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Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study.", The American Journal of dermatopathology, vol. 40, issue 10, pp. 727-735, 2018 Oct. Abstract

Hypopigmented interface T-cell dyscrasia (HITCD) is a distinct form of lymphoid dyscrasia that may progress to hypopigmented mycosis fungoides (HMF). We compared both diseases as regards their CD4/CD8 phenotype and expression of granzyme B and tumor necrosis factor-alpha (TNF-α) and how these are affected by narrow-band UVB (nb-UVB). The study included 11 patients with HITCD and 9 patients with HMF. They received nb-UVB thrice weekly until complete repigmentation or a maximum of 48 sessions. Pretreatment and posttreatment biopsies were stained using anti CD4, CD8, TNF-α, and granzyme B monoclonal antibodies. Epidermal lymphocytes were CD8 predominant in 54.5% and 66.7% of HITCD and HMF cases, respectively, whereas dermal lymphocytes were CD4 predominant in 63.6% and 66.7%, respectively. Significantly, more dermal infiltrate was encountered in HMF (P = 0.041). In both diseases, granzyme B was only expressed in the dermis, whereas TNF-α was expressed both in the epidermis and dermis. No difference existed as regards the number of sessions needed to achieve repigmentation or cumulative nb-UVB dose reached at end of study. (P > 0.05). Narrow-band UVB significantly reduced only the epidermal lymphocytes in both diseases (P ≤ 0.05) with their complete disappearance in 8 (72.7%) HITCD and 6 (66.7%) HMF cases. In both diseases, nb-UVB did not affect granzyme B or TNF-α expression (P > 0.05). In conclusion, both diseases share the same phenotype, with HITCD being a milder form of T-cell dysfunction. In both diseases, epidermal lymphocytes are mainly CD8-exhausted cells lacking cytotoxicity, whereas dermal cells are mostly reactive cells exerting antitumor cytotoxicity. Tumor necrosis factor-alpha mediates hypopigmentation in both diseases and prevents disease progression. Repigmentation after nb-UVB in both diseases occurs before and independently from disappearance of the dermal infiltrate.

Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study", The American Journal of Dermatopathology, vol. 40, issue 10, pp. 727-735, 2018.
TAHA, O. M. A. R. A., A. L. A. A. BARAKAT, H. k.AbdelHakim, M. A. Shemis, and Z. A. I. N. A. B. ZAKARIA, "Hypolipidimic and anti-fatty liver effects exerted by standardized punica granatum L.peel extract in HEPG2 cell-line and high fat diet induced mice", International journal of pharmacy and pharmaceutical science , vol. 8, issue 6, pp. 156-161, 2016. 11226-42912-2-pb.pdf
Rashed, M. M., M. Shallan, D. A. Mohamed, K. Fouda, and L. M. Hanna, "Hypolipidemic effect of vegetable and cereal dietary mixtures from Egyptian sources", Grasas y Aceites, vol. 61, no. 3, pp. 261–270, 2010. Abstract
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Helmy, S. A., N. F. S. Morsy, S. M. Elaby, and M. A. A. Ghaly, "Hypolipidemic Effect of Moringa oleifera Lam Leaf Powder and its Extract in Diet-Induced Hypercholesterolemic Rats.", Journal of medicinal food, vol. 20, issue 8, pp. 755-762, 2017 Aug. Abstract

The leaves of Moringa oleifera Lam possess some potential medicinal value. The aim of this study was to evaluate the protective effect of M. oleifera leaf powder and its extract against hyperlipidemia in rats. Adult male albino rats were divided into six groups. The first group was fed on a basal diet that served as a negative control, whereas the others were fed on a high-fat diet (HFD) containing moringa leaf powder at 0.737% or 1.475% or administered daily with 200 or 400 mg dry moringa leaf extract/kg bw for 60 days. A positive control group was fed on the HFD. Serum indices related to lipid profile, oxidative status, and liver function were analyzed. Feeding rats on an HFD containing moringa leaf powder at 0.737% or an oral dose of its dry extract at 400 mg/kg bw alleviated the harmful elevation of cholesterol, triglycerides, low-density lipoprotein cholesterol, malondialdehyde, and the activities of alanine aminotransferase and aspartate aminotransferase in serum that were induced by the HFD. This is the first study demonstrating the hypocholesterolemic effect of M. oleifera leaf powder.

