Publications

Export 15769 results:
Sort by: Author [ Title  (Desc)] Type Year
A B C D [E] F G H I J K L M N O P Q R S T U V W X Y Z   [Show ALL]
E
Elbanna, A. H., M. M. Nooh, E. A. Mahrous, A. E. Khaleel, and T. S. El Alfy, "Extract of Bauhinia vahlii Shows Antihyperglycemic Activity, Reverses Oxidative Stress, and Protects against Liver Damage in Streptozotocin-induced Diabetic Rats.", Pharmacognosy magazine, vol. 13, issue Suppl 3, pp. S607-S612, 2017 Oct. Abstract

Background: Several studies have affirmed the effectiveness of some Bauhinia plants as antihyperglycemic agents.

Objective: We investigated the possible effect of Bauhinia vahlii leaves extract in reducing hyperglycemia and reversing signs of organ damage associated with diabetes in streptozotocin (STZ) rat model.

Materials and Methods: Both polar fraction of the B. vahlii leaves (defatted ethanolic extract [DEE]) and nonpolar fraction (n-hexane extract) were evaluated in vitro for α-glucosidase inhibition and 2,2-diphenyl-1-picrylhydrazyl radical scavenging potential. DEE was selected for further in vivo studies and was administered at two doses, i.e., 150 or 300 mg/kg to STZ-diabetic rats for 4 weeks.

Results: Only DEE exhibited in vitro antioxidant and antihyperglycemic activities and its oral administration at both dose levels resulted in significant reduction in fasting blood glucose and glycated hemoglobin. Furthermore, signs of oxidative stress as indicated by hepatic reduced glutathione, nitric oxide, and malondialdehyde levels were completely reversed. In addition, histopathological examination and measurement of serum aspartate transaminase and alanine transaminase levels showed that DEE protected the liver from signs of liver pathogenesis when compared to diabetic untreated animals and those treated with metformin. Phytochemical analysis of DEE showed high flavonoids content with quercitrin as the major constituent along with other quercetin glycosides.

Conclusion: This study strongly highlights the possible beneficial effect of B. vahlii leaves extract in relieving hyperglycemia and liver damage in STZ-diabetic rats and recommends further investigation of the value of quercetin derivatives in controlling diabetes and ameliorating liver damage associated with it.

SUMMARY: The polar fraction of the Bauhinia vahlii leaves (defatted ethanolic extract [DEE]) exhibited both in vitro antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenging assay and strong α-glucosidase inhibition while the nonpolar fraction (n-hexane extract) failed to show any activity in both assays. DEE was further investigated in streptozotocin-induced diabetic rat model where oral administration of DEE at 2 doses (150 and 300 mg/kg) for 4 weeks resulted in significant reduction in fasting blood glucose and glycated hemoglobin and reversal of oxidative stress signs as indicated by measurement of hepatic reduced glutathione, nitric oxide, and malondialdehyde levels. In addition, histopathological examination and measurement of serum aspartate transaminase and alanine transaminase levels showed that DEE protected the liver from signs of pathogenesis observed in diabetic untreated rats. Phytochemical analysis of DEE showed high flavonoid content with quercitrin as the major constituent (62.9 ± 0.18 mg/mg). Abbreviations used: ALT: Alanine transaminase, AST: Aspartate transaminase, DEE: Defatted ethanol extract, DPPH: 2,2-diphenyl-1-picrylhydrazyl, FBG: Fasting blood glucose, GAE: Gallic acid equivalent, GSH: Reduced glutathione, Hb1Ac: Glycated hemoglobin, HE: Hexane extract MDA: Malondialdehyde, QE: Quercetin equivalent, STZ: Streptozotocin, TAC: Total antioxidant capacity.

