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Ibrahim, W. W., A. S. Kamel, A. Wahid, and N. F. Abdelkader, "Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/D-galactose Alzheimer's rat model.", Inflammopharmacology, 2022. Abstract

Autophagy and mitochondrial deficits are characteristics of early phase of Alzheimer's disease (AD). Sodium-glucose cotransporter-2 inhibitors have been nominated as a promising class against AD hallmarks. However, there are no available data yet to discuss the impact of gliflozins on autophagic pathways in AD. Peripherally, dapagliflozin's (DAPA) effect is mostly owed to autophagic signals. Thus, the goal of this study is to screen the power of DAPA centrally on LKB1/AMPK/SIRT1/mTOR signaling in the ovariectomized/D-galactose (OVX/D-Gal) rat model. Animals were arbitrarily distributed between 5 groups; the first group undergone sham operation, while remaining groups undergone OVX followed by D-Gal (150 mg/kg/day; i.p.) for 70 days. After 6 weeks, the third, fourth, and fifth groups received DAPA (1 mg/kg/day; p.o.); concomitantly with the AMPK inhibitor dorsomorphin (DORSO, 25 µg/rat, i.v.) in the fourth group and the SIRT1 inhibitor EX-527 (10 µg/rat, i.v.) in the fifth group. DAPA mitigated cognitive deficits of OVX/D-Gal rats, as mirrored in neurobehavioral task with hippocampal histopathological examination and immunohistochemical aggregates of p-Tau. The neuroprotective effect of DAPA was manifested by elevation of energy sensors; AMP/ATP ratio and LKB1/AMPK protein expressions along with autophagic markers; SIRT1, Beclin1, and LC3B expressions. Downstream the latter, DAPA boosted mTOR and mitochondrial function; TFAM, in contrary lessened BACE1. Herein, DORSO or EX-527 co-administration prohibited DAPA's actions where DORSO elucidated DAPA's direct effect on LKB1 while EX-527 mirrored its indirect effect on SIRT1. Therefore, DAPA implied its anti-AD effect, at least in part, via boosting hippocampal LKB1/AMPK/SIRT1/mTOR signaling in OVX/D-Gal rat model.

Hussein, T., M. S. Saad, A. L. Elshafei, and A. Bahgat, "Damping inter-area modes of oscillation using an adaptive fuzzy power system stabilizer", Electric Power Systems Research, vol. 80, no. 12: Elsevier, pp. 1428–1436, 2010. Abstract
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El-Anwar, H. H., H. M. Serror, and S. H. Sayed, "Damping Identification Procedure for Linear Systems: Mixed Numerical-Experimental Approach", Earthquakes and Structures, an International Journal, Techno Press, vol. 4, issue 2, pp. 203-217, 2013.
El-Anwar, H. H., M. H. Serror, and H. S. Sayed, "Damping identification procedure for linear systems: mixed numerical-experimental approach", EARTHQUAKES AND STRUCTURES, vol. 4, no. 2: TECHNO-PRESS PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA, pp. 203–217, 2013. Abstract
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Nakamura, N., S. Kojima, Y. A. Lim, M. R. Meselhy, M. Hattori, M. P. Gupta, and M. Correa, "Dammarane-type triterpenes from Cordia spinescens", Phytochemistry, vol. 46, issue 6: Pergamon, pp. 1139-1141, 1997. Abstract
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Zou, K., S. Zhu, M. R. Meselhy, C. Tohda, S. Cai, and K. Komatsu, "Dammarane-Type Saponins from Panax j aponicus and Their Neurite Outgrowth Activity in SK-N-SH Cells", Journal of natural products, vol. 65, issue 9: American Chemical Society, pp. 1288-1292, 2002. Abstract
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Malaka, M. A., and P. D. M. hamza Alhaddad, "DAMAT RÜSTEM PASHA KHANS IN ISTANBUL: A STUDY OF THE ARCHITECTURE HISTORY", Othello's Island 2018: 6th international conference on Medival studies, At CVAR in Nicosia, Cyprus , 23-27 March, 2018. final_presentation_of_m._malaka.ppt_autosaved.pdf
, "DAMAT RÜSTEM PASHA KHANS IN ISTANBUL: A STUDY OF THE ARCHITECTURE HISTORY", Othello's Island 2018: 6th conference on medieval studies, Nicosia, Cyprus, 23-27 march, 2018.
Mmalaka, "DAMAT RÜSTEM PASHA KHANS IN ISTANBUL: A STUDY OF THE ARCHITECTURE HISTORY", Othello's Island 2018: 6th conference on medieval studies, Nicosia, Cyprus, 23-27 march, 2018.
Mmalaka, "DAMAT RÜSTEM PASHA KHANS IN ISTANBUL: A STUDY OF THE ARCHITECTURE HISTORY", Othello's Island 2018: 6th conference on medieval studies, Nicosia, Cyprus, 23-27 march, 2018.
Mmalaka, "DAMAT RÜSTEM PASHA KHANS IN ISTANBUL: A STUDY OF THE ARCHITECTURE HISTORY", Othello's Island 2018: 6th conference on medieval studies, Nicosia, Cyprus, 23-27 march, 2018.
Malaka, M., and M. H. Alhaddad, "DAMAT RÜSTEM PASHA KHANS IN ISTANBUL: A STUDY OF THE ARCHITECTURE HISTORY", Othello's Island 2018: the 6th international conference on medieval studies, Cyprus, 23-27 march, 2018.
Mohammed, A. M. Y., and K. Maekawa, "DAMAGESTABILITY CONTROL OF MULTI-STORY FRAMES SUPPORTED BY RAFT AND SHEET PILE FOUNDATIONS", International Conference on Earthquake Geotechnical Engineering: From Case History to Practice, Istanbul, June, 2013. damage-stability_control_of_multi-story_frames_supported_by_raft_and_sheet_pile_foundations.pdf
Tawfik, W., W. Aslam Farooq, and Z. A. Alahmed, "Damage profile of HDPE polymer using laser-induced plasma", Journal of the Optical Society of Korea, vol. 18, no. 1: Optical Society of Korea, pp. 50-54, 2014. AbstractWebsite

