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2023
Obeida, A., M. A. Latif, M. Marey, S. Kaddah, and K. Abdellatif, "Delayed presentation of type I colonic atresia", Journal of Pediatric Surgery Case Reports, vol. 88, pp. 102527, 2023. AbstractWebsite

Colonic atresia is a rare cause of neonatal intestinal obstruction which is usually diagnosed and corrected during the neonatal period. An even rarer entity is isolated intraluminal membrane causing partial obstruction which is usually suspected antenatally or diagnosed early postnatal with a contrast enema. However, there is no consensus regarding operative management for these cases described in literature. We present a three-month male with a rare subtype of colonic atresia presented repeatedly with ambiguous symptoms. Exclusion of associated Hirschsprung's disease and primary anastomosis was performed. It was safe to perform primary colonic anastomosis in our delayed presentation case. Patient showed complete resolution of symptoms and thrived well after surgery.

Hassan, A. A., S. Z. Mansour, D. M. Mostafa, and S. S. ABDELGAYED, "DELVING INTO THE DEATH SIGNALING PATHWAY OF HEMP OIL AND GAMMA RADIATION IN SOLID TUMOR BEARING MICE", Can. J. Physiol. Pharmacol, vol. 101, pp. 226–234 , 2023. cjpp-2022-0319.pdf
Abdalgeleel, S. A., M. M. Moneer, A. S. Refaee, M. M. Samir, O. O. Khalaf, and R. A. S. H. A. M. A. H. M. O. U. D. ALLAM, "Depression and fatigue among Egyptian health care workers: cross‑sectional survey", Journal of Public Health , 2023. depression_and_fatigue_among_egyptian_health_care_workers_.pdf
Aboubakr, A. F. S., G. M. Ismail, M. M. Khader, M. A. E. Abdelrahman, A. M. T. AbdEl-Bar, and M. ADEL, "Derivation of an approximate formula of the Rabotnov fractional-exponential kernel fractional derivative and applied for numerically solving the blood ethanol concentration system", AIMS Mathematics, vol. 8, issue 12, pp. 30704–30716, 2023. 46-_blood_aims_2023.pdf
N El Malahany, M. Abdeltawab, H Elwy, H. Fahmy, and M. E. R. Nashar, "Design and Application of Molecularly Imprinted Electrochemical Sensor for the New Generation Antidiabetic Drug Saxagliptin", Electroanalysis, vol. 35 , issue 5, pp. e202200313, 2023.
Halim, A. A. S., M. Mostafa, and O. Hamdy, "Design and Implementation of 3.2-GHz Co-Planar Miniaturized Antenna for S-Band Communication and Wireless Applications", Wireless Personal Communications, vol. 132, issue 3, pp. 1887-1897, 2023.
El-Wasif, Z., T. Ismail, and O. Hamdy, "Design and optimization of highly sensitive multi-band terahertz metamaterial biosensor for coronaviruses detection", Optical and Quantum Electronics, vol. 55, issue 7, pp. 604, 2023.
El-Wasif, Z., T. Ismail, and O. Hamdy, "Design and optimization of highly sensitive multi-band terahertz metamaterial biosensor for coronaviruses detection", Optical and Quantum Electronics, vol. 55, no. 7: Springer US New York, pp. 604, 2023. Abstract
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Al-Qadhi, M. A., H. A. Allam, S. H. Fahim, T. A. A. Yahya, and F. A. F. Ragab, "Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo {1,5-a}Pyrimidines as multikinase inhibitors", European journal of medicinal chemistry, vol. 262, pp. 115918, 2023. paper_20.pdf
Al-Qadhi, M. A., H. A. Allam, S. H. Fahim, T. A. A. Yahya, and F. A. F. Ragab, "Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo {1,5-a}Pyrimidines as multikinase inhibitors", European journal of medicinal chemistry, vol. 262, pp. 115918, 2023. paper_20.pdf
Elanany, M. A., E. E. A. Osman, E. M. Gedawy, and S. M. Abou-Seri, "Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis.", Scientific reports, vol. 13, issue 1, pp. 4144, 2023. Abstract

To exploit the advantageous properties of approved drugs to hasten anticancer drug discovery, we designed and synthesized a series of fluoroquinolone (FQ) analogs via functionalization of the acid hydrazides of moxifloxacin, ofloxacin, and ciprofloxacin. Under the NCI-60 Human Tumor Cell Line Screening Assay, (IIIf) was the most potent among moxifloxacin derivatives, whereas (VIb) was the only ofloxacin derivative with significant effects and ciprofloxacin derivatives were devoid of activity. (IIIf) and (VIb) were further selected for five-dose evaluation, where they showed potent growth inhibition with a mean GI of 1.78 and 1.45 µM, respectively. (VIb) elicited a more potent effect reaching sub-micromolar level on many cell lines, including MDA-MB-468 and MCF-7 breast cancer cell lines (GI = 0.41 and 0.42 µM, respectively), NSCLC cell line HOP-92 (GI = 0.50 µM) and CNS cell lines SNB-19 and U-251 (GI = 0.51 and 0.61 µM, respectively). (IIIf) and (VIb) arrested MCF-7 cells at G1/S and G1, respectively, and induced apoptosis mainly through the intrinsic pathway as shown by the increased ratio of Bax/Bcl-2 and caspase-9 with a lesser activation of the extrinsic pathway through caspase-8. Both compounds inhibited topoisomerase (Topo) with preferential activity on type II over type I and (VIb) was marginally more potent than (IIIf). Docking study suggests that (IIIf) and (VIb) bind differently to Topo II compared to etoposide. (IIIf) and (VIb) possess high potential for oral absorption, low CNS permeability and low binding to plasma proteins as suggested by in silico ADME calculations. Collectively, (IIIf) and (VIb) represent excellent lead molecules for the development of cytotoxic agents from quinolone scaffolds.

