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2023
Mousa, M. S., S. H. Ahmed, F. A. W. A. Maksoud, S. B. Soliman, and A. A. Tantawy, The diagnostic role of C2PAC index in cases of sepsis-induced coagulopathy (SIC), , vol. 17, issue 1, pp. 58, 2023. AbstractWebsite

To study the potential role of the C2PAC index (a ratio of soluble type C lectin-like receptor 2 level sCLEC-2 and platelet count) in sepsis-induced coagulopathy with the possibility of using this index as an early predictor in sepsis and sepsis-induced coagulopathy.

Ezat, A. A., J. M. Abduljalil, A. M. Elghareib, A. Samir, and A. A. Elfiky, "The discovery of novel antivirals for the treatment of mpox: is drug repurposing the answer?", Expert Opinion on Drug Discovery, vol. 18, issue 5, pp. 551 - 561, 2023. AbstractWebsite

Introduction: Drugs that have demonstrated good activity against any member of the Orthopoxvirus genus are good candidates for repurposing studies against the mpox virus (MPXV). The conserved biology of poxviruses has proven beneficial from a clinical virology perspective. Evolutionarily conserved proteins tend to function in a highly similar way. Indeed, the smallpox vaccine was found to be 85% effective in protecting humans from mpox virus infection. Similarly, tecovirimat, the drug of choice for smallpox infections, was recently repurposed as a treatment option for mpox cases in Europe. Area covered: This review article focuses on drug repurposing strategies to combat the newly emerged MPXV outbreak. The viral and host cell protein targets are challenged with a bunch of drugs and drug-like molecules in silico, in vitro, and in vivo. Some drugs show promising results and can be repurposed to eradicate MPXV infection. The authors also highlight potential limitations and provide their expert perspectives. Expert opinion: Overall, it is clear that we cannot solely rely on the conventional drug discovery pipeline to find new treatments, despite advances in computational and experimental advances in the last few decades. Drug repurposing has successfully identified good candidate drugs against MPXV as it is one of the Orthopoxvirus genus family. Tecovirimat, brincidofovir, and cidofovir have shown promising results in preventing virus propagation. Consequently, drug repurposing represents an important strategy for the fast identification of new therapeutic options. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

Huang, D. - C., Z. He, D. Guo, F. Deng, Q. Bian, H. Zhang, A. S. Ali, M. - Z. Zhang, W. - H. Zhang, and Y. - C. Gu, "Discovery of Novel Benzoxaborole-Containing Streptochlorin Derivatives as Potential Antifungal Agents", Journal of Agricultural and Food Chemistry, vol. 71, issue 16, pp. 6226 - 6235, 2023. AbstractWebsite
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Arabi, D., O. Hamdy, M. S. M. Mohamed, Z. Abdel-Salam, and M. Abdel-Harith, "Discriminating two bacteria via laser-induced breakdown spectroscopy and artificial neural network", AMB Express, vol. 13, issue 1, 2023. Abstract

Rapid and successful clinical diagnosis and bacterial infection treatment depend on accurate identification and differentiation between different pathogenic bacterial species. A lot of efforts have been made to utilize modern techniques which avoid the laborious work and time-consuming of conventional methods to fulfill this task. Among such techniques, laser-induced breakdown spectroscopy (LIBS) can tell much about bacterial identity and functionality. In the present study, a sensitivity-improved version of LIBS, i.e. nano-enhanced LIBS (NELIBS), has been used to discriminate between two different bacteria (Pseudomonas aeruginosa and Proteus mirabilis) belonging to different taxonomic orders. Biogenic silver nanoparticles (AgNPs) are sprinkled onto the samples’ surface to have better discrimination capability of the technique. The obtained spectroscopic results of the NELIBS approach revealed superior differentiation between the two bacterial species compared to the results of the conventional LIBS. Identification of each bacterial species has been achieved in light of the presence of spectral lines of certain elements. On the other hand, the discrimination was successful by comparing the intensity of the spectral lines in the spectra of the two bacteria. In addition, an artificial neural network (ANN) model has been created to assess the variation between the two data sets, affecting the differentiation process. The results revealed that NELIBS provides higher sensitivity and more intense spectral lines with increased detectable elements. The ANN results showed that the accuracy rates are 88% and 92% for LIBS and NELIBS, respectively. In the present work, it has been demonstrated that NELIBS combined with ANN successfully differentiated between both bacteria rapidly with high precision compared to conventional microbiological discrimination techniques and with minimum sample preparation. © 2023, The Author(s).

