-fatty liver effects exerted by standardized punica granatum L.peel extract in HEPG2 cell-line and high fat diet induced mice", International journal of pharmacy and pharmaceutical science , vol. 8, issue 6, pp. 156-161, 2016. 11226-42912-2-pb.pdf
Rashed, M. M., M. Shallan, D. A. Mohamed, K. Fouda, and L. M. Hanna, "Hypolipidemic effect of vegetable and cereal dietary mixtures from Egyptian sources", Grasas y Aceites, vol. 61, no. 3, pp. 261–270, 2010. Abstract
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Helmy, S. A., N. F. S. Morsy, S. M. Elaby, and M. A. A. Ghaly, "Hypolipidemic Effect of Moringa oleifera Lam Leaf Powder and its Extract in Diet-Induced Hypercholesterolemic Rats.", Journal of medicinal food, vol. 20, issue 8, pp. 755-762, 2017 Aug. Abstract

The leaves of Moringa oleifera Lam possess some potential medicinal value. The aim of this study was to evaluate the protective effect of M. oleifera leaf powder and its extract against hyperlipidemia in rats. Adult male albino rats were divided into six groups. The first group was fed on a basal diet that served as a negative control, whereas the others were fed on a high-fat diet (HFD) containing moringa leaf powder at 0.737% or 1.475% or administered daily with 200 or 400 mg dry moringa leaf extract/kg bw for 60 days. A positive control group was fed on the HFD. Serum indices related to lipid profile, oxidative status, and liver function were analyzed. Feeding rats on an HFD containing moringa leaf powder at 0.737% or an oral dose of its dry extract at 400 mg/kg bw alleviated the harmful elevation of cholesterol, triglycerides, low-density lipoprotein cholesterol, malondialdehyde, and the activities of alanine aminotransferase and aspartate aminotransferase in serum that were induced by the HFD. This is the first study demonstrating the hypocholesterolemic effect of M. oleifera leaf powder.

Helmy, S. A., N. F. S. Morsy, S. M. Elaby, and M. A. A. Ghaly, "Hypolipidemic Effect of Moringa oleifera Lam Leaf Powder and its Extract in Diet-Induced Hypercholesterolemic Rats", JOURNAL OF MEDICINAL FOOD, vol. 20, issue 8, pp. 755-762, 2017.
El-Garf, I. A., R. J. Grayer, G. C. Kite, and N. C. Veitch, "Hypolaetin 8- O- glucuronide and related flavonoids from Lavandula coronopifolia and L. pubescens", Biochemical Systematics and Ecology , vol. 27, pp. 843-846, 1999.
El-Zayat, E., and A. Rawi, S. and Gawish, "Hypogonadal dysfunction induced by aluminium intoxication in male rat and the protective role of antioxidants", J. Egy. Ger Soc. Zool, vol. 12, pp. 71-97, 1996. Abstract

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El-Zayat, E., S. Rawi, and A. Gawish, "Hypogonadal dysfunction induced by aluminium intoxication and the protective role of zinc and vitamin E supplementation in male albino rats", JOURNAL-EGYPTIAN GERMAN SOCIETY OF ZOOLOGY, vol. 54, issue A: EGYPTIAN GERMAN SOCIETY OF ZOOLOGY, pp. 1, 2007. Abstract
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Abdelrahman, N., R. El-Banna, M. M. Arafa, and M. M. Hady, "Hypoglycemic efficacy of Rosmarinus officinalis and/or Ocimum basilicum leaves powder as a promising clinico-nutritional management tool for diabetes mellitus in Rottweiler dogs", Veterinary World, vol. 13, issue January-2020, pp. 73-79, 2020. 11.pdf
Essawy, G. S., H. M. Sobbhy, and H. A. El-Banna, "The hypoglycemic effect of volatile oil of some Egyptian plants.", Vet. Med. J., (Giza), vol. 43, issue 2, pp. 167-172., 1995.
undefined, H. M. Salem, and M. S. Abdel-latif, "The hypoglycemic effect of B-Pyridoxyl Carbinol (Ronicol)", Annals. Agric. Sci. Moshtohor , vol. 20, pp. 93, 1983.
El-Beltagi, H. S., A. E. - M. M. R. Afify, S. A. Fayed, and A. E. El-Ansary, "Hypoglycemic and iron status ameliorative effects of Olea Europea cv.‘Picual’ leaves extract in streptozotocin induced diabetic rats", Fresenius Environmental Bulletin, vol. 26, issue 11, pp. 6898-6908, 2017. 73feb_17_01171_cr.pdf
A.A, S., S. H.A, Z. M, and E. S.H, "Hypoglycemic and Hypolipidemic actions of Vanadyl acetylacetonate and Nigella sativa in streptozotocin induced diabetic rats", Egyptian Journal of basic And Applied Physiology, vol. 15, issue No.1, pp. 23-45, 2015.
Salib A.A., S. H.A, Z. M, and E. S.H., "Hypoglycemic and Hypolipidemic actions of Vanadyl acetylacetonate and Nigella sativa in streptozotocin induced diabetic rats", Egyptian Journal of Basic and Applied Physiology, vol. 15, issue 1, pp. 23-45, 2015.