Elanany, M. A., E. E. A. Osman, E. M. Gedawy, and S. M. Abou-Seri, "Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis.", Scientific reports, vol. 13, issue 1, pp. 4144, 2023. Abstractmohamed_adel_el_anany.pdf

To exploit the advantageous properties of approved drugs to hasten anticancer drug discovery, we designed and synthesized a series of fluoroquinolone (FQ) analogs via functionalization of the acid hydrazides of moxifloxacin, ofloxacin, and ciprofloxacin. Under the NCI-60 Human Tumor Cell Line Screening Assay, (IIIf) was the most potent among moxifloxacin derivatives, whereas (VIb) was the only ofloxacin derivative with significant effects and ciprofloxacin derivatives were devoid of activity. (IIIf) and (VIb) were further selected for five-dose evaluation, where they showed potent growth inhibition with a mean GI of 1.78 and 1.45 µM, respectively. (VIb) elicited a more potent effect reaching sub-micromolar level on many cell lines, including MDA-MB-468 and MCF-7 breast cancer cell lines (GI = 0.41 and 0.42 µM, respectively), NSCLC cell line HOP-92 (GI = 0.50 µM) and CNS cell lines SNB-19 and U-251 (GI = 0.51 and 0.61 µM, respectively). (IIIf) and (VIb) arrested MCF-7 cells at G1/S and G1, respectively, and induced apoptosis mainly through the intrinsic pathway as shown by the increased ratio of Bax/Bcl-2 and caspase-9 with a lesser activation of the extrinsic pathway through caspase-8. Both compounds inhibited topoisomerase (Topo) with preferential activity on type II over type I and (VIb) was marginally more potent than (IIIf). Docking study suggests that (IIIf) and (VIb) bind differently to Topo II compared to etoposide. (IIIf) and (VIb) possess high potential for oral absorption, low CNS permeability and low binding to plasma proteins as suggested by in silico ADME calculations. Collectively, (IIIf) and (VIb) represent excellent lead molecules for the development of cytotoxic agents from quinolone scaffolds.

Roy, J., A. Kyani, M. Hanafi, Y. Xu, J. Takyi-Williams, D. Sun, E. E. A. Osman, and N. Neamati, "Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer.", Journal of medicinal chemistry, vol. 66, issue 3, pp. 1990-2019, 2023. Abstract

Sigma 2 receptor (σ2R) is overexpressed in select cancers and is regarded as a biomarker for tumor proliferation. σ2R ligands are emerging as promising theranostics for cancer and neurodegenerative diseases. Herein, we describe the design and synthesis of a series of novel quinolyl pyrazinamides as selective and potent σ2R ligands that show sub-micromolar potency in pancreatic cancer cell lines. Compounds (JR1-157) and (JR2-298) bind σ2R with of 47 and 10 nM, respectively. Importantly, compound has an oral bioavailability of 60% and shows significant in vivo efficacy without obvious toxicity in a syngeneic model of pancreatic cancer. The cytotoxicity of the quinolyl pyrazinamides significantly enhanced in the presence of copper and diminished in the presence of the copper-chelator tetrathiomolybdate. In conclusion, compound is water-soluble, metabolically stable, orally active, and increases the expression of the autophagy marker LC3B and warrants further development for the treatment of pancreatic cancer.

Oudah, K. H., W. R. Mahmoud, F. M. Awadallah, A. T. Taher, S. E. - S. Abbas, H. A. Allam, D. Vullo, and C. T. Supuran, "Design and synthesis of some new benzoylthioureido benzene sulfonamide derivatives and their analogues as carbonic anhydrase inhibitors", Journal of Enzyme Inhibition and Medicinal Chemistry , vol. 38, issue 1, pp. 12-23, 2023. paper_15.pdf
Ahmed, M. R., A. E. Damatty, and K. Dai, "Design load provisions for simulating the critical effect of downbursts on wind turbines", Engineering Structures, vol. 294, 2023.
Amgad, A., H. A. Attia, A. G. Radwan, and M. T. M. M. Elbarawy, "Design of Fractional-order Filters From The Fractional Chebyshev Polynomials: A Meta-Heuristic Approach", Authorea Preprints: Authorea, 2023. Abstract
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El-Hanboushy, S., A. M. Mahmoud, Y. M. Fayez, H. M. Lotfy, M. A. Kawy, and H. M. Marzouk, "Design of Green Polypyrrole-based Solid-contact Ion-selective Sensors for Determination of Antihypertensive Drugs in Combined Dosage Forms and Spiked Human Plasma", Journal of The Electrochemical Society, vol. 170, 2023.
Aldehim, G., R. Marzouk, M. A. Al-Hagery, A. M. Hilal, and A. A. Alneil, "Design of Information Feedback Firefly Algorithm with a Nested Deep Learning Model for Intelligent Gesture Recognition of Visually Disabled People", Journal of Disability Research, vol. 2, issue 2, pp. 120–128, 2023.
Tawfik, A. M., "Design of Open Drains by Solving Richards Equation and Artificial Neural Networks", Ain Shams Engineering Journal, vol. 14, issue 10, pp. 102192, 2023.
Mouhamed, A. A., B. M. Eltanany, N. M. Mostafa, T. A. Elwaie, and A. H. Nadim, "Design of screen-printed potentiometric platform for sensitive determination of mirabegron in spiked human plasma; molecular docking and transducer optimization", RSC advances, vol. 13, issue 33: Royal Society of Chemistry, pp. 23138-23146, 2023. Abstract
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