Saleh, A. A., A. Hafez, K. Amber, A. R. Y. Abdelhady, H. M. Salem, M. Fathy, M. A. Kamal, M. Alagawany, and M. H. Alzawqari, Drug-independent control strategy of clostridial infection in broiler chickens using anti-toxin environmentally friendly multienzymes, , vol. 13, issue 1: Nature Publishing Group UK London, pp. 5614, 2023. Abstract
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Gebremedhn, S., A. Gad, G. M. Ishak, N. G. Menjivar, M. O. Gastal, J. M. Feugang, R. Prochazka, D. Tesfaye, and E. L. Gastal, "Dynamics of extracellular vesicle-coupled microRNAs in equine follicular fluid associated with follicle selection and ovulation", Molecular Human Reproduction, 02, 2023. AbstractWebsite

{Innumerable similarities in reproductive cyclicity and hormonal alterations highlight the considerable utility of the mare to study aspects of follicular dynamics and reproductive function in view of the largely constricted, human research subjects. The bi-directional communication between the growing oocyte and the surrounding somatic cells embodies the hallmark of mammalian follicular development, partially mediated by extracellular vesicles (EVs) encapsulated with microRNAs (miRNAs) and present in the follicular fluid (FF). Here, we aimed to decipher the dynamics of the miRNAs in EVs from equine FF aspirated in vivo during different stages of follicular development, namely, predeviation (PreDev; 18–20 mm), deviation (Dev; 22–25 mm), postdeviation (PostDev; 26–29 mm), preovulatory (PreOV; 30–35 mm), and impending ovulation (IMP; ∼40 mm). Approximately 176 known miRNAs were found in all groups with 144 mutually detected among all groups. Cluster analysis exhibited 15 different expression patterns during follicular development. Among these patterns, a group of 22 miRNAs (including miR-146b-5p, miR-140, and miR-143) exhibited a sharp reduction in expression from the PreDev until the PreOV stage. Another cluster of 23 miRNAs (including miR-106b, miR-199a-5p, and miR-125a-5p) exhibited a stable expression pattern at the PreDev stage until the PostDev stage, with a significant increase at the PreOV stage followed by a significant decrease at the IMP stage. In conclusion, this study provides greater insights into the stage-specific expression dynamics of FF EV-miRNAs during equine follicular development, which may propose novel approaches to improve ART and provide new biomarkers to facilitate the assessment of ovarian pathophysiological conditions.}

Sabry, N., A. M. Kamel, A. Cordie, and G. Esmat, "Daclatasvir as a hepatitis C infection treatment option: An up-to-date evaluation", Expert opinion on pharmacotherapy, vol. 24, no. 2: Taylor & Francis, pp. 159–170, 2023. Abstract
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Sabry, N., A. M. Kamel, A. Cordie, and G. Esmat, "Daclatasvir as a hepatitis C infection treatment option: an up-to-date evaluation.", Expert opinion on pharmacotherapy, vol. 24, issue 2, pp. 159-170, 2023. Abstract

INTRODUCTION: Globally, it is estimated that 290,000 patients infected with hepatitis C virus (HCV) died from hepatitis C consequences, including cirrhosis and hepatocellular carcinoma in 2019. Although daclatasvir (DCV), combined with sofosbuvir (SOF), is effective in HCV patients, the new pan-genotypic combinations are considered by many as more cost-effective and successful in eradicating HCV infection.

AREAS COVERED: This review discusses the safety, efficacy, and cost-effectiveness of DCV as an HCV treatment option based on real-world studies and pharmacoeconomic evaluations.

EXPERT OPINION: Real-life studies suggest that SOF/DCV has acceptable sustained virological response and can be used successfully to manage HCV. Nonetheless, the use of SOF/DCV is limited by the longer treatment duration in genotype (GT)-3 patients and the need for ribavirin (RBV) in treatment-experienced patients which increases the likelihood of adverse effects. DCV is likely to remain as a therapeutic option for the management of GT-1, GT-2, and GT-4 patients in resource limited settings, while GT-3 patients are more likely to benefit from RBV-free direct-acting antiviral combinations such as SOF/velpatasvir for 12 weeks or glecaprevir/pibrentasvir for 8 weeks. The introduction of generics for these new pan-genotypic drugs would likely eliminate the need for SOF/DCV in the near future.

