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Youssef, R. M., D. Mahgoub, H. M. Mashaly, E. El-Nabarawy, N. Samir, and M. El-Mofty, "Different narrowband UVB dosage regimens in dark skinned psoriatics: a preliminary study", Photodermatology, photoimmunology & photomedicine, vol. 24, no. 5: Wiley Online Library, pp. 256–259, 2008. Abstract
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Youssef, A. S. E. - D., A. R. N. Zekri, M. Mohanad, S. A. Loutfy, N. F. Abdel Fattah, M. H. Elberry, A. A. El Leithy, A. El-Touny, A. S. Rabie, M. Shalaby, et al., "Deleterious and ethnic-related BRCA1/2 mutations in tissue and blood of Egyptian colorectal cancer patients and its correlation with human papillomavirus.", Clinical and experimental medicine, vol. 23, issue 8, pp. 5063-5088, 2023. Abstract

This study aimed to identify BRCA1/2 mutational patterns in the tissue and blood of Egyptian colorectal cancer (CRC) patients and to study the possible correlation of this mutational pattern with Human papillomavirus (HPV) infection. Eighty-two colonoscopic biopsies and forty-six blood samples were collected from Egyptian CRC patients, as well as blood samples of age and sex-matched healthy controls (n = 43) were enrolled. The libraries were performed using Qiaseq Human BRCA1 and BRCA2 targeted DNA panel and sequenced via Ion proton sequencer. Also, the CRC tissues were subjected to conventional PCR targeting the HPV Late 1 (L1) region. Our analysis revealed that the BRCA-DNA damage pathway had been altered in more than 65% of the CRC patients. Comparing tissue and blood samples from CRC patients, 25 somatic mutations were found exclusively in tissue, while 41 germline mutations were found exclusively in blood. Additionally, we identified 23 shared BRCA1/2 pathogenic (PVs) mutations in both blood and tissue samples, with a significantly higher frequency in blood samples compared to tissue samples. The most affected exon in BRCA1 was exon 10, while the most affected exons in BRCA2 were 11, 14, 18, 24, and 27 exons. Notably, we revealed an ethnic-related cluster of polymorphism variants in our population closely related to South Asian and African ethnicities. Novel PVs were identified and submitted to the ClinVar database. HPV was found in 23.8% of the CRC tissues, and 54% of HPV-positive cases had somatic BRCA1/2 PVs. The results of this research point to a possible connection between infection with HPV and BRCA1/2 mutations in the occurrence of colorectal cancer in the Egyptian population, which has a mixed ethnic background. Our data also indicate that liquid biopsy (blood samples) may be more representative than tissue samples for detecting BRCA1/2 mutations. These findings may have implications for cancer screening and the development of personalized, targeted therapies, such as PARP inhibitors, which can effectively target BRCA1/2 mutations.

Youssef, R., O. Shaker, S. Sobeih, H. Mashaly, and W. Z. Mostafa, "Detection of herpes simplex virus DNA in serum and oral secretions during acute recurrent herpes labialis", Journal of dermatology, vol. 29, no. 7: JAPANESE DERMATOLOGICAL ASSOC, pp. 404–410, 2002. Abstract
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Youssef, A. F. A., Y. M. Issa, O. R. Shehab, and H. Sherief, "Determination of Microgram Amounts of Copper in Real Samples Using New Modified Carbon Paste Electrode", International Journal of Electrochemical Science, vol. 10, pp. 4752-4769, 2015.
Yousry, A., R. Fouad, A. H. Hafez, B. EL-Kholy, and T. Gad, "Diagnostic value of bedside tests ( urine reagent strips and semi quantitative procalcitonin( PCT-Q) in the diagnosis of bacterial meningitis in Egyptian patients.", International Journal of Microbiology and Immunology Research , vol. 2(1), pp. 1-9, 2014.
Yousri, D., A. M. AbdelAty, M. A. A. Al-qaness, A. A. Ewees, A. G. Radwan, and M. abd elaziz, "Discrete fractional-order Caputo method to overcome trapping in local optima: Manta Ray Foraging Optimizer as a case study", Expert Systems with Applications, vol. 192: Pergamon, pp. 116355, 2022. Abstract
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Yousri, D., A. M. AbdelAty, M. A. A. Al-qaness, A. A. Ewees, A. G. Radwan, and M. abd elaziz, "Discrete fractional-order Caputo method to overcome trapping in local optima: Manta Ray Foraging Optimizer as a case study", Expert Systems with Applications, vol. 192: Pergamon, pp. 116355, 2022. Abstract
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Yousri, R., M. Alsenwi, S. M. Darweesh, and T. Ismail, "A Design for An Efficient Hybrid Compression System for EEG Data", 2021 International Conference on Electronic Engineering (ICEEM): IEEE, pp. 1–6, 2021. Abstract
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Yousof, H. - A. S., M. M. Khater, S. H. El-Sayed, and A. A. El-Badry, "Diagnostic biomarkers in murine Cryptosporidiosis: dose-and age-related infection", Journal of Parasitic Diseases, vol. 41: Springer India, pp. 831–836, 2017. Abstract
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Yousof, H. - A. S., M. M. Khater, S. H. El-Sayed, and A. A. El-Badry, "Diagnostic biomarkers in murine Cryptosporidiosis: dose-and age-related infection", Journal of Parasitic Diseases, vol. 41, issue 3: Springer India, pp. 831-836, 2017. Abstract
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Yousof, H. - A. S., M. M. Khater, S. H. El-Sayed, and A. A. El-Badry, "Diagnostic biomarkers in murine Cryptosporidiosis: dose- and age-related infection", Journal of Parasitic Diseases, pp. 1–6, 2017. AbstractWebsite

