Publications

Export 5900 results:
Sort by: Author Title Type [ Year  (Desc)]
2023
Eissa, I. H., R. G. Yousef, H. Elkady, E. B. Elkaeed, A. A. Alsfouk, D. Z. Husein, I. M. Ibrahim, M. A. Elhendawy, M. Godfrey, and A. M. Metwaly, "Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and apoptosis inducers", Computational Biology and Chemistry, vol. 107: Elsevier, pp. 107953, 2023. Abstract
n/a
Helmy, M. T., F. M. Sroor, A. M. Othman, H. M. Hassaneen, F. M. Saleh, and M. M. A. Teleb, "Design, synthesis and in‐vitro evaluation of new furan‐substituted thiadiazolyl hydrazone derivatives as promising antimicrobial agents", Journal of Heterocyclic Chemistry, vol. 60, issue 4: John Wiley & Sons, Inc. Chichester, UK, pp. 585-595, 2023. Abstract
n/a
Helmy, M. T., F. M. Sroor, A. M. Othman, H. M. Hassaneen, F. M. Saleh, and M. M. A. Teleb, "Design, synthesis and in‐vitro evaluation of new furan‐substituted thiadiazolyl hydrazone derivatives as promising antimicrobial agents", Journal of Heterocyclic Chemistry, vol. 60, issue 4: John Wiley & Sons, Inc. Chichester, UK, pp. 585-595, 2023. Abstract
n/a
Ramadan, W. S., M. M. Saber-Ayad, E. Saleh, H. H. M. Abdu-Allah, A. -nasserA. El-Shorbagi, V. Menon, H. Tarazi, M. H. Semreen, N. C. Soares, S. Hafezi, et al., "Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives", IScience, vol. 27, issue 2589-0042, pp. 108659, 2023.
Srour, A. M., D. H. Dawood, E. S. Nossier, R. A. El-Shiekh, A. E. Mahmoud, A. G. Hussien, M. M. Omran, and M. M. Ali, "Design, synthesis and molecular docking simulation of oxindole-based derivatives with dual VEGFR-2 and cholinesterase inhibitory activities", Journal of Molecular Structure, vol. 1271: Elsevier, pp. 134130, 2023. Abstract
n/a
Aladdin M. Srour, Dina H. Dawood, Eman S. Nossier, R. A.El-shiekh, Abeer E. Mahmoud, Amal G. Hussien, M. M. Omran, and M. M. Ali, "Design, synthesis and molecular docking simulation of oxindole-based derivatives with dual VEGFR-2 and cholinesterase inhibitory activities, ", Journal of Molecular Structure,, vol. 1271, 2023.
Osman, E. O., H. Attia, R. Samir, and Z. Mahmoud, "Design, synthesis, and antibacterial activity of a new series of ciprofloxacin-thiadiazole hybrid", Journal of Molecular Structure, vol. 1282, pp. 135135, 2023.
Osman, E. O., H. Attia, R. Samir, and Z. Mahmoud, "Design, synthesis, and antibacterial activity of a new series of ciprofloxacin-thiadiazole hybrid", Journal of Molecular Structure, vol. 1282, pp. 135135, 2023.
Osman, E. O., H. Attia, R. Samir, and Z. Mahmoud, "Design, synthesis, and antibacterial activity of a new series of ciprofloxacin-thiadiazole hybrid", Journal of Molecular Structure, vol. 1282, pp. 135135, 2023. AbstractWebsite