Zaazaa, A., M. N. E. Din, S. F. G. E. Din1, A. Zeidan, M. Y. M. Saleh, A. Adel, and M. Shokr, "Daily intake of 30 mg duloxetine is efective in decreasing premature ejaculation severity: a prospective randomized placebo-controlled cross over clinical trial", . Basic and Clinical Andrology , vol. 33:34, pp. 1-8, 2023.
Mazen, B. S. M., B. M. Ismail, R. R. A. Hassan, and M. Ali, "Damage caused by black inks to the chemical properties of archaeological papyrus – analytical study", Pigment & Resin Technology, vol. 52, issue 1, 2023.
Kamel, A. S., S. M. Farrag, H. M. Mansour, N. N. Nassar, and M. A. Saad, "Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model.", Expert opinion on therapeutic targets, vol. 27, issue 4-5, pp. 373-392, 2023. Abstract

BACKGROUND: However, disturbances in cellular energy demarcate neuronal hyperexcitability in essential tremor (ET); nevertheless, no available data relates energy sensors and GABAergic neurotransmission in ET. Noteworthy, reports have asserted dapagliflozin's (DAPA) role in enhancing autophagic sensors in other disorders. Herein, this study aims to investigate DAPA's impact on the GABA receptor subunit (GABA R2), notwithstanding the GABA A involvement, in an ET model.

METHODS: ET was induced by a single dose of harmaline (30 mg/kg; i.p.), while DAPA (1 mg/kg/day; p.o.) was given for 5 days before ET induction. The autophagic sensors were examined by injecting a single dose of dorsomorphin (DORSO) AMPK inhibitor (0.2 mg/kg; i.p.) on the 5 day before ET induction.

RESULTS: DAPA decreased the HAR-induced tremor score and alleviated motor disabilities observed in the open field, rotarod, wire grip strength, and gait kinematics confirmed by reduced electrical activity in electroencephalogram. In the cerebella, DAPA curbed HAR-evoked inflammatory cytokines, apoptotic markers, and glutamate while restoring the disturbed GABA, BDNF, LKB1, p-AMPK, and GABA R2 levels. DAPA's effect was mostly obliterated by DORSO.

CONCLUSION: DAPA offers a potential neuroprotective effect in ET by augmenting the neuronal inhibitory machinery via suppressing the inflammatory and excitotoxicity systems through LKB1/p-AMPK/GABA R2 signaling.

Farag, M. M., W. El-Sebaie, E. B. Basalious, and O. N. El-Gazayerly, "Darifenacin Self-assembled Liquid Crystal Cubic Nanoparticles: a Sustained Release Approach for an Overnight Control of Overactive Bladder", AAPS PharmSciTech, vol. 24, issue 5: Springer, pp. 120, 2023. Abstract
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Farag, M. M., W. El-Sebaie, E. B. Basalious, and O. N. El-Gazayerly, "Darifenacin Self-assembled Liquid Crystal Cubic Nanoparticles: a Sustained Release Approach for an Overnight Control of Overactive Bladder.", AAPS PharmSciTech, vol. 24, issue 5, pp. 120, 2023. Abstract

The current study is regarding the development and characterization of Darifenacin-loaded self-assembled liquid crystal cubic nanoparticles (LCCN). An anhydrous approach was used for the preparation of these cubic nanoparticles using a hydrotropic agent (propylene glycol), with minimal energy input. Upon dispersion in aqueous medium, the system was successfully transformed to cubosomal nanoparticles counterpart as depicted by transmission electron micrographs. A Box-Behnken design was used to optimize formulation variables, namely A: amount of GMO, B: amount of Pluronic F127, C: amount of PG, and D: amount of HPMC. The design has generated 29 formulae which were tested regarding drug content uniformity, dispersibility in water, particle size, zeta potential, polydispersity index, and in vitro release behavior. The numerical optimization algorithms have generated an optimized formula with high desirability ≈ 1. The optimized formula displayed small particle size, good homogeneity, and zeta potential along with controlled in vitro release profile and ex vivo permeation through rabbit intestine. Thus, self-assembled LCCN might offer an alternative anhydrous approach for the preparation of cubosomal nanoparticles with controlled release profile for a possibly better control of overactive bladder syndrome which tremendously affect the overall life quality.