Increasing prevalence of Cryptosporidium raises the importance to explore different aspects of its infection. In the absence of reproducible in vitro culturing, animal model is the only experimental method to study Cryptosporidium. Our study evaluated Cryptosporidium infection using coproscopy, copro-antigen and copro-DNA for early detection of murine cryptosporidiosis. Hundred and forty albino mice (neonates and adult) were divided into two groups, control group received sterile PBS solution, and infected groups were inoculated with molecularly characterized Cryptosporidium parvum oocysts and further subdivided into three subgroups for infectious dose response detection. Mice fecal samples were collected every 4 h on the first day and then daily and examined for fecal oocysts, copro-antigen and copro-DNA. Four mice from each subgroup were killed at 12, 24 and 48 h post-infection (P-I), and their intestines were examined for cryptosporidial mucosal DNA. Cryptosporidium copro-antigen and copro-DNA were detected 4 and 8 h P-I in infected neonatal and adult mice, respectively, and intestinal mucosal DNA was detected after 12 h in both. Microscopy was able to detect oocysts 48 h P-I. Inoculated C. parvum oocysts were recovered in feces of infected mice without genotypic changes. Neonate mice showed higher susceptibility for cryptosporidial infection than adults without statistical differences for the given infectious doses. Both copro-immunoassay and copro-nPCR assays can early detect Cryptosporidium infection; however, nPCR was able to identify Cryptosporidium species, making nPCR a reliable biomarker for early detection in murine model.

Yousof, H. - A. S., M. M. Khater, S. H. El-Sayed, and A. A. El-Badry, "Diagnostic biomarkers in murine Cryptosporidiosis: dose- and age-related infection", J. Parasit. Dis., vol. 41, no. 3, pp. 831–836, sep, 2017. Abstract

Increasing prevalence of Cryptosporidium raises the importance to explore different aspects of its infection. In the absence of reproducible in vitro culturing, animal model is the only experimental method to study Cryptosporidium. Our study evaluated Cryptosporidium infection using coproscopy, copro-antigen and copro-DNA for early detection of murine cryptosporidiosis. Hundred and forty albino mice (neonates and adult) were divided into two groups, control group received sterile PBS solution, and infected groups were inoculated with molecularly characterized Cryptosporidium parvum oocysts and further subdivided into three subgroups for infectious dose response detection. Mice fecal samples were collected every 4 h on the first day and then daily and examined for fecal oocysts, copro-antigen and copro-DNA. Four mice from each subgroup were killed at 12, 24 and 48 h post-infection (P-I), and their intestines were examined for cryptosporidial mucosal DNA. Cryptosporidium copro-antigen and copro-DNA were detected 4 and 8 h P-I in infected neonatal and adult mice, respectively, and intestinal mucosal DNA was detected after 12 h in both. Microscopy was able to detect oocysts 48 h P-I. Inoculated C. parvum oocysts were recovered in feces of infected mice without genotypic changes. Neonate mice showed higher susceptibility for cryptosporidial infection than adults without statistical differences for the given infectious doses. Both copro-immunoassay and copro-nPCR assays can early detect Cryptosporidium infection; however, nPCR was able to identify Cryptosporidium species, making nPCR a reliable biomarker for early detection in murine model.

Yousif, M., I. Amin, and Y. Ibrahim, "D3-Modules", Communications in Algebra, vol. 42, pp. 578–592, 2014.
Yousef, H. A., A. Afifi, H. M. Mohamed, and A. Abdel Meguid, "DNA damage in haemocyte of Schistocerca gregaria (Orthoptera:Acrididae),exposed to contaminated food with Cd and Pb", Natural Science, , vol. Vol.2(4) , pp. p:292-297, 2010. dna_damage_in_hemocytes.pdf
Yousef, M., A. Hosny, W. Gamil, M. ADEL, H. M. Fahmy, S. M. Darweesh, and H. Mostafa, "Dual-Mode Forward Collision Avoidance Algorithm Based on Vehicle-to-Vehicle (V2V) Communication", IEEE International Midwest Symposium on Circuits and Systems (MWSCAS 2018), Windsor, Ontario, Canada, pp. 739-742, 2018. [PDF]
Yousef, S., H. O. Alsaab, S. Sau, and A. K. Iyer, "Development of asialoglycoprotein receptor directed nanoparticles for selective delivery of curcumin derivative to hepatocellular carcinoma.", Heliyon, vol. 4, issue 12, pp. e01071, 2018. Abstract