This study synthesized novel ciprofloxacin analogs bearing the 2-amino-1,3,4-thiadiazole ring, including tryptophan and different sulfonamides, to act as antimicrobial agents. Then, the activities of the synthesized hybrids were screened against 18 tested bacterial isolates from 4 standard strains (Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 25,923, Acinetobacter baumannii ATCC 19,606, and Pseudomonas aeruginosa PAO1) and 14 clinical strains (2 Enterobacter cloacae and 12 Klebsiella pneumonia isolates). Investigations revealed that compound 2 showed better antimicrobial activities among the synthesized compounds than the standard drug, ciprofloxacin, demonstrated by its lower MIC and MBC values. We also notably observed that compared to ciprofloxacin, compound 2 maintained its activity for a longer time without inducing resistance in the tested bacterium. Hence, we conducted a time-to-kill assay and compared the results with its parent drug, followed by a molecular modeling simulation study through the docking of compound 2 into E. coli DNA gyrase enzyme active site to elucidate its binding modes to the receptor. Then, we compared these results with ciprofloxacin and calculated the physicochemical descriptors, ADME parameters, pharmacokinetic properties, and drug-like nature profile of compound 2 as the most potent were also calculated. Based on our findings, we conclude that with further modifications of compound 2, the design of a new and optimized fluoroquinolone generation should be possible.

Ezzat, M. A. F., G. F. Elmasry, M. A. M. A. El‐Mageed, M. A. Fouad, H. A. Abdel‐Aziz, and S. I. Elewa, Design, synthesis, and biological evaluation of furan‐bearing pyrazolo[3,4‐b]pyridines as novel inhibitors of CDK2 and P53–MDM2protein–proteininteraction, , 2023.
Swedan, H. K., A. S. M. A. A. E. KASSAB, E. M. Gedawy, and S. E. Elmeligie, "Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme", Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 38, issue 1, pp. 118–137, 2023.
Eissa, K. I., M. M. Kamel, L. W. Mohamed, A. S. Doghish, R. Alnajjar, A. A. Al‐Karmalawy, and A. S. M. A. A. E. KASSAB, "Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease", Drug Development Research, vol. 84, pp. 937–961, 2023.
El-Metwally, S. A., H. Elkady, M. Hagras, D. Z. Husein, I. M. Ibrahim, M. S. Taghour, H. A. El-Mahdy, A. Ismail, B. A. Alsfouk, E. B. Elkaeed, et al., "Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno [2, 3-d] pyrimidines targeting VEGFR-2", RSC advances, vol. 13, no. 33: Royal Society of Chemistry, pp. 23365–23385, 2023. Abstract
n/a
Sayed, M. T. M., P. A. Halim, A. K. El-Ansary, and R. A. Hassan, "Design, synthesis, anticancer evaluation, and in silico studies of some thieno [2, 3-d] pyrimidine derivatives as EGFR inhibitors", Drug Development Research, vol. 84, no. 6: Wiley Online Library, pp. 1299–1319, 2023. Abstract
n/a
Osman, E. O., S. H. Emam, A. Sonousi, M. M. Kandil, A. M. Abdou, and R. A. Hassan, "Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone-based derivatives as DHFR inhibitors", Drug Development Research, vol. 84, no. 5, pp. 888-906, 2023. AbstractWebsite

Abstract Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and antitumor activities. Antibacterial activity was evaluated against three strains of Gram-positive and Gram-negative bacteria. Compound 3d exhibited the highest inhibitory activity against Staphylococcus aureus DHFR (SaDHFR) with IC50 of 0.769 ± 0.04 μM compared to 0.255 ± 0.014 μM for trimethoprim. Compound 3e was also more potent than trimethoprim against Escherichia coli DHFR (EcDHFR) with IC50 of 0.158 ± 0.01 μM and 0.226 ± 0.014 μM, respectively. Compound 3e exhibited a promising antiproliferative effect against most of the tested cancer cells. It also showed potent activity against leukemia (CCRF-CEM, and RPMI-8226); lung NCI-H522, and CNS U251 with GI% of 65.2, 63.22, 73.28, and 97.22, respectively. The cytotoxic activity of compound 3e was almost half the activity of doxorubicin against CCRF-CEM cell line with IC50 of 1.569 ± 0.06 μM and 0.822 ± 0.03 µM, respectively. In addition, compound 3e inhibited human DHFR with IC50 value of 0.527 ± 0.028 µM in comparison to methotrexate (IC50 = 0.118 ± 0.006 µM). Compound 3e caused an arrest of the cell cycle mainly at the S phase and caused a rise in the overall apoptotic percentage from 2.03% to 48.51%. (23.89-fold). Treatment of CCRF-CEM cells with compound 3e produced a significant increase in the active caspase-3 level by 6.25-fold compared to untreated cells. Molecular modeling studies were performed to evaluate the binding pattern of the most active compounds in the bacterial and human DHFR.