Elbanna, A. H., M. M. Nooh, E. A. Mahrous, Amal E. Khaleel, and T. S. El Alfy, "Extract of Bauhinia vahlii Shows Antihyperglycemic Activity, Reverses Oxidative Stress, and Protects against Liver Damage in Streptozotocin-induced Diabetic Rats", Pharmacognosy magazine, vol. 13 (suppl 3), pp. S607-S612, 2017.
Elbanna, A. H., M. M. Nooh, E. A. Mahrous, A. E. Khaleel, and T. S. El Alfy, "Extract of Bauhinia vahlii Shows Antihyperglycemic Activity, Reverses Oxidative Stress, and Protects against Liver Damage in Streptozotocin-induced Diabetic Rats", Pharmacognosy Magazine, vol. 13, issue Suppl 3, pp. S607-S612, 2017. Abstract

Several studies have affirmed the effectiveness of some Bauhinia plants as antihyperglycemic agents. We investigated the possible effect of Bauhinia vahlii leaves extract in reducing hyperglycemia and reversing signs of organ damage associated with diabetes in streptozotocin (STZ) rat model. Both polar fraction of the B. vahlii leaves (defatted ethanolic extract [DEE]) and nonpolar fraction (n-hexane extract) were evaluated in vitro for α-glucosidase inhibition and 2,2-diphenyl-1-picrylhydrazyl radical scavenging potential. DEE was selected for further in vivo studies and was administered at two doses, i.e., 150 or 300 mg/kg to STZ-diabetic rats for 4 weeks. Only DEE exhibited in vitro antioxidant and antihyperglycemic activities and its oral administration at both dose levels resulted in significant reduction in fasting blood glucose and glycated hemoglobin. Furthermore, signs of oxidative stress as indicated by hepatic reduced glutathione, nitric oxide, and malondialdehyde levels were completely reversed. In addition, histopathological examination and measurement of serum aspartate transaminase and alanine transaminase levels showed that DEE protected the liver from signs of liver pathogenesis when compared to diabetic untreated animals and those treated with metformin. Phytochemical analysis of DEE showed high flavonoids content with quercitrin as the major constituent along with other quercetin glycosides. This study strongly highlights the possible beneficial effect of B. vahlii leaves extract in relieving hyperglycemia and liver damage in STZ-diabetic rats and recommends further investigation of the value of quercetin derivatives in controlling diabetes and ameliorating liver damage associated with it. The polar fraction of the Bauhinia vahlii leaves (defatted ethanolic extract [DEE]) exhibited both in vitro antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenging assay and strong α-glucosidase inhibition while the nonpolar fraction (n-hexane extract) failed to show any activity in both assays. DEE was further investigated in streptozotocin-induced diabetic rat model where oral administration of DEE at 2 doses (150 and 300 mg/kg) for 4 weeks resulted in significant reduction in fasting blood glucose and glycated hemoglobin and reversal of oxidative stress signs as indicated by measurement of hepatic reduced glutathione, nitric oxide, and malondialdehyde levels. In addition, histopathological examination and measurement of serum aspartate transaminase and alanine transaminase levels showed that DEE protected the liver from signs of pathogenesis observed in diabetic untreated rats. Phytochemical analysis of DEE showed high flavonoid content with quercitrin as the major constituent (62.9 ± 0.18 mg/mg). The polar fraction of the Bauhinia vahlii leaves (defatted ethanolic extract [DEE]) exhibited both in vitro antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenging assay and strong α-glucosidase inhibition while the nonpolar fraction (n-hexane extract) failed to show any activity in both assays. DEE was further investigated in streptozotocin-induced diabetic rat model where oral administration of DEE at 2 doses (150 and 300 mg/kg) for 4 weeks resulted in significant reduction in fasting blood glucose and glycated hemoglobin and reversal of oxidative stress signs as indicated by measurement of hepatic reduced glutathione, nitric oxide, and malondialdehyde levels. In addition, histopathological examination and measurement of serum aspartate transaminase and alanine transaminase levels showed that DEE protected the liver from signs of pathogenesis observed in diabetic untreated rats. Phytochemical analysis of DEE showed high flavonoid content with quercitrin as the major constituent (62.9 ± 0.18 mg/mg). Abbreviations used: ALT: Alanine transaminase, AST: Aspartate transaminase, DEE: Defatted ethanol extract, DPPH: 2,2-diphenyl-1-picrylhydrazyl, FBG: Fasting blood glucose, GAE: Gallic acid equivalent, GSH: Reduced glutathione, Hb1Ac: Glycated hemoglobin, HE: Hexane extract MDA: Malondialdehyde, QE: Quercetin equivalent, STZ: Streptozotocin, TAC: Total antioxidant capacity.

