Background: Favipiravir is an antiviral drug that was recently approved for the management of COVID-19 infection. Aim: This work aimed to develop a new method, using sugaring-out induced homogeneous liquid-liquid microextraction followed by HPLC/UV for the determination of favipiravir in human plasma. Materials & methods: The optimum extraction conditions were attained using 500 μl of tetrahydrofuran as an extractant and 1400 mg of fructose as a phase-separating agent. Results: The developed method was validated according to the US FDA bioanalytical guidelines and was found linear in the range of 25-80,000 ng/ml with a correlation coefficient of 0.999. Conclusion: These results showed that the developed method was simple, easy, valid and adequately sensitive for determination of favipiravir in plasma for bioequivalence studies. © 2022 Newlands Press.

n/a

This paper presents a novel differential 0.13mum CMOS active inductor circuit, which is employed in the design of an integrated negative refractive index metamaterial phase shifter. The active inductor circuit employs a digital/analog tunable feedback resistance to allow controlling both the inductance and the quality factor. The inductance is tunable from 2.5nH to 13.6nH at 5GHz while having a fixed peak quality factor of 100. This results in a phase shift of 36.7deg/stage, at 5GHz, with less than 0.67dB insertion loss

A decision feedback equalizer, transceiver, and method are provided, the equalizer having at least one comparator, the at least one comparator comprising a first stage, comprising a main branch having two track switches with a resistive load, an offset cancellation branch, a plurality of tap branches with transistor sizes smaller than the main branch, in which previous decisions of the equalizer are mixed with the tap weights using current-mode switching, and a cross coupled latch branch; and a second stage, comprising a comparator module for making decisions based on the outputs of the first stage and a clock input, and a plurality of flip-flops for storing the output of the comparator module.

n/a