Salem, M. E., M. Samir, A. H. M. Elwahy, A. M. Farag, A. M. Selim, A. A. Alsaegh, Marwa Sharaky, N. Bagato, and I. T. Radwan, "Design, synthesis, docking study, cytotoxicity evaluation, and PI3K inhibitory activity of Novel di-thiazoles, and bis (di-thiazoles)", Journal of Molecular Structure: Elsevier, pp. 137379, 2023. Abstract
n/a
Sobh, E. A., M. A. Dahab, E. B. Elkaeed, A. A. Alsfouk, I. M. Ibrahim, A. M. Metwaly, and I. H. Eissa, "Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno [2, 3-d] pyrimidine derivatives as new EGFR inhibitors", Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 38, no. 1: Taylor & Francis, pp. 2220579, 2023. Abstract
n/a
Ezzat, M. A. F., S. M. Abdel Hamid, M. A. Fouad, H. A. Abdel‐Aziz, and H. A. Allam, "Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease", Drug Development Research, pp. 1-16, 2023. paper_18.pdf
Saber, F. R., A. H. Elosaily, E. A. Mahrous, Ł. Pecio, S. Pecio, Y. A. El-Amier, M. Korczak, J. P. Piwowarski, Ł. Świątek, and K. Skalicka-Woźniak, "Detailed metabolite profiling and in vitro studies of Urospermum picroides as a potential functional food.", Food chemistry, vol. 427, pp. 136677, 2023. Abstract

Wild edible plants (WEP) are part of the Mediterranean culinary culture and can be used as famine foods in times of severe food shortages. Urospermum picroides is a WEP that grows under harsh conditions and represents an opportunity to expand and diversify the global food supply. However, little is known about its chemical profile. In this study, liquid chromatography coupled to HRESIMS allowed the identification of 77 metabolites in U. picroides extract, among which 12 sesquiterpene-amino acid conjugates are reported here for the first time. Due to the novelty of these conjugates, GNPS molecular networking was used to provide information on their fragmentation pathway. Further, the sesquiterpene enriched U. picroides extract showed a moderate anti-inflammatory effect in LPS-stimulated THP1-macrophages by increasing IL-10 secretion while decreasing pro-inflammatory IL-6 secretion at 50 µg/mL. Our study provides evidence for the potential use of U. picroides as an anti-inflammatory functional food and nutraceutical agent.

Alshammari, M. A., A. A. Abd El-Aziz, and H. HAMDI, "Detecting Traffic Diversion Using Metaheuristic Algorithm in SDN", International Journal of INTELLIGENT SYSTEMS AND APPLICATIONS IN ENGINEERING, vol. 12, no. 9, pp. 369–379, 2023. Abstract
n/a
Taha, M. H. N., M. H. N. Taha, A. E. Hassanien, and S. Elghamrawy, "Detection of coronavirus (COVID-19) associated pneumonia based on generative adversarial networks and a fine-tuned deep transfer learning model using chest X-ray dataset", Proceedings of the 8th International Conference on Advanced Intelligent Systems and Informatics 2022 , pp. 234–247, 2023.
Salem, M., A. Gomaa, and N. Tsurusaki, "Detection of Earthquake-Induced Building Damages Using Remote Sensing Data and Deep Learning: A Case Study of Mashiki Town, Japan", IEEE International Symposium on Geoscience and Remote Sensing (IGARSS), California, US, pp. 4, 2023.
Ramadan, E. M., A. M. Badr, F. Abdelradi, A. Negm, and A. M. Nosair, "Detection of Groundwater Quality Changes in Minia Governorate, West Nile River", Sustainability , vol. 15, issue 5, pp. 4076, 2023.