Abdel-Rahman, R. F., S. M. Ezzat, H. A. Ogaly, R. M. Abd-Elsalam, A. F. Hessin, M. I. Fekry, D. I. N. A. F. Mansour, and S. O. Mohamed, "extract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism.", Journal of nutritional science, vol. 9, pp. e2, 2020. Abstractjournal_of_nutritional_science.pdf

var. Jack (FD) is a well-known plant used in Malay folklore medicine to lower blood glucose in diabetic patients. For further research of the antihyperglycemic mechanisms, the protein tyrosine phosphatase 1B (PTP1B)-inhibitory effect of FD was analysed both and To optimise a method for FD extraction, water, 50, 70, 80, 90 and 95 % ethanol extracts were prepared and determined for their total phenolic and triterpene contents, and PTP1B-inhibition capacity. Among the tested extracts, 70 % ethanol FD extract showed a significant PTP1B inhibition (92·0 % inhibition at 200 µg/ml) and high phenolic and triterpene contents. A bioassay-guided fractionation of the 70 % ethanol extract led to the isolation of a new triterpene (3β,11β-dihydroxyolean-12-en-23-oic acid; F3) along with six known compounds. , 4 weeks' administration of 70 % ethanol FD extract (125, 250 and 500 mg/kg/d) to streptozotocin-nicotinamide-induced type 2 diabetic rats reversed the abnormal changes of blood glucose, insulin, total Hb, GLUT2, lipid profile, and oxidative stress in liver and pancreas. Moreover, FD reduced the mRNA expression of the key gluconeogenic enzymes (phosphoenolpyruvate carboxykinase and glucose 6-phosphatase) and restored insulin receptor and GLUT2 encoding gene () expression. In addition, FD significantly down-regulated the hepatic PTP1B gene expression. These results revealed that FD could potentially improve insulin sensitivity, suppress hepatic glucose output and enhance glucose uptake in type 2 diabetes mellitus through down-regulation of PTP1B. Together, our findings give scientific evidence for the traditional use of FD as an antidiabetic agent.

M.A., 11. N., A. A. Mogahed, O. S. El-Kobisy, and K. S. Emara, "Extract and evaluation of local tomato lines with high yielding and improved quality", J. Agric. Sci. Mansoura Univ., vol. 27, issue 4, pp. 2107 – 2124, 2002.
Sherif, I. O., N. H. Al-Shaalan, and D. Sabry, "Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression.", Biomolecules, vol. 9, issue 11, 2019. Abstract

Renal injury induced by the chemotherapeutic agent methotrexate (MTX) is a serious adverse effect that has limited its use in the treatment of various clinical conditions. The antioxidant activity of extract (GB) was reported to mitigate renal injury induced by MTX. Our research was conducted to examine the nephroprotective role of GB versus MTX-induced renal injury for the first time through its impact on the regulation of phosphatidylinositol 3-kinase/protein kinase B/ mammalian target of rapamycin (PI3K/Akt/mTOR) signaling together with the renal level of TGF-β mRNA and long non-coding RNA-metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) expression. A group of adult rats was intraperitoneally (ip) injected with MTX 20 mg/kg as a single dose to induce kidney injury (MTX group). The other group of rats was orally administered with GB 60 mg/kg every day for 10 days (GB+ MTX group). The MTX increased the serum creatinine and urea levels, renal TGF-β mRNA and MALAT1 expression, in addition to dysregulation of the PI3K/Akt/mTOR signaling when compared with normal control rats that received saline only (NC group). Moreover, renal damage was reported histopathologically in the MTX group. The GB ameliorated the renal injury induced by MTX and reversed the changes of these biochemical analyses. The involvement of PI3K/Akt/mTOR signaling and downregulation of TGF-β mRNA and MALAT1 renal expressions were firstly reported in the nephroprotective molecular mechanism of GB versus MTX-induced renal injury.

Biswas, A., E. A. Samadoni, A. Elbassiouny, K. Sobh, and A. Hegazy, "Extracranial to intracranial by-pass anastomosis: Review of our preliminary experience from a low volume center in Egypt.", Asian journal of neurosurgery, vol. 10, issue 4, pp. 303-9, 2015 Oct-Dec. Abstract

BACKGROUND: Cerebral revascularization is a useful microsurgical technique for the treatment of steno-occlusive intracranial ischemic disease, complex intracranial aneurysms that require deliberate occlusion of a parent artery and invasive skull base tumors. We describe our preliminary experience with extracranial-to-intracranial by-passes at a low volume center; and discuss clinical indications and microsurgical techniques, challenges in comparison to large advanced referral centers.