In this paper we studied the laser-induced crater depth, mass, and emission spectra of laser-ablated high-density polyethylene (HDPE) polymer using the laser-induced plasma spectroscopy (LIPS) technique. This study was performed using a Nd:YAG laser with 100 mJ energy and 7 ns pulse width, focused normal to the surface of the sample. The nanoscale change in ablated depth versus number of laser pulses was studied. By using scanning electron microscope (SEM) images, the crater depth and ablated mass were estimated. The LIPS spectral intensities were observed for major and minor elements with depth. The comparison between the LIPS results and SEM images showed that LIPS could be used to estimate the crater depth, which is of interest for some applications such as thin-film lithography measurements and online measurements of thickness in film deposition techniques.

Tawfik, W., A. W. Farooq, and Z. A. Alahmed, "Damage profile of HDPE polymer using laser-induced plasma", Journal of the Optical Society of Korea, vol. 18, no. 1: Optical Society of Korea, pp. 50–54, 2014. Abstract
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Tawfik, W., A. W. Farooq, and Z. A. Alahmed, "Damage profile of HDPE polymer using laser-induced plasma", Journal of the Optical Society of Korea, vol. 18, issue 1: Optical Society of Korea, pp. 50-54, 2014. Abstract
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Kamal, M. A., A. F. Farid, and Y. F. Rashed, "Damage modeling using Eshelby inclusions", International Journal of Fracture, vol. 229, no. 1: Springer Netherlands, pp. 95–111, 2021. Abstract
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Kamal, M. A., A. F. FARID, and Y. F. Rashed, "Damage modeling using Eshelby inclusions", International Journal of Fracture, vol. 229, issue 1, pp. 95-111, 2021.
undefined, L. HM, M. A, K. AM, and F. N, "Damage index in childhood-onset systemic lupus erythematosus in Egypt.Pediatr Rheumatol ", Pediatr Rheumatology., vol. 9, issue 1, 2011. damage_index_jsle.pdf
Salah, S., H. M. Lotfy, A. N. Mokbel, A. M. Kaddah, and N. Fahmy, "Damage index in childhood-onset systemic lupus erythematosus in Egypt", Pediatric Rheumatology, vol. 9: 36, 2011. AbstractCU-PDF.pdf

Background: To investigate the prevalence of cumulative organ damage among Egyptian children with juvenileonset systemic lupus erythematosus (jSLE) and the relationships between the organ damage and the demographic data, clinical variables, and disease activity.

Salah, S., hala lotfy, A. Mokbel, ahmed kaddah, and N. Fahmy, "Damage index in Childhood-onset systemic lupus erythematosus in Egypt", Pediatr Rheumatol Online J, vol. 9, issue 1, 2011.
Salah, S., hala lotfy, A. Mokbel, ahmed kaddah, and N. Fahmy, "Damage index in Childhood-onset systemic lupus erythematosus in Egypt", Pediatr Rheumatol Online J, vol. 9, issue 1, 2011.
Salah, S., hala lotfy, abir nabil, and ahmed kaddah, "Damage index in childhood -onset systemic lupus erythematosus in Egypt ", Pediatr Rheumatol Online J. 2011 Dec 9;9(1):36. doi: 10.1186/1546-0096-9-36, vol. 1, issue 9, pp. 36, 2011. damage.pdf
Mooty, A. M., and F. E. A. Thabit, "Damage Identification Using Frequency Sensitivity Functions", CSCE Annual Conference, Regina, Saskatchewan, Canada ., May 27-30, 2015.