Helmy, S. A., N. F. S. Morsy, S. M. Elaby, and M. A. A. Ghaly, "Hypolipidemic Effect of Moringa oleifera Lam Leaf Powder and its Extract in Diet-Induced Hypercholesterolemic Rats", JOURNAL OF MEDICINAL FOOD, vol. 20, issue 8, pp. 755-762, 2017.
El-Garf, I. A., R. J. Grayer, G. C. Kite, and N. C. Veitch, "Hypolaetin 8- O- glucuronide and related flavonoids from Lavandula coronopifolia and L. pubescens", Biochemical Systematics and Ecology , vol. 27, pp. 843-846, 1999.
Abdelrahman, N., R. El-Banna, M. M. Arafa, and M. M. Hady, "Hypoglycemic efficacy of Rosmarinus officinalis and/or Ocimum basilicum leaves powder as a promising clinico-nutritional management tool for diabetes mellitus in Rottweiler dogs", Veterinary World, vol. 13, issue January-2020, pp. 73-79, 2020. 11.pdf
Essawy, G. S., H. M. Sobbhy, and H. A. El-Banna, "The hypoglycemic effect of volatile oil of some Egyptian plants.", Vet. Med. J., (Giza), vol. 43, issue 2, pp. 167-172., 1995.
undefined, H. M. Salem, and M. S. Abdel-latif, "The hypoglycemic effect of B-Pyridoxyl Carbinol (Ronicol)", Annals. Agric. Sci. Moshtohor , vol. 20, pp. 93, 1983.
El-Beltagi, H. S., A. E. - M. M. R. Afify, S. A. Fayed, and A. E. El-Ansary, "Hypoglycemic and iron status ameliorative effects of Olea Europea cv.‘Picual’ leaves extract in streptozotocin induced diabetic rats", Fresenius Environmental Bulletin, vol. 26, issue 11, pp. 6898-6908, 2017. 73feb_17_01171_cr.pdf
A.A, S., S. H.A, Z. M, and E. S.H, "Hypoglycemic and Hypolipidemic actions of Vanadyl acetylacetonate and Nigella sativa in streptozotocin induced diabetic rats", Egyptian Journal of basic And Applied Physiology, vol. 15, issue No.1, pp. 23-45, 2015.
Salib A.A., S. H.A, Z. M, and E. S.H., "Hypoglycemic and Hypolipidemic actions of Vanadyl acetylacetonate and Nigella sativa in streptozotocin induced diabetic rats", Egyptian Journal of Basic and Applied Physiology, vol. 15, issue 1, pp. 23-45, 2015.
M.M.Hady, and H. M. Elanzy, "Hypoglycemic and antioxidative impacts of Cardamom and Rosemary on Alloxan-induced diabetic rats.", International journal of Health and Medicine, vol. 1, issue 1, 2015.
Marzouk, M., A. M. Soliman, and T. Y. Omar, "Hypoglycemic and antioxidative effects of fenugreek and termis seeds powder in streptozotocin-diabetic rats", European Review for Medical and Pharmacological Sciences, vol. 17, pp. 559-565, 2013. 10.pdf
Abdel-Kawy, M. A., M. S. Abdel-Kader, A. J. Al-Rehaily, and K. H. El-Taher, "Hypoglycemic and antidiabetic activit of some Saudi plants", 9 th Iternational Pharmaceutical Sciences Conference, , King Saud University, April,2005.
Ali, H. F. M., "Hypoglycemic activity of methyl chavicol and cuminaldehyde as major components of basil and cumin essential oils.", First conference on the role of biochemistry in the environment.: Biochemistry Department Faculty of Agriculture, Cairo University, 2001. Abstract
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A.Afifi, N., E. H. S.M., F. M.M., and S. O.A., "Hypoglycemic activity of certain Egyptian plants containing mucilage and / or pectin.", Bull. Fac. Pharm. Cairo Univ.,, vol. 34(3), pp. 189- 202, 1996.
.Afifi, N. A., E. H. S.M, F. M.M., and S. O.A., "Hypoglycemic activity of certain Egyptian plants containing mucilage and / or pectin.", Bull. Fac. Pharm. Cairo Univ., , vol. 34(3):, pp. 189-202, 1996.
Cabrera, W., S. Genta, A. Said, A. Farag, K. Rashed, and S. Sánchez, "Hypoglycemic Activity of Ailanthus excelsa Leaves in Normal and Streptozotocin-induced Diabetic Rats", Phytotherapy Research, vol. 22, issue 3, pp. 303-307, 2008.