MATERIALS AND METHODS: Twenty-seven patients with hemodynamic ischemia or complex aneurysms or skull base tumors were operated at Cairo University Hospitals in the period between May 2009 and June 2014. All patients operated by a low flow by-pass were operated through a superficial temporal artery to middle cerebral artery (MCA) anastomosis. All patients chosen for a high flow by-pass were operated using a radial artery graft interposed between the MCAs distally and the common or the external carotid artery proximally. Patency was confirmed at the end of surgery using appearance on the table and confirmed after surgery by transcranial color-coded duplex or computed tomography angiography. All patient data were prospectively collected and retrospectively analyzed at the end of surgery.

RESULTS: Nineteen patients (70.4%) were operated upon for flow augmentation and eight patients (29.6%) were operated upon for flow replacement. A total of 30 anastomoses were performed. All except one were patent which gives a patency rate of 96.3%. There was one death in the present series resulting from a hyperperfusion syndrome. 89.5% of patients with hemodynamic ischemia stopped having symptoms after surgery. All but one patient operated for hemodynamic ischemia showed a considerable cognitive improvement after surgery. None of the patients operated upon for flow replacement showed improvement of oculomotor nerve function in spite of adequate intraoperative decompression. All patients treated for flow replacement showed the absence of recurrence on follow-up.

CONCLUSION: Our initial results for both low and high flow by-pass procedures in our low volume center indicate that such complex surgical procedures are possible with results comparable to those obtained in other larger referral centers throughout the world. This procedure not only represents a more definitive treatment when compared to other endovascular or radiation treatments but is also much less costly when compared to other treatment modalities.

Shaeer, O., and K. Shaeer, "Extracorporeal Transseptal Penile Prosthesis Implantation for Extreme Cases of Corporeal Fibrosis: Shaeer Implantation Technique.", The journal of sexual medicine, vol. 15, issue 9, pp. 1350-1356, 2018 Sep. Abstract

BACKGROUND: Penile prosthesis implantation into scarred corporeal bodies is one of the most challenging procedures in prosthetic urologic surgery, especially following infection and extrusion of a penile implant. Several instruments and techniques have been used for making dilatation of scarred corporeal bodies easier and safer in expert hands. Nevertheless, in some cases, implantation is not possible.

AIM: This work presents extracorporeal transseptal implantation as a last resort in such cases.

METHODS: In 39 patients with extensive corporeal fibrosis, penile prosthesis implantation is attempted. After failure of alternative techniques, extracorporeal implantation is resorted to in 10 patients. The corpus spongiosum is identified and protected. Diathermy knife is used to cut a longitudinal window into 1 corpus cavernosum, through the septum and into the contralateral corpus cavernosum. A single semirigid implant rod is inserted through the window at the base of the penis, halfway through. The 2 limbs of the rod are bent upward toward the glans, to assume a U shape. The limbs of the U are brought together at midshaft by a gathering suture passed through the corpora cavernosa and septum. The tips of the U are anchored under the glans.

OUTCOMES: Achievement of acceptable coital relationship.

RESULTS: The procedure allowed acceptable coital relationship and concealment in 9/10 cases. In 1 case, infection occurred. Reimplantation with the same method was performed 6 months later, and the implant survived adequately. Perforation, migration, and urethral injury were not encountered.

CLINICAL IMPLICATIONS: This technique may help salvage abandoned cases with corporal fibrosis, particularly when the necessary expertise for alternative techniques is unavailable or when such techniques fail.

STRENGTHS & LIMITATIONS: The technique presented is fairly straightforward and safe. However, the number of cases and duration of follow-up are limited.

CONCLUSION: Extracorporeal transseptal penile prosthesis implantation can salvage cases with severe corporeal fibrosis when all alternatives fail. Shaeer O, Shaeer K. Extracorporeal Transseptal Penile Prosthesis Implantation for Extreme Cases of Corporeal Fibrosis: Shaeer Implantation Technique. J Sex Med 2018;15:1350-1356.

