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Zaki, M. M., W. A. A. El-Ghany, M. M. Hady, and R. M. S. Korany, "Effect of Certain Phytobiotics on the Immune Response of Newcastle Disease Vaccinated Broiler Chickens", International Journal of Poultry Science, vol. 10, issue 3, pp. 134-140, 2016. asian_j_poult_sci_phytobiotic_immunity.pdf
ZAKI, S. H. E. R. I. F. M., and L. K. Effat, "Evaluation of the Physical Growth in Egyptian Children with Phenylketonuria Under Diet Therapy", The Medical Journal of Cairo University, vol. 81, no. 2, 2013. Abstract
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Zaki, S. M., "Evaluation of antioxidant and anti-lipid peroxidation potentials of Nigella sativa and onion extract on nicotine-induced lung damage.", Folia morphologica, vol. 78, issue 3, pp. 554-563, 2019. Abstract

BACKGROUND: The present work aimed to compare the protective effect of Nigella sativa (NS) and onion extract on the nicotine-induced lung damage in rats. The antioxidant and anti-lipid peroxidation potentials of both agents on nicotine-induced lung damage were studied.

MATERIALS AND METHODS: Thirty-six Sprague-Dawley albino rats, treated for 18 weeks, were divided into six groups: one negative control group, two positive control groups (oral onion and oral NS), nicotine-treated group, onion extract-treated group (concomitant nicotine and onion extract) and NS-treated group (concomitant nicotine and NS oil). The assessment of lung structure was based on haematoxylin and eosin and transmission electron microscopy. Lung malondialdehyde (MDA), superoxide dismutase activity (SOD), catalase (CAT), lung glutathione (GSH), and epithelial lining fluid GSH (ELF GSH) were used for assessment of the antioxidant and anti-lipid peroxidation potentials of NS and onion extract.

RESULTS: The lung of the nicotine-treated group exhibited emphysematous air spaces, collapsed corrugated alveoli with ruptured interalveolar septa in some specimen and thickened septa in the others, massive congestion, extravasation of red blood cells, inflammatory cellular infiltration and fluid exudate. Much improvement was observed in the onion-treated group despite the presence of residual pathological affection. The lung in the NS-treated group showed the nearly normal architecture with slight congestion. Administration of nicotine promoted lipid peroxidation (elevation of MDA) and decreased the level of the antioxidant markers (SOD, CAT, lung GSH and ELF GSH). With the use of onion extract and NS, the level of MDA decreased by 17.85% and 35.71% while the levels of SOD, CAT, GSH, and ELF GSH increased. The increase was more prominent in the NS-treated group. The levels in the NS-treated group reached nearly the level markers of the control group.

CONCLUSIONS: Nigella sativa and onion extract attenuate the pathological effect of nicotine in the lung rats through antioxidative and anti-lipid peroxidative mechanisms with higher protection to NS.

Zaki, S. M., and E. A. Mohamed, "Effect of glucocorticoids on indomethacin-induced gastric ulcer in the adult male albino rat–histological, morphometric and electron microscopy study", Archives of Medical Science: AMS, vol. 10, no. 2: Termedia Publishing, pp. 381, 2014. Abstract
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Zaki, N. M., I. Helal, A. Awad, and E. E. Hassanein, "Efficient Checking of Timed Order Compliance Rules over Graph-encoded Event Logs", arXiv preprint arXiv:2206.09336, 2022. Abstract
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Zaki, S. A., M. S. Abou-Zekri, A. T. Alakel, L. Almahdy, and H. N. Y., "Evaluation of defatted soy based formulas prepared for infants and young children with acute diarrhea", 20th International Congress of Nutrition., Granada, Spain, 15-20 September, 2013: IUNS 2013, 2013. Abstract
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Zaki, S. A., A. A M, N. S. Taha, and N. Saadeldin, "Effect of Cold Storage on Quality and Safety of Kofta. 37, 49-61.", Egypt. J. of Food Sci., vol. 37, pp. 49-61, 2009. Abstract
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Zaki, C., N. Alshayab, and N. Seleem, "Employment Intensity and Sectoral Output Growth: A Comparative Analysis for Egyptian and Jordanian Economies", New Medit – Mediterranean Journal for Agriculture, Economics and Environment, vol. 19, issue 1, pp. 35-54, 2020.
Zaki, H. F., H. A. Salem, M. F. El-Yamany, and N. M. Shaffie, "Effects of certain natural products in adjuvant-induced arthritis", The New Egyptian Journal of Medicine, vol. 38, no. 4 suppl., pp. 7–20, 2008. Abstract
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Zaki, N. M., A. Awad, and E. Ezat, "Extracting accurate performance indicators from execution logs using process models", Computer Systems and Applications (AICCSA), 2015 IEEE/ACS 12th International Conference of: IEEE, pp. 1-8, 2015. Abstract
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Zaki, S. M., and E. A. Mohamed, "Effect of glucocorticoids on indomethacin-induced gastric ulcer in the adult male albino rat–histological, morphometric and electron microscopy study", Archives of medical science: AMS, vol. 10, no. 2: Termedia Publishing, pp. 381, 2014. Abstract
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Zaki, O. M., M. Sadek, H. Aly, and O. Abdelaziz, "Experimental assessment and modeling of radiant cooling technology using constant and variable water flow rate", Science and Technology for the Built Environment, vol. 29, no. 5: Taylor & Francis, pp. 560–573, 2023. Abstract
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Zaki, N. M., I. Helal, A. Awad, and E. E. Hassanein, "Efficient Checking of Timed Order Compliance Rules over Graph-encoded Event Logs", arXiv preprint arXiv:2206.09336, 2022. Abstract
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Zaki, M. H., A. Awad, and O. Hegazy, Enabling Compliance Monitoring for Process Execution Engines- Extended Version, , pp. 1-14, March 2017. paper.pdf
Zaki, M. M., and A. S. Al-Ankari, "The effect of dietary Vitamin E and Selenium on overall performance and immune response of broilers fed either basal or oxytetracycline treated diet", VETERINARY MEDICAL JOURNAL-GIZA-, vol. 52, no. 1: COMPUTER CENTRE PUBLISHING, pp. 99–106, 2004. Abstract
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Zaki, M. M., H. Y. El Zorba, H. A. Kaoud, and others, "Environmental Organisms as Risk Factors in the Occurrence of Mastitis in Dairy Buffaloes with Suggested Methods of Control. A Field Study", Global Veterinaria, vol. 5, no. 2: IDOSI Publications, pp. 97–105, 2010. Abstract
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Zaki, H. M. B. A., M. M. Zaki, M. M. M. Abdulla, and E. F. Abdel-Latif, "Evaluation of Fatty Acid Indices and Fatty Acid Content Including Trans Fat of Different Fried Food Types Using Gas-Liquid Chromatography Technique", Advances in Animal and Veterinary Sciences, vol. 9, issue 6, pp. 887-894, 2021.
Zaki, G. F., H. M. Elsayed, H. H. Amer, and M. S. El-Soudani, "Energy balanced model for data gathering in wireless sensor networks with fixed and mobile sinks", Computer Communications and Networks, 2009. ICCCN 2009. Proceedings of 18th Internatonal Conference on: IEEE, pp. 1–6, 2009. Abstract
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Zaki, H. F., H. A. Salem, M. F. El-Yamany, and N. M. Shaffie, "Effects of certain natural products in adjuvant-induced arthritis", The New Egyptian Journal of Medicine, vol. 38, no. 4 suppl., pp. 7–20, 2008. Abstract
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