Elasraag, Y. H. A., and Y. N. Ahmed, "Data Envelopment Analysis for Chickpeas Production in Egypt", Journal of Agricultural Economics and Social Sciences, vol. 14, issue 3: Mansoura University, Faculty of Agriculture, pp. 139-141, 2023. Abstract
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Mesbah, M., M. Shafik, A. Saleem, H. Yousef, and H. Soliman, "A data-driven controller for position tracking of a long-stroke piezoelectric actuator", Microsystem Technologies, 2023.
Jamei, M., N. Bailek, K. Bouchouicha, M. A. Hassan, A. Elbeltagi, A. Kuriqi, N. Al-Ansari, J. Almorox, and E. - S. M. El-kenawy, "Data-driven models for predicting solar radiation in semi-arid regions", Computers, Materials and Continua, vol. 74, issue 1: Tech Science Press, pp. 1625-1640, 2023. Abstract
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Chen, R., N. Xiao, Y. Lu, T. Tao, Q. Huang, S. Wang, Z. Wang, M. Chuan, Q. Bu, Z. Lu, et al., "A de novo evolved gene contributes to rice grain shape difference between indica and japonica.", Nature communications, vol. 14, issue 1, pp. 5906, 2023. Abstractde_novo_.pdf

The role of de novo evolved genes from non-coding sequences in regulating morphological differentiation between species/subspecies remains largely unknown. Here, we show that a rice de novo gene GSE9 contributes to grain shape difference between indica/xian and japonica/geng varieties. GSE9 evolves from a previous non-coding region of wild rice Oryza rufipogon through the acquisition of start codon. This gene is inherited by most japonica varieties, while the original sequence (absence of start codon, gse9) is present in majority of indica varieties. Knockout of GSE9 in japonica varieties leads to slender grains, whereas introgression to indica background results in round grains. Population evolutionary analyses reveal that gse9 and GSE9 are derived from wild rice Or-I and Or-III groups, respectively. Our findings uncover that the de novo GSE9 gene contributes to the genetic and morphological divergence between indica and japonica subspecies, and provide a target for precise manipulation of rice grain shape.

Al-Zahrani, H. S., T. A. A. Moussa, H. Alsamadany, R. M. Hafez, and M. P. Fuller, "De Novo Transcriptome Analysis of SolanuM lycopersicuM cv. Super Strain B under Drought Stress", agronomy, vol. 13, issue 2360, 2023. agronomy-13-02360.pdf
Soliman, H. M., E. Bayoumi, F. El-Sheiki, and M. D. Santis, "Decentralized Sensor Fault-Tolerant Control of DC Microgrids Using the Attracting Ellipsoid Method", snsors, vol. 23, issue 16, pp. art. no. 7160, 2023.
Borham, A., M. K. Okla, M. A. El-Tayeb, A. Gharib, H. Hafiz, L. Liu, C. Zhao, R. Xie, N. He, S. Zhang, et al., "Decolorization of Textile Azo Dye via Solid-State Fermented Wheat Bran by Lasiodiplodia sp. YZH1", Journal of Fungi, vol. 9, issue 1, pp. 1069, 2023. jof-09-01069_published.pdf
Abdelhay1, M., and A. Mohammed, "Deep Learning approach for Arabic Healthcare: MedicalBot", Social Network Analysis and Mining volume, vol. 13, issue 1, pp. 71, 2023.
Abdelhay, M., A. Mohammed, and H. A. Hefny, "Deep learning for Arabic healthcare: MedicalBot", Social Network Analysis and Mining, vol. 13, pp. 2-17, 2023.
Gerardi, V., M. A. Rohaim, R. E. F. Naggar, M. O. Atasoy, and M. Munir, "Deep Structural Analysis of Myriads of Omicron Sub-Variants Revealed Hotspot for Vaccine Escape Immunity.", Vaccines, vol. 11, issue 3, 2023. Abstract

The emergence of the Omicron variant has reinforced the importance of continued SARS-CoV-2 evolution and its possible impact on vaccine effectiveness. Specifically, mutations in the receptor-binding domain (RBD) are critical to comprehend the flexibility and dynamicity of the viral interaction with the human agniotensin-converting enzyme 2 (hACE2) receptor. To this end, we have applied a string of deep structural and genetic analysis tools to map the substitution patterns in the S protein of major Omicron sub-variants (n = 51) with a primary focus on the RBD mutations. This head-to-head comparison of Omicron sub-variants revealed multiple simultaneous mutations that are attributed to antibody escape, and increased affinity and binding to hACE2. Our deep mapping of the substitution matrix indicated a high level of diversity at the N-terminal and RBD domains compared with other regions of the S protein, highlighting the importance of these two domains in a matched vaccination approach. Structural mapping identified highly variable mutations in the up confirmation of the S protein and at sites that critically define the function of the S protein in the virus pathobiology. These substitutional trends offer support in tracking mutations along the evolutionary trajectories of SAR-CoV-2. Collectively, the findings highlight critical areas of mutations across the major Omicron sub-variants and propose several hotspots in the S proteins of SARS-CoV-2 sub-variants to train the future design and development of COVID-19 vaccines.

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