Omar, M. T. A., R. F. M. Gwada, A. A. M. Shaheen, and R. Saggini, "Extracorporeal Shockwave Therapy for the Treatment of Chronic Wound of Lower Extremity: Current Perspective and Systematic Review", international Wound Journal, vol. 14, issue 6, pp. 898-908, 2017.
Serie, A. Y. A., N. A. H. elnour, and M. M. Eid, "Extracorporeal shock wave versus ultrasound wave therapy on venous ulcer", International Journal of Recent Advances in Multidisciplinary Research , vol. 5, issue 9, pp. 4107-4112, 2018. Extracorporeal shock wave versus ultrasound wave therapy on venous ulcer
Abdul-RahmanA, R. S., and A. E. - A. A. A. El-AzizB, "Extracorporeal Shock wave Therapy versus Ultrasonic Therapy on Functional Abilities in Children with Tennis Elbow A randomized controlled trial", International Journal of Therapies and Rehabilitation Research, vol. 6, issue 1, pp. 154-161, 2017.
Shouman, A. M., A. M. Ziada, I. A. Ghoneim, and H. A. Morsi, "Extracorporeal shock wave lithotripsy monotherapy for renal stones >25 mm in children.", Urology. 2009 Jul;74(1):109-11. doi: 10.1016/j.urology.2008.09.083. Epub 2009 May 9. PMID: 19428070, 2009.
Ghoneim, I., M. El-Ghoneimy, A. El-Naggar, K. M. Hammoud, M. El-Gammal, and A. Morsi, "Extracorporeal Shock Wave Lithotripsy in Impacted Upper Ureteral Stones: A Prospective Randomized Comparison Between Stented and Non-stented Techniques", Urology, vol. 75, issue 1, pp. 45-50, 2010. khaled_stent_vs_non-stented.pdf
Sajjad, M., A. Osman, S. Mohsen, M. Alanazi, M. Ugurlucan, and C. Canver, "Extracorporeal membrane oxygenation in adults: experience from the Middle East", Asian Cardiovascular & Thoracic Annals 0(0) 1–7, 2012. Extracorporeal membrane oxygenation in adults: experience from the Middle East.pdf
Sajjad, M., A. Osman, S. Mohsen, M. Alanazi, M. Ugurlucan, and C. Canver, "Extracorporeal membrane oxygenation in adults: experience from the Middle East", Asian Cardiovascular & Thoracic Annals, pp. 1-7, 2012.
EL-KOSERY, S. O. H. E. I. R. M., G. E. El-Refaye, A. B. D. - E. L. A. T. I. F. G. EL-KHOLY, and A. M. A. N. Y. M. EL-AHWAL, "Extracorpeal Shock Wave Therapy Versus Ultrasound for Carpal Tunnel Syndrome in Post Menopausal Women", http://medicaljournalofcairouniversity.net/home2/images/pdf/2017/December/59.pdft, vol. 85, issue 8, pp. 2895-2901, 2017.
Farrag, A., N. A. Razek, S. Bakhoum, and G. Youssef, "Extracoronary calcification may help prediction of significant coronary atherosclerosis in young patients", Heart Mirror, vol. 3, issue 2, pp. 70-75, 2009.
Youssef, G., A. Farrag, S. Bakhoum, and M. A. Salem, "Extracoronary calcification as a marker of the extent of coronary artery disease in symptomatic patients less than 65 years. A multislice computed tomography study", Canadian Cardiovascular Congress, Toronto, Canada, 2008.
Madkour, O., M. Mustafa, M. A. E. Nosseir, Z. Ashour, and N. M. El-Fayoumy, "Extracerebral Vascular Disease, A Masked Mechanism for Cerebral stroke", Egyptian Journal of Neurology, Psychiatry and Neurosurgery, vol. vol 36, issue i, pp. 63, 1999.
Madkour, O., M. Mustafa, M. A. E. Nosseir, Z. Ashour, and N. M. El-Fayoumy, "Extracerebral Vascular Disease, A Masked Mechanism for Cerebral stroke", Egyptian Journal of Neurology, Psychiatry and Neurosurgery, vol. vol 36, issue i, pp. 63, 1999.