Hepatocellular cellular carcinoma (HCC) is one of the most challenging liver cancer subtypes. Due to lack of cell surface biomarkers and highly metastatic nature, early detection and targeted therapy of HCC is an unmet need. Galactosamine (Gal) is among the few selective ligands used for targeting HCCs due to its high binding affinity to asialoglycoprotein receptors (ASGPRs) overexpressed in HCC. In the present work, we engineered nanoscale G4 polyamidoamine (PAMAM) dendrimers anchored to galactosamine and loaded with the potent anticancer curcumin derivative (CDF) as a platform for targeted drug delivery to HCC. targeting ability and bio-distribution of PAMAM-Gal were assessed via its labeling with the clinically used, highly contrast, near infrared (NIR) dye: S0456, with testing of the obtained conjugate in aggressive HCC xenograft model. Our results highlighted the targeted dendrimer PAMAM-Gal ability to achieve selective high cellular uptake via ASGPR mediated endocytosis and significantly enhance the delivery of CDF into the studied HCC cell lines. Cytotoxicity MTT assays in HCC cell lines, interestingly highlighted, the comparative high potency of CDF, where CDF was more potent as a chemotherapeutic anticancer small molecule than the currently in use Doxorubicin, Sorafenib and Cisplatin chemotherapeutic agents. In conclusion the proof-of-concept study using nanoscale PAMAM-Gal dendrimer has demonstrated its competency as an efficient delivery system for selective delivery of potent CDF for HCC anticancer therapy as well as HCC diagnosis via NIR imaging.

Yousef, H. A., A. A. Afify, H. M. Hasan, and A. Abdel Meguid, "DNA damage in hemocytes of Schistocerca gregaria (Orthoptera: Acrididae) exposed to contaminated food with cadmium and lead.", Natural Science, vol. 2, issue 4, pp. 292-297, 2010.
Yousef, W. H., D. K. Ibrahim, and E. Abo El-Zahab, "Discrimination of Internal Faults and Inrush Currents For Large Modern Power Transformer", 14th International Middle East Power Systems Conference (MEPCON’10), Cairo University, Egypt, 2010. Abstract

This paper presents a differential protection approach for large high quality power transformers that have
low inrush currents of about 3.14 times rated currents. Such transformers have low second harmonic level, which results in conventional differential protection malfunction. A scheme for internal faults and inrush currents discrimination based on both discrete Fourier transform DFT and discrete Wavelet Transform
DWT is proposed. The proposed method has been designed based on the percentage of the sum of wavelet transform coefficients D1 and fundamental differential current (based on a 1 kHz sampling
rate). It has been tested by extensive EMTP/ ATP simulations for different faults and switching conditions on El Tebbin Power Plant 220/21 kV generator/power transformer. It is proved that it has a high capability for discrimination even in the case of inrush with low second harmonic content and internal fault currents with high second harmonic component. All tests proved that the proposed scheme is reliable, accurate, and fast.

Yousef, R. H., N. Elrashidi, sahar khairat, M. Gaafar, M. E. Nady, M. balah, and N. soiiman, "Detection of Mycobacterium tuberculosis and drug resistance by GeneXpert® MTB/RIF and Anyplex™ II MTB/MDR in a tertiary care hospital", Medical sciences, vol. 24, issue 105, pp. 3003-3011, 2020.
Yousef, W. H., D. K. Ibrahim, and E. Abo El-Zahab, "Discrimination of Internal Faults and Inrush Currents For Large Modern Power Transformer", Proceedings of 14th International Middle East Power Systems Conference (MEPCON 2010), Cairo, Egypt, 2010. Abstract

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Younis., M. H., E. R. Mohammed, A. R. Mohamed, M. M. Abdel-Aziz, H. H. Georgey, and N. A. M. Gawad, "Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo[3,2-a][1,3,5]triazine derivatives. ", Bioorg. Chem., vol. 124, , pp. 105807- 105824., 2022.
Younis, S. M., R. S. M. Sheded, T. H. Ali, and M. M. Ibrahim, "Development of a drum seeding metering unit for sowing vegetable plug tray seedlings", Plant Archives, vol. 20, issue Supplement 1, pp. 3119-3130, 2020. 204-3119-3130.pdf
Younis, S. M., and G. M. A. and G. M. Nasr, "Development of cotton transplanter", The 12th Annual Conference of MJAE, 15-16 Oct., 2004. Abstract
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Younis, M. H., E. R. Mohammed, A. R. Mohamed, M. M. Abdel-Aziz, H. H. Georgey, and N. A. M. Gawad, "Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo[3,2-a][1,3,5]triazine derivatives.", Bioorganic Chemistry, vol. 124, pp. 105807, 2022. Bioorg. Chem